Native/modified dextran-based nanogel in delivering drug and management of ocular complications: a review DOI
Biswajit Basu,

S. Mallick,

Suman Dhauria

et al.

Zeitschrift für Naturforschung C, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Abstract Ocular nanogels have emerged as a promising therapeutic approach, and nanotechnology has speed up the growth of pharmaceutical medical technology sectors. The physiological anatomical barriers eye limit use traditional ocular preparations, which leads to low drug bioavailability brief retention period. This presents serious problem for patients, doctors, chemists. Nevertheless, can encapsulate medications within three-dimensional crosslinked polymeric networks provide controlled prolonged delivery by using particular structural layouts unique preparation techniques, improving efficacy patient compliance. Dextran its variants, naturally occurring polysaccharide, drawn lot interest in developing systems applications. Many dextran-based with customized geometries features been fabricated recently, such hydrogels, nanogels, magnetic nanoparticles, nanoemulsions, self-assembled micelles microparticles. review advancement potential treatment various conditions, cataract, conjunctivitis, glaucoma, dry syndrome, age-related macular degeneration, corneal ulcers. Moreover, process development assessing these nanomedicines, emphasizing their safety effectiveness established preclinical, toxicological, clinical assessments, patent updates, elaborated.

Language: Английский

High-Tech Sustainable Beauty: Exploring Nanotechnology for the Development of Cosmetics Using Plant and Animal By-Products DOI Creative Commons
Gabriela Braga Barros Nhani, Leonardo Delello Di Filippo, Geanne Aparecida de Paula

et al.

Cosmetics, Journal Year: 2024, Volume and Issue: 11(4), P. 112 - 112

Published: July 6, 2024

In a world increasingly focused on eco-conscious living, the cosmetic industry is actively adopting nanotechnology to transform plant and animal by-products into high-value beauty products. This comprehensive review explores innovative sustainable approaches for extracting utilizing bioactive compounds from these by-products. The application of nanocarrier systems highlighted their role in enhancing delivery efficacy safety ingredients skincare Consumer demand environmental concerns drive shift towards natural Traditional production often involves significant ecological impacts, prompting seek greener alternatives. addresses critical need solutions that align with global sustainability goals, particularly those outlined 2030 Agenda Sustainable Development. provides valuable insights current trends future directions cosmetics by focusing uniquely integrates practices industry. It details benefits using nanocarriers improve stability, bioavailability, derived waste. intersection high-tech methodologies offers novel perspective innovation. Future research should focus overcoming technical, regulatory, economic challenges scaling up applications. Investigations include development transparent supply chains, standardization methods characterizing nanoparticles, lifecycle assessments ensure safety. Additionally, fostering collaboration between scientific research, practices, consumer education vital advancing practices. contributes broader discourse presenting clear pathway integrating approaches. ensures products meet expectations promote stewardship circular economy, ultimately benefiting both skin planet.

Language: Английский

Citations

7
Navigating the future of cancer management through carbon nanodots: A review DOI

Arprita Malhan,

Mridul Guleria,

Ushasi Das

et al.

Nano-Structures & Nano-Objects, Journal Year: 2024, Volume and Issue: 39, P. 101217 - 101217

Published: June 17, 2024

Language: Английский

Citations

6
Advancing cancer therapy: Unveiling the cutting-edge potential of carmustine nano carriers for targeted treatment DOI

Amirhossein Khanizadeh,

Amirhossein Ghaemi, Mehrab Pourmadadi

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 99, P. 105943 - 105943

Published: July 4, 2024

Language: Английский

Citations

6
SLNs and NLCs for Skin Applications: Enhancing the Bioavailability of Natural Bioactives DOI Creative Commons
Diana Antonia Safta, Cătălina Bogdan, Mirela Moldovan

