Exploring the Correlation between the PASI and DLQI Scores in Psoriasis Treatment with Topical Ointments Containing Rosa × damascena Mill. Extract DOI Creative Commons
Diana Ioana Gavra, Dóra Kósa, Ágota Pető

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 1092 - 1092

Published: Aug. 20, 2024

Psoriasis is a chronic autoimmune skin condition characterized by red, circumscribed, scaly, and erythematous plaques that can cover large areas. While conventional treatments such as topical corticosteroids systemic medications are commonly prescribed, the interest in natural remedies for psoriasis has grown due to concerns about potential side effects desire alternative treatment options. Rosa × damascena Mill. rich bioactive compounds possess anti-inflammatory, antioxidant, antimicrobial properties; these properties make promising candidate management of disorders psoriasis. In our previous studies, we successfully formulated tested different preparations containing this study, investigated correlation between Area Severity Index (PASI) Dermatology Life Quality (DLQI) scores using abovementioned creams extract. Several tests were performed study PASI DLQI patients. Consequently, able observe an improvement terms area, induration, desquamation, erythema; implicitly produces patients’ quality life. The showed significant progress visits. These results confirm be psoriatic lesions.

Language: Английский

Development of Salvia officinalis–Based Self-Emulsifying Systems for Dermal Application: Antioxidant, Anti-Inflammatory, and Skin Penetration Enhancement DOI Creative Commons

Krisztina Bodnár,

Boglárka Papp,

Dávid Sinka

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 140 - 140

Published: Jan. 21, 2025

Background/Objectives: The present study focused on the formulation and evaluation of novel topical systems containing Salvia officinalis (sage), emphasizing their antioxidant anti-inflammatory properties. Sage, rich in carnosol, offers considerable therapeutic potential, yet its low water solubility limits effectiveness traditional formulations. aim our experimental work was to improve thus bioavailability active ingredient by developing self-nano/microemulsifying drug delivery (SN/MEDDSs) with help Labrasol Labrafil M as nonionic surfactants, Transcutol HP co-surfactant, isopropyl myristate oily phase. Methods: formulations were characterized for droplet size, zeta polydispersity index (PDI), encapsulation efficacy, stability. composition exhibiting most favorable characteristics, particle sizes falling within nanoscale range, incorporated into a cream gel, which compared textural properties, carnosol penetration, biocompatibility efficacy. Results: Release studies conducted using Franz diffusion cells demonstrated that SNEDDS-based achieved up 80% release, outperforming gels. 2,2-diphenyl-1-picrylhydrazyl (DPPH) test enzyme-linked immunosorbent assays (ELISA) showed strong an vivo carrageenan-induced rat paw edema model revealing significantly reduced inflammation. Conclusions: These findings highlight potential SNEDDS-enhanced improving outcomes. Further research is warranted confirm long-term safety

Language: Английский

Citations

1
A complete sojourn on nanotechnological advancements and nanocarrier applications in psoriasis management DOI
Rahul Thakur, Aman Kumar, K.K. Aggarwal

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Language: Английский

Citations

0
Topical Therapy in Psoriasis: Clinical Benefits, Advances in Novel Drug Delivery Strategies, and Gene Therapy Regimen DOI Creative Commons
Ying Zhu, Yong Zhou, Xiao-Nan Ma

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 283 - 283

Published: Feb. 20, 2025

Psoriasis is a chronic inflammatory disease with complex pathogenesis, influenced by various factors involving environment, genes, and immunity. The main symptoms of psoriasis include erythema, scales, itching, etc. At present, therapeutic drugs for are continually evolving towards enhancing treatment efficacy reducing side effects. Firstly, the pathogenesis characteristics were summarized. Then, types benefits topical therapy introduced, such as aspects avoiding systemic toxic effects, first pass effect, gastrointestinal reactions accelerating onset time improving its efficacy, compared to drugs. In case methotrexate, cyclosporin A, Janus kinase (JAK) inhibitors, phosphodiesterase-4 (PDE-4) this review had further discussion on improvement translation these molecules from in clinical practice. To augment limitation skin permeability, nanotechnology novel drug delivery system including nanomedicines, hydrogels, ionic liquids, microneedles elaborated management. Also, exploration targeting pathogenic genes through small interfering RNA (siRNA) using nanoparticles liquids (ILs) great significance long-term psoriasis. Taken together, development numerous platforms expected achieve enhanced penetration, precise efficient molecule interference (RNAi) therapeutics prospects.

