PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(1), P. e0294769 - e0294769
Published: Jan. 4, 2024
Severe
Acute
Respiratory
Syndrome
Corona
Virus
(SARS-CoV-2)
is
the
causative
agent
of
COVID-19
pandemic,
which
has
resulted
in
global
fatalities
since
late
December
2019.
Alkaloids
play
a
significant
role
drug
design
for
various
antiviral
diseases,
makes
them
viable
candidates
treating
COVID-19.
To
identify
potential
agents,
102
known
alkaloids
were
subjected
to
docking
studies
against
two
key
targets
SARS-CoV-2,
namely
spike
glycoprotein
and
main
protease.
The
vital
mediating
viral
entry
into
host
cells,
protease
plays
crucial
replication;
therefore,
they
serve
as
compelling
therapeutic
intervention
combating
disease.
From
selection
alkaloids,
top
6
dual
inhibitory
compounds,
liensinine,
neferine,
isoliensinine,
fangchinoline,
emetine,
acrimarine
F,
emerged
lead
compounds
with
favorable
docked
scores.
Interestingly,
most
shared
bisbenzylisoquinoline
alkaloid
framework
belong
Nelumbo
nucifera,
commonly
lotus
plant.
Docking
analysis
was
conducted
by
considering
active
site
residues
selected
proteins.
stability
three
ligands
receptor
proteins
further
validated
through
dynamic
simulation
analysis.
leads
underwent
ADMET
profiling,
bioactivity
score
analysis,
evaluation
drug-likeness
physicochemical
properties.
Neferine
demonstrated
particularly
strong
affinity
binding,
-7.5025
kcal/mol
-10.0245
glycoprotein,
therefore
interaction
both
target
Of
emetine
fangchinoline
lowest
toxicity
high
LD50
values.
These
may
support
body's
defense
reduce
symptoms
their
numerous
biological
potentials,
even
though
some
properties
naturally
point
direct
nature.
findings
demonstrate
promising
anti-COVID-19
six
making
design.
This
study
will
be
beneficial
effective
discovery
negligible
side
effects.
BMC Medical Education,
Journal Year:
2023,
Volume and Issue:
23(1)
Published: Sept. 22, 2023
Abstract
Introduction
Healthcare
systems
are
complex
and
challenging
for
all
stakeholders,
but
artificial
intelligence
(AI)
has
transformed
various
fields,
including
healthcare,
with
the
potential
to
improve
patient
care
quality
of
life.
Rapid
AI
advancements
can
revolutionize
healthcare
by
integrating
it
into
clinical
practice.
Reporting
AI’s
role
in
practice
is
crucial
successful
implementation
equipping
providers
essential
knowledge
tools.
Research
Significance
This
review
article
provides
a
comprehensive
up-to-date
overview
current
state
practice,
its
applications
disease
diagnosis,
treatment
recommendations,
engagement.
It
also
discusses
associated
challenges,
covering
ethical
legal
considerations
need
human
expertise.
By
doing
so,
enhances
understanding
significance
supports
organizations
effectively
adopting
technologies.
Materials
Methods
The
investigation
analyzed
use
system
relevant
indexed
literature,
such
as
PubMed/Medline,
Scopus,
EMBASE,
no
time
constraints
limited
articles
published
English.
focused
question
explores
impact
applying
settings
outcomes
this
application.
Results
Integrating
holds
excellent
improving
selection,
laboratory
testing.
tools
leverage
large
datasets
identify
patterns
surpass
performance
several
aspects.
offers
increased
accuracy,
reduced
costs,
savings
while
minimizing
errors.
personalized
medicine,
optimize
medication
dosages,
enhance
population
health
management,
establish
guidelines,
provide
virtual
assistants,
support
mental
care,
education,
influence
patient-physician
trust.
Conclusion
be
used
diagnose
diseases,
develop
plans,
assist
clinicians
decision-making.
Rather
than
simply
automating
tasks,
about
developing
technologies
that
across
settings.
However,
challenges
related
data
privacy,
bias,
expertise
must
addressed
responsible
effective
healthcare.
Meta-Radiology,
Journal Year:
2023,
Volume and Issue:
1(2), P. 100017 - 100017
Published: Aug. 18, 2023
This
paper
presents
a
comprehensive
survey
of
ChatGPT-related
(GPT-3.5
and
GPT-4)
research,
state-of-the-art
large
language
models
(LLM)
from
the
GPT
series,
their
prospective
applications
across
diverse
domains.
Indeed,
key
innovations
such
as
large-scale
pre-training
that
captures
knowledge
entire
world
wide
web,
instruction
fine-tuning
Reinforcement
Learning
Human
Feedback
(RLHF)
have
played
significant
roles
in
enhancing
LLMs'
adaptability
performance.
We
performed
an
in-depth
analysis
194
relevant
papers
on
arXiv,
encompassing
trend
analysis,
word
cloud
representation,
distribution
various
application
The
findings
reveal
increasing
interest
predominantly
centered
direct
natural
processing
applications,
while
also
demonstrating
considerable
potential
areas
ranging
education
history
to
mathematics,
medicine,
physics.
study
endeavors
furnish
insights
into
ChatGPT's
capabilities,
implications,
ethical
concerns,
offer
direction
for
future
advancements
this
field.
Recent
progress
in
large
language
models
has
pushed
the
boundaries
of
natural
processing,
setting
new
standards
for
performance.
It
is
remarkable
how
artificial
intelligence
can
mimic
human
behavior
and
writing
style
such
a
convincing
way.
