International Journal of Drug Delivery Technology,
Journal Year:
2023,
Volume and Issue:
13(04), P. 1527 - 1532
Published: Dec. 25, 2023
The
current
study
aimed
to
increase
the
stability
and
therapeutic
efficacy
of
antitubercular
medication
rifampicin
by
reducing
or
preventing
its
breakdown
in
stomach
pH
state.
Ascorbic
acid
was
used
as
an
antioxidant
preparation
rifampicin-loaded
Poly(lactic-co-glycolic
acid)
(PLGA)
nanoparticles
for
investigation.
A
multistep
emulsion
process
create
dig-laden
nanoparticles,
different
techniques
were
then
assess
final
product.
Ten
kinds
formulations
created
this
study.
According
study’s
findings,
ascorbic
can
rifampicin’s
bioavailability
acidic
conditions.
results
also
show
that
changing
concentration
makes
a
statistically
important
difference
way
medicine
breaks
down.
Open Chemistry,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Jan. 1, 2024
Abstract
The
rising
instances
of
drug
resistance
in
Mycobacterium
tuberculosis
strains
pose
a
significant
global
health
challenge.
Conventional
(TB)
treatments,
which
typically
involve
multiple
antibiotics,
face
hurdles
like
resistance,
reduced
effectiveness,
and
heightened
toxicity.
Consequently,
there
is
pressing
need
for
innovative
anti-TB
agents
with
new
modes
action.
Decaprenyl-phosphoryl-β-
d
-ribose
2′-epimerase
1(DprE1),
crucial
enzyme
,
plays
vital
role
cell
wall
biosynthesis
–
critical
aspect
the
bacterium’s
survival.
Building
on
success
diarylquinolines
bedaquiline,
targeting
DprE1
presents
promising
avenue
developing
drugs,
especially
against
drug-resistant
strains.
Our
research
focused
discovering
novel
inhibitors
using
ligand-based
design
strategy,
starting
established
non-covalent
inhibitor
Ty38c.
We
assembled
library
16
molecules,
modifying
them
based
factors
drug-like
properties,
chemical
accessibility,
synthetic
feasibility.
Molecular
docking
analyses
this
identified
three
molecules
binding
affinities
comparable
to
Among
these,
KS_QD_05
KS_QD_04
are
candidates,
were
further
validated
through
molecular
dynamics
simulation
studies
where
root-mean-square
deviation
(RMSD)
values
all
complexes
reached
plateau,
measuring
around
0.3
nm,
indicating
that
apoprotein
stabilized
during
simulation.
ligands
displayed
significantly
stable
deviation.
about
0.1
nm
equilibrium
value.
However,
ligand
an
RMSD
value
0.17
showed
distress
at
70
nm.
average
1-3
H-bond
interaction
regarding
RMSF
values,
both
compounds
fluctuations
less
than
0.5
case
Mtb.
enzyme.
This
indicates
potential
become
lead
pursuit
TB
treatment.
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
1(1)
Published: Nov. 11, 2024
Antiretroviral
Therapy
(ART)
has
revolutionized
Human
Immunodeficiency
Virus
(HIV)
treatment,
yet
challenges
remain,
such
as
drug
toxicity,
resistance,
and
inadequate
access
to
infected
tissues.
Novel
delivery
systems,
liposomes
receptor-targeted
mechanisms,
offer
promising
solutions
improve
ART
efficacy
minimize
its
limitations.
This
study
aims
evaluate
the
potential
of
liposomal
systems
(DDS)
for
enhancing
bioavailability,
selectivity,
therapeutic
outcomes
ART,
with
a
focus
on
targeting
HIV-infected
cells
reducing
resistance.
A
systematic
review
published
articles
was
conducted,
drawing
from
electronic
databases
PubMed,
Scopus,
Web
Science.
Keywords
"liposomes,"
"receptor-targeted
delivery,"
"HIV"
were
used
identify
preclinical
clinical
studies
relevant
ART.
The
evaluated
their
design,
intervention
specifics,
key
findings.
Data
synthesized
narratively
highlight
efficacy,
safety,
pharmacokinetics
these
systems.
Liposomal
formulations
significantly
improved
zidovudine
(AZT)
showing
an
85%
increase,
lamivudine
(3TC)
90%,
efavirenz
(EFV)
80%,
indinavir
(IDV)
75%.
Galactosylated
highly
effective
in
(92%)
showed
strong
preventing
drug-resistant
strains
(85%).
Receptor-targeted
approaches,
those
Cluster
Differentiation
4
(CD4),
Chemokine
Receptor
Type
5
(CCR5),
(CXCR4),
enhance
precision
reduce
viral
load
HIV
reservoirs.
DDS
significant
improving
by
increasing
Further
research
is
needed
optimize
technologies
translate
success
into
practice,
paving
way
more
therapies.
Therapeutic Delivery,
Journal Year:
2024,
Volume and Issue:
15(9), P. 717 - 735
Published: Sept. 1, 2024
Apigenin,
a
potent
natural
flavonoid,
has
emerged
as
key
therapeutic
agent
due
to
its
multifaceted
medicinal
properties
in
combating
various
diseases.
However,
apigenin's
clinical
utility
is
greatly
limited
by
poor
water
solubility,
low
bioavailability
and
stability
issues.
To
address
these
challenges,
this
review
paper
explores
the
innovative
field
of
nanotechnology-based
delivery
systems,
which
have
shown
significant
promise
improving
effectiveness
apigenin.
This
also
synergistic
potential
co-delivering
apigenin
with
conventional
agents.
Despite
advantageous
nanoformulations,
critical
challenges
such
scalable
production,
regulatory
approvals
comprehensive
long-term
safety
assessments
remain
hurdles
their
adoption
must
be
addressed
for
commercialization
apigenin-based
formulations.
Gels,
Journal Year:
2024,
Volume and Issue:
10(11), P. 719 - 719
Published: Nov. 7, 2024
Microneedle
(MN)
technology
has
emerged
as
a
promising
approach
for
delivering
therapeutic
agents
to
the
skin,
offering
significant
potential
in
treating
various
dermal
conditions.
Among
these
technologies,
hydrogel-forming
microneedles
(HFMNs)
represent
transformative
advancement
management
of
diseases
through
non-invasive
drug
delivery.
These
innovative
devices
consist
micrometer-sized
needles
made
native
or
crosslinked
hydrophilic
polymers,
capable
penetrating
stratum
corneum
without
damaging
underlying
tissues.
Upon
insertion,
HFMNs
rapidly
absorb
interstitial
fluid,
swelling
form
hydrogel
conduit
that
enables
efficient
transport
directly
into
microcirculation.
The
nature
enhances
patient
compliance
by
eliminating
pain
and
discomfort
associated
with
traditional
hypodermic
needles.
This
allows
delivery
wide
range
drugs,
including
macromolecules
biomacromolecules,
which
are
often
difficult
administer
dermally
due
their
size
polarity.
Moreover,
provide
controlled
regulated
release
profiles,
enabling
sustained
effects
while
minimizing
systemic
side
effects.
Additionally,
can
be
used
both
real-time
fluid
monitoring,
valuable
insights
disease
states
treatment
responses.
dual
functionality
positions
versatile
dermatology
tool
effectively
addressing
complications.
review
explores
use
polymeric
biomaterials
HFMN
fabrication
application
major
disorders,
such
acne,
psoriasis,
other
skin
Furthermore,
highlights
MN-based
treatments,
underscoring
reduce
improve
adherence,
supported
recent
literature.
