Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 12
Published: Dec. 14, 2024
Abstract Periodontitis, a widespread inflammatory disease, is the major cause of tooth loss in adults. While mechanical periodontal therapy benefits disease treatment, adjunctive also necessary. Topically applied anti-inflammatory agents have gained considerable attention periodontitis therapy. Although azithromycin (AZM) possesses excellent properties, its bioavailability limited owing to poor water solubility and absence sustained release mechanisms. Herein, we synthesized biodegradable microspheres (AZM@PLGA-SF) for AZM locally ameliorate inflammation facilitate tissue regeneration. was encapsulated poly (lactic-co-glycolic acid) (PLGA) (AZM@PLGA) using single emulsion-solvent evaporation, followed by surface coating with silk fibroin (SF) via electrostatic adsorption, reducing initial burst AZM. In vivo, local treatment AZM@PLGA-SF significantly reduced restored healthy levels. Mechanically, formulated regulated microenvironment levels pro-inflammatory cytokines (tumor necrosis factor -α, interleukin [IL]-6, interferon-γ, IL-2, IL-17A) gingival crevicular fluid promoted expression (IL-4 IL-10). demonstrated biological safety. Therefore, introduce an substantial potential mitigating encouraging repair regeneration tissues.
Language: Английский
Citations
1INNOVATIONS IN THE TREATMENT OF PEDIATRIC CONJUNCTIVITIS: MODERN SOLUTIONS FOR SMALL PATIENTS
Published: March 15, 2024
Conjunctivitis, a common inflammation of the conjunctiva, commonly affects children and can be caused by bacterial, viral infections or allergic reactions. This condition, manifested redness, itching, eye discharge, negatively influence children's quality life lead to school absenteeism. In addition, rapid spread infection in communities such as schools kindergartens underlines need for effective safe treatment solutions. article explores recent innovations pediatric conjunctivitis, highlighting modern methods advanced technologies that promise improve management this condition. These include state-of-the-art antibiotic antiviral therapies, nanoparticle use, probiotics LED light therapy applications, new immunomodulatory strategies conjunctivitis. It also discusses psychological impact conjunctivitis on importance education prevention By presenting these solutions, emphasizes prompt adequate prevent long-term complications ensure better small patients. At same time, continuous development research innovation ophthalmology is emphasized.
Language: Английский
Citations
1A Journey Along the Boulevard of Bioactive Compounds from Natural Sources, with Cosmetic and Pharmaceutical Potential: Bee Venom, Cobra Venom, Ficus carica
Cosmetics, Journal Year: 2024, Volume and Issue: 11(6), P. 195 - 195
Published: Nov. 18, 2024
Animal venom and plant extracts have been used since ancient times in traditional medicine worldwide. Natural components, valued for their safety effectiveness, consistently cosmetic pharmaceutical applications. We propose a journey along the boulevard of active compounds from natural sources, where bee (BV), cobra (CV), Ficus carica reveal individual therapeutic properties. The originality this review lies exploring synergy these bioactive an approach that has not presented literature. Although BV, CV, different origins compositions, they multiple common pharmacological actions, which make them ideal inclusion various products can be skin care health general. Their anti-inflammatory, antioxidant, immunomodulatory, antimicrobial, neuroprotective, regenerative properties give essential role creation potential innovative effective cosmetics industry. many antioxidant anti-inflammatory properties, was chosen due to its complex biochemical composition, provides valuable benefits regeneration protection against oxidative stress. According International Nomenclature Cosmetic Ingredients (INCI), is form extract fruits, leaves, juice, bark or stem, each having specific applicability topical formulations; diversity compounds, it amplify effectiveness BV helping enhance beneficial effects reducing risk adverse effects, well-tolerated nature. Thus, combination ingredients opens up new perspectives development products, optimizing efficiency maintaining favorable profile. In context, reported experimental results, three sources caught our attention, we conceived present work, made following analysis current progress study carica. focused on novelties regarding actions literature, highlighted profile, as well modern approaches delivery transport systems substances evaluated prospects use. This paper only expands knowledge but also generate ideas motivations research treatments skincare methods.
