RSC Advances, Journal Year: 2024, Volume and Issue: 14(45), P. 33206 - 33222
Published: Jan. 1, 2024
Synthesis and decomposition of KGN molecule.
Language: Английский
Experimental and Therapeutic Medicine, Journal Year: 2023, Volume and Issue: 26(4)
Published: Aug. 25, 2023
Knee osteoarthritis (KOA) is a common chronic articular disease worldwide. It also the most form of OA and characterized by high morbidity disability rates. With gradual increase in life expectancy ageing population, KOA not only affects quality patients, but poses burden on global public health. unknown etiology complex pathogenesis. commonly joints subjected to greater loads higher levels activity. The knee joint, which joint human body bears greatest load among all joints, therefore susceptible development OA. lesions may involve cartilage, synovium, capsule periarticular muscles, causing irreversible damage. Factors such as mechanical overload, inflammation, metabolism, hormonal changes serve key roles acceleration progression. clinical diagnosis primarily based combined analysis symptoms, signs, imaging laboratory examination results. At present, there no cure for currently available therapies focus symptomatic treatment delay replacement surgery typically performed patients with advanced disease. current study presents review epidemiological characteristics, risk factors, histopathological manifestations, pathogenesis, diagnosis, modalities progress research.
Language: Английский
Citations
88
BioMedical Engineering OnLine, Journal Year: 2025, Volume and Issue: 24(1)
Published: Feb. 7, 2025
Articular cartilage injury is a serious bone disease that can result in disabilities. With the rapid increase aging population, this disorder has become an increasingly important public health issue. Recently, stem cell-based tissue engineering emerged as promising therapeutic option for treating articular damage. Cellular scaffolds, which are among three key elements of engineering, play significant roles repair damaged by regulating cellular responses and promoting regeneration. Biological macromolecules commonly used scaffold materials owing to their unique properties. For example, natural synthetic polymer hydrogel scaffolds effectively mimic microenvironment extracellular matrix; exhibit high cytocompatibility, biocompatibility, biodegradability; have attracted increasing attention regeneration medicine. Several types been fabricated treat abnormalities. This article outlines recent progress field manufactured from various biomaterials repairing cartilage, discusses advantages disadvantages, proposes directions future development.
Language: Английский
Citations
4
ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(8), P. 4823 - 4838
Published: July 26, 2024
Itaconic acid and its derivative 4-octyl itaconate (OI) represent a novel anti-inflammatory medication that has demonstrated efficacy in multiple inflammation models because of minimal side effects. Recently, natural polymers conjugated with small molecule drugs, known as polymer-drug conjugates (PDCs), have emerged promising approach to sustained drug release. In this work, we reported an prepare PDC containing OI make it into injectable hydrogel. Chitosan (CS) was selected for synthesis abundant free amino groups can be molecules carboxyl by carbodiimide chemistry. We used ethanol/water cosolvent system synthesize CS-OI conjugate via EDC/NHS catalysis. The had improved water solubility unique activity did not show compromised antibacterial compared unmodified CS. Beta-glycerophosphate (β-GP) cross-linked hydrogel exhibited good injectability sustainable release effectively modulated inflammatory response rat model. Therefore, study provides valuable insights the design hydrogels modulatory properties.
Language: Английский
Citations
6
RSC Advances, Journal Year: 2024, Volume and Issue: 14(7), P. 4930 - 4945
Published: Jan. 1, 2024
Biobran encapsulated PCL/PVA core shell nanofibers.
Language: Английский
Citations
5
Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 187, P. 82 - 97
Published: Aug. 23, 2024
Superficial cartilage defects represent the most prevalent type of injury encountered in clinical settings, posing significant treatment challenges. Here, we fabricated a extracellular matrix mimic hydrogel (GHC, consisting Gelatin, Hyaluronic acid, and Chondroitin sulfate) to avoid exacerbation deterioration, which is often driven by accumulation reactive oxygen species (ROS) pro-inflammatory microenvironment. The GHC exhibited multifunctional properties, including situ formation, tissue adhesiveness, anti-ROS capabilities, promotion chondrogenesis. enhancement adhesion was achieved chemically modifying hyaluronic acid chondroitin sulfate with o-nitrobenzene, enabling covalent connection surface upon light irradiation. In vitro characterization revealed that facilitated chondrocyte adhesion, migration, differentiation into cartilage. Additionally, hydrogels demonstrated ability scavenge ROS inhibit production inflammatory factors chondrocytes. animal model superficial injury, effectively promoted ECM regeneration interface integration between host material. These findings suggest hold considerable promise as strategy for defect repair. STATEMENT OF SIGNIFICANCE: clinic. Previous engineering materials are only suitable full-thickness or osteochondral defects. developed composed gelatin, sulfate, natural components. drug-free cell-free not avoids immune rejection drug toxicity, but also shows good mechanical properties biocompatibility. More importantly, could adhere tightly promote while protecting against oxidation. This ingredients potential material repairing
Language: Английский
Citations
4
Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107618 - 107618
Published: Jan. 1, 2025
Language: Английский
Citations
0
Advanced Biology, Journal Year: 2023, Volume and Issue: 7(12)
Published: Aug. 27, 2023
Abstract Cartilage injury is a common disease in daily life. Especially aging populations, the incidence of osteoarthritis increasing. However, due to poor regeneration ability cartilage, most cartilage injuries cannot be effectively repaired. Even tissue engineering still faces many problems such as complex composition and integration scaffolds host tissues. In this study, chondroitin sulfate, one main components extracellular matrix (ECM), chosen natural component material, which can protect variety ways. Moreover, results show that addition sulfate improves mechanical properties gelatin methacrylate (GelMA) hydrogel, making it able bear loads vivo. Further, modified obtain oxidized (OCS) containing aldehyde groups via sodium periodate. This special group interface adhesion hydrogel through schiff base reactions. summary, GelMA/OCS promising candidate for with good biocompatibility, properties, ability, excellent repair ability.
Language: Английский
Citations
8
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 503, P. 158242 - 158242
Published: Dec. 3, 2024
Language: Английский
Citations
2
Nano LIFE, Journal Year: 2024, Volume and Issue: 14(02)
Published: Feb. 3, 2024
Scaffolds offer a three-dimensional framework supporting cell growth, proliferation, and differentiation of cells which are used to repair regenerate tissues. Recent advancements in scaffold technology have significantly exploited the field tissue engineering regenerative medicine. This comprehensive review provides in-depth exploration materials, fabrication techniques, their recent progress applications. Composite scaffolds promising applications bone dental regeneration due greater mechanical properties ability promote growth. The inherent crosslinking present hydrogels allows them maintain integrity structure without dissolving. However, there is growing interest smart can respond changes external surroundings like pH, ionic strength, temperature, or specific molecules. dECM an alternative potential technique for reconstructing functional organs/tissues by excluding cell-associated antigens while maintaining native ECM compositions growth factors, basement membrane structural proteins, GAG’s. degree porosity be increased various techniques such as TIPS, SCPL, gas foaming, freeze drying. GelMA shown proliferation regeneration. In addition, graphene its derivatives been instrumental bioactive cartilage introduction additive manufacturing technologies, specifically 3D bioprinting, has improved precision control fabrication.
Language: Английский
Citations
1
Progress in Organic Coatings, Journal Year: 2024, Volume and Issue: 192, P. 108466 - 108466
Published: May 3, 2024
Language: Английский
Citations
0