Citrus Pomace as a Source of Plant Complexes to Be Used in the Nutraceutical Field of Intestinal Inflammation

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 869 - 869

Published: July 19, 2024

This study aims to recover the main by-product of Citrus fruits processing, raw pomace, known also as pastazzo, produce plant complexes be used in treatment inflammatory bowel disease (IBD). Food-grade extracts from orange (OE) and lemon (LE) pomace were obtained by ultrasound-assisted maceration. After a preliminary phytochemical biological screening vitro assays, primary secondary metabolites characterized proton nuclear magnetic resonance (1H-NMR) liquid chromatography coupled diode array detection electrospray ionization mass spectrometry (LC-DAD-ESI-MS) analyses. The intestinal bioaccessibility antioxidant anti-inflammatory properties investigated simulated gastro-intestinal digestion followed treatments on lipopolysaccharide (LPS)-stimulated human colorectal adenocarcinoma cell line (Caco-2). tight junctions-associated structural proteins (ZO-1, Claudin-1, Occludin), transepithelial electrical resistance (TEER), reactive oxygen species (ROS)-levels, expression some key (CAT, NRF2 SOD2) (IL-1β, IL-6, TNF-α, IL-8) genes, pNFkB p65 translocation, evaluated. OE LE digesta, which did not show any significant difference terms profile, showed effects protecting against LPS-induced barrier damage, oxidative stress response. In conclusion, both emerged potential candidates for further preclinical studies vivo IBD models.

Language: Английский

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Efficacy Study of Eco-Friendly Bleaching Agent for Skeleton Preservation in Animal Skeleton

Journal of Biota, Journal Year: 2024, Volume and Issue: unknown, P. 84 - 91

Published: Feb. 5, 2024

The currently used bleaching materials in skeletal preservation are hydrogen and carbamide peroxide with specific concentrations techniques that impact environmental sustainability. This research describes a simple eco-friendly technique for preserving skeletons. qualitative approach. Data were collected through observation documentation. data analyzed descriptively. results show natural extracts, such as lemon combined baking soda commercial cloth agent, can bleach the skull bone to preserve skeleton. agent is more capable of animal skulls bones skeletons than extracts do; however, result brittle Although specimens extract solution slowly clean skeleton solution, animals have bond strength environment-friendly processes. study recommends an should be applied because it cope biological practices about osteology other science subjects.

Language: Английский

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Citrus seed waste and circular bioeconomy: insights on nutritional profile, health benefits, and application as food ingredient

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 67 - 84

Published: Jan. 1, 2024

Language: Английский

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Ultrasound-assisted vacuum drying of limequat peels and characterization of thermal, morphological and functional properties

Thermal Science and Engineering Progress, Journal Year: 2024, Volume and Issue: 54, P. 102841 - 102841

Published: Aug. 26, 2024

Language: Английский

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Anticancer Activity of Flavanone Isolated from Citrus medica and its Combination Effect with a Synthetic Drug 2-Deoxy-D-Glucose

Oriental Journal Of Chemistry, Journal Year: 2024, Volume and Issue: 40(4), P. 1116 - 1126

Published: Aug. 30, 2024

Cancer research is an on-going field aimed at discovering novel treatments for various stages of the disease. Although chemo and hormonal therapy have been found to be effective in treating cancer, there are still challenges draw a parallel with them, such as therapeutic resistance repetitiveness, which make disease difficult control. Therefore, it imperative explore alternative therapies that can provide better treatment outcomes. The present work towards potential use phytochemicals, particularly flavonoids Citrus medica leaves, breast cancer. Using chromatographic techniques, flavanone, compound citrus extract, was isolated its structure characterized using UV, FTIR, HPLC, NMR, MS analyses, well comparisons literature. anticancer activity flavanone evaluated standard MTT test against commonly used cancer cell(MCF-7). Additionally, study investigated combination effect synthetic drug, 2-deoxy-D-glucose (2DG), on MCF-7 cells. findings reveal combined flavones 2DG had IC50 values 57.10 34.09µg/ml, respectively. This fusion provides promising evidence drug may enhance effectiveness by improving transport reducing required dose. Additional confirm these results investigate phytochemicals' replacement

