A Review of the Effects of Collagen Treatment in Clinical Studies

Polymers, Journal Year: 2021, Volume and Issue: 13(22), P. 3868 - 3868

Published: Nov. 9, 2021

Collagen, an abundant extracellular matrix protein, has been found to have a lot of pharmaceuticals, medicine, food, and cosmetics applications. Increased knowledge collagen sources, extraction techniques, structure, properties in the last decades helped develop more collagen-based products tissue engineering biomaterials. Collagen playing important role benefiting health human body, especially for aging people. In this paper, effects treatment different clinical studies including skin regeneration, bone defects, sarcopenia, wound healing, dental therapy, gastroesophageal reflux, osteoarthritis, rheumatoid arthritis reviewed. The treatments were significant these studies. addition, associations between diseases discussed. comorbidity might be closely related deficiency, good choice when patient than one diseases, coronavirus disease 2019 (COVID-19). It concludes that medication is useful treating comorbid preventing complications.

Language: Английский

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4D bioprinting of smart polymers for biomedical applications: recent progress, challenges, and future perspectives

Reactive and Functional Polymers, Journal Year: 2022, Volume and Issue: 179, P. 105374 - 105374

Published: Aug. 10, 2022

4D bioprinting is the next-generation additive manufacturing-based fabrication platform employed to construct intricate, adaptive, and dynamic soft hard tissue structures as well biomedical devices. It achieved by using stimuli-responsive materials, especially shape memory polymers (SMPs) hydrogels, which possess desirable biomechanical characteristics. In last few years, numerous efforts have been made printing community develop novel polymeric materials considering their perspective. This review presents an up-to-date overview of technology incorporating functionalities biomaterials focused approach towards different engineering regenerative medicine (TERM) applications. includes bone, cardiac, neural, cartilage, drug delivery systems, other high-value also addresses current limitations challenges in provide a basis for foreseeable advancements TERM applications that could be helpful successful utilization clinical settings.

Language: Английский

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Cosmetic, Biomedical and Pharmaceutical Applications of Fish Gelatin/Hydrolysates

Marine Drugs, Journal Year: 2021, Volume and Issue: 19(3), P. 145 - 145

Published: March 8, 2021

There are several reviews that separately cover different aspects of fish gelatin including its preparation, characteristics, modifications, and applications. Its packaging application in food industry is extensively covered but other applications not or alongside with those collagen. This review comprehensive, specific to gelatin/hydrolysate cites recent research. It covers cosmetic applications, intrinsic activities, biomedical wound dressing healing, gene therapy, tissue engineering, implants, bone substitutes. also pharmaceutical manufacturing capsules, coating microparticles/oils, tablets, stabilization emulsions drug delivery (microspheres, nanospheres, scaffolds, microneedles, hydrogels). The main outcomes immunologically safe, protects from the possibility transmission bovine spongiform encephalopathy foot mouth diseases, has an economic environmental benefits, may be suitable for practice religious-based restrictions, i.e., people Muslim, Jewish Hindu faiths. unique rheological properties, making it more certain than mammalian gelatins. can easily modified enhance mechanical properties. However, extensive research still needed characterize hydrolysates, elucidate Structure Activity Relationship (SAR), formulate them into dosage forms. Additionally, expansion needed.

Language: Английский

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Gelatin-Based Hydrogels: Potential Biomaterials for Remediation

Polymers, Journal Year: 2023, Volume and Issue: 15(4), P. 1026 - 1026

Published: Feb. 18, 2023

Hydrogels have become one of the potential polymers used with great performance for many issues and can be promoted as biomaterials highly innovative characteristics different uses. Gelatin is obtained from collagen, a co-product meat industry. Thus, converting wastes such cartilage, bones, skins into gelatin would give them added value. Furthermore, biodegradability, non-toxicity, easy cross-linking other substances promote high low cost applications, turning sustainable products acceptance in society. Gelatin-based hydrogels been shown to useful applications important characteristics. For instance, these biomedical bone reconstruction or drug delivery. they also substantial remediation removing pollutants water, watercourse, effluents. After its uses, gelatin-based easily biodegrade and, thus, sustainably environment. In this study, was polymer hydrogel synthesis renewable multiple

Language: Английский

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3D and 4D Bioprinting Technologies: A Game Changer for the Biomedical Sector?

