Scaffold for the Minimally Invasive Repair of Soft Tissue Inspired by Soggy Shrunk Puffed Food DOI Creative Commons
Yong He

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 4, 2023

Abstract Minimally invasive injection of tissue engineering scaffolds has been gaining attention due to featuring several advantages requiring a small incision, entailing simple operation procedure, and involving quick recovery. However, it remains challenge because larger must pass through an extremely thin needle. Herein, inspired by the phenomenon that puffed food becomes soggy shrinks when exposed air, novel scaffold treatment method is proposed; namely, lyophilization & dampening (L&D) treatment, which reduces printed hydrogel volume around 90%. Lyophilization can remove water inside scaffolds; Dampening is, placing freeze-dried into vapor atmosphere, make shrunk suitable size for minimally injection. Moreover, unlike existing air-dried technique feature high mechanical modulus, developed herein low modulus (2.88 kPa), thus minimizing foreign body sensation after implantation. Furthermore, injected rapidly swell their original act as regeneration media. Accordingly, specialized tool namely “BioGun” designed ("BioBullet”). This strategy would potentially overcome technical bottlenecks limiting clinical soft defect repair.

Language: Английский

Photo-/thermo-responsive bioink for improved printability in extrusion-based bioprinting DOI Creative Commons
Seo Hyung Moon, Tae Yoon Park, Hyung Joon

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 25, P. 100973 - 100973

Published: Jan. 26, 2024

Extrusion-based bioprinting has demonstrated significant potential for manufacturing constructs, particularly 3D cell culture. However, there is a greatly limited number of bioink candidates exploited with extrusion-based bioprinting, as they meet the opposing requirements printability indispensable rheological features and biochemical functionality desirable microenvironment. In this study, blend silk fibroin (SF) iota-carrageenan (CG) was chosen cell-friendly printable material. The SF/CG ink exhibited suitable viscosity shear-thinning properties, coupled rapid sol-gel transition CG. By employing photo-crosslinking SF, Pr value close to 1 structural integrity constructs were significantly improved within matter seconds. printed Young's modulus approximately 250 kPa, making them keratinocyte myoblast Furthermore, high adhesiveness viability (maximum >98%) loaded cells underscored considerable culture scaffold applied skin muscle tissues, which can be easily manipulated using an bioprinter.

Language: Английский

Citations

17
Designing advanced hydrogel inks with direct ink writing based 3D printability for engineered biostructures DOI
Dimpy Bhardwaj,

Ritu Singhmar,

Megha Garg

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 205, P. 112736 - 112736

Published: Jan. 4, 2024

Language: Английский

Citations

16
3D printed Aloe barbadensis loaded alginate-gelatin hydrogel for wound healing and scar reduction: In vitro and in vivo study DOI

Shahabaj S Mujawar,

Gajanan K Arbade, N. S. Bisht

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139745 - 139745

Published: Jan. 1, 2025

Language: Английский

Citations

1
Review of alginate-based composites for 3D printing material DOI
Bunga Fisikanta Bukit, Firda Aulya Syamani, Emma Rochima

et al.

Polymers from Renewable Resources, Journal Year: 2024, Volume and Issue: 15(2), P. 256 - 277

Published: Jan. 18, 2024

The ability of alginates to form hydrogel solutions makes them a promising biomaterial for three-dimensional (3D) printing. Researchers are investigating several techniques improve the alginate hydrogels’ quality, such as using alginate-based nanocomposites materials 3D This review examines material composites, printing technique, and applications composites. Material composites include with clay, combination polymers or biopolymers, mixture metal oxide carbon. from combined is usually used in medical green packaging industries, whereas oxide, carbon utilized environmental field. When considering procedures, extrusion most affordable. Furthermore, purpose composite characterization determine impact generated by combinations. carried out based on intended application. However, it common employ mechanical, thermal, rheological, scanning electron, XRD, FTIR analysis identify fundamental characteristics according research.

Language: Английский

Citations

6
3D Bioprinting of Cultured Meat: A Promising Avenue of Meat Production DOI
Xudong Guo, Dingyi Wang, Bin He

et al.

Food and Bioprocess Technology, Journal Year: 2023, Volume and Issue: 17(7), P. 1659 - 1680

Published: Sept. 2, 2023

Language: Английский

Citations

13
Alginate-gelatin based nanocomposite hydrogel scaffold incorporated with bioactive glass nanoparticles and fragmented nanofibers promote osteogenesis: From design to in vitro studies DOI

Kimia Eslami Shahrebabaki,

Sheyda Labbaf, Fathallah Karimzadeh

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137104 - 137104

Published: Nov. 5, 2024

Language: Английский

Citations

5
Biopolymers for Tissue Engineering: Crosslinking, Printing Techniques, and Applications DOI Creative Commons
David Patrocinio, Victor Galván-Chacón, J. Carlos Gómez-Blanco

et al.