Language: Английский

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Recovery of nutraceutical compounds from citrus fruit processing waste: A circular economy strategy to lessen environmental impact

Future Postharvest and Food, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

The processing waste from citrus fruits is the largest worldwide among other fruits. Therefore, strategies to retrieve valuable compounds are necessary reduce environmental impact. This because sources of bioactive endowed with well-exploitable pharmacological activities. A socio-economic imbalance has resulted lack raw materials used for food production around world. led indiscriminate exploitation natural resources, an increase in price items, and a daily rise number people who experience extreme hunger (Tomiyama et al., 2020). arose current economic model (i.e., linear model), which based on premise "extract-make-dispose," thus resulting serious disaster (Garza-Reyes 2019). circular economy, whose motto "grow-make-use-restore," paradigm that, contrast tries keep components, products at their peak utility order eliminate system. strategy applies best fruit vegetable waste, foods that consumed most. Their comes manufacture many goods, including but not limited juices, juice concentrates, jams, canned fruit, dried fresh-cut fruit. valorization this type can be guaranteed by industries using downstream processes, turning it into secondary resources. by-products contain variety interesting compounds, most significant possess greater market value. It noteworthy possible recover following such extraction, like vitamins, minerals, metabolites polyphenols, alkaloids, carotenoids, saponins, terpenoids; Campos Furthermore, biological properties, plant extracts byproducts employed as functional ingredients or create items. cellulosic directly non-food paper biodiesel, well sustainable packaging, helping impact environment increasing acceptance when compared those currently (Barros In sphere commercial cultivation consumption, undoubtedly main crop. With expected global over 170 million tons 2026, stands world's important tree China represents leading producer fruits, estimated more than 60 2022 (FAOSTAT, 2023). Specifically, tangerines, mandarins clementines accounts 27 tons, oranges 7.7 pomelos grapefruits 5.2 while lemons limes 2.6 tons. Consequently, export these consistent income country 1 billion US dollars just sector half total production, allocation fresh markets citrus-producing nations varies. As result, industry roughly 70% 90% United States Brazil, respectively, 80%–85% Mediterranean basin Spain intended local (Zacarias China, clementines, being top rather processed juices), one greatest importers also depends heavily citrus-based sweets, jellies, extracts, even though sizable portion industrially make essential oils (Ben Hsouna amount generated annually emerged major issue perspective. Peels, seeds, leaves up majority 15 produced (Safranko Citrus appropriate industrial management therefore strongly advised, they have lately key scientific research priority. Indeed, been suggested potential advantageous use by-products, mostly focusing novel extraction techniques yield high substances. Because quantity naturally contained demonstrated wide range health-beneficial effects (Kaur 2023; Musumeci Russo 2024). outer part exploited extract oils, represent final product great Nevertheless, weight peels discarded, its recovery crucial, giving richness flavonoids, phenolic acids (Martinidou On line, orange peel possesses molecules anti-anxiety properties (Mannucci 2018). Newhall peel, source showed potent antioxidant, antibacterial tyrosinase inhibitory activities (Guo Green-solvent evaluated provide rich antioxidant (Vinas-Ospino view economy strategy, mandarin was shown activity (Hou 2019), wound healing (Ishfaq 2021) anti-cancer ones (Park 2016). Also bergamot peels, oil widely perfume industry, flavonoids brutieridin melitidin albedo antihyperlipemic (Nauman & Johnson, Notably, itself revealed relevant (Cirmi Apart small molecules, plenty fibers pectins extracted only prebiotic additive, tools boost defense regulate lipid metabolism (Liu 2022; Yu vast cultivated nutritional value, apart taste, sweet sour, depending species. juices obtained squeezing pulps therefore, loss compounds. present juice, worldwide, proved