Unraveling the microbial puzzle: exploring the intricate role of gut microbiota in endometriosis pathogenesis

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Feb. 16, 2024

Endometriosis (EMs) is a prevalent gynecological disorder characterized by the growth of uterine tissue outside cavity, causing debilitating symptoms and infertility. Despite its prevalence, exact mechanisms behind EMs development remain incompletely understood. This article presents comprehensive overview relationship between gut microbiota imbalance pathogenesis. Recent research indicates that plays pivotal role in various aspects EMs, including immune regulation, generation inflammatory factors, angiopoietin release, hormonal endotoxin production. Dysbiosis can disrupt responses, leading to inflammation impaired clearance endometrial fragments, resulting endometriotic lesions. The dysregulated contribute release lipopolysaccharide (LPS), triggering chronic promoting ectopic adhesion, invasion, angiogenesis. Furthermore, involvement estrogen metabolism affects levels, which are directly related development. review also highlights potential as diagnostic tool therapeutic target for EMs. Interventions such fecal transplantation (FMT) use preparations have demonstrated promising effects reducing symptoms. progress made, further needed unravel intricate interactions paving way more effective prevention treatment strategies this challenging condition.

Language: Английский

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Mutual influence of clinical manifestations of intestinal disorders and intestinal microbiot indicators in patients with deep endometriosis

Vestnik ohrany materinstva i mladenčestva., Journal Year: 2025, Volume and Issue: 1(3), P. 10 - 24

Published: Jan. 13, 2025

Summary. Endometriosis is a chronic multifactorial disease that affects more than 170 million women of reproductive age worldwide, causing pelvic pain syndrome, dyspareunia, and symptoms gastrointestinal dyspepsia, thereby having negative impact on the psycho-emotional state patients. Despite wide range medical surgical treatments, relapse rate reaches 50%, which global economic social problem. The purpose study. to evaluate mutual influence clinical manifestations intestinal disorders microbiota in patients with deep endometriosis. Materials methods. study included 83 who underwent treatment common forms external genital first group consisted 32 repeated due infiltrative endometriosis, second — 51 without one year after primary operation, third 30 age. not suffering from An analysis somatic anamnesis was carried out, as well questionnaire data visual analogue scale (VAS) functional bowel infiltrating depending status disease. composition assessed by quantitative real-time PCR using test system for determining DNA intestinal-associated microorganisms. Results discussion. results demonstrate bidirectional relationships between microbiological parameters recurrent course Patients main significantly often suffered diseases tract, spectrum represented gastritis irritable syndrome. Correlation indicators Bacillota domain anamnestic pathology, values scales endometriosis moderate positive weight number Lachnospiraceae (r = 0.63299), bloating Streptococcus spp (r=0.67402). Bacteroidota corresponding strong amount E.Coli level VAS 1 0.62366) 3 months 0. 72598) surgery. Moderate correlations were revealed Enterobacterales (r=0.58169) (r=0.57706) Conclusions. accompanied disorders, persist treatment, mediated changes microbiota. In decrease species taxonomic diversity found, an increase Bacillota/Bacteroidota ratio, pathobionts, commensal bacteria genus Bifidobacterium spp. These parallels need harmonize comprehensive prevention relapse.

Language: Английский

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Evaluation of Long-COVID Syndrome in a Cohort of Patients with Endometriosis or Adenomyosis

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 1835 - 1835

Published: March 8, 2025

Background: Long-COVID is characterized by the persistency of COVID-19 symptoms beyond 12 weeks, and it probably consequent to immune dysregulation induced SARS-CoV-2 infection. Immune associated with involved in pathogenesis chronic gynecological conditions like endometriosis adenomyosis. This study evaluated whether presence or adenomyosis increases risk long-COVID, i.e., persistence weeks since Methods: retrospective observational was performed at outpatient service for pelvic pain, a university hospital. The diagnosis endometriosis/adenomyosis primarily based on clinical ultrasonography assessment. Data regarding infection, vaccination, their minimum were collected. Results: included 247 women, 149 controls without 98 cases endometriosis/adenomyosis. Among these, 194 (116 78 cases) had suffered from Rates infection vaccination similar two groups. distribution vaccine uniform across cohorts. patients exhibited higher prevalence (p < 0.001) dyspnea chest pain. long-COVID than (42% vs. 12%; p pain ageusia 0.05), forming most representative symptoms. Conclusions: Symptoms are more frequent women

Language: Английский

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Unraveling the relationship between gut microbiota and site-specific endometriosis: a Mendelian randomization analysis

