Fortschritte der Neurologie · Psychiatrie, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 23, 2024
Introduction Preclinically, fluvoxamine and other antidepressants (AD) exerted antiviral anti-inflammatory properties also against SARS-COV-2. Therfore, It makes sense to test the clinical effect of AD COVID-19 Long COVID.
Language: Английский
Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16
Published: March 12, 2025
A review of scientific literature suggests that the use antidepressants can be broadly extended to address various forms stress and inflammation as an adjunctive therapy enhances host resistance. While effects on mood are well-documented in terms their emotional, cognitive, behavioral impacts, these aspects do not fully explain cellular mechanisms action. At level, exert trophic promote neurogenesis synaptic connectivity. Studies demonstrate improve cell survival, enhance stem proliferation, reduce danger perception (mood effects) depressed patients animal models depression. These properties highlight a deeper biological mechanism beyond mood-related benefits. The acid sphingomyelinase (ASM) theory offers more compelling explanation compared monoamine hypothesis. Antidepressants functionally inhibit ASM enzyme, thereby reducing production ceramide, which directs cells toward increased cytoprotection, reproduction, well improved mood. This also highlights research demonstrating resistance infections, immunological challenges, stress, findings support potential bolster resilience scenarios involving vaccinations, aggression, depression, even aging.
Language: Английский
Citations
0
Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11
Published: Feb. 20, 2024
OPINION article Front. Med., 20 February 2024Sec. Infectious Diseases: Pathogenesis and Therapy Volume 11 - 2024 | https://doi.org/10.3389/fmed.2024.1305184
Language: Английский
Citations
2
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 5, 2024
Abstract M is the most abundant structural membrane protein in coronaviruses and essential for formation of infectious virus particles. SARS-CoV-2 adopts two conformations, short long , regulated transition between states hypothesized to coordinate viral assembly budding. However, factors that regulate conformation roles each state are unknown. Here, we discover a direct M-sphingolipid interaction controls conformational dynamics assembly. We show binds Golgi-enriched anionic lipids including ceramide-1-phosphate (C1P). Molecular simulations C1P promotes energetically stabilizes . Cryo-EM structures specifically at conserved site bridging transmembrane cytoplasmic regions. Disrupting -C1P alters subcellular localization, reduces with Spike E, impairs subsequent virus-like particle cell entry. Together, these results endogenous signaling structure support model which stabilized early endomembrane system organize other proteins prior
Language: Английский
Citations
2
Published: March 4, 2024
The pandemic caused by SARS-CoV-2 is still a major health problem. Newly emerging variants and long-COVID-19 represent challenge for the global system. In particular, individuals in developing countries with insufficient care need easily accessible, affordable effective treatments of COVID-19. Previous studies have demonstrated efficacy functional inhibitors acid sphingomyelinase (FIASMA) against infections various viruses, including early SARS-CoV-2. This work investigated whether fluoxetine sertraline, usually used as antidepressant molecules clinical practice, can inhibit replication former recently emerged vitro. Fluoxetine sertraline potently inhibited infection pseudotyped virus like particles D614G, alpha, delta, omicron BA.1 BA.5. These results highlight priority candidates large-scale phase 3 trials at different stages infections, either alone or combination other medications.
Language: Английский
Citations
1
Viruses, Journal Year: 2024, Volume and Issue: 16(4), P. 545 - 545
Published: March 30, 2024
The pandemic caused by SARS-CoV-2 is still a major health problem. Newly emerging variants and long-COVID-19 represent challenge for the global system. In particular, individuals in developing countries with insufficient care need easily accessible, affordable effective treatments of COVID-19. Previous studies have demonstrated efficacy functional inhibitors acid sphingomyelinase against infections various viruses, including early SARS-CoV-2. This work investigated whether fluoxetine sertraline, usually used as antidepressant molecules clinical practice, can inhibit replication former recently emerged vitro. Fluoxetine sertraline potently inhibited infection pseudotyped virus-like particles D614G, alpha, delta, omicron BA.1 BA.5. These results highlight priority candidates large-scale phase 3 trials at different stages infections, either alone or combination other medications.
Language: Английский
Citations
1
V M BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY, Journal Year: 2024, Volume and Issue: 58(2), P. 79 - 88
Published: April 25, 2024
The aim of this study is to examine the relationship between severity and duration criteria COVID-19 psychopharmacotherapy administered patients in within a psychiatric hospital. Materials Methods. We analyzed 169 case histories involving completed clinical cases treatment specialized infectious department St. Petersburg, covering period from May 2020 January 2021. Correlation, dispersion, regression analyses were employed evaluate severe mild progression indicators, as well persistent SARS-CoV-2 viral shedding. assessed laboratory parameters patients, along with administered, including antidepressants, antipsychotics, acid sphingomyelinase inhibitors (FIASMA-active drugs). Results. Cardiovascular diseases emerged predictor when combined an increasing platelet-to-lymphocyte ratio (PLR), risk course by over two-fold. use any psychotropic agents was associated 0.9% increase for each unit systemic inflammation index PLR, specifically intellectual disability (ICD-10 codes F70-79), compared schizophrenia F20-29). High PLR values FIASMA-active drugs prolonged duration, while antidepressant therapy elevated C-reactive protein levels reduced predicted shedding 13.8% variance. Additional consideration nosology disorders model increased proportion explained variance 22.8%. Conclusion. Consideration should be given thymoanaleptic individuals during periods disease incidence leading up potential infection, it may serve protective factor against COVID-19. Furthermore, there no evidence suggest adverse effects antipsychotics on Further research required investigate psychopharmacological nosologically homogeneous groups.
Language: Английский
Citations
1
Medicine, Journal Year: 2024, Volume and Issue: 103(22), P. e38378 - e38378
Published: May 31, 2024
Patients with severe COVID-19 and those sepsis have similar clinical manifestations. We used bioinformatics methods to identify the common hub genes in these 2 diseases. Two RNA-seq datasets from Gene Expression Omnibus were differentially expressed (DEGs) sepsis. These for analysis of functional enrichment; pathway analysis; identification associated transcription factors, metabolites, miRNAs; mapping protein–protein interaction networks. The major identified, validation assess value using receiver operating characteristic (ROC) curves. Analysis 800 DEGs sepsis, as well miRNAs, demonstrated that immune response had a key role both DLGAP5, BUB1, CDK1, CCNB1 , BUB1B most important genes. cohort indicated 5 significantly higher expression patients than corresponding controls, area under ROC curves ranged 0.832 0.981 0.840 0.930 tools DEGs, factors identified cohorts good or excellent diagnostic performance based on analysis, therefore potential use novel markers therapeutic targets.
Language: Английский
Citations
1
Fortschritte der Neurologie · Psychiatrie, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 23, 2024
Introduction Preclinically, fluvoxamine and other antidepressants (AD) exerted antiviral anti-inflammatory properties also against SARS-COV-2. Therfore, It makes sense to test the clinical effect of AD COVID-19 Long COVID.
Language: Английский
Citations
1