Language: Английский
Citations
0Chlorhexidine-loaded microneedles for treatment of oral diseases
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 670, P. 125143 - 125143
Published: Dec. 27, 2024
Language: Английский
Citations
0"ALL-ON-6", ADVANTAGES AND DISADVANTAGES OF THIS MODERN DENTAL RESTORATION SOLUTION
Published: Dec. 20, 2024
The All-on-6 technique is a modern and effective solution for complete tooth restoration, using six dental implants to support fixed denture. This method provides excellent long-term results, with significant benefits in terms of durability, stability, functionality the implants. Titanium implants, once integrated into bone through osseointegration process, can last decades, prosthesis attached them patients an experience similar that natural teeth. One major advantages prevention resorption, common problem who have lost stimulate jawbone, maintaining volume preventing facial changes associated loss. In long term, success this treatment depends on rigorous oral hygiene regular visits dentist denture maintenance monitoring condition Although risks complications such as peri-implantitis or failure exist, they are rare be prevented proper care. conclusion, offers durable, aesthetic functional severe
Language: Английский
Citations
0IMPACT OF ORTHODONTIC DYSFUNCTIONS ON THE DEVELOPMENT OF JOINT OSTEOARTHRITIS
Published: Dec. 20, 2024
Orthodontic dysfunctions, including malocclusion, open occlusion and retrognathism, can contribute to the development of articular osteoarthritis by increasing mechanical stress on temporomandibular joint (TMJ). Osteoarthritis is a chronic degenerative condition that affects cartilage, leading pain, dysfunction decreased quality life. This article investigates mechanisms which orthodontic dysfunctions accelerate TMJ degeneration, emphasizing influence biomechanical pathophysiological factors. Understanding connection between dental malpositions essential for establishing effective methods prevention treatment, having potential reduce incidence severity among patients with dysfunctions. The proposed multidisciplinary approach aims at collaboration orthodontics rheumatology ensure proactive clinical intervention, thus contributing long-term health patients.
Language: Английский
Citations
0THE ROLE OF SALIVARY GLANDS IN ORAL REHABILITATION: FUNCTIONS, IMPORTANCE, PATHOLOGY AND THERAPEUTIC APPROACHES
Published: March 15, 2024
The salivary glands are essential for oral health, providing not only environments digestion and taste, but also protection from pathogens. This review examines the functions of salivation, importance in context pathology, therapeutic approaches their dysfunctions. Pathologies range minor conditions, such as sialadenitis, to severe cancer glands. These conditions can affect quality life, ability eat speak, have systemic implications. Treatment gland dysfunctions includes pharmacological therapies stimulate secretion, use saliva substitutes, physical ultrasound therapy. Management is aimed at relieving symptoms improving function affected Antioxidant supplements, depending on your circadian rhythm, may help reduce oxidative stress associated with glandular pathologies.
Language: Английский
Citations
0THE IMPACT OF MASSETER MUSCLE DYSFUNCTION ON ORAL REHABILITATION: CHALLENGES AND TREATMENT STRATEGIES
Published: March 15, 2024
Dysfunctions of the masseter muscles represent a significant challenge in field oral rehabilitation, negatively influencing success prosthetic, orthodontic, and surgical treatments. This review explores impact these dysfunctions on various aspects identifying main challenges providing effective treatment strategies. Initially, anatomy function are discussed, followed by an analysis common types dysfunction their causes. The then details complications encountered rehabilitation process due to dysfunctions, highlighting difficulties diagnosis planning. Various strategies presented, including conservative methods, drug interventions, options, emphasizing importance interdisciplinary approach. By case studies, practical applications outcomes proposed treatments illustrated. In conclusion, article emphasizes need for early adequate ensure long-term presence muscles.
Language: Английский
Citations
0BIRTH CONTROL PILLS AND POSSIBLE INFLUENCES ON THE FETUS
Published: March 15, 2024
Birth control pills are widely used around the world for birth and prevention of unwanted pregnancy. However, there concerns about their safety during pregnancy possible effects on fetus. This article aims to examine in depth current evidence impact foetus. By analysing mechanism action pills, relevant clinical trials associated potential complications, risks contraceptive use explored. The different types contraceptives specific with each discussed, providing recommendations women who become or pregnant. Through this literature review, aim is provide a clearer understanding topic practical guidance healthcare professionals situation. Further investigation into mechanisms how they may influence fetal development could useful information managing counseling pregnant planning
Language: Английский
Citations
0IMPACT OF ORAL REHABILITATION ON THE QUALITY OF LIFE OF PATIENTS WITH PSYCHIATRIC CONDITIONS AND MEDICATION MANAGEMENT
Published: March 15, 2024
Language: Английский
Citations
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