Language: Английский

Citations

0
A new era of psoriasis treatment: Drug repurposing through the lens of nanotechnology and machine learning DOI

M Taha Tarek,

Riham I. El-Gogary, Amany O. Kamel

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125385 - 125385

Published: Feb. 1, 2025

Language: Английский

Citations

0
Novel strategies in topical delivery for psoriasis treatment: nanocarriers and energy-driven approaches DOI
Cheng-Yu Lin, Zih‐Chan Lin,

Yen-Tzu Chang

et al.

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Psoriasis is characterized by abnormal differentiation and hyperproliferation of epidermal keratinocytes. This condition presents significant challenges for effective drug delivery. In addition to overcoming the thickness skin, topical treatments must navigate complex hydrophobic hydrophilic properties skin barrier. Recent advancements in nanocarrier technologies, including energy-driven methods microneedles that penetrate stratum corneum, present promising strategies enhancing permeation through tailored physicochemical properties. A literature search was performed using databases Google Scholar, PubMed, ScienceDirect. review highlights recent studies on novel delivery psoriasis treatment, addressing current therapeutic options their limitations. We provide a comprehensive overview chemical nanoformulations explore physical improve rates. Furthermore, we discuss advantages various formulations can carry different types payloads, offering patients diverse symptom management. The covers conventional treatments, emphasizing nanoparticle design macromolecular drugs. includes Ribonucleic acid (RNA)-based therapies protect drugs from rapid clearance body. argue intelligent approaches enhance efficacy across applications while allowing precision treatment strategies, ultimately improving patient outcomes.

Language: Английский

Citations

0
Development and Evaluation of Hydrogel-Based Sulfasalazine-Loaded Nanosponges for Enhanced Topical Psoriasis Therapy DOI Creative Commons
Sunil Kumar, Anroop B. Nair, Varsha Kadian

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 391 - 391

Published: March 10, 2025

Background: The low solubility and poor skin permeability of sulfasalazine (SLZ) present significant challenges for its effective topical delivery. objective the current investigation is to formulate a hydrogel-based SLZ-loaded cyclodextrin nanosponge therapy in psoriasis. Methods: nanosponges were prepared by melt polymerization method evaluated physiochemical characteristics, drug release, cytocompatibility. selected (SLZ-NS4) transformed hydrogel further rheology, texture, safety, permeability, vivo anti-psoriatic effect mouse tail imiquimod-induced psoriasis-like inflammation models mice. Results: Physiochemical data confirms nanoscale architecture, inclusion nanosponges, crystalline structure, formulation stability. release profile SLZ-NS4 revealed sustained behavior (22.98 ± 2.24% 3 h). Cytotoxicity assays indicated negligible toxicity against THP1 cells, resulting higher viability cells than pure SLZ (p < 0.05). HET-CAM assay confirmed while confocal laser scanning microscopy demonstrated deeper permeation SLZ. In model, remarkable decline relative epidermal thickness, potential improvement percent orthokeratosis, activity with respect control was observed animals treated hydrogel. efficiency developed SLZ-NS4-loaded treating psoriasis PASI score (81.68 3.61 84.86 5.74 1 2% w/v SLZ-NS-HG). Histopathological analysis assessment oxidative stress markers profound fabricated Conclusions: These findings highlight delivery system as an

Language: Английский

Citations

0
Enhancing alopecia areata management: Nanocrystal-driven strategy for targeting hair follicles DOI

Pawan Kumar,

Virendra Kumar, S. K. Sahoo

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125557 - 125557

Published: April 1, 2025

Language: Английский

Citations

0
PAMAM dendrimers as mediators of dermal and transdermal drug delivery: a review DOI Creative Commons
Melissa Kirkby, Akmal Hidayat Bin Sabri, Amy Holmes

et al.

