Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(12), P. 1588 - 1588
Published: Dec. 12, 2024
Background:
Resveratrol
(RSV)
is
a
natural
polyphenol
that
offers
antioxidant,
anti-inflammatory,
and
chemopreventive
benefits.
This
project
determined
the
ability
of
RSV-loaded
nanoparticles
(NP)
to
inhibit
growth
lung
tumor
spheroids
in
vitro.
Methods:
RSV
was
encapsulated
NP
comprised
biodegradable
polymer,
acetalated
dextran.
A549
cancer
cells
two-dimensional
three-dimensional
cell
culture
models
were
exposed
free
evaluate
their
effect
on
proliferation
spheroid
formation
growth.
For
prevention
studies,
day
0,
for
treatment
dosed
with
same
formulations
5
after
had
fully
formed.
Results:
The
resulting
200
nm
diameter
neutral
surface
charge
exhibited
control
release
vitro
based
environmental
pH.
In
comparison
RSV,
exerted
greater
inhibitory
spheroids.
Conclusions:
have
potential
be
used
as
agent
cancer.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2529 - 2529
Published: Feb. 21, 2024
Glioblastoma
(GB)
stands
out
as
the
most
prevalent
and
lethal
form
of
brain
cancer.
Although
great
efforts
have
been
made
by
clinicians
researchers,
no
significant
improvement
in
survival
has
achieved
since
Stupp
protocol
became
standard
care
(SOC)
2005.
Despite
multimodality
treatments,
recurrence
is
almost
universal
with
rates
under
2
years
after
diagnosis.
Here,
we
discuss
recent
progress
our
understanding
GB
pathophysiology,
particular,
importance
glioma
stem
cells
(GSCs),
tumor
microenvironment
conditions,
epigenetic
mechanisms
involved
growth,
aggressiveness
recurrence.
The
discussion
on
therapeutic
strategies
first
covers
SOC
treatment
targeted
therapies
that
shown
to
interfere
different
signaling
pathways
(pRB/CDK4/RB1/P16
Journal of Imaging,
Journal Year:
2025,
Volume and Issue:
11(2), P. 59 - 59
Published: Feb. 15, 2025
Artificial
intelligence
(AI)
transforms
image
data
analysis
across
many
biomedical
fields,
such
as
cell
biology,
radiology,
pathology,
cancer
and
immunology,
with
object
detection,
feature
extraction,
classification,
segmentation
applications.
Advancements
in
deep
learning
(DL)
research
have
been
a
critical
factor
advancing
computer
techniques
for
mining.
A
significant
improvement
the
accuracy
of
detection
algorithms
has
achieved
result
emergence
open-source
software
innovative
neural
network
architectures.
Automated
now
enables
extraction
quantifiable
cellular
spatial
features
from
microscope
images
cells
tissues,
providing
insights
into
organization
various
diseases.
This
review
aims
to
examine
latest
AI
DL
mining
microscopy
images,
aid
biologists
who
less
background
knowledge
machine
(ML),
incorporate
ML
models
focus
images.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(1), P. 134 - 134
Published: Jan. 19, 2025
Resveratrol
is
a
natural
polyphenol
(stilbenoid),
which
can
be
found
in
grape
skin,
red
wine,
blueberries,
peanuts
and
others.
The
biological
properties
of
resveratrol,
particular
antioxidant,
anti-inflammatory,
anticancer,
estrogenic,
vasorelaxant
cardioprotective
activity,
are
the
main
reason
for
its
importance
medicine
pharmacy.
Despite
all
advantages,
however,
there
many
problems
related
to
this
polyphenolic
substance,
such
as
low
stability,
water
insolubility,
poor
bioavailability
fast
metabolism.
For
reason,
scientists
currently
searching
different
approaches
dealing
with
these
problematic
improving
therapeutic
usage
resveratrol.
This
review
summarizes
mechanisms
effects
determined
vitro
vivo,
limitations
drug.
article
emphasizes
new
improvement
resveratrol
delivery,
nanoencapsulation,
formation
nanocrystals,
prodrugs
structure
analogues.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(19), P. 3323 - 3323
Published: Sept. 28, 2024
Gastric
cancer
(GC)
is
the
second
most
common
cause
of
cancer-related
death
worldwide
and
a
serious
public
health
concern.
This
high
rate
mostly
caused
by
late-stage
diagnoses,
which
lead
to
poor
treatment
outcomes.
Radiation
immunotherapy
targeted
therapies
are
becoming
increasingly
popular
in
GC
treatment,
addition
surgery
systemic
chemotherapy.
In
this
review,
we
have
focused
on
both
vitro
vivo
research,
presents
summary
recent
developments
for
gastric
cancer.
We
explore
therapy
approaches,
including
integrin
receptors,
HER2,
Claudin
18,
glutathione-responsive
systems.
For
instance,
targeting
receptors
such
as
αvβ3
αvβ5
integrins
shown
promise
enhancing
diagnostic
precision
efficacy.
Furthermore,
nanotechnology
provides
novel
approaches
drug
delivery
imaging.
These
include
nanoplatforms
cyclic
RGD
peptide-conjugated
nanoparticles.
strategies
seek
reduce
toxicity
while
increasing
specificity
To
sum
up,
review
addresses
significance
personalized
medicine
advancements
cancer-targeted
therapies.
It
explores
potential
methods
prognosis
future.
