Materials,
Journal Year:
2022,
Volume and Issue:
15(19), P. 6521 - 6521
Published: Sept. 20, 2022
Chitosan
is
a
biodegradable
and
biocompatible
natural
polymer
that
has
been
extensively
explored
in
recent
decades.
The
Food
Drug
Administration
approved
chitosan
for
wound
treatment
nutritional
use.
Furthermore,
paved
the
way
advancements
different
biomedical
applications
including
as
nanocarrier
tissue-engineering
scaffold.
Its
antibacterial,
antioxidant,
haemostatic
properties
make
it
an
excellent
option
dressings.
Because
of
its
hydrophilic
nature,
ideal
starting
material
hydrogels.
To
suit
specific
application
demands,
can
be
combined
with
fillers,
such
hydroxyapatite,
to
modify
mechanical
characteristics
pH-sensitive
cationic
have
made
popular
choice
gene
delivery
cancer
therapy.
Thus,
use
nanoparticles
developing
novel
drug
systems
received
special
attention.
This
review
aims
provide
overview
chitosan-based
nanoparticles,
focusing
on
their
versatile
sciences
engineering.
Medicinal Research Reviews,
Journal Year:
2023,
Volume and Issue:
43(6), P. 2115 - 2176
Published: May 11, 2023
Abstract
Breast
cancer
is
the
most
malignant
tumor
in
women,
and
there
no
absolute
cure
for
it.
Although
treatment
modalities
including
surgery,
chemotherapy,
radiotherapy
are
utilized
breast
cancer,
it
still
a
life‐threatening
disease
humans.
Nanomedicine
has
provided
new
opportunity
treatment,
which
focus
of
current
study.
The
nanocarriers
deliver
chemotherapeutic
agents
natural
products,
both
increase
cytotoxicity
against
cells
prevent
development
drug
resistance.
efficacy
gene
therapy
boosted
by
nanoparticles
delivery
CRISPR/Cas9,
Noncoding
RNAs,
RNAi,
promoting
their
potential
expression
regulation.
codelivery
can
exert
synergistic
impact
on
tumors
enhance
cellular
uptake
via
endocytosis.
Nanostructures
able
to
induce
photothermal
photodynamic
ablation
cell
death
induction.
provide
microenvironment
remodeling
repolarization
macrophages
antitumor
immunity.
stimuli‐responsive
nanocarriers,
pH‐,
redox‐,
light‐sensitive,
mediate
targeted
suppression
tumors.
Besides,
diagnosis
detect
biomarkers.
Various
kinds
have
been
employed
therapy,
carbon‐,
lipid‐,
polymeric‐
metal‐based
nanostructures,
different
terms
biocompatibility
efficiency.
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: April 28, 2022
Cancer
has
become
a
main
public
health
issue
globally.
The
conventional
treatment
measures
for
cancer
include
surgery,
radiotherapy
and
chemotherapy.
Among
the
various
available
measures,
chemotherapy
is
still
one
of
most
important
treatments
patients.
However,
cancers
faces
many
problems
associated
with
lot
adverse
effects,
which
limit
its
therapeutic
potency,
low
survival
quality
discount
prognosis.
In
order
to
decrease
these
side
effects
improve
effectiveness
patient's
compliance,
more
targeted
are
needed.
Sustainable
controlled
deliveries
drugs
controllable
toxicities
expected
address
hurdles.
Chitosan
second
abundant
natural
polysaccharide,
excellent
biocompatibility
notable
antitumor
activity.
Its
biodegradability,
biocompatibility,
biodistribution,
nontoxicity
immunogenicity
free
have
made
chitosan
widely
used
polymer
in
pharmacology,
especially
oncotherapy.
Here,
we
make
brief
review
achievements
derivatives
pharmacology
special
focus
on
their
agents
delivery
applications,
immunomodulation,
signal
pathway
modulation
activity
highlight
role
treatment.
Despite
large
number
successful
studies,
commercialization
copolymers
big
challenge.
further
development
polymerization
technology
may
satisfy
unmet
medical
needs.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(4), P. 3188 - 3188
Published: Feb. 6, 2023
Biopolymeric
nanoparticles
are
gaining
importance
as
nanocarriers
for
various
biomedical
applications,
enabling
long-term
and
controlled
release
at
the
target
site.
Since
they
promising
delivery
systems
therapeutic
agents
offer
advantageous
properties
such
biodegradability,
biocompatibility,
non-toxicity,
stability
compared
to
toxic
metal
nanoparticles,
we
decided
provide
an
overview
on
this
topic.
