Nanocarrier-Based Drug Delivery to Brain: Interventions of Surface Modification DOI
Surbhi Sharma, Shweta Dang

Current Neuropharmacology, Journal Year: 2022, Volume and Issue: 21(3), P. 517 - 535

Published: July 7, 2022

Brain disorders are a prevalent and rapidly growing problem in the medical field as they adversely affect quality of life human. With an increase expectancy, it has been reported that diseases like Alzheimer's, Parkinson's, stroke brain tumors, along with neuropsychological disorders, also being at alarmingly high rate. Despite various therapeutic methods for treating drug delivery to challenging because very complex Blood Barrier, which precludes most drugs from entering effective concentrations. Nano-carrier-based systems have widely by researchers overcome this barrier layer. These due their small size, offer numerous advantages; however, short residence time body owing opsonization hinders success vivo. This review article focuses on aspects modifying surfaces these nano-carriers polymers, surfactants, protein, antibodies, cell-penetrating peptides, integrin binding peptides glycoproteins such transferrin & lactoferrin leading enhanced time, desirable characteristics ability cross blood-brain (BBB), increased bioavailability regions targeted delivery.

Language: Английский

Solid lipid-based nanoparticulate system for sustained release and enhanced in-vitro cytotoxic effect of 5-fluorouracil on skin Melanoma and squamous cell carcinoma DOI Creative Commons
Ahsan Ali, Asadullah Madni,

Hassan Shah

et al.

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(2), P. e0281004 - e0281004

Published: Feb. 28, 2023

The present study aimed to prepare solid lipid-based nanoparticles (SLNs) using Precirol ® ATO 5 as lipid and Poloxamer 188 Tween 80 surfactant co-surfactant respectively, SLNs-derived gel for sustained delivery, enhanced in-vitro cytotoxicity, cellular uptake of 5-FU permeation across the skin. 5-FU-loaded SLNs were prepared by hot melt encapsulation method converted into SLN-derived a gelling agent (Carbopol 940). had particle size in range 76.82±1.48 327±4.46 nm, zeta potential between -11.3±2.11 -28.4±2.40 mV, entrapment efficiency (%) 63.46±1.13 76.08±2.42. FTIR analysis depicted that there was no chemical interaction formulation components. Differential scanning calorimetric showed thermal stability powdered X-ray diffraction revealed successful incorporation nanoparticles. release biphasic behavior with initial burst followed over 48 hr. greater cytotoxic effect on skin melanoma (B16F10 cells) squamous cell carcinoma (A-431 compared free drug solution after Flow cytometry fluorescence microscopy displayed quantitative qualitative SLNs. acceptable safety biocompatible profile an acute toxicity Wistar rats. Moreover, ex-vivo studies 2.13±0.076 folds flux SLN derived plain gel, retention target 2.54±0.03 gel.

Language: Английский

Citations

16
Parenteral Lipid-Based Nanoparticles for CNS Disorders: Integrating Various Facets of Preclinical Evaluation towards More Effective Clinical Translation DOI Creative Commons
Jela Milić, Jelena Đoković, Ines Nikolić

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 443 - 443

Published: Jan. 29, 2023

Contemporary trends in combinatorial chemistry and the design of pharmaceuticals targeting brain disorders have favored development drug candidates with increased lipophilicity poorer water solubility, expected improvement delivery across blood-brain barrier (BBB). The growing availability innovative excipients/ligands allowing improved controlled release makes lipid nanocarriers a reasonable choice to overcome factors impeding through BBB. However, wide variety methods, study designs experimental conditions utilized literature hinder their systematic comparison, thus slows advances brain-targeting by lipid-based nanoparticles. This review provides an overview methods most commonly during preclinical testing liposomes, nanoemulsions, solid nanoparticles nanostructured carriers intended for treatment various CNS via parenteral route. In order fully elucidate structure, stability, safety profiles, biodistribution, metabolism, pharmacokinetics immunological effects such nanoparticles, transdisciplinary approach characterization is mandatory, covering comprehensive set physical, chemical, vitro vivo biological testing.

