In-silico evaluation of natural alkaloids against the main protease and spike glycoprotein as potential therapeutic agents for SARS-CoV-2 DOI Creative Commons
Mohibullah Shah,

Ramsha Yamin,

Iqra Ahmad

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(1), P. e0294769 - e0294769

Published: Jan. 4, 2024

Severe Acute Respiratory Syndrome Corona Virus (SARS-CoV-2) is the causative agent of COVID-19 pandemic, which has resulted in global fatalities since late December 2019. Alkaloids play a significant role drug design for various antiviral diseases, makes them viable candidates treating COVID-19. To identify potential agents, 102 known alkaloids were subjected to docking studies against two key targets SARS-CoV-2, namely spike glycoprotein and main protease. The vital mediating viral entry into host cells, protease plays crucial replication; therefore, they serve as compelling therapeutic intervention combating disease. From selection alkaloids, top 6 dual inhibitory compounds, liensinine, neferine, isoliensinine, fangchinoline, emetine, acrimarine F, emerged lead compounds with favorable docked scores. Interestingly, most shared bisbenzylisoquinoline alkaloid framework belong Nelumbo nucifera, commonly lotus plant. Docking analysis was conducted by considering active site residues selected proteins. stability three ligands receptor proteins further validated through dynamic simulation analysis. leads underwent ADMET profiling, bioactivity score analysis, evaluation drug-likeness physicochemical properties. Neferine demonstrated particularly strong affinity binding, -7.5025 kcal/mol -10.0245 glycoprotein, therefore interaction both target Of emetine fangchinoline lowest toxicity high LD50 values. These may support body's defense reduce symptoms their numerous biological potentials, even though some properties naturally point direct nature. findings demonstrate promising anti-COVID-19 six making design. This study will be beneficial effective discovery negligible side effects.

Language: Английский

Revolutionizing healthcare: the role of artificial intelligence in clinical practice DOI Creative Commons
Shuroug A. Alowais, Sahar S. Alghamdi, Nada Alsuhebany

et al.

BMC Medical Education, Journal Year: 2023, Volume and Issue: 23(1)

Published: Sept. 22, 2023

Abstract Introduction Healthcare systems are complex and challenging for all stakeholders, but artificial intelligence (AI) has transformed various fields, including healthcare, with the potential to improve patient care quality of life. Rapid AI advancements can revolutionize healthcare by integrating it into clinical practice. Reporting AI’s role in practice is crucial successful implementation equipping providers essential knowledge tools. Research Significance This review article provides a comprehensive up-to-date overview current state practice, its applications disease diagnosis, treatment recommendations, engagement. It also discusses associated challenges, covering ethical legal considerations need human expertise. By doing so, enhances understanding significance supports organizations effectively adopting technologies. Materials Methods The investigation analyzed use system relevant indexed literature, such as PubMed/Medline, Scopus, EMBASE, no time constraints limited articles published English. focused question explores impact applying settings outcomes this application. Results Integrating holds excellent improving selection, laboratory testing. tools leverage large datasets identify patterns surpass performance several aspects. offers increased accuracy, reduced costs, savings while minimizing errors. personalized medicine, optimize medication dosages, enhance population health management, establish guidelines, provide virtual assistants, support mental care, education, influence patient-physician trust. Conclusion be used diagnose diseases, develop plans, assist clinicians decision-making. Rather than simply automating tasks, about developing technologies that across settings. However, challenges related data privacy, bias, expertise must addressed responsible effective healthcare.

Language: Английский

Citations

1069

Summary of ChatGPT-Related research and perspective towards the future of large language models DOI Creative Commons
Yiheng Liu,

Tianle Han,

Siyuan Ma

et al.

Meta-Radiology, Journal Year: 2023, Volume and Issue: 1(2), P. 100017 - 100017

Published: Aug. 18, 2023

This paper presents a comprehensive survey of ChatGPT-related (GPT-3.5 and GPT-4) research, state-of-the-art large language models (LLM) from the GPT series, their prospective applications across diverse domains. Indeed, key innovations such as large-scale pre-training that captures knowledge entire world wide web, instruction fine-tuning Reinforcement Learning Human Feedback (RLHF) have played significant roles in enhancing LLMs' adaptability performance. We performed an in-depth analysis 194 relevant papers on arXiv, encompassing trend analysis, word cloud representation, distribution various application The findings reveal increasing interest predominantly centered direct natural processing applications, while also demonstrating considerable potential areas ranging education history to mathematics, medicine, physics. study endeavors furnish insights into ChatGPT's capabilities, implications, ethical concerns, offer direction for future advancements this field.

Language: Английский

Citations

392

ChatGPT: Fundamentals, Applications and Social Impacts DOI
Malak Abdullah, Alia Madain, Yaser Jararweh

et al.

Published: Nov. 29, 2022

Recent progress in large language models has pushed the boundaries of natural processing, setting new standards for performance. It is remarkable how artificial intelligence can mimic human behavior and writing style such a convincing way. As result, it hard to tell if or machine wrote something. Deep learning processing have recently advanced models. These newer learn from amounts data better capture nuances language, making them more accurate robust than ever before. Additionally, these now be applied tasks as summarizing text, translating between languages, even generating original content. ChatGPT (NLP) model developed 2022 by OpenAI open-ended conversations. based on GPT-3.5, third-generation OpenAI. power conversational AI applications like virtual assistants chatbots. In this paper, we describe current version discuss model's potential possible social impact. Disclaimer: This paper was not written ChatGPT: listed authors.