Therefore,
review
focuses
use
of
biopolymeric
animal,
plant,
algal,
fungal,
bacterial
origin
a
sustainable
material
potential
drug
systems.
A
particular
focus
is
encapsulation
many
different
categorized
bioactive
compounds,
drugs,
antibiotics,
other
antimicrobial
agents,
extracts,
essential
oils
into
protein-
polysaccharide-based
nanocarriers.
These
show
benefits
human
health,
especially
successful
anticancer
activity.
The
article,
divided
protein-based
further
according
biopolymer,
enables
reader
select
appropriate
more
easily
incorporation
desired
component.
latest
research
results
from
last
five
years
in
field
production
loaded
with
healthcare
applications
included
review.
Materials,
Journal Year:
2024,
Volume and Issue:
17(2), P. 456 - 456
Published: Jan. 18, 2024
Biomaterials
embody
a
groundbreaking
paradigm
shift
in
the
field
of
drug
delivery
and
human
applications.
Their
versatility
adaptability
have
not
only
enriched
therapeutic
outcomes
but
also
significantly
reduced
burden
adverse
effects.
This
work
serves
as
comprehensive
overview
biomaterials,
with
particular
emphasis
on
their
pivotal
role
delivery,
classifying
them
terms
biobased,
biodegradable,
biocompatible
nature,
highlighting
characteristics
advantages.
The
examination
delves
into
extensive
array
applications
for
biomaterials
encompassing
diverse
medical
fields
such
cancer
therapy,
cardiovascular
diseases,
neurological
disorders,
vaccination.
explores
actual
challenges
within
this
domain,
including
potential
toxicity
complexity
manufacturing
processes.
These
emphasize
necessity
thorough
research
continuous
development
regulatory
frameworks.
second
aim
review
is
to
navigate
through
compelling
terrain
recent
advances
prospects
envisioning
healthcare
landscape
where
they
empower
precise,
targeted,
personalized
delivery.
transform
staggering,
promise
treatments
tailored
individual
patient
needs,
offering
hope
improved
efficacy,
fewer
side
effects,
brighter
future
practice.
Polymers,
Journal Year:
2023,
Volume and Issue:
15(13), P. 2928 - 2928
Published: July 1, 2023
The
limitations
associated
with
the
conventional
treatment
of
cancer
have
necessitated
design
and
development
novel
drug
delivery
systems
based
mainly
on
nanotechnology.
These
include
various
kinds
nanoparticles,
such
as
polymeric
solid
lipid
nanostructured
carriers,
hydrogels,
micelles.
Among
systems,
chitosan-based
nanoparticles
attracted
attention
researchers
to
treat
cancer.
Chitosan
is
a
polycationic
polymer
generated
from
chitin
characteristics
biocompatibility,
biodegradability,
non-toxicity,
mucoadhesiveness,
making
it
an
ideal
fabricate
systems.
However,
chitosan
poorly
soluble
in
water
acidic
aqueous
solutions.
Furthermore,
owing
presence
reactive
amino
groups,
can
be
chemically
modified
improve
its
physiochemical
properties.
derivatives
employed
which
are
used
most
frequently
pharmaceutical
sector
due
their
possession
nanosize,
appropriate
pharmacokinetic
pharmacodynamic
properties,
non-immunogenicity,
improved
stability,
loading
capacity.
capable
delivering
nucleic
acids,
chemotherapeutic
medicines,
bioactives
using
chitosan.
derivative-based
targeted
specific
sites
via
active
passive
mechanisms.
Based
many
anticancer
drugs
now
better
effectiveness,
potency,
cytotoxicity,
or
biocompatibility.
tailored
derivatives,
well
use
therapy,
will
examined
this
review.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(2), P. 503 - 503
Published: Feb. 2, 2023
Chitosan
is
a
positively
charged
polysaccharide
obtained
through
chitin
deacetylation.
It
belongs
to
group
of
biodegradable,
bioavailable,
and
non-toxic
materials
natural
origin;
thus,
it
promising
matrix
for
creating
delivery
systems
different
active
agents.
Recently,
much
attention
has
been
paid
nanodelivery
as
carriers
enable
better
bioavailability,
thus
higher
efficiency
the
loaded
drug.
The
present
review
focused
on
progress
in
chitosan-based
nanoparticles
targeted
antitumor
drugs.
paper
discusses
literature
reports
from
last
three
years
which
chitosan
were
applied
substances
used
therapy
potential
new
drugs
with
anticancer
properties.
Special
was
treatments
increase
therapeutic
effectiveness
minimize
side
effects
specific
substance.