Language: Английский

Citations

13
Nose to Brain Delivery of Transferrin conjugated PLGA nanoparticles for clonidine DOI
Surbhi Sharma, Amit Tyagi, Shweta Dang

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 252, P. 126471 - 126471

Published: Aug. 22, 2023

Language: Английский

Citations

13
Parenteral microemulsions for drug delivery: Advances and update DOI Creative Commons
Vivek P. Chavda, Niva Rani Gogoi, Dixa A. Vaghela

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 89, P. 104991 - 104991

Published: Sept. 23, 2023

Language: Английский

Citations

13
Functional Polyphenol-Based Nanoparticles Boosted the Neuroprotective Effect of Riluzole for Acute Spinal Cord Injury DOI
Taoyang Yuan, Tianyou Wang, Jianhua Zhang

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(4), P. 2607 - 2620

Published: March 26, 2024

Riluzole is commonly used as a neuroprotective agent for treating traumatic spinal cord injury (SCI), which works by blocking the influx of sodium and calcium ions reducing glutamate activity. However, its clinical application limited because poor solubility, short half-life, potential organ toxicity, insufficient bioabilities toward upregulated inflammation oxidative stress levels. To address this issue, epigallocatechin gallate (EGCG), natural polyphenol, was employed to fabricate nanoparticles (NPs) with riluzole enhance effects. The resulting NPs demonstrated good biocompatibility, excellent antioxidative properties, promising regulation effects from M1 M2 macrophages. Furthermore, an in vivo SCI model successfully established, could be obviously aggregated at site. More interestingly, properties through regulating levels stress, inflammation, ion channels fully RNA sequencing sophisticated biochemistry evaluations. Together, work provided new opportunities design fabrication robust multifunctional inflammation-related diseases via biological integration polyphenols small-molecule drugs.

Language: Английский

Citations

5
New insight into brain disease therapy: nanomedicines-crossing blood–brain barrier and extracellular space for drug delivery DOI Creative Commons

Ziqi Gu,

Haishu Chen,

Zhao Han

et al.

Expert Opinion on Drug Delivery, Journal Year: 2022, Volume and Issue: 19(12), P. 1618 - 1635

Published: Oct. 26, 2022

Brain diseases including brain tumor, Alzheimer's disease, Parkinson's etc. are difficult to treat. The blood-brain barrier (BBB) is a major obstacle for drug delivery into the brain. Although nano-package and receptor-mediated of nanomedicine markedly increases BBB penetration, it yet did not extensively improve clinical cure rate. Recently, extracellular space (ECS) interstitial fluid (ISF) drainage in ECS have been found determine whether dissolved ISF can reach its target cells. Notably, an increase tortuosity associated with slower induced by accumulated harmful substances, such as: amyloid-beta (Aβ), α-synuclein, metabolic wastes, causes failure.The methods penetration efficacy nanomedicines across assessed.Invasive delivering via noninvasive near-infrared photo-sensitive may provide promising benefit patients disease.

Language: Английский

Citations

20
Nanostructured Lipid Carriers Enriched Hydrogels for Skin Topical Administration of Quercetin and Omega-3 Fatty Acid DOI Creative Commons
Marlene Lúcio,

Nicole Giannino,

Sérgio V. P. Barreira

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(8), P. 2078 - 2078

Published: Aug. 3, 2023

Chronic skin exposure to external hostile agents (e.g., UV radiation, microorganisms, and oxidizing chemicals) may increase oxidative stress, causing damage aging. Because of their well-known skincare protective benefits, quercetin (Q) omega-3 fatty acids (ω3) have attracted the attention dermocosmetic pharmaceutical sectors. However, both bioactives inherent properties that limit efficient delivery. Therefore, nanostructured lipid carriers (NLCs) enriched PFC® hydrogels (HGs) been developed as a dual-approach vehicle for Q and/or ω3 topical administration improve bioactives’ stability permeation. Two NLC formulations were prepared with same composition but differing in surfactant (NLC1—soy lecithin poloxamer 407; NLC2—Tween® 80 dioctyl sodium sulfosuccinate (DOSS)), which an impact on physicochemical therapeutic performance. Despite NLCs presenting high loading capacity, NLC2′s make them more suitable ensure longer colloidal stability. Additionally, NLC2 demonstrated sustained release, indicating higher bioactive storage while improving permeability. The occlusive effect NLCs-enriched HGs also has positive Q-loaded NLC2, or without ω3, -enriched efficacy antioxidant photoprotective well effective reduction S. aureus growth, they constitute promising approach prevent aging other damaging cutaneous processes.