Gels, Journal Year: 2023, Volume and Issue: 9(11), P. 890 - 890

Published: Nov. 10, 2023

Currently, tissue engineering has been dedicated to the development of 3D structures through bioprinting techniques that aim obtain personalized, dynamic, and complex hydrogel structures. Among different materials used for fabrication such structures, proteins polysaccharides are main biological compounds (biopolymers) selected bioink formulation. These biomaterials obtained from natural sources commonly compatible with tissues cells (biocompatibility), friendly digestion processes (biodegradability), provide specific macromolecular structural mechanical properties (biomimicry). However, rheological behaviors these natural-based bioinks constitute challenge cell-laden printing process (bioprinting). For this reason, usually requires chemical modifications and/or inter-macromolecular crosslinking. In sense, a comprehensive analysis describing biopolymers (natural polysaccharides)-based bioinks, their modifications, stimuli-responsive nature is performed. This manuscript organized into three sections: (1) application, (2) crosslinking, (3) techniques, analyzing current challenges strengths in bioprinting. conclusion, all hydrogels try resemble extracellular matrix bioprinted while maintaining good printability stability during process.

Language: Английский

Citations

12
Fabrication of Injectable Kartogenin-Conjugated Composite Hydrogel with a Sustained Drug Release for Cartilage Repair DOI Creative Commons
Chao Li, Yubo Liu, Tujun Weng

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1949 - 1949

Published: July 14, 2023

Cartilage tissue engineering has attracted great attention in defect repair and regeneration. The utilization of bioactive scaffolds to effectively regulate the phenotype proliferation chondrocytes become an elemental means for cartilage On account simultaneous requirement mechanical biological performances tissue-engineered scaffolds, this work we prepared a naturally derived hydrogel composed kartogenin (KGN)-linked chitosan (CS-KGN) aldehyde-modified oxidized alginate (OSA) via highly efficient Schiff base reaction multifarious physical interactions mild conditions. basis rigid backbones excellent biocompatibility these two natural polysaccharides, composite demonstrated favorable morphology, easy injectability, good strength adhesiveness, low swelling ratio, long-term sustainable KGN release, facilitated bone marrow mesenchymal stem cell activity, which could simultaneously provide supports promote chondrogenic differentiation articular defects. Therefore, believe can offer designable consideration potential alternative candidate other soft implants.

Language: Английский

Citations

11
Bioprinting: Mechanical Stabilization and Reinforcement Strategies in Regenerative Medicine DOI

Ashleigh Ballard,

Rebecca Patush,

Jenesis Perez

et al.

Tissue Engineering Part A, Journal Year: 2024, Volume and Issue: 30(13-14), P. 387 - 408

Published: Jan. 11, 2024

Bioprinting describes the printing of biomaterials and cell-laden or cell-free hydrogels with various combinations embedded bioactive molecules. It encompasses precise patterning cells to create scaffolds for different biomedical needs. There are many requirements that bioprinting face, it is ultimately interplay between scaffold's structure, properties, processing, performance will lead its successful translation. Among essential properties must possess—adequate appropriate application-specific chemical, mechanical, biological performance—the mechanical behavior hydrogel-based bioprinted key their stable in vivo at site implantation. Hydrogels typically constitute main scaffold material medium biomolecules very soft, often lack sufficient stability, which reduces printability and, therefore, potential. The aim this review article highlight reinforcement strategies used approaches achieve enhanced stability bioinks printed scaffolds. Enabling robust materials processes creation truly complex remarkable structures could accelerate application smart, functional settings. a powerful tool fabrication 3D applications. has gained tremendous attention recent years, bioink library expanding include more combinations. From practical perspective, need be considered, such as structure's performances. these, constructs critical translation into clinic. explore stabilization structures.

Language: Английский

Citations

4
3D printed sodium Alginate-Gelatin hydrogel loaded with Santalum album oil as an antibacterial Full-Thickness wound healing and scar reduction Scaffold: In vitro and in vivo study DOI

Shahabaj S Mujawar,

Gajanan K Arbade,

Sonali Rukwal

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 670, P. 125164 - 125164

Published: Jan. 5, 2025

Language: Английский

Citations

0