Microorganisms, Journal Year: 2024, Volume and Issue: 12(11), P. 2291 - 2291
Published: Nov. 11, 2024
Liver abscesses, which occur in finishing cattle, are of significant economic concern to the feedlot industry. The causative agents include both
Language: Английский
Journal of Umm Al-Qura University for Applied Sciences, Journal Year: 2024, Volume and Issue: unknown
Published: April 3, 2024
Abstract Rosemary ( Rosmarinus officinalis Linn. or Salvia rosmarinus Spenn. ) is an aromatic herb renowned for its culinary, medicinal, and industrial significance. This review offers a multifaceted exploration of rosemary, delving into nutritional composition, traditional culinary applications, historical uses in medicine. The extends to cosmetic pharmaceutical elucidating rosemary’s role as natural preservative integration cosmeceutical formulations. Extraction methods, both classical contemporary, are critically examined, with emphasis on recent sustainable approaches their impact bioactive compounds. work concludes forward-looking perspective, discussing innovative extraction techniques, advanced technologies, the potential commercial viability rosemary-related industries. comprehensive serves valuable resource, offering insights diverse dimensions from applications cutting-edge advancements science.
Language: Английский
Citations
9
Biocatalysis and Agricultural Biotechnology, Journal Year: 2024, Volume and Issue: 58, P. 103223 - 103223
Published: May 11, 2024
Exploring secondary outputs, specifically leftover materials from steam distillation of Rosmarinus tournefortii de Noé, as agents for reducing metals introduces a novel approach to eco-friendly nanomaterial production. This concept aligns with the creation environmentally conscious nanoparticles, showcasing potential across various fields, notably biomedicine. The paper seamlessly fits into this context. By utilizing R. successful synthesis silver nanoparticles (AgNPs) was achieved, yielding nanoscale variations influenced by plant's by-products. Beyond structural aspects, investigating biomedical applications, focusing on antioxidant and antimicrobial properties. Consistently observing ∼94.9–97.3% scavenging inhibition in water residues at different concentrations enhanced efficacy against Gram-negative Gram-positive bacteria Rhodotorula glutinis yeast due these residues. Moreover, thorough examination using density functional theory unveiled robust interaction between clusters specific biomolecules found within residues, namely homoplantaginin, protocatechuic acid-glycoside, caffeic, rosmarinic acids (ranging 130.62 357.05 kcal/mol). These compounds enhance Ag+ ions contribute enduring stability AgNPs (ζ values: -22.8 mV -17.2 mV). Furthermore, study recognizes challenges finding alternative surface modification explores intricate toxicity mechanisms emphasizing their interactions inflammation. Introducing promising nanomedicine approaches involving acid inflammatory bowel disease rheumatoid arthritis, highlighting rosemary by-products derived innovative therapeutic interventions diverse conditions.
Language: Английский
Citations
5
Marine Drugs, Journal Year: 2024, Volume and Issue: 22(6), P. 240 - 240
Published: May 25, 2024
In this research, the chemical compositions of various extracts obtained from Ulva lactuca, a type green seaweed collected Nador lagoon in northern region Morocco, were compared. Their antioxidant and anti-diabetic properties also studied. Using GC–MS technology, fatty acid content samples was analyzed, revealing that palmitic acid, eicosenoic linoleic most abundant unsaturated acids present all samples. The HPLC analysis indicated sinapic naringin, rutin, quercetin, cinnamic salicylic apigenin, flavone, flavanone prevalent phenolic compounds. aqueous extract by maceration showed high levels polyphenols flavonoids, with values 379.67 ± 0.09 mg GAE/g 212.11 0.11 QE/g, respectively. This exhibited an impressive ability to scavenge DPPH radicals, as its IC50 value 0.095 0.12 mg/mL. Additionally, methanolic using Soxhlet method demonstrated preventing β-carotene discoloration, 0.087 0.14 Results in-vitro studies U. lactuca able significantly inhibit enzymatic activity α-amylase α-glucosidase. Among extracts, (S) has been identified potent inhibitor, exhibiting statistically similar effect acarbose. Furthermore, molecular docking models used evaluate interaction between primary phytochemicals found these human pancreatic α-glucosidase enzymes. These findings suggest contain bioactive substances are capable reducing enzyme more effectively than commercially available drug,
Language: Английский
Citations
5
Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 681 - 681
Published: Jan. 11, 2025
Our study reports for the first time, over a 12-month period, seasonal variations in chemical composition and antibacterial antioxidant activity of Rosmarinus officinalis L. essential oil (RoEO) from Southwestern Romania (Oltenia region). To analyze constituents RoEO, comprehensive gas chromatography/mass spectrometry (GC/MS) method was employed. The analysis aimed to identify quantify various components by comparing their mass spectra with reference National Institute Standards Technology (NIST) Library 2020. minimum inhibitory concentration (MIC) values Staphylococcus aureus were determined using microdilution (96-well plates). analyzed 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), hydrogen peroxide (H2O2) radical scavenging assays. This provided detailed profile RoEO’s constituents, revealing significant monthly variations. Key compounds, such as camphor, eucalyptol, α-pinene, camphene, α-myrcene, quantified, alongside lesser-studied like β-pinene, α-terpinene, linalool, terpinolene, carvacrol. Comparisons made sample Tunisia. Oxygenated monoterpenes reach highest (56.82–66.94%), followed monoterpene hydrocarbons (30.06–40.28%), sesquiterpene (0.90–2.44%), oxygenated sesquiterpenes (0.02–0.23%). Camphor found high concentrations ranging 29.41% 40.03%. 1,8-Cineole another dominant compound, 13.07% 16.16%, significantly lower compared Tunisian (52.77%). α-Pinene ranged 11.36% 19.33%, while α-myrcene 1.65% 3.08%. Correlations between specific compounds bioactivity explored understand contributions overall efficacy RoEO. provides valuable insights into potential applications variability RoEO Romania.