Language: Английский

Citations

12
Riluzole-loaded lipid nanoparticles for brain delivery: Preparation, optimization and characterization DOI Creative Commons
Maria Inês Teixeira, Carla M. Lopes, Hugo Gonçalves

et al.

Journal of Molecular Liquids, Journal Year: 2023, Volume and Issue: 388, P. 122749 - 122749

Published: Aug. 4, 2023

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, with median survival of only 2 to 4 years. Riluzole, drug commonly used in the management ALS, has low aqueous solubility and limited bioavailability. ALS treatment also hindered by presence blood-brain barrier (BBB) that preserves delicate homeostasis cerebral milieu, isolating it making brain delivery exceptionally hard. To overcome these issues, use lipid nanocarriers, such as solid nanoparticles (SLN) nanostructured carriers (NLC), promising strategy. In this study, SLN NLC were prepared optimized facilitate riluzole uptake into for therapy. The characterized through different techniques, respect their physicochemical properties (size, zeta potential (ZP), polydispersity index (PDI)), well encapsulation efficiency, morphology, stability, vitro release, crystallinity, biocompatibility. Riluzole-loaded nanocarriers exhibited characteristics suitable delivery, including mean diameters between 147.2 203.1 nm, PDI (< 0.3), negative ZP −22.5 −27.5 mV. Additionally, they physically stable over 3 months under storage conditions (5) ℃ 25 ℃), promoting slow sustained release drug, which was shown be inside core matrix. Cytotoxicity assays demonstrated both did not significantly affect viability an hCMEC/D3 cell monolayer at concentration up 10 μM. results suggest developed could viable platform target central nervous system (CNS). Nevertheless, further vivo studies are needed validate therapeutic efficacy safety.

Language: Английский

Citations

12
Harnessing whey protein nanobiomaterials for tissue regeneration and cancer therapy: A comprehensive guide to recent innovations DOI
Minahil Hayat,

Sayyad Ali Raza Bukhari,

Zhanmin Liu

et al.

Journal of Industrial and Engineering Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
In Vitro Evaluation of the Safety and Antineoplastic Effects in Gastrointestinal Tumors of Nanostructured Lipid Carriers Loaded with Berberine DOI Creative Commons
Denitsa Stefanova, Yordan Yordanov,

Radostina Bogdanova

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 331 - 331

Published: March 4, 2025

Background/Objectives: Natural substances have been a widely studied source of both pharmaceutical excipients and drugs. Berberine (BRB) is benzylisoquinoline alkaloid isolated from different plant sources. It possesses various pharmacological properties including antibacterial, antitumor, antidiabetic, neuroprotective, hepatoprotective, anti-inflammatory, antioxidant, etc. However, the limited aqueous solubility hinders its application. Nanosized drug delivery systems are an innovative approach for addressing challenges regarding via routes administration. Their utilization could improve active constituents. Methods: A melt-emulsification ultrasonication technique was applied preparation nanostructured lipid carriers (NLCs). They were thoroughly physicochemically characterized by means Dynamic Light Scattering, TEM, FTIR, DSC, TGA, In Vitro release. The efficacy safety evaluated on cholangiocarcinoma, colorectal adenocarcinoma, hepatocellular carcinoma, lymphoma, fibroblast, cardioblast cells, as well rat liver microsomes cytotoxicity assays comet assay. Results: obtained nanoparticles had spherical shape size around 158.2 ± 1.8 nm with negative zeta potential. revealed successful loading improved dissolution berberine in physiological conditions. studies showed that BRB NLCs resulted or retained to tumor cell lines reduced normal microsomes. NLC itself increased microsomal malondialdehyde (MDA) formation. Conclusions: presented. nanocarriers show favorable physicochemical biopharmaceutical properties. cellular experiments anticancer safety. These findings highlight potential applicability gastrointestinal neoplasms build foundation future practical translation.

Language: Английский

Citations

0