The Safety of Drug Treatment in Patients with Neuropathic Pain: Data from Ambulatory Care in a Real-Life Setting DOI Creative Commons

Cristina Vocca,

Vincenzo Rania, Antonio Siniscalchi

et al.

Reports — Medical Cases Images and Videos, Journal Year: 2023, Volume and Issue: 6(4), P. 57 - 57

Published: Dec. 1, 2023

Introduction: Drug treatment can be related to the development of adverse drug reactions (ADRs). Aim: In this paper, we evaluated ADRs in patients admitted Ambulatory Pain Medicine University Hospital Renato Dulbecco Catanzaro. Methods: We conducted a prospective analysis between 1 February 2021 and 20 July 2023 on with neuropathic pain referred “Renato Dulbecco” Catanzaro (Calabria, Italy). Patients aged >18 years clinical signs neurologic score upon completing Douleur Neuropathique en 4 Questions (DN4) questionnaire ≥4 were included. The association drugs ADR or drug–drug-interactions (DDIs) was using Naranjo’s probability scale Interaction Probability Scale (DIPS), respectively. Results: During study period, analyzed 2370 ambulatory medicine. After evaluation inclusion exclusion criteria, 33.5% enrolled. All presented at least one comorbidity daily used mean five (range 3–11). Using Naranjo score, documented 112 (score 6). parametric non-parametric statistical analysis, failed report an dosage patient characteristics. Conclusion: Our results show 18% pain. This low percentage interaction could limitation real life because it is probably due site appropriate prescription drugs. Therefore, shows that necessary motivate healthcare pay attention poly-treated reduce risk ADRs.

Language: Английский

Unraveling the Connection: Pain and Endoplasmic Reticulum Stress DOI Open Access

Ryoko Kawanaka,

Hisayo Jin,

Tomohiko Aoe

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4995 - 4995

Published: May 3, 2024

Pain is a complex and multifaceted experience. Recent research has increasingly focused on the role of endoplasmic reticulum (ER) stress in induction modulation pain. The ER an essential organelle for cells plays key protein folding calcium dynamics. Various pathological conditions, such as ischemia, hypoxia, toxic substances, increased production, may disturb folding, causing increase misfolding proteins ER. Such overload process leads to causes unfolded response (UPR), which increases capacity Uncompensated impairs intracellular signaling cell function, resulting various diseases, diabetes degenerative neurological diseases. be critical universal mechanism underlying human sensations involve central well peripheral nervous systems. Several preclinical studies indicate that system enhanced painful states, especially neuropathic pain conditions. purpose this narrative review uncover intricate relationship between pain, exploring molecular pathways, implications potential therapeutic strategies.

Language: Английский

Citations

8
Ultramicronized N-palmitoylethanolamine associated with analgesics: Effects against persistent pain DOI Creative Commons
Stefania Nobili, Laura Micheli, Elena Lucarini

et al.

Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 258, P. 108649 - 108649

Published: April 12, 2024

Current epidemiological data estimate that one in five people suffers from chronic pain with considerable impairment of health-related quality life. The pharmacological treatment is based on first- and second-line analgesic drugs, including COX-2 selective nonselective nonsteroidal anti-inflammatory paracetamol, antidepressants, anti-seizure drugs opioids, are characterized by important side effects. N-palmitoylethanolamine (PEA) a body's own fatty-acid ethanolamide belonging to the family autacoid local injury antagonist amides. pain-relieving properties PEA have been recognized for decades prompted depict its role endogenous mechanisms control. Together relative abundance food sources, this opened way use as nutritional intervention. Naïve large particle size lipid molecule low solubility bioavailability. Reducing useful method increase surface area, thereby improving dissolution rate bioavailability accordingly. Micron-size formulations (e.g., ultramicronized co-(ultra)micronized) shown higher oral efficacy compared naïve PEA. In particular, has efficiently cross intestinal wall and, more importantly, blood-brain blood-spinal cord barrier. Several preclinical clinical studies efficacy, safety tolerability This narrative review summarizes available pharmacokinetic/pharmacodynamic focuses contribution control, particular 'add-on' Data showing ability limit opioid effects, development tolerance, also reviewed.

Language: Английский

Citations

6
A novel microglia-targeting strategy based on nanoparticle-mediated delivery of miR-26a-5p for long-lasting analgesia in chronic pain DOI Creative Commons
Yitian Lu, Shuai Liu, Peng Wang

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 23, 2024

Abstract Accumulating evidence supports the notion that microglia play versatile roles in different chronic pain conditions. However, therapeutic strategies of by targeting remain largely overlooked. This study seeks to develop a miRNA-loaded nano-delivery system microglia, which could provide decent and long-lasting analgesia for pain. Surface aminated mesoporous silica nanoparticles were adopted load miR-26a-5p, potent analgesic miRNA, electrostatic adsorption, can avoid miR-26a-5p is rapidly released degraded. Then, peptide MG1 was modified on surface particles targeting. In peripheral nerve injury induced neuropathic model, satisfactory anti-allodynia effect with about 6 weeks pain-relief duration achieved through strategy, decreased activation inflammation Wnt5a, non-canonical Wnt pathway. inflammatory chemotherapy pain, strategy also exhibited more efficient longer than others. Overall, we developed microglia-targeting system, facilitates precisely delivery enhance several Graphical

Language: Английский

Citations

4
Efficacy and Safety of Intra-Articular Therapy with Cross-Linked Hyaluronic Acid in Patients with Knee Osteoarthritis DOI Creative Commons
Vincenzo Rania, Gianmarco Marcianò,