Journal of Pharmacy and Pharmacology, Journal Year: 2024, Volume and Issue: 76(10), P. 1284 - 1300

Published: July 23, 2024

Abstract Objectives Poly(amidoamine) dendrimers have been widely investigated as potential nanomaterials that can enhance the skin permeation of topically applied drugs. This article reviews studies used penetration enhancers and examines mechanisms by which enhancement is claimed. Key findings A wide range demonstrated that, in certain circumstances for drugs, incorporation into a formulation significantly increase amount drug passing through skin. In some cases, offered little or no permeation, suggesting drug-dendrimer interaction selection specific dendrimer were central to ensuring optimal permeation. Significant interactions between other components also reported cases. Summary Dendrimers offer substantial enhancing delivery across skin, putatively include occlusion changes surface tension. However, most these are conducted vitro limited progress has made beyond such laboratory studies, using membranes relevance humans, rodent Thus, outcomes claims should be treated with caution.

Language: Английский

Citations

3
Aquaporin Channels in Skin Physiology and Aging Pathophysiology: Investigating Their Role in Skin Function and the Hallmarks of Aging DOI Creative Commons
Nazli Karimi Ahmadi, Vahid Ahmadi Moshiran

Biology, Journal Year: 2024, Volume and Issue: 13(11), P. 862 - 862

Published: Oct. 24, 2024

This study examines the critical role of aquaporins (AQPs) in skin physiology and aging pathophysiology. The plays a vital maintaining homeostasis by acting as protective barrier against external pathogens excessive water loss, while also contributing to appearance self-esteem individuals. Key physiological features, such elasticity repair capability, are essential for its proper function. However, with aging, these characteristics deteriorate, reducing skin's ability tolerate environmental stressors which contribute well internal processes, negatively affect function, immune response, overall well-being. AQPs, primarily known facilitating transport, significant normal functions, including hydration movement molecules like glycerol hydrogen peroxide, influence various cellular processes functions. In this context, we categorized aquaporin dysfunction into several hallmarks mitochondrial dysfunction, senescence, stem cell depletion, impaired macroautophagy, dysbiosis, inflamm-aging. Eight (AQP1, 3, 5, 7, 8, 9, 10, 11) expressed cells, regulating migration, proliferation, differentiation, response. Dysregulation or altered expression proteins can enhance related pathologies activating hallmarks. provides valuable insights potential targeting mitigate improve physiologic

Language: Английский

Citations

3
New Insights in Psoriasis Management using Herbal Drug Nanocarriers DOI

Shreyas P. Salgaonkar,

Japneet Singh Purewal,

Gaurav Doshi

et al.

Current Pharmaceutical Design, Journal Year: 2024, Volume and Issue: 30(32), P. 2550 - 2561

Published: July 25, 2024

Psoriasis (Pso) is an autoimmune inflammatory skin disease characterized by red plaques covered in silver scales. The existing treatments provide limited benefits and are associated with certain drawbacks which limit their use. Thus, there a need to explore more options that highly target-specific minimal side effects. Researchers have thoroughly investigated the use of herbal drugs for therapeutic potential. Preclinical studies demonstrate phytochemicals such as curcumin, psoralen, dithranol antipsoriatic These phytoconstituents inhibit signalling pathways, interleukin (IL) 23/Th17 axis IL-36 loop involved pathogenesis Pso. down-regulate pro-inflammatory cytokines like IL-17 tumor necrosis factor (TNF)-α. However, application clinical settings due poor bioavailability access target sites. Combining modern delivery platforms nanocarriers can address these shortcomings improve efficacy. This review explores potential remedies substitute conventional therapies, emphasizing trials conducted medicines. paper supported discussion on liposomes, niosomes, emulsomes, ethosomes, nanostructured lipid carriers, nanoemulsions, dendrimers used deliver

Language: Английский

Citations

2