Language: Английский
Citations
0
Journal of Natural Remedies, Journal Year: 2025, Volume and Issue: unknown, P. 33 - 48
Published: Jan. 31, 2025
Herbal remedies have long been esteemed for their substantial contribution to human health. The healthcare sector is increasingly acknowledging the significance of various herbs and plants, leading a surge in global popularity. This resurgence interest spurring closer examination potential benefits creation new drugs. unique compounds found these plants are seen as valuable sources meeting different pharmacological objectives, inspired by historical usage folk medicine. purpose this review was thoroughly current research on Rosmarinus officinalis L., with aim uncovering key chemicals biological effects linked herb. Evidence from studies highlights medicinal specific such carnosol, rosmarinic acid, carnosic acid addition plant extracts essential oils. paper explores most frequently observed related R. its components. Understanding uses can implications that extend beyond herbal therapy, reaching into field research. Given properties herb, further evaluate developing versatile medicines suitable clinical application. Major Findings: exhibits significant anticancer, antioxidant, antimicrobial, antidiabetic, neuroprotective properties. Key like carnosol contribute effects, highlighting plant’s therapeutic applications.
Language: Английский
Citations
0
Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 922 - 922
Published: Feb. 17, 2025
This study examines the intricacies of Alzheimer's disease (AD), its origins, and potential advantages various herbal extracts natural compounds for enhancing memory cognitive performance. Future studies into AD treatments are encouraged by review's demonstration effectiveness phytoconstituents that were extracted from a number plants. In addition to having many beneficial effects, such as improved cholinergic function, medicines also much less harmful, more readily available, easier use than other treatments. They pass without difficulty through blood-brain barrier (BBB). focused on substances their effects using academic databases identify peer-reviewed published between 2015 2024. According literature review, 66 isolated 21 distinct plants have shown efficacy, which could be encouraging future research therapies. Since most clinical trials produce contradictory results, suggests larger-scale with longer treatment durations necessary validate or refute therapeutic efficacy
Language: Английский
Citations
0
Food Research International, Journal Year: 2025, Volume and Issue: 206, P. 116078 - 116078
Published: Feb. 25, 2025
Language: Английский
Citations
0
Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 13
Published: March 6, 2025
Gout is the most common inflammatory arthritis, characterized by hyperuricemia, tophus formation, joint disease, and kidney stones. Uric acid, final byproduct of purine catabolism, eliminated via kidneys digestive system. Xanthine oxidase (XO) catalyzes conversion hypoxanthine xanthine into uric making XO inhibitors crucial for treating hyperuricemia gout. Currently, three are clinically used, showing significant efficacy. A molecular modeling study on triazole derivatives aims to identify novel using 3D-QSAR, docking, MD simulations, ADMET analysis, DFT calculations. These computational approaches facilitate drug discovery while reducing research costs. Our work focuses a series synthesized anti-xanthine inhibitors, aiming develop new inhibitors. was carried out inhibitory structural features method. model based CoMFA CoMSIA/SEA has been built predict derivatives. The optimal established from successfully evaluated its predictive capability. Visualization contour maps both models showed that modifying substituents plays key role in enhancing biological activity anti-gout Molecular docking results complexes N°8-3NVY N°22-3NVY scores -7.22 kcal/mol -8.36 kcal/mol, respectively, indicating substantial affinity enzyme. Complex forms two hydrogen bonds with SER 69 ASN 71, alkyl ALA 70, LEU 74, 75, one Pi-Pi T-shaped bond PHE 68. HIS 99, ARG 29, ILE 91, halogen 128 at 3.60 Å. revealed complex remained highly stable throughout simulation. Therefore, we proposed six molecules, their activities were predicted models, they Lipinski's rule, properties. show Pred 4 5 have better pharmacokinetic properties than height potent molecule studied series, these compounds valuable candidates drugs. Subsequently, evaluate chemical reactivity compounds, energy gap molecules exhibit moderate stability reactivity.
Language: Английский
Citations
0
Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 7, P. 100952 - 100952
Published: March 14, 2025
Language: Английский
Citations
0
Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101320 - 101320
Published: April 1, 2025
Language: Английский
Citations
0