Cristina Vocca

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 302 - 302

Published: Feb. 22, 2025

Background/Objectives: Knee osteoarthritis (OA) is a degenerative chronic disease characterized by reduction in articular cartilage, as well pain and functional limitations. We evaluated both the efficacy safety of cross-linked high-molecular-weight hyaluronic acid patients with knee OA. Methods: In this observational prospective single-arm study, (DIART ONE 90 mg 3 mL) was administered single injections to 50 aged 18–65 years, follow-up at 3, 6, 12 months. Several scores were evaluated, including Injury Osteoarthritis Outcome Score primary outcome measure Visual Analogue Scale, Timed Up Go Test, Six-Minute Walking General Health Assessment 36-Item Short Form Survey, Zung’s Self-Rating Anxiety Depression Scale secondary measures. Both physicians knew kind treatment they received. Results: During follow-ups, we observed statistically significant improvement clinical 6 months, decrease benefit Functional psychological benefits No side effects described except associated site injection. Conclusions: conclusion, documented that represents an effective option management mild–moderate osteoarthritis.

Language: Английский

Citations

0
The therapeutic application of hydrogels in chronic pain DOI
Zhicheng Pan, Gang Liu,

Jun-xiang Liao

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106829 - 106829

Published: March 1, 2025

Language: Английский

Citations

0
Pancreatic Adenocarcinoma Patients with Pain have Abnormal Central Pain Processing DOI
Mahya Faghih, Marko Damm,

Conrad Bandhauer

et al.

Pancreatology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Synergistic Antinociceptive Effect of β-Caryophyllene Oxide in Combination with Paracetamol, and the Corresponding Gastroprotective Activity DOI Creative Commons
Josué Vidal Espinosa‐Juárez, Jesús Arrieta, Alfredo Briones-Aranda

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(5), P. 1037 - 1037

Published: May 8, 2024

Pain is the most frequent symptom of disease. In treating pain, a lower incidence adverse effects found for paracetamol versus other non-steroidal anti-inflammatory drugs. Nevertheless, can trigger side when taken regularly. Combined therapy common way lowering dose drug and thus reducing reactions. Since β-caryophyllene oxide (a natural bicyclic sesquiterpene) known to produce an analgesic effect, this study aimed determine anti-nociceptive gastroprotective activity administering combination plus CD1 mice. Anti-nociception was evaluated with formalin model gastroprotection ethanol-induced gastric lesions. According isobolographic analysis, interaction synergistic. Various pain-related pathways were explored their possible participation in mechanism action effect oxide, finding that NO, opioid receptors, serotonin K+ATP channels are not involved. The combined treatment showed against damage. Hence, synergistic combining could be advantageous management inflammatory should help protect chronic use.

Language: Английский

Citations

3
Recent Advances in Biomolecular Patho-Mechanistic Pathways behind the Development and Progression of Diabetic Neuropathy DOI Creative Commons
Yashumati Ratan, Aishwarya Rajput, Ashutosh Pareek

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1390 - 1390

Published: June 23, 2024

Diabetic neuropathy (DN) is a neurodegenerative disorder that primarily characterized by distal sensory loss, reduced mobility, and foot ulcers may potentially lead to amputation. The multifaceted etiology of DN linked range inflammatory, vascular, metabolic, other factors. Chronic inflammation, endothelial dysfunction, oxidative stress are the three basic biological changes contribute development DN. Although our understanding intricacies has advanced significantly over past decade, distinctive mechanisms underlying condition still poorly understood, which be reason behind lack an effective treatment cure for present study delivers comprehensive highlights potential role several pathways molecular etiopathogenesis Moreover, Schwann cells satellite glial cells, as integral factors in pathogenesis DN, have been enlightened. This work will motivate allied research disciplines gain better analysis current state biomolecular essential effectively address every facet from prevention treatment.

Language: Английский

Citations

3
Habituation to Pain in Patients with Chronic Pain: Clinical Implications and Future Directions DOI Open Access
Maite M. van der Miesen, Catherine J. Vossen,

Elbert A.J. Joosten

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(13), P. 4305 - 4305

Published: June 27, 2023

In this review, the latest insights into habituation to pain in chronic are summarized. Using a systematic search, results of studies on evidence (experimental) migraine, low back pain, fibromyalgia, and variety indications presented. reduced based self-report EEG-based N1 N2–P2 amplitude is reported, but presence contradictory demands further replication larger, well-designed studies. Habituation seems not differ from controls, with exception EEG measures. fibromyalgia patients, there some for amplitude. Our analysis shows that variability between outcomes high. As mechanisms underlying still fully understood likely involve several pathways, it now too early conclude related clinical can be used as diagnostic marker. The review ends discussion future directions research including use standard outcome measures improve comparisons patients well focus individual differences.

Language: Английский

Citations

8
Intravenous lidocaine for refractory pain in patients with pancreatic ductal adenocarcinoma and chronic pancreatitis (LIDOPAN): a multicenter prospective non-randomized pilot study DOI Creative Commons
Simone Augustinus, Matthanja Bieze,

Charlotte L. van Veldhuisen

et al.

Clinical and Translational Gastroenterology, Journal Year: 2024, Volume and Issue: 15(9), P. e1 - e1

Published: Aug. 19, 2024

Refractory pain is a major clinical problem in patients with pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). New, effective therapies to reduce are urgently needed. Intravenous lidocaine used practice PDAC CP, but its efficacy has not been studied prospectively.

Language: Английский

Citations

2