Recent advancements in conducting polymer bionanocomposites and hydrogels for biomedical applications

International Journal of Polymeric Materials, Journal Year: 2020, Volume and Issue: 71(7), P. 513 - 530

Published: Dec. 21, 2020

Recently electrically conducting polymeric bionanocomposites (ECPBs) have emerged as materials for use in biomedical, food and agricultural engineering due to their inherently plastic biodegradable nature. ECPBs display biocompatibility, unique architecture, biodegradability, so on, thereby improving performance opening novel horizons applicability especially tissue scaffolds, drug-conveying devices, electrochemical biosensors on. In field, conductive hydrogels (CH) are biomaterials efficiently mimicking biologically inclined behavior of tissues the human system. Therefore, this paper elucidates recently emerging trends ECPBs, CH, applications biomedical other relevant areas.

Language: Английский

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Fabrication and Characterization of Drug-Loaded Conductive Poly(glycerol sebacate)/Nanoparticle-Based Composite Patch for Myocardial Infarction Applications

ACS Applied Materials & Interfaces, Journal Year: 2020, Volume and Issue: 12(6), P. 6899 - 6909

Published: Jan. 22, 2020

Heart tissue engineering is critical in the treatment of myocardial infarction, which may benefit from drug-releasing smart materials. In this study, we load a small molecule (3i-1000) new biodegradable and conductive patches for application infarcted myocardium. The composite consist biocompatible elastomer, poly(glycerol sebacate) (PGS), coupled with collagen type I, used to promote cell attachment. addition, polypyrrole incorporated because its electrical conductivity induce signaling. Results vitro experiments indicate high density cardiac myoblast cells attached on patches, stay viable at least 1 month. degradation does not show any cytotoxic effect, while 3i-1000 delivery induces proliferation. Conductive blood wettability drug release, correlating rate PGS matrix. Together elongation characteristics, developed biomaterial fits mechanical, conductive, biological demands required treatment.

Language: Английский

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Conductive Polymer‐Based Bioelectronic Platforms toward Sustainable and Biointegrated Devices: A Journey from Skin to Brain across Human Body Interfaces

Advanced Materials Technologies, Journal Year: 2021, Volume and Issue: 7(2)

Published: July 1, 2021

Abstract Over the last few years, organic bioelectronics has experienced an exponential growth with applications encompassing platforms for tissue engineering, drug delivery systems, implantable, and wearable sensors. Although reducing physical mechanical mismatch human tissues allows to increase coupling efficiency, several challenges are still open in terms of matching biological curvature, size, interface stiffness. In this context, replacement bulky more flexible conformable devices is required, implying transition from inorganic conventional electronics electronics. Indeed, advent materials bioelectronics, due indisputable benefits related biocompatibility, flexibility, electrical properties, granted superior properties increasing performances both sensing stimulation platforms. review ease functionalization patterning conductive polymers (CPs) will be analyzed as a strategy that enables fabrication high structural flexibility ranging macro micro/nano‐scales, leading sensitivity. Drawing concept biomimicry, body interfaces explored through ideal journey starting epidermal stimulation. Then, capable establishing dynamic heart reviewed finally, following circulatory system crossing blood‐brain barrier, brain reached novel computing implants advances pave way possibility emulate well interact neural functions analyzed.

Language: Английский

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Poly(3,4‐ethylenedioxythiophene)‐Based Neural Interfaces for Recording and Stimulation: Fundamental Aspects and In Vivo Applications

Advanced Science, Journal Year: 2022, Volume and Issue: 9(12)

Published: Feb. 21, 2022

Next-generation neural interfaces for bidirectional communication with the central nervous system aim to achieve intimate integration tissue minimal neuroinflammatory response, high spatio-temporal resolution, very sensitivity, and readout stability. The design manufacturing of devices low power/low noise recording safe energy-efficient stimulation that are, at same time, conformable brain, matched mechanical properties biocompatibility, is a convergence area research where neuroscientists, materials scientists, nanotechnologists operate synergically. biotic-abiotic interface, however, remains formidable challenge prompts new platforms innovation in device layouts. Conductive polymers (CP) are attractive be interfaced used as sensing/stimulating electrodes because their mixed ionic-electronic conductivity, contact impedance, charge storage capacitance, chemical versatility, biocompatibility. This manuscript reviews state-of-the-art poly(3,4-ethylenedioxythiophene)-based extracellular stimulation, focusing on those technological approaches successfully demonstrated vivo. highlight most reliable ready-for-clinical-use solutions, terms technology performance, other than spot major limitations identify future trends this field.

Language: Английский

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A comprehensive overview of common conducting polymer-based nanocomposites; Recent advances in design and applications

European Polymer Journal, Journal Year: 2021, Volume and Issue: 160, P. 110773 - 110773

Published: Sept. 14, 2021

Language: Английский

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