Tropical Journal of Natural Product Research,
Journal Year:
2024,
Volume and Issue:
8(1)
Published: Feb. 1, 2024
The
Ternate
Blue
Pea,
renowned
for
its
antibacterial
properties
and
native
to
the
northern
Maluku
islands,
has
been
a
subject
of
scientific
investigation.
Despite
previous
studies
on
this
plant,
potential
antibiofilm
activity
against
Staphylococcus
aureus
(SA)
remained
unexplored.
This
research
aimed
assess
efficacy
Pea
flower
extract
(TBPE)
in
inhibiting
eradicating
SA
biofilm
activity.
Antibiofilm
was
evaluated
using
microtiter
broth
method,
with
minimum
inhibitory
concentration
(MBIC50)
eradication
(MBEC50)
values
serving
as
determinants.
mechanism
elucidated
through
scanning
electron
microscopy
(SEM).
Statistical
analysis
conducted
ANOVA
(p<0.05).
Results
revealed
that
TBPE
inhibited
growth
by
85.20%
±
0.01,
slightly
lower
than
control
Vancomycin
at
88.00%
0.01.
In
test,
exhibited
significant
during
mid-phase
(81.40%
0.01)
preventing
formation
maturation
phase
(78.14%
biofilm,
whereas
demonstrated
higher
both
(85.40%
(82.00%
biofilm.
disrupted
74.44%
while
marginally
more
effective
disruption
value
77.00%
SEM
confirmed
could
inhibit
breakdown
damaged
extracellular
polymer
(EPS)
matrix
biofilms.
conclusion,
exhibits
promising
SA.Keywords:
Antibacterial,
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(2), P. 259 - 259
Published: Feb. 18, 2024
Owing
to
the
spread
of
resistance
between
pathogenic
bacteria,
searching
for
novel
compounds
with
antibacterial
activity
is
essential.
Here,
we
investigated
potential
Greek
clover
or
Trigonella
foenum-graecum
herb
extract
on
Salmonella
typhimurium
clinical
isolates.
The
chemical
profile
was
initially
determined
using
LC-ESI-MS/MS,
which
explored
36
different
compounds.
Interestingly,
fenugreek
possessed
action
in
vitro
minimum
inhibitory
concentrations
64
512
µg/mL.
mechanism
studied
by
elucidating
effect
membrane
properties
S.
including
inner
and
outer
permeability
integrity.
Remarkably,
had
detrimental
effects
40–60%
Moreover,
vivo
a
gastrointestinal
infection
model
bacteria.
(200
mg/kg)
improved
outcomes
tested
mice.
This
represented
noteworthy
decrease
(p
<
0.05)
bacterial
count
small
intestine
caecum
tissues.
survival
rate
fenugreek-extract-treated
mice
significantly
increased
compared
typhimurium-infected
group.
Additionally,
there
an
improvement
histological
immunohistochemical
features
tumor
necrosis
factor-alpha.
In
addition,
ELISA
qRT-PCR,
proinflammatory
oxidative
stress
markers
Consequently,
should
be
further
other
food
pathogens.
DELETED,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 13, 2024
Throughout
history,
from
ancient
times
to
the
present
day
in
our
contemporary
and
industrialized
period,
ensuring
availability
of
safe
hygienic
food
has
been
a
significant
challenge
for
human
population.
With
global
population
steadily
increasing,
there
is
growing
need
animal-based
items.
Consequently,
livestock
sectors
face
mounting
pressure
enhance
productivity
sustainability.
Hence,
farmer,
manufacturer,
producers,
researchers
are
seeking
nutritional
supplements
that
might
improve
production
performance
animals.
Lactoferrin
(Lf)
miracle
molecule
newly
discovered
multifunction
protein
found
milk
other
exocrine
secretions.
LF
demonstrated
wide
range
biological
activities,
including
antimicrobial,
anti-inflammatory,
anti-oxidant,
immunomodulatory,
hepatoprotective,
anti-osteoporotic
allied
pathophysiological
conditions.
These
properties
make
lactoferrin
promising
candidate
improving
health
livestock.
used
as
dietary
supplement
animals
growth,
productivity,
overall
health.
Additionally,
it
improves
digestibility
absorption
nutrients
intestine.
Furthermore,
also
reduces
dependency
on
antibiotics
alleviates
environmental
consequences
caused
by
cattle
husbandry.
Although
existing
data
indicates
may
be
beneficial
element
sustainable
production,
further
research
required
comprehensively
comprehend
its
molecular
processes,
appropriate
doses,
possible
negative
effects
when
supplement.
This
review
aims
provide
comprehensive
understanding
applications
surrounding
industry.
