Recent Progress on Physiologically Based Pharmacokinetic (PBPK) Model: A Review Based on Bibliometrics DOI Creative Commons
Huang He, Wenjing Zhao, Ning Qin

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(6), P. 433 - 433

Published: June 14, 2024

Physiologically based pharmacokinetic/toxicokinetic (PBPK/PBTK) models are designed to elucidate the mechanism of chemical compound action in organisms on physiological, biochemical, anatomical, and thermodynamic properties organisms. After nearly a century research practice, good results have been achieved fields medicine, environmental science, ecology. However, there is currently lack more systematic review progress main directions PBPK models, especially comprehensive understanding application aquatic research. In this review, total 3974 articles related from 1996 24 March 2024 were collected. Then, areas model categorized keyword co-occurrence maps cluster obtained by CiteSpace. The showed that medicine area PBPK. Four major included medical field “drug assessment”, “cross-species prediction”, “drug–drug interactions”, “pediatrics pregnancy drug development”, which assessment” accounted for 55% publication volume. addition, bibliometric analyses indicated rapid growth trend research, predicting residual levels revealing relationship between internal external exposure. Despite facing limitation insufficient species-specific parameters, still an effective tool improving chemical–biological effectiveness will provide theoretical basis accurately assessing potential risks ecosystems human health. combination with quantitative structure–activity model, Bayesian method, machine learning technology solutions previous gaps.

Language: Английский

Recent Progress on Physiologically Based Pharmacokinetic (PBPK) Model: A Review Based on Bibliometrics DOI Creative Commons
Huang He, Wenjing Zhao, Ning Qin

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(6), P. 433 - 433

Published: June 14, 2024

Physiologically based pharmacokinetic/toxicokinetic (PBPK/PBTK) models are designed to elucidate the mechanism of chemical compound action in organisms on physiological, biochemical, anatomical, and thermodynamic properties organisms. After nearly a century research practice, good results have been achieved fields medicine, environmental science, ecology. However, there is currently lack more systematic review progress main directions PBPK models, especially comprehensive understanding application aquatic research. In this review, total 3974 articles related from 1996 24 March 2024 were collected. Then, areas model categorized keyword co-occurrence maps cluster obtained by CiteSpace. The showed that medicine area PBPK. Four major included medical field “drug assessment”, “cross-species prediction”, “drug–drug interactions”, “pediatrics pregnancy drug development”, which assessment” accounted for 55% publication volume. addition, bibliometric analyses indicated rapid growth trend research, predicting residual levels revealing relationship between internal external exposure. Despite facing limitation insufficient species-specific parameters, still an effective tool improving chemical–biological effectiveness will provide theoretical basis accurately assessing potential risks ecosystems human health. combination with quantitative structure–activity model, Bayesian method, machine learning technology solutions previous gaps.

Language: Английский

Citations

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