Language: Английский

Citations

193

Opportunities and risks of ChatGPT in medicine, science, and academic publishing: a modern Promethean dilemma DOI Creative Commons
Jan Homolak

Croatian Medical Journal, Journal Year: 2023, Volume and Issue: 64(1), P. 1 - 3

Published: Feb. 1, 2023

Language: Английский

Citations

165

Using AI to write scholarly publications DOI
Mohammad Hosseini, Lisa M. Rasmussen, David B. Resnik

et al.

Accountability in Research, Journal Year: 2023, Volume and Issue: 31(7), P. 715 - 723

Published: Jan. 25, 2023

Language: Английский

Citations

164

Fighting reviewer fatigue or amplifying bias? Considerations and recommendations for use of ChatGPT and other large language models in scholarly peer review DOI Creative Commons
Mohammad Hosseini, Serge P. J. M. Horbach

Research Integrity and Peer Review, Journal Year: 2023, Volume and Issue: 8(1)

Published: May 17, 2023

The emergence of systems based on large language models (LLMs) such as OpenAI's ChatGPT has created a range discussions in scholarly circles. Since LLMs generate grammatically correct and mostly relevant (yet sometimes outright wrong, irrelevant or biased) outputs response to provided prompts, using them various writing tasks including peer review reports could result improved productivity. Given the significance reviews existing publication landscape, exploring challenges opportunities seems urgent. After generation first with LLMs, we anticipate that too would be generated help these systems. However, there are currently no guidelines how should used tasks.

Language: Английский

Citations

128

Attention is all you need: utilizing attention in AI-enabled drug discovery DOI Creative Commons
Yang Zhang, Caiqi Liu, Mujiexin Liu

et al.

Briefings in Bioinformatics, Journal Year: 2023, Volume and Issue: 25(1)

Published: Nov. 22, 2023

Abstract Recently, attention mechanism and derived models have gained significant traction in drug development due to their outstanding performance interpretability handling complex data structures. This review offers an in-depth exploration of the principles underlying attention-based advantages discovery. We further elaborate on applications various aspects development, from molecular screening target binding property prediction molecule generation. Finally, we discuss current challenges faced application mechanisms Artificial Intelligence technologies, including quality, model computational resource constraints, along with future directions for research. Given accelerating pace technological advancement, believe that will increasingly prominent role anticipate these usher revolutionary breakthroughs pharmaceutical domain, significantly development.

Language: Английский

Citations

124

Gender bias and stereotypes in Large Language Models DOI Open Access
Hadas Kotek, Rikker Dockum,

David Sun

et al.

Published: Oct. 13, 2023

Large Language Models (LLMs) have made substantial progress in the past several months, shattering state-of-the-art benchmarks many domains. This paper investigates LLMs' behavior with respect to gender stereotypes, a known issue for prior models. We use simple paradigm test presence of bias, building on but differing from WinoBias, commonly used bias dataset, which is likely be included training data current LLMs. four recently published LLMs and demonstrate that they express biased assumptions about men women's occupations. Our contributions this are as follows: (a) 3-6 times more choose an occupation stereotypically aligns person's gender; (b) these choices align people's perceptions better than ground truth reflected official job statistics; (c) fact amplify beyond what or truth; (d) ignore crucial ambiguities sentence structure 95% time our study items, when explicitly prompted, recognize ambiguity; (e) provide explanations their factually inaccurate obscure true reason behind predictions. That is, rationalizations behavior. highlights key property models: trained imbalanced datasets; such, even recent successes reinforcement learning human feedback, tend reflect those imbalances back at us. As other types societal biases, we suggest must carefully tested ensure treat minoritized individuals communities equitably.

Language: Английский

Citations

117

Using ChatGPT in Medical Research: Current Status and Future Directions DOI Creative Commons
Suebsarn Ruksakulpiwat,

Ayanesh Kumar,

Anuoluwapo Ajibade

et al.

Journal of Multidisciplinary Healthcare, Journal Year: 2023, Volume and Issue: Volume 16, P. 1513 - 1520

Published: May 1, 2023

This review aims to evaluate the current evidence on use of Generative Pre-trained Transformer (ChatGPT) in medical research, including but not limited treatment, diagnosis, or medication provision.

Language: Английский

Citations

116

Integrating Artificial Intelligence for Drug Discovery in the Context of Revolutionizing Drug Delivery DOI Creative Commons
Anita Ioana Vișan, Irina Neguț

Life, Journal Year: 2024, Volume and Issue: 14(2), P. 233 - 233

Published: Feb. 7, 2024

Drug development is expensive, time-consuming, and has a high failure rate. In recent years, artificial intelligence (AI) emerged as transformative tool in drug discovery, offering innovative solutions to complex challenges the pharmaceutical industry. This manuscript covers multifaceted role of AI encompassing AI-assisted delivery design, discovery new drugs, novel techniques. We explore various methodologies, including machine learning deep learning, their applications target identification, virtual screening, design. paper also discusses historical medicine, emphasizing its profound impact on healthcare. Furthermore, it addresses AI’s repositioning existing drugs identification combinations, underscoring potential revolutionizing systems. The provides comprehensive overview programs platforms currently used illustrating technological advancements future directions this field. study not only presents current state but anticipates trajectory, highlighting opportunities that lie ahead.

Language: Английский

Citations

82