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: July 4, 2024

Background Although numerous studies have illustrated the connection between gut microbiota and endometriosis, a conspicuous gap exists in research focusing on pathogenesis of endometriosis at various sites its linkage with infertility. Methods In this study, we used two-sample Mendelian randomization analysis to investigate effect development different regions, including uterus, ovary, fallopian tube, pelvic peritoneum, vagina, rectovaginal septum, as well intestine. Additionally, explored correlation endometriosis-induced Genetic associations microbes were obtained from genome-wide association study (GWAS) datasets provided by MiBioGen consortium, whereas endometriosis-related GWAS data sourced FinnGen dataset. our analysis, single-nucleotide polymorphisms instrumental variables, primary estimation causal performed via inverse variance weighting method. Our sensitivity analyses incorporated heterogeneity tests, pleiotropy leave-one-out Results We identified genus level four bacterial communities endometriosis. Subsequently, several subtypes anatomical recognized. Specifically, three genera linked ovarian six associated tubal showed links peritoneum five connected vaginal septum seven demonstrated linkages intestinal one was adenomyosis, exhibited Conclusion elucidates site-specific thereby augmenting understanding pathophysiology Moreover, findings pave way for potential therapeutic strategies targeting individuals grappling

Language: Английский

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The causality between gut microbiota and endometriosis: a bidirectional Mendelian randomization study

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 22, 2024

Observational studies and animal experiments had suggested a potential relationship between gut microbiota abundance pathogenesis of endometriosis (EMs), but the relevance this remains to be clarified.

Language: Английский

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Endometriosis: Pathogenesis, diagnosis, treatment and the role of gut microbiota

Journal of Education Health and Sport, Journal Year: 2024, Volume and Issue: 59, P. 87 - 101

Published: Feb. 13, 2024

Endometriosis is a common disease. It affects 5-10% of women reproductive age worldwide. However, despite the prevalence, diagnosis typically delayed by years, misdiagnosis common, and effective treatment takes years to achieve. Determining mechanisms involved in its pathogenesis vital, not only pave way for early identification, but also disease management development less invasive successful strategies. Three main typed endometriosis have been described literature: peritoneal, ovarian deep infiltrative. This mainly due most locations ectopis endometrium. .Determining precise has proved challenging controversial gynecologists, endocrinologists researchers, recent studies focused on finding answers. often asymptomatic diagnosed incidentally during various surgical interventions or follow-up gynecological examinations. Epidemiological research reports that with this are more vulnerable breast cancer, asthma, skin cancer suhc as melanoma, cardiovascular rheumatoid arthritis. The connection gut microbiota nowadays higly suspected exist. Scientists influence microbiome estrogens, estrogens-dependent disorders, immune system inflammation. strongly velieved correction antibiotica, probiotics, fecal bacterial transplantation sie hopeful method improving clinical endometriosis.

Language: Английский

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The effect of oral progestogens on the intestinal microbiota composition in patients with endometriosis: pilot study

ASTRAKHAN MEDICAL JOURNAL, Journal Year: 2024, Volume and Issue: 19(2), P. 78 - 84

Published: July 15, 2024

Today, the contribution of microbiota to genesis many diseases, including endometriosis, is widely discussed. However, literature data on microbiological composition endometriosis are contradictory. In addition, indicating effect conservative therapy limited only estrogen-containing drugs, while there no progestogens. Objective: evaluate intestinal patients with external genital oral progestogen therapy. A single-stage pilot study was conducted, which included 17 (average age 30.9 (7.8) years, average body mass index 20.2 (2.0) kg/m 2 ). The women received (dienogest at a dose mg per day in continuous mode). Microbiological examination faecal samples by culturomics methods inoculation selective and non-selective nutrient media, followed species identification microorganisms, carried out using time-of-flight spectrometry (MALDI-TOF MS) two points: initially after 6 months taking dienogest. Dienogest showed an improvement number indicators form tendency increase taxonomic diversity, decrease Bacillota / Bacteroidota index, titer conditionally pathogenic microorganisms Staphylococcus spp. increased colonization symbiotic bacteria Collinsella aerofaciens Lactobacillus Thus, dienogest can have both direct indirect demonstrated results study.

Language: Английский

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Nutrition Interventions in the Treatment of Endometriosis: A Scoping Review

Journal of Human Nutrition and Dietetics, Journal Year: 2024, Volume and Issue: 38(1)

Published: Dec. 18, 2024

Pain, poor quality of life (QOL) and gastrointestinal (GI) symptoms are commonly experienced by individuals with endometriosis. Although diet nutrition supplements frequently used to manage endometriosis-related symptoms, there is limited understanding the breadth research in this field. Our aim was undertake a scoping review supplement intervention studies people endometriosis, diagnosed ultrasound or surgery.

Language: Английский

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