Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: June 8, 2024
Language: Английский
Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 92, P. 105316 - 105316
Published: Dec. 27, 2023
Language: Английский
Citations
12
Antibiotics, Journal Year: 2024, Volume and Issue: 13(4), P. 369 - 369
Published: April 17, 2024
The compounds present in hemp show multidirectional biological activity. It is related to the presence of secondary metabolites, mainly cannabinoids, terpenes, and flavonoids, synergy their aim this study was assess activity Henola Cannabis sativae extract its combinations with selected carriers (polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol graft copolymer, magnesium aluminometasilicate, hydroxypropyl-β-cyclodextrin) terms antimicrobial, probiotic, immunobiological effects. As a result conducted research, antimicrobial confirmed relation following microorganisms: Clostridium difficile, Listeria monocytogenes, Enterococcus faecalis, Staphylococcus aureus, pyrogenes, Escherichia coli, Klebsiella pneumoniae, Salmonella typhimurium, Pseudomonas aereuginosa, Candida albicans (microorganism count reduced from ~102 CFU mL−1 <10 most cases). Additionally, for system hydroxypropyl-β-cyclodextrin, significant probiotic potential against bacterial strains established Lactobacillus acidophilus, casei, plantarum, brevis, rhamnosus, reuteri, Pediococcus pentosaceus, Lactococcus lactis, fermentum, Streptococcus thermophilus increased 104–107). In immunomodulatory properties, it determined that tested systems caused changes IL-6, IL-8, TNF-α levels.
Language: Английский
Citations
4
Green Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 100270 - 100270
Published: April 1, 2025
Language: Английский
Citations
0
Antioxidants, Journal Year: 2023, Volume and Issue: 12(10), P. 1827 - 1827
Published: Oct. 4, 2023
Cannabis sativa, a versatile plant with numerous varieties, holds promising potential for wide range of biological activity. As raw materials research, we chose leaves and inflorescences hemp varieties such as Białobrzeskie, Henola, Tygra, which are cultivated mainly their fibers or seeds. The choice extraction is key step in obtaining the selected compositions active compounds from material. Bearing mind lipophilic nature cannabinoids, performed supercritical carbon dioxide (scCO2) at 50 °C under 2000 (a) 6000 PSI (b). cannabinoid contents were determined use HPLC-DAD method. antioxidant capabilities assessed through series procedures, including DPPH, ABTS, CUPRAC, FRAP methods. capacity to inhibit enzymes that play role progression neurodegenerative diseases, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase was also studied. dominant cannabinoids extracts cannabidiol (CBD) cannabidiolic acid (CBDA). highest concentration eight detected Tygra extract most notable properties provided by Nonetheless, it Henola (b) demonstrated efficient inhibition AChE BChE, inhibited significantly Białobrzeskie Multidimensional comparative analysis enrolled all assays revealed showed substantial neuroprotective potential.
Language: Английский
Citations
8
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 663, P. 124375 - 124375
Published: June 22, 2024
Language: Английский
Citations
2
Molecules, Journal Year: 2024, Volume and Issue: 29(15), P. 3574 - 3574
Published: July 29, 2024
This study delves into the transformative effects of supercritical carbon dioxide (scCO
Language: Английский
Citations
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: June 8, 2024
Language: Английский
Citations
0