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1270 - 1270

Published: Sept. 28, 2024

Natural bioactives are mixtures of compounds extracted from plants with physicochemical properties that usually not favorable for penetrating the skin's complex barrier. Nanoparticles have important advantages both in dermatology and cosmetology: improved solubility stability encapsulated phytocompounds, controlled sustained skin delivery, enhanced permeation, leading to an bioavailability. This review focuses on two generations lipid-based nanoparticles: solid lipid nanoparticles (SLNs) nanostructured carriers (NLCs). An extensive overview recent studies SLNs NLCs entrapping essential oils, herbal extracts, phytocompounds topical applications is presented, emphasizing their composition, characterization, efficacy, methodologies used evaluate them. also summarizes systems containing natural incorporated into NLCs, commercially available products registered patents field. turn out be effective nanocarriers applications, offering significantly encapsulation efficiency, stability, delivery. However, full potential underexplored. Future should study new show more specialized solutions address specific requirements; product performance a pleasant sensory profile could lead increased customer compliance use.

Language: Английский

Citations

6
Ferulic Acid: A Comprehensive Review DOI Open Access

J. Purushothaman,

Md. Rizwanullah

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

Ferulic acid (FA), a phenolic compound abundant in the cell walls of seeds, leaves, and roots various fruits, vegetables, cereals, grains, is renowned for its wide range biological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer properties. Despite therapeutic potential, clinical application FA hindered by challenges such as poor water solubility, limited bioavailability, rapid metabolism, instability under physiological conditions. To address these issues, nanotechnology has emerged transformative approach, enhancing FA's pharmacokinetic profile. Various nanoparticle-based systems, polymer-based lipid-based nanoparticles, have been developed to encapsulate FA. These systems demonstrated significant improvements stability, with studies showing enhanced antioxidant activity controlled release profiles. Further, surface engineering nanoparticles provides targeted drug/phytochemical delivery potential. The drugs/phytochemicals significantly enhances efficacy minimizes systemic side effects. This review explores potential FA, limitations application, advancements that are paving way effective use.

Language: Английский

Citations

4
New insight into the protective effect of Citrullus colocynthis loaded with ZnONP cream on glutaraldehyde-induced dermatitis in health care workers DOI Creative Commons
Walaa A. Ali, Walaa A. Moselhy,

Marwa A. Ibrahim

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 9, 2025

Abstract Glutaraldehyde (GLU) is mainly used in medicine by healthcare workers during infection control as a chemical disinfectant. It has been linked to numerous health hazards that range from asthma irritation of the eye contact dermatitis. Citrullus colocynthis (C.C.) utilized supplement combat health-related problems. This study aimed assess effectiveness locally applied extract and loaded with ZnONPs against dermatitis caused disinfectant glutaraldehyde (2%).The female mice were divided into five groups (G1, G2, G3, G4, G5). Group 1 was control. The other 4 (2,3,4,and 5) sprayed 2% GLU (2 mg/kg body weight), (3,4,and subjected local application natural products ( cream, ZnONP on cream), respectively. Each experimental animal followed for 5 days per week 30 days.Our findings revealed GLU-induced via upregulation TNF-α, IL-1b, NFkb 1, ptgs2 mRNA expression downregulation TGFB1 oxidative stress altered biochemical markers histological appearance. However, these effects improved , C.C. extract, C.C.-ZnONPs .Local had preventive -induced through suppression inflammatory enhancement antioxidants.

Language: Английский

Citations

0
Strontium-substituted hydroxyapatite nanoparticles associated with type I-collagen enhances the obliteration of dentinal tubules and the mineralization by human dental pulp stem cells DOI

Jeferson Mateus Moussa Macedo,

Paula Consul Kazmirczak,

Larwsk Hayann

et al.

Emergent Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Language: Английский

Citations

0
Berberine loaded glyceryl monooleate nanoparticles exhibited potent intrinsic anticancer activity against pancreatic cancer therapy: In vitro and in silico studies DOI Creative Commons

Md. Harun Al Rashid,

Sweta Mishra,

Saswati Pattnaik

et al.

