Efficient Biosynthesis of Monacolin J through Enzymatic Hydrolysis Using a Recombinant Lovastatin Hydrolase DOI Open Access
He Wei,

Benshun Chen,

Bin Yin

et al.

Processes, Journal Year: 2024, Volume and Issue: 12(9), P. 2006 - 2006

Published: Sept. 18, 2024

Simvastatin is a widely used statin medication that commonly prescribed to lower cholesterol levels and reduce the risk of cardiovascular events. It marketed under brand name Zocor known for its effectiveness in treating high managing disease. Monacolin J an important precursor synthesize simvastatin mainly produced by chemical methods industry. Here, monacolin was synthesized through enzymatic method optimized reaction conditions. One recombinant Escherichia coli BL21 (DE3) strain containing lovastatin hydrolase (encoded CDV55_102090) from Aspergillus turcosus constructed, which effectively transformed 100 g/L within 3.5 h at pH 8.0 30 °C, with conversion rate >99.8%. Furthermore, T5010, temperature residual activity half initial after 10 min heat treatment, >50 indicating tremendous potential this bioprocess synthesizing industrial scale.

Language: Английский

Simvastatin-Loaded Polymeric Nanoparticles: Targeting Inflammatory Macrophages for Local Adipose Tissue Browning in Obesity Treatment DOI
Neda Mohaghegh, Amir Ahari, Claire Buttles

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 29, 2024

Obesity is defined as chronic, low-grade inflammation within specific tissues. Given the escalating prevalence of obesity among individuals all ages, has reached epidemic proportions, posing an important public health challenge. Despite significant advancements in treating obesity, conventional approaches remain largely ineffective or involve severe side effects, thus underscoring pressing need to explore and develop treatment approaches. Targeted local immunomodulation using nanoparticles (NPs) can influence fat production utilization processes. Statins, known for their anti-inflammatory properties, show potential mitigating obesity-related inflammation. A localized delivery option offers several advantages over oral parenteral methods. Here, we developed simvastatin (Sim) encapsulated PLGA NPs (Sim-NP) Sim adipose tissues (ATs) treat obesity. In vitro experiments revealed strong effects Sim-NPs, which resulted enhanced modulation macrophage (MΦ) polarization induction AT browning. We then extended our investigation

Language: Английский

Citations

9
Statins Reduce Delirium Risk in Older Adults With Type 2 Diabetes DOI
Mingyang Sun,

Xiaoling Wang,

Zhongyuan Lu

et al.

Journal of the American Medical Directors Association, Journal Year: 2025, Volume and Issue: 26(4), P. 105490 - 105490

Published: Feb. 22, 2025

Language: Английский

Citations

0
HMG-CoA reductase inhibitor simvastatin ameliorates trimethyltin neurotoxicity and cognitive impairment through reversal of Alzheimer’s-associated markers DOI
Ali‐Akbar Salari, Mehrdad Roghani, Mohsen Khalili

et al.

Metabolic Brain Disease, Journal Year: 2024, Volume and Issue: 40(1)

Published: Dec. 20, 2024

Language: Английский

Citations

3
Efficacy of a novel glioma therapy based on ferroptosis induced by layered double hydroxide loaded with simvastatin DOI
Wei Peng, Yufeng Qian, Xuchen Qi

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 238, P. 117112 - 117112

Published: Sept. 15, 2023

Language: Английский

Citations

8
The Association between Statin Use and Reduced Migraine Likelihood: A Comprehensive Analysis of Migraine Subtypes and Statin Types in a Nationwide Korean Cohort DOI Creative Commons
Ho Suk Kang, Joo Hee Kim, Ji Hee Kim

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 1056 - 1056

Published: Aug. 10, 2024

Despite growing interest in the preventive effects of statins, as lipid-lowering agents, on migraine attacks, comprehensive nationwide studies comparing likelihood between statin users and controls are lacking. Our nested case–control study within Korean National Health Insurance Service-Health Screening Cohort (2002–2019) investigated this association using 38,957 patients 155,828 controls, considering subtypes (with/without aura) types (lipophilic vs. hydrophilic). Using propensity score matching adjusting for confounders, use was linked to reduced overall (odds ratio (OR) 0.93), particularly migraines with aura (OR 0.75) without 0.94). Lipophilic statins were effective both subtypes, while hydrophilic mainly aura. Subgroup analyses showed consistent benefits across demographics, but varied effectiveness based weight, smoking, alcohol use, hemoglobin levels, dyslipidemia history. In summary, cohort suggests that may reduce among adults diverse demographics clinical profiles, certain lifestyle comorbidity factors underscores importance individual patient profiles when assessing potential therapy prevention.