Annals of Biomedical Engineering, Journal Year: 2023, Volume and Issue: 51(8), P. 1683 - 1712

Published: June 1, 2023

Language: Английский

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Applications and multidisciplinary perspective on 3D printing techniques: Recent developments and future trends

Materials Science and Engineering R Reports, Journal Year: 2023, Volume and Issue: 156, P. 100760 - 100760

Published: Nov. 3, 2023

In industries as diverse automotive, aerospace, medical, energy, construction, electronics, and food, the engineering technology known 3D printing or additive manufacturing facilitates fabrication of rapid prototypes delivery customized parts. This article explores recent advancements emerging trends in from a novel multidisciplinary perspective. It also provides clear overview various techniques used for producing parts components three dimensions. The application these bioprinting an up-to-date comprehensive review their positive negative aspects are covered, well variety materials used, with emphasis on composites, hybrids, smart materials. updated 4D technology, including biomaterial functions, materials, targeted approach to tissue regenerative medicine (TERM) applications. As foundation anticipated developments TERM applications that could be useful successful usage clinical settings, this examines present challenges obstacles technology. Finally, outlines future regulations will assist researchers manufacture complex products exploration potential solutions technological issues.

Language: Английский

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Application of Poultry Gelatin to Enhance the Physicochemical, Mechanical, and Rheological Properties of Fish Gelatin as Alternative Mammalian Gelatin Films for Food Packaging

Foods, Journal Year: 2023, Volume and Issue: 12(3), P. 670 - 670

Published: Feb. 3, 2023

This study aimed to describe the properties of cold water fish gelatin (FG) blended with poultry (PG) for a production sachet containing olive oil. To find desirable film, different ratio FG-PG-based films were characterized in terms mechanical properties. As proportion PG PG-FG-based increased, tensile strength and Young's modulus elongation at break heat seal decreased. The 50-50 film had favorable characteristics use as sachet. amount acid index peroxide oil stored sachets after 14 days showed that there is significant difference (p < 0.05) between films. barrier including vapor permeability oxygen increased from 1.21 4.95 × 10-11 g m-1 Pa-1 s-1 48 97 cm3 mµ/m2 d kPa, respectively. Dark, red, yellow, opaque realized increasing PG. Fourier transform infrared (FTIR) spectra approved wide peak approximately 2500 cm-1. rheological analysis indicated that, by adding PG, viscosity, elastic (G') loss (G'') significantly about 9.5, 9.32 18 times, Therefore, an easy modification FG will make it suitable packaging applications food industry.

Language: Английский

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Addition of κ-carrageenan increases the strength and chewiness of gelatin-based composite gel

Food Hydrocolloids, Journal Year: 2022, Volume and Issue: 128, P. 107565 - 107565

Published: Feb. 3, 2022

Language: Английский

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Tailoring a Gelatin/Agar Matrix for the Synergistic Effect with Cells to Produce High-Quality Cultured Meat

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(33), P. 38235 - 38245

Published: Aug. 15, 2022

Edible scaffolds are needed in cultured meat to mimic meat's three-dimensional structure by organizing cells and replenishing the insufficient mass of alone. However, there is still a large gap between slaughtered developed into tissues using scaffolds. This mainly due difference size, texture, flavor, taste. In this study, we develop coating matrix modify surface textured vegetable protein (TVP), cell support, produce having essential characteristics. We optimized fish gelatin/agar matrix's microstructure controlling ratio two biopolymers, stably introducing adhesive environment on TVP. By TVP's an easy fast dipping method, hybrid composed animal plant was produced. As proliferated, their synergistic effect permitted taste reach level comparable that meat. The TVP-based prepared with present technology has been recreated as high-quality satisfying five challenging factors: cells, cost, mass, flavor.

Language: Английский

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Long-term storage stability of type A and type B gelatin gels: The effect of Bloom strength and co-solutes

Food Hydrocolloids, Journal Year: 2022, Volume and Issue: 127, P. 107535 - 107535

Published: Jan. 21, 2022

For gelatin-based confectionery, nutraceutical, and pharmaceutical products, storage stability is important for maintaining textural properties during transportation throughout the shelf life of final product. Exposure to elevated temperatures causes degradation gelatin molecule, which results in a reduction average molecular weight, further impacting its mechanical properties. In this study, long-term systems prepared with different gelatins (type B from bovine, type A pig skin, or fish skin) stored below above sol-gel transition temperature was compared. The effect temperature, Bloom strength, inclusion co-solutes (sugar alcohols gum arabic) on evaluated. investigated using small amplitude oscillatory shear measurements weight analyses via size-exclusion chromatography coupled online multiangle laser light scattering. modulus gels indicated that incubation close equilibrium resulted an increased rate gelatin. Type exhibited better than gels. addition, high strength improved compared low gelatins. addition sugar stability, whereas arabic did not have large impact gel.

Language: Английский

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