As
result,
it
hard
to
tell
if
or
machine
wrote
something.
Deep
learning
processing
have
recently
advanced
models.
These
newer
learn
from
amounts
data
better
capture
nuances
language,
making
them
more
accurate
robust
than
ever
before.
Additionally,
these
now
be
applied
tasks
as
summarizing
text,
translating
between
languages,
even
generating
original
content.
ChatGPT
(NLP)
model
developed
2022
by
OpenAI
open-ended
conversations.
based
on
GPT-3.5,
third-generation
OpenAI.
power
conversational
AI
applications
like
virtual
assistants
chatbots.
In
this
paper,
we
describe
current
version
discuss
model's
potential
possible
social
impact.
Disclaimer:
This
paper
was
not
written
ChatGPT:
listed
authors.
Research Integrity and Peer Review,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: May 17, 2023
The
emergence
of
systems
based
on
large
language
models
(LLMs)
such
as
OpenAI's
ChatGPT
has
created
a
range
discussions
in
scholarly
circles.
Since
LLMs
generate
grammatically
correct
and
mostly
relevant
(yet
sometimes
outright
wrong,
irrelevant
or
biased)
outputs
response
to
provided
prompts,
using
them
various
writing
tasks
including
peer
review
reports
could
result
improved
productivity.
Given
the
significance
reviews
existing
publication
landscape,
exploring
challenges
opportunities
seems
urgent.
After
generation
first
with
LLMs,
we
anticipate
that
too
would
be
generated
help
these
systems.
However,
there
are
currently
no
guidelines
how
should
used
tasks.
Briefings in Bioinformatics,
Journal Year:
2023,
Volume and Issue:
25(1)
Published: Nov. 22, 2023
Abstract
Recently,
attention
mechanism
and
derived
models
have
gained
significant
traction
in
drug
development
due
to
their
outstanding
performance
interpretability
handling
complex
data
structures.
This
review
offers
an
in-depth
exploration
of
the
principles
underlying
attention-based
advantages
discovery.
We
further
elaborate
on
applications
various
aspects
development,
from
molecular
screening
target
binding
property
prediction
molecule
generation.
Finally,
we
discuss
current
challenges
faced
application
mechanisms
Artificial
Intelligence
technologies,
including
quality,
model
computational
resource
constraints,
along
with
future
directions
for
research.
Given
accelerating
pace
technological
advancement,
believe
that
will
increasingly
prominent
role
anticipate
these
usher
revolutionary
breakthroughs
pharmaceutical
domain,
significantly
development.
Large
Language
Models
(LLMs)
have
made
substantial
progress
in
the
past
several
months,
shattering
state-of-the-art
benchmarks
many
domains.
This
paper
investigates
LLMs'
behavior
with
respect
to
gender
stereotypes,
a
known
issue
for
prior
models.
We
use
simple
paradigm
test
presence
of
bias,
building
on
but
differing
from
WinoBias,
commonly
used
bias
dataset,
which
is
likely
be
included
training
data
current
LLMs.
four
recently
published
LLMs
and
demonstrate
that
they
express
biased
assumptions
about
men
women's
occupations.
Our
contributions
this
are
as
follows:
(a)
3-6
times
more
choose
an
occupation
stereotypically
aligns
person's
gender;
(b)
these
choices
align
people's
perceptions
better
than
ground
truth
reflected
official
job
statistics;
(c)
fact
amplify
beyond
what
or
truth;
(d)
ignore
crucial
ambiguities
sentence
structure
95%
time
our
study
items,
when
explicitly
prompted,
recognize
ambiguity;
(e)
provide
explanations
their
factually
inaccurate
obscure
true
reason
behind
predictions.
That
is,
rationalizations
behavior.
highlights
key
property
models:
trained
imbalanced
datasets;
such,
even
recent
successes
reinforcement
learning
human
feedback,
tend
reflect
those
imbalances
back
at
us.
As
other
types
societal
biases,
we
suggest
must
carefully
tested
ensure
treat
minoritized
individuals
communities
equitably.
Journal of Multidisciplinary Healthcare,
Journal Year:
2023,
Volume and Issue:
Volume 16, P. 1513 - 1520
Published: May 1, 2023
This
review
aims
to
evaluate
the
current
evidence
on
use
of
Generative
Pre-trained
Transformer
(ChatGPT)
in
medical
research,
including
but
not
limited
treatment,
diagnosis,
or
medication
provision.
Life,
Journal Year:
2024,
Volume and Issue:
14(2), P. 233 - 233
Published: Feb. 7, 2024
Drug
development
is
expensive,
time-consuming,
and
has
a
high
failure
rate.
In
recent
years,
artificial
intelligence
(AI)
emerged
as
transformative
tool
in
drug
discovery,
offering
innovative
solutions
to
complex
challenges
the
pharmaceutical
industry.
This
manuscript
covers
multifaceted
role
of
AI
encompassing
AI-assisted
delivery
design,
discovery
new
drugs,
novel
techniques.
We
explore
various
methodologies,
including
machine
learning
deep
learning,
their
applications
target
identification,
virtual
screening,
design.
paper
also
discusses
historical
medicine,
emphasizing
its
profound
impact
on
healthcare.
Furthermore,
it
addresses
AI’s
repositioning
existing
drugs
identification
combinations,
underscoring
potential
revolutionizing
systems.
The
provides
comprehensive
overview
programs
platforms
currently
used
illustrating
technological
advancements
future
directions
this
field.
study
not
only
presents
current
state
but
anticipates
trajectory,
highlighting
opportunities
that
lie
ahead.