Nanotechnology for the Diagnosis and Treatment of Liver Cancer DOI Creative Commons
Yong Cai, Weiwei Wang,

Qinlian Jiao

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 13805 - 13821

Published: Dec. 1, 2024

Liver cancer has become a major global health challenge due to its high incidence, rate of late diagnosis and limited treatment options. Although there are many clinical treatments available for liver cancer, the cure is still very low, now researchers have begun explore new aspects treatment, nanotechnology shown great potential improving diagnostic accuracy therapeutic efficacy therefore promising option. In diagnosis, nanomaterials such as gold nanoparticles, magnetic silver nanoparticles can realize highly sensitive specific detection biomarkers, supporting real-time monitoring disease process. terms nanocarriers precise targeted delivery drugs, improve bioavailability drugs reduce systemic toxic side effects. addition, advanced technologies nanoparticle-based photothermal therapy photodynamic provide innovative solutions overcome drug resistance local tumor ablation. Therefore, in this paper, we will introduce hepatocellular carcinoma marker detection, delivery, synergistic PDT/CDT therapy.

Language: Английский

Lactate and lactylation in cancer DOI Creative Commons
Jie Chen, Ziyue Huang,

Ya Chen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 11, 2025

Abstract Accumulated evidence has implicated the diverse and substantial influence of lactate on cellular differentiation fate regulation in physiological pathological settings, particularly intricate conditions such as cancer. Specifically, been demonstrated to be pivotal molding tumor microenvironment (TME) through its effects different cell populations. Within cells, impacts signaling pathways, augments shuttle process, boosts resistance oxidative stress, contributes lactylation. In various populations, interplay between immune cells governs processes differentiation, response, surveillance, treatment effectiveness. Furthermore, communication stromal/endothelial supports basal membrane (BM) remodeling, epithelial-mesenchymal transitions (EMT), metabolic reprogramming, angiogenesis, drug resistance. Focusing production transport, specifically dehydrogenase (LDH) monocarboxylate transporters (MCT), shown promise Inhibitors targeting LDH MCT act both suppressors enhancers immunotherapy, leading a synergistic therapeutic effect when combined with immunotherapy. The review underscores importance progression provides valuable perspectives potential approaches that target vulnerability metabolism, highlighting Heel Achilles for cancer treatment.

Language: Английский

Citations

9
Nanomaterials in cancer immunotherapy: targeting cancer-associated fibroblasts DOI Creative Commons

Zhongsong Zhang,

Long Chen

Cancer Nanotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 17, 2025

Emphasizing the significance of cancer-associated fibroblasts (CAFs), non-malignant yet pivotal players within tumor microenvironment (TME), this review illuminates role inflammatory subtype (iCAF) as catalysts in cancer proliferation, metastasis, and therapeutic resistance. Given their paramount importance, targeting CAFs emerges a robust strategy evolving landscape immunotherapy. Nanomaterials, distinguished by unique features malleability, hold considerable promise biomedicine, especially precision-oriented domain therapy. Their aptitude for modulating immune responses, amplifying drug efficacy through precise delivery, discerningly focusing on cells TME situates nanomaterials formidable tools to transcend boundaries set conventional treatments. This scrutinizes convoluted interplay among CAFs, cells, TME. It further showcases widely utilized management. We underscore potential nanoscale delivery systems directed at underscoring transformative power revolutionizing therapies, enhancing precision, culminating improved patient outcomes.

Language: Английский

Citations

2
Recent advances in biomimetic cell membrane–camouflaged nanoparticles for cancer therapy DOI Creative Commons
Sajjad Alimohammadvand,

Masoumeh Kaveh Zenjanab,

Milad Mashinchian

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 116951 - 116951

Published: June 19, 2024

The emerging strategy of biomimetic nanoparticles (NPs) via cellular membrane camouflage holds great promise in cancer therapy. This scholarly review explores the utilization membranes derived from diverse entities; blood cells, immune stem and bacterial cells as examples NP coatings. camouflaging endows NPs with nuanced tumor-targeting abilities such self-recognition, homotypic targeting, long-lasting circulation, thus also improving tumor therapy efficacy overall. comprehensive examination encompasses a variety cell camouflaged (CMCNPs), elucidating their underlying targeted mechanisms delineating strategies for anti-cancer applications. Furthermore, systematically presents synthesis source materials methodologies employed order to construct characterize these CMCNPs, specific emphasis on use treatment.

Language: Английский

Citations

13
Cancer-associated fibroblasts promote proliferation, angiogenesis, metastasis and immunosuppression in gastric cancer DOI Creative Commons
Peiyuan Li, Huan Zhang, Tao Chen

et al.

Matrix Biology, Journal Year: 2024, Volume and Issue: 132, P. 59 - 71

Published: June 25, 2024

Despite advances in surgery, radiotherapy and immunotherapy, the mortality rate for gastric cancer remains one of highest world. A large body evidence has demonstrated that cancer-associated fibroblasts (CAFs), as core members stroma, can secrete cytokines, proteins exosomes to create a tumour microenvironment is conducive cell survival. CAFs also interact with cells form complex signalling network, enabling more easily metastasise other organs tissues develop metastatic foci. In this review, we provide an overview concept activators. We focus on elucidating their effects immune cells, intratumoural vasculature, extracellular matrix, well activity, power metabolism, enhancing ability through activation JAK/STAT, NF/κB CXCL12/CXCR4. Various therapeutic agents targeting are under development expected improve prognosis combination existing treatment options.