anti-inflammatory 2020), extract, known (Celano 2015). decoction exhausted both mandarin, recovering carotenoids violaxanthin β-cryptoxanthin) phytosterols β-sitosterol β-campesterol). retrieval impact, given cholesterol-managing (Reynoso-Camacho 2021). Interestingly, discarded processing, studied antimicrobial (Filocamo 2015) anticancer activities, vitro (Ferlazzo 2016) vivo settings (Navarra These ascribed polyphenolic content (Gattuso 2007; 2022). flavonoid-rich fraction hypolipemic hypoglycemic (Mollace 2011), along (Gugliandolo Recently, pulp wash, second pulps, promising effluent induce fungal enzymes laccase manganese peroxidase) textile, pharmaceutical industries, degradation emerging pollutants (Santana economically cultivation, seeds products. enclosed re-evaluate parts. different cultivars beneficial due (Costanzo 2020; Hamdan Moreover, together components fatty acids, phytosterols, tocopherols. uses manufacturing additives, antioxidants, particularly grapefruit (Zayed Similarly, effects, tocopherols, sustain radical scavenging capability (Jorge addition, lemon seed investigated protecting capacity against diabetic complications, showing counteract diabetes-induced hepatic renal damage (Demir Celik, able hamper replication HTLV-1 HIV-1 infected cells, exploitable antiviral (Balestrieri 2011). employable agriculture green nanoemulsions, nutritious prime improve germination (Acharya yields branches stalks, pollution, if properly (Russo active principles last decade. Murcott coumarin derivatives limonoids. gastro-protective anti-ulcerogenic (Hamdan protected obese mice inflammation caused hyperinsulinemia reverted leptin-resistance burden severely overweight subjects. restore insulin resistance, oxidative stress low-grade (Nakandakare-Maia presence terpenoids, phenols short-chain tanning process hives employment polluting preservatives preventing skins bacterial (Tamil Selvi agri-food field creates considerable may food, medicine, cosmetic So far, studies show found residues ability protect chronic illnesses anti-inflammatory, capabilities. health field, detergents utilized cleaning solutions replace dangerous chemical alternatives. composted soil, eliminating demand synthetic fertilizers. biofuel recently investigated, might energy could help our dependence fossil fuels. Additionally, pectin gelling agent, thickener, stabilizer sector. For all possibilities, crucial follow path paved must sensitive change. approach lot offer battle pollution large amounts disposal. Priority reuse, recycling, reduction, lessens new conserves reserves lowering levels environment. encourage innovation development nutraceutical powerful tool fight since promotes sustainability growth, benefiting planet people. Michele Navarra: Conceptualization; writing—original draft. Ester Tellone: Writing—original authors declare no conflict interest. Data sharing applicable article data were created analyzed study.

Language: Английский

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Recovery, Bioactivity, and Utilization of Bioactive Phenolic Compounds in Citrus Peel

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(12), P. 9974 - 9997

Published: Nov. 7, 2024

ABSTRACT Citrus peels are rich in bioactive phenolic compounds with various health effects including antioxidant, antiobesity, antiinflammatory, antihypertensive, antihypercholesterolemic, antimicrobial, antidiabetic, and anticarcinogenic activities. Both extractable nonextractable phenolics present significant amounts peel diverse bioactivities. While can be recovered from the fruit by conventional extraction methods, remaining residues must released cell matrix first hydrolysis acid, alkali, or enzymes. Novel processing technologies help improvement of efficiency. Extreme process medium conditions degrade their bioactivity where encapsulation applied to improve stability, solubility, bioactivity. powder ascorbic acid dietary fiber besides extracts therefrom used as functional food ingredients extend shelf life provide benefits. In addition, antioxidant antimicrobial agents active packaging applications. Phenolic have also a potential nutraceuticals pharmaceuticals. this review, different forms peels, recovery, possible applications for upcycling industry presented.

Language: Английский

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