Language: Английский

Citations

2
Altered Brain Cholesterol Machinery in a Down Syndrome Mouse Model: A Possible Common Feature with Alzheimer’s Disease DOI Creative Commons
Erica Staurenghi, Gabriella Testa, Valerio Leoni

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 435 - 435

Published: April 3, 2024

Down syndrome (DS) is a complex chromosomal disorder considered as genetically determined form of Alzheimer’s disease (AD). Maintenance brain cholesterol homeostasis essential for functioning and development, its dysregulation associated with AD neuroinflammation oxidative damage. Brain imbalances also likely occur in DS, concurring the precocious AD-like neurodegeneration. In this pilot study, we analyzed, Ts2Cje (Ts2) mouse model expression genes encoding key enzymes involved metabolism levels main precursors products (i.e., oxysterols). The results showed, Ts2 mice compared to euploid mice, downregulation transcription 3-hydroxy-3-methylglutaryl-CoA reductase 24-dehydrocholesterol reductase, latter originally recognized an indicator AD, consequent reduction total levels. Moreover, responsible oxidation amounts resulting oxysterols were modified brains, autoxidation increased, suggesting exacerbation cerebral stress. We observed enhanced inflammatory response underlined by upregulation α-interferon interleukin-6, two cytokines whose synthesis increased brains patients. Overall, these suggest that DS share cycle derangements altered oxysterol levels, which may contribute events both diseases.

Language: Английский

Citations

1
Simvastatin, Its Antimicrobial Activity and Its Prevention of Alzheimer’s Disease DOI Creative Commons
Sudip Dhakal, Ian Macreadie

Microorganisms, Journal Year: 2024, Volume and Issue: 12(6), P. 1133 - 1133

Published: June 1, 2024

Simvastatin, a blockbuster drug for treating hypercholesterolemia, has multifactorial benefits as an antimicrobial agent and plays preventative role in reducing the incidence of Alzheimer’s Disease (AD). Although most beneficial effects simvastatin have been attributed to its ability reduce cholesterol levels, recent scientific studies suggested that are largely due pleiotropic targeting other pathways, e.g., by inhibiting protein lipidation. There certain can be predicted from inhibition mevalonate pathway; however, some proteostasis lead reduced levels amyloid beta, key contributor AD. This review discusses use anti-AD drug.

Language: Английский

Citations

1
SALIQ in Rhabdomyosarcoma: A Repurposed Multidrug Regimen to Augment Standard Treatments by Adding Simvastatin, All Trans Retinoic Acid, Lithium, Itraconazole, and Quercetin DOI Open Access
Richard E. Kast, Mohamed S. Zaghloul, Iacopo Sardi

et al.

Published: Sept. 28, 2023

Rhabdomyosarcoma is a cancer arising from arrested myogenic differentiation, seen mainly in children or adolescents. Metastatic rhabdomyosarcoma often fatal even with aggressive cytotoxic chemotherapies, surgery, and irradiation. SALIQ an acronym for multidrug augmentation regimen designed as adjunct to current chemotherapies. uses five common non-oncology drugs, repurposed general medicine use, promote malignant clone maturation inhibit growth. The drugs are: the cholesterol lowering drug simvastatin, acne tretinoin (ATRA), psychiatric lithium carbonate, antifungal itraconazole, food supplement quercetin. All are use non-cancer conditions, cheap, have eminently safe side effect profile, all preclinical evidence good rationale inhibiting

Language: Английский

Citations

1
Delayed simvastatin treatment improves neurological recovery after cryogenic traumatic brain injury through downregulation of ELOVL1 by inhibiting mTOR signaling DOI Creative Commons
Jing Huo, Lin Feng,

Yao Cheng

et al.

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 217, P. 111072 - 111072

Published: Sept. 6, 2024

Language: Английский

Citations

0
Efficient Biosynthesis of Monacolin J through Enzymatic Hydrolysis Using a Recombinant Lovastatin Hydrolase DOI Open Access
He Wei,

Benshun Chen,

Bin Yin

et al.

Processes, Journal Year: 2024, Volume and Issue: 12(9), P. 2006 - 2006

Published: Sept. 18, 2024

Simvastatin is a widely used statin medication that commonly prescribed to lower cholesterol levels and reduce the risk of cardiovascular events. It marketed under brand name Zocor known for its effectiveness in treating high managing disease. Monacolin J an important precursor synthesize simvastatin mainly produced by chemical methods industry. Here, monacolin was synthesized through enzymatic method optimized reaction conditions. One recombinant Escherichia coli BL21 (DE3) strain containing lovastatin hydrolase (encoded CDV55_102090) from Aspergillus turcosus constructed, which effectively transformed 100 g/L within 3.5 h at pH 8.0 30 °C, with conversion rate >99.8%. Furthermore, T5010, temperature residual activity half initial after 10 min heat treatment, >50 indicating tremendous potential this bioprocess synthesizing industrial scale.

Language: Английский

Citations

0