Language: Английский

Citations

8
Regulatory role of PPAR in colorectal cancer DOI Creative Commons
Cong Wang,

Tingcong Lv,

Binghui Jin

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 28, 2025

Language: Английский

Citations

1
Ferroptosis: CD8+T cells’ blade to destroy tumor cells or poison for self-destruction DOI Creative Commons
Yuan Liang, Yixin Zhao, Zhili Qi

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 1, 2025

Abstract Ferroptosis represents an emerging, iron-dependent form of cell death driven by lipid peroxidation. In recent years, it has garnered significant attention in the realm cancer immunotherapy, particularly studies involving immune checkpoint inhibitors. This not only enhances our comprehension tumor microenvironment but is also considered a promising therapeutic strategy to address resistance, investigate activation mechanisms, and facilitate development vaccines. The combination immunotherapy with ferroptosis provides innovative targets fresh perspectives for advancing treatment. Nevertheless, cells appear possess wider array evasion strategies compared CD8 + T cells, which have been conclusively shown be more vulnerable ferroptosis. Furthermore, TME can create favorable environment survival invasion. Under this premise, both inducing inhibiting will impact antitumor immunity some extent, even make final result run counter purpose. paper systematically elucidates dual-edged sword role process briefly outlining complexity within TME. It explores potential side effects associated ferroptosis-inducing therapies critically considers combined application ferroptosis-based ICIs. highlights current challenges faced approach points out future directions development.

Language: Английский

Citations

1
Exosome crosstalk between cancer stem cells and tumor microenvironment: cancer progression and therapeutic strategies DOI Creative Commons
Qi Li, Guangpeng He, Yifan Yu

et al.

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 22, 2024

Abstract Cancer stem cells (CSCs) represent a small yet pivotal subset of tumor endowed with self-renewal capabilities. These are intricately linked to progression and central drug resistance, metastasis, recurrence. The microenvironment (TME) encompasses the cancer their surrounding milieu, including immune inflammatory cells, cancer-associated fibroblasts, adjacent stromal tissues, vasculature, variety cytokines chemokines. Within TME, such as endothelial adipocytes, fibroblasts release growth factors, cytokines, chemokines, exosomes, which can either sustain or disrupt CSCs, thereby influencing progression. Conversely, CSCs also secrete affecting various components TME. Exosomes, extracellular vesicles (EVs), carry complex cargo nucleic acids, proteins, lipids, playing crucial role in communication between This review primarily focuses on impact exosomes secreted by (CSC-exo) progression, roles maintaining stemness, promoting angiogenesis, facilitating inducing suppression, contributing resistance. Additionally, we discuss how different within TME affect CSCs. Finally, explore potential utilizing mitigate detrimental effects target eliminate them. A thorough understanding exosome-mediated crosstalk could provide valuable insights for developing targeted therapies against

Language: Английский

Citations

8
Tumor-derived extracellular vesicles regulate macrophage polarization: role and therapeutic perspectives DOI Creative Commons
Lijuan Wang,

Weihua Wang,

Die Hu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 16, 2024

Extracellular vesicles (EVs) are important cell-to-cell communication mediators. This paper focuses on the regulatory role of tumor-derived EVs macrophages. It aims to investigate causes tumor progression and therapeutic directions. Tumor-derived can cause macrophages shift M1 or M2 phenotypes. indicates they alter M1/M2 cell ratio have pro-tumor anti-inflammatory effects. discusses several key points: first, factors that stimulate macrophage polarization cytokines released as a result; second, an overview methods used isolate them; third, how from various cancer sources, such hepatocellular carcinoma, colorectal lung breast glioblastoma sources promote development by inducing in macrophages; fourth, pancreatic lungs carcinoma also contribute promoting Modified sourced breast, pancreatic, repolarize exhibits anti-tumor activities offers novel approaches for treatment. Therefore, we discovered either phenotypes regulate development. is based description altering vesicle contents.

Language: Английский

Citations

7
Triple‑negative breast cancer cell‑derived piR‑31115 promotes the proliferation and migration of endothelial cells via METTL3‑mediated m6A modification of YAP1 DOI Creative Commons
Sihao Du, Na Li, Wenjing Xu

et al.

Oncology Reports, Journal Year: 2025, Volume and Issue: 53(3)

Published: Jan. 16, 2025

Language: Английский

Citations

0
IFIT3: a crucial mediator in innate immunity and tumor progression with therapeutic implications DOI Creative Commons
Rihan Wu, Hao Yang, Chunlei Liu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 24, 2025

Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) plays a dual role in innate immunity and tumor immunity, functioning as both viral defense molecule regulator of progression. This review explores the mechanisms through which IFIT3 modulates immune responses, including interferon signaling, RIG-I-like receptors, NF-κB pathway. facilitates evasion promotes inflammation-mediated growth by regulating checkpoints microenvironment, its emerging target for cancer immunotherapy opens new avenues therapeutic strategies. Finally, this paper underscores IFIT3's potential clinical applications modulation highlighting need further research on IFIT3-targeted therapies.

Language: Английский

Citations

0