Ultrasonics Sonochemistry, Journal Year: 2024, Volume and Issue: 111, P. 107105 - 107105
Published: Oct. 15, 2024
Language: Английский
Chemical Communications, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 23, 2024
This review explores the synthesis, drug loading, and surface modifications of metal–organic frameworks (MOFs), highlighting their role in improving cancer immunotherapy paving way for safer more effective treatments.
Language: Английский
Citations
34
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 109 - 135
Published: Jan. 1, 2024
Abstract: The tumor microenvironment (TME) plays an important role in various stages of generation, metastasis, and evasion immune monitoring treatment. TME targeted therapy is based on components, related pathways or active molecules as therapeutic targets. Therefore, environmental differences between normal cells has been widely studied. Biomimetic nanocarriers with low clearance, immunogenicity, high targeting have enormous potential This review introduces the composition characteristics TME, including cancer‑associated fibroblasts (CAFs), extracellular matrix (ECM), blood vessels, non-tumor cells, latest research progress biomimetic nanoparticles (NPs) TME. It also discusses opportunities challenges clinical transformation nanoparticles. Keywords: nanoparticles, delivery system, therapy, cell membrane-coating
Language: Английский
Citations
30
Biotechnology Advances, Journal Year: 2025, Volume and Issue: 81, P. 108546 - 108546
Published: Feb. 26, 2025
Language: Английский
Citations
2
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 654, P. 123923 - 123923
Published: Feb. 23, 2024
Language: Английский
Citations
4
Acta Pharmacologica Sinica, Journal Year: 2024, Volume and Issue: 45(12), P. 2455 - 2473
Published: July 31, 2024
Language: Английский
Citations
4
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 5581 - 5603
Published: June 1, 2024
Lenvatinib (LVN) is a potentially effective multiple-targeted receptor tyrosine kinase inhibitor approved for treating hepatocellular carcinoma, metastatic renal cell carcinoma and thyroid cancer. Nonetheless, poor pharmacokinetic properties including water solubility rapid metabolic, complex tumor microenvironment, drug resistance have impeded its satisfactory therapeutic efficacy. This article comprehensively reviews the uses of nanotechnology in LVN to improve antitumor effects. With characteristic high modifiability loading capacity nano-drug delivery system, an active targeting approach, controllable release, biomimetic strategies been devised deliver target tumors sequence, compensating lack passive targeting. The existing applications advances improving efficacy include longer-term efficiency, achieving higher combination therapy, tracking diagnosing application reducing toxicity. Therefore, using multiple combined with photothermal, photodynamic, immunoregulatory therapies overcomes multi-drug resistance, regulates unfavorable yields synergistic In brief, nano-LVN system has brought light war against cancer while at same time effect. More intelligent multifunctional nanoparticles should be investigated further converted into clinical future.
Language: Английский
Citations
3
Current Pharmaceutical Design, Journal Year: 2024, Volume and Issue: 30(10), P. 727 - 741
Published: March 1, 2024
Abstract: This review investigates the revolutionary application of cell membrane-coated nanoparticles (CMNPs) as a promising avenue for cancer therapy within embryonic landscape nanotechnology. Nanoparticles, pivotal in treatment, are systematically examined their diverse physicochemical structures, categorized organic (lipid-based, protein-based, and polymer-assisted) inorganic (carbon-based metal) varieties. A significant focus is placed on CMNPs, which serve an innovative drug delivery vehicle, overcoming limitations associated with conventional nanoparticle therapies. manuscript accurately explores advantages challenges various membranes, including those derived from cells, red blood platelets, stem white cells. Importance roles enhancing precision, immune system circumvention, targeted recognition. Detailed insights into crafting CMNPs provided, elucidating membrane extraction fusion techniques, such sonication, extrusion, co-extrusion, microfluidic electroporation. Maintaining integrity during benefits coating techniques augmenting biocompatibility underscored. comprehensive resource consolidates latest advancements delivery, positioning itself at forefront nanotechnology biomedicine research. Encapsulating methodologies like electrospray, chemical conjugation, this showcases expanding toolbox available to researchers dynamic field. Focusing unique characteristics multifaceted applications biomedical research, particularly tumour therapy. It provides indepth analysis stability, evasion capabilities, increased payload capacity, retained biological functionality. The outlines current future prospects chemotherapy, photothermal photodynamic therapy, immunotherapy, gene therapeutic methods. concludes by highlighting transformative potential reshaping treatment.
Language: Английский
Citations
2
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 98, P. 105935 - 105935
Published: July 2, 2024
Language: Английский
Citations
2
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113085 - 113085
Published: Sept. 13, 2024
Language: Английский
Citations
1
Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110493 - 110493
Published: Sept. 1, 2024
Language: Английский
Citations
0