Heliyon,
Journal Year:
2025,
Volume and Issue:
11(4), P. e42739 - e42739
Published: Feb. 1, 2025
This
review
explores
the
synergistic
potential
of
natural
products
and
nanotechnology
for
viral
infections,
highlighting
key
antiviral,
immunomodulatory,
antioxidant
properties
to
combat
pandemics
caused
by
highly
infectious
viruses.
These
often
result
in
severe
public
health
crises,
particularly
affecting
vulnerable
populations
due
respiratory
complications
increased
mortality
rates.
A
cytokine
storm
is
initiated
when
an
overload
pro-inflammatory
cytokines
chemokines
released,
leading
a
systemic
inflammatory
response.
Viral
mutations
limited
availability
effective
drugs,
vaccines,
therapies
contribute
continuous
transmission
virus.
The
coronavirus
disease-19
(COVID-19)
pandemic
has
sparked
renewed
interest
product-derived
antivirals.
efficacy
traditional
medicines
against
infections
examined.
Their
anti-inflammatory,
are
highlighted.
discusses
how
enhances
herbal
combating
infections.
Drug Development and Industrial Pharmacy,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 31
Published: March 21, 2025
This
review
examines
recent
advancements
in
nanoparticle-based
delivery
systems
for
phytochemicals,
focusing
on
their
role
overcoming
multidrug
resistance,
improving
therapeutic
efficacy,
and
facilitating
clinical
translation.
highlights
advances
nanoparticle-enabled
phytochemical
to
enhance
bioavailability,
improve
outcomes,
enable
targeted
applications.
By
comparing
various
nanoparticle
systems,
formulation
methods,
efficacy
data,
it
identifies
gaps
current
research
guides
the
development
of
more
effective,
next-generation
phytochemical-loaded
nanocarriers.
A
systematic
literature
published
between
2000
2024
was
conducted
using
PubMed,
Scopus,
Web
Science.
Articles
cancer
therapy
were
included.
Compounds
such
as
curcumin,
resveratrol,
quercetin,
epigallocatechin
gallate
demonstrate
enhanced
anti-cancer
when
encapsulated
nanoparticles,
leading
improved
increased
tumor
cell
targeting,
reduced
toxicity.
Clinical
trials
indicate
regression
fewer
adverse
effects.
Emerging
approaches-such
nanogels,
hybrid
combination
therapies
with
immune
checkpoint
inhibitors-further
refine
treatment
efficacy.
Nanoparticle-based
significantly
potential
making
them
promising
candidates
safer,
effective
treatments.
However,
challenges
related
regulatory
guidelines,
scalability,
long-term
safety
must
be
addressed
fully
realize
potential.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(7), P. 782 - 782
Published: June 27, 2024
Cadmium
(Cd)
toxicity
poses
a
significant
threat
to
human
health
and
the
environment
due
its
widespread
occurrence
persistence.
In
recent
years,
considerable
attention
has
been
directed
towards
exploring
natural
compounds
with
potential
protective
effects
against
Cd-induced
toxicity.
Among
these
compounds,
resveratrol
(RV)
emerged
as
promising
candidate,
demonstrating
range
of
beneficial
attributed
antioxidant
anti-inflammatory
properties.
This
literature
review
systematically
evaluates
role
RV
Cd
toxicity,
considering
various
mechanisms
action
involved.
A
comprehensive
analysis
both
in
vitro
vivo
studies
is
conducted
provide
understanding
efficacy
mitigating
damage.
Additionally,
this
highlights
importance
phytoremediation
strategies
addressing
contamination,
emphasizing
enhancing
efficiency
such
remediation
techniques.
Through
integration
diverse
research
findings,
underscores
therapeutic
combating
need
for
further
investigation
elucidate
precise
optimize
application
environmental
clinical
settings.
Life,
Journal Year:
2024,
Volume and Issue:
14(6), P. 751 - 751
Published: June 12, 2024
Rheumatoid
arthritis
(RA)
is
a
systemic
autoimmune
disorder
caused
by
inflammation
of
cartilaginous
diarthrodial
joints
that
destroys
and
cartilage,
resulting
in
synovitis
pannus
formation.
Timely
detection
effective
management
RA
are
pivotal
for
mitigating
inflammatory
consequences,
potentially
influencing
disease
progression.
Nuclear
medicine
using
radiolabeled
targeted
vectors
presents
promising
avenue
diagnosis
response
to
treatment
assessment.
Radiopharmaceutical
such
as
technetium-99m
(
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(1), P. 49 - 49
Published: Jan. 3, 2025
The
relationship
between
oxidative
stress
and
cancer
has
been
extensively
studied
highlighted,
along
with
its
role
in
various
aspects
of
angiogenesis.
modulation
levels
the
adaptive
mechanisms
systems
are
attractive
research
themes
for
developing
anti-cancer
strategies.
Reactive
oxygen
species
(ROS)
involved
pathophysiological
processes
play
crucial
roles
DNA
damage
Although
cells
have
developed
defense
against
stress,
excessive
ROS
production
proposed
as
an
strategy
to
induce
cellular
apoptosis.
In
particular,
natural-source-based
antioxidants
identified
effective
cancers,
delivery
platforms
enhance
their
efficacy.
this
review,
we
highlighted
components
(plumbagin,
quercetin,
resveratrol,
curcumin,
xanthatin,
carvacrol,
telmisartan,
sulforaphane)
that
modulate
recent
targeting
used
increase
application
drugs
diverse
action.
Further,
summarized
actual
doses
effects
these
drug
candidates
systems.
Overall,
review
provides
beneficial
expanding
cancer-targeting
fields
addressing
limited
applications
types.
