Total synthesis of the HDAC inhibitor (+)-(R)-trichostatin A via O-directed dialkylacetylene free radical hydrostannation with Ph3SnH/Et3B. The unusual inhibitory effect of a proximal α-OPv group on the course of a vinyl iodide Stille cross-coupling
Ke Pan,
No information about this author
Soraya Manaviazar,
No information about this author
Karl J. Hale
No information about this author
et al.
Organic & Biomolecular Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
A
new
total
synthesis
of
(+)-(
R
)-trichostatin
is
reported
in
which
a
room
temperature,
O
-directed,
free
radical
hydrostannation
reaction
employed
with
Ph
3
SnH/cat.
Et
B
disubstituted
dialkylanilino-alkynol
system
for
the
very
first
time.
Language: Английский
Role of DNA methylation transferase in urinary system diseases: From basic to clinical perspectives (Review)
Yipin Yang,
No information about this author
Yafen Wang,
No information about this author
Xiying Fan
No information about this author
et al.
International Journal of Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
55(2)
Published: Nov. 19, 2024
DNA
methylation
is
one
of
the
earliest
discovered
and
most
extensively
studied
epigenetic
regulatory
mechanisms.
Broadly,
refers
to
transfer
a
methyl
group
on
S‑adenosine‑L‑methionine
(SAM)
C5
site
cytosine,
reaction
catalysed
by
methyltransferase
(DNMT).
This
process
can
either
up‑
or
down‑regulate
gene
expression
due
promoter
methylation,
leading
occurrence
certain
diseases.
Urinary
system
diseases,
known
for
their
high
prevalence
complex
pathogenesis,
significantly
affect
lives
health
patients.
Urological
tumours,
in
particular,
represent
non‑negligible
disease
burden
worldwide.
With
development
epigenetics,
an
increasing
number
studies
have
demonstrated
that
DNMT
plays
important
role
urinary
disease.
The
present
review
aims
explore
relationship
between
diseases
potential
clinical
management
these
Language: Английский