Nano Trends, Journal Year: 2025, Volume and Issue: unknown, P. 100092 - 100092

Published: Feb. 1, 2025

Language: Английский

Citations

0
Nanoparticle-Based Delivery Systems for Phytochemicals in Cancer Therapy: Molecular Mechanisms, Clinical Evidence, and Emerging Trends DOI
Mahmoud A.H. Mostafa, Hani M. J. Khojah

Drug Development and Industrial Pharmacy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 31

Published: March 21, 2025

This review examines recent advancements in nanoparticle-based delivery systems for phytochemicals, focusing on their role overcoming multidrug resistance, improving therapeutic efficacy, and facilitating clinical translation. highlights advances nanoparticle-enabled phytochemical to enhance bioavailability, improve outcomes, enable targeted applications. By comparing various nanoparticle systems, formulation methods, efficacy data, it identifies gaps current research guides the development of more effective, next-generation phytochemical-loaded nanocarriers. A systematic literature published between 2000 2024 was conducted using PubMed, Scopus, Web Science. Articles cancer therapy were included. Compounds such as curcumin, resveratrol, quercetin, epigallocatechin gallate demonstrate enhanced anti-cancer when encapsulated nanoparticles, leading improved increased tumor cell targeting, reduced toxicity. Clinical trials indicate regression fewer adverse effects. Emerging approaches-such nanogels, hybrid combination therapies with immune checkpoint inhibitors-further refine treatment efficacy. Nanoparticle-based significantly potential making them promising candidates safer, effective treatments. However, challenges related regulatory guidelines, scalability, long-term safety must be addressed fully realize potential.

Language: Английский

Citations

0
Natural products as promising therapeutics for fine particulate matter–induced skin damage: a review of pre-clinical studies on skin inflammation and barrier dysfunction DOI Creative Commons

Saowanee Jeayeng,

Jaturon Kwanthongdee,

Ratima Jittreeprasert

et al.

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19316 - e19316

Published: April 28, 2025

Particulate matter less than 2.5 µm (PM2.5) is a significant air pollutant and linked to an increased risk of health conditions, including skin diseases. The skin, as the first barrier largest organ, primarily damaged by PM2.5 through different pathways. Several studies have shown that upregulates inflammatory responses excessive production reactive oxygen species (ROS) several cytokines, leading PM2.5-induced damage. ROS/mitogen-activated protein kinase (MAPK) Cyclooxygenase-2-Prostaglandin E2 (COX2/PGE2) pathways are activated free radical scavenging phase II detoxification. Natural products been suggested therapeutic agents for mitigating We elaborate on mechanisms action natural their functions protectants against environmental This review highlights optimal doses clinical study, which may benefit dermatologists, molecular biologists, clinicians, healthcare professionals in preventive alternative medicine. available scientific literature published between 1999 2024 was searched using PubMed Google Scholar. Multiple keywords related topic were used. Only 41 screened articles chosen this review, they most relevant publications advantages specific targeting injury. All meeting criteria being original full written English included. summarized products, phenolic/polyphenolic compounds flavonoids, can act anti-inflammatory antioxidant protecting oxidative stress, inhibiting enzymes promote formation, enhancing enzyme activity, reducing overall ROS formation. demonstrated efficacy alleviating intracellular ROS, mitochondrial dysfunction, autophagy, apoptosis caused PM2.5. In addition, phytochemical support restoration wound healing process muscle contraction impaired pollutants, such UV rays. promising protect environment-mediated problems focusing action. Particular emphasis placed compounds, sulforaphane, hesperidin, quercetin, catechin, diphloroethohydroxycarmalol, resveratrol, ginsenoside, become interesting candidates nutraceuticals due potential reduce reliance conventional medicines. However, low stability bioavailability remain challenges use; therefore, further research development warranted.

Language: Английский

Citations

0