Polymers,
Journal Year:
2024,
Volume and Issue:
16(15), P. 2161 - 2161
Published: July 30, 2024
Glioblastoma
(GBM)
conventional
treatment
is
not
curative,
and
it
associated
with
severe
toxicity.
Thus,
natural
compounds
anti-cancer
properties
lower
systemic
toxicity,
such
as
gallic
acid
(GA),
have
been
explored
alternatives.
However,
GA’s
therapeutic
effects
are
limited
due
to
its
rapid
metabolism,
low
bioavailability,
permeability
across
the
blood–brain
barrier
(BBB).
This
work
aimed
develop
poly
(lactic-co-glycolic
acid)
(PLGA)
nanoparticles
(NPs)
modified
folic
(FA),
receptor
overexpressed
in
BBB
GBM
cells,
for
GA
delivery
enhance
efficacy.
The
preparation
of
NPs
was
optimized
by
a
central
composite
design
(CCD).
obtained
showed
physicochemical
features
suitable
drug
internalization
tumor
cells
(sizes
below
200
nm,
monodispersity,
negative
surface
charge)
ability
maintain
slow
sustained
release
40
days.
In
vitro
studies
using
human
cell
line
(U215)
revealed
NPs’
accumulate
target
further
promoting
antiproliferative
activity
inducing
production
intracellular
reactive
oxygen
species
(ROS).
Furthermore,
encapsulation
developed
nanosystems
conferred
higher
protection
healthy
cells.
Nanomaterials,
Journal Year:
2022,
Volume and Issue:
13(1), P. 155 - 155
Published: Dec. 29, 2022
Amphotericin
B
is
an
antifungal
drug
used
for
the
treatment
of
invasive
fungal
infections.
However,
its
clinical
use
limited
due
to
serious
side
effects,
such
as
renal
and
cardiovascular
toxicity.
Furthermore,
amphotericin
administered
in
high
doses
poor
water
solubility.
Hence,
it
necessary
develop
on-demand
release
strategy
delivery
reduce
cytotoxicity.
The
present
report
describes
a
novel
encapsulation
into
lipase-sensitive
polycaprolactone
form
nanocomposite.
Nanocomposites
were
produced
by
oil-in-water
method
their
physicochemical
properties
size,
hydrodynamic
diameter,
loading,
zeta
potential
determined.
vitro
was
characterized
presence
absence
lipase.
activity
nanocomposites
verified
against
lipase-secreting
Candida
albicans,
cytotoxicity
tested
primary
human
dermal
fibroblasts.
In
lipase,
from
minimal.
enzyme
that
abundant
at
infection
sites,
fungicidal
concentration
released
nanocomposites.
showed
enhanced
effect
fungus,
comparison
free
same
concentration.
nanoencapsulation
significantly
reduced
B-related
compared
drug.
synthesized
can
serve
potent
carrier
responsive
applications.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(25)
Published: Aug. 10, 2023
Restoring
bone
homeostasis
is
the
key
to
treatment
of
osteoporosis.
How
increase
osteogenic
ability
or
inhibit
osteoclast
activity
has
always
been
a
topic
great
concern.
In
recent
years,
short
peptides
with
biological
have
received
attention
in
repair.
However,
application
still
limited
due
lack
stable
and
targeted
delivery
system.
Poly(lactic-co-glycolic
acid)
(PLGA)
nanoparticles
modified
by
alendronate
(AL)
transport
(OGP)
(AL-PLGA@P
NPs)
are
designed.
Benefiting
from
high
affinity
AL
for
hydroxyapatite,
AL-PLGA@P
NPs
target
bone.
this
system,
OGP
that
promotes
osteogenesis
synergizes
AL,
which
inhibits
osteoclasts,
regulate
homeostasis,
gives
them
more
advantages
The
data
shows
can
selectively
deliver
surface
without
systemic
toxicity.
Moreover,
upregulate
osteogenesis-related
factors
(ALP,
Runx-2,
BMP2)
downregulate
osteoclast-related
(TRAP
CTSK)
vitro.
With
NPs,
microarchitecture
mass
improved
ovariectomized
osteoporosis
rats.
Therefore,
study
proposes
novel
osteoporosis-based
drug
system
effectively
improves
density.
Cancers,
Journal Year:
2023,
Volume and Issue:
15(24), P. 5807 - 5807
Published: Dec. 12, 2023
Artificial
cells
have
been
extensively
used
in
many
fields,
such
as
nanomedicine,
biotherapy,
blood
substitutes,
drug
delivery,
enzyme/gene
therapy,
cancer
and
the
COVID-19
vaccine.
The
unique
properties
of
superparamagnetic
Fe3O4
nanoparticles
contributed
to
increased
interest
using
artificial
(PLGA-Fe3O4
micro/nanocapsules)
for
targeted
therapy.
In
this
review,
preparation
methods
NPs
cell
PLGA-drug-Fe3O4
micro/nanocapsules
are
discussed.
This
review
also
focuses
on
recent
progress
therapeutics.
We
shall
concentrate
use
form
nanocapsules
magnetic
hyperthermia/photothermal
therapy
therapies,
including
lung
breast
glioblastoma.
Current Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
31(39), P. 6371 - 6392
Published: Aug. 23, 2023
Although
leishmaniasis
is
one
of
the
most
common
parasitic
diseases,
its
traditional
treatments
suffer
from
some
serious
problems.
To
solve
such
issues,
we
can
take
advantage
effective
nanoparticle-based
approaches
to
deliver
anti-leishmanial
agents
into
leishmania-infected
macrophages
either
using
passive
targeting
or
macrophagerelated
receptors.
Despite
high
potential
nanotechnology,
Liposomal
Amphotericin
B
(AmBisome
Polymers,
Journal Year:
2024,
Volume and Issue:
16(15), P. 2161 - 2161
Published: July 30, 2024
Glioblastoma
(GBM)
conventional
treatment
is
not
curative,
and
it
associated
with
severe
toxicity.
Thus,
natural
compounds
anti-cancer
properties
lower
systemic
toxicity,
such
as
gallic
acid
(GA),
have
been
explored
alternatives.
However,
GA’s
therapeutic
effects
are
limited
due
to
its
rapid
metabolism,
low
bioavailability,
permeability
across
the
blood–brain
barrier
(BBB).
This
work
aimed
develop
poly
(lactic-co-glycolic
acid)
(PLGA)
nanoparticles
(NPs)
modified
folic
(FA),
receptor
overexpressed
in
BBB
GBM
cells,
for
GA
delivery
enhance
efficacy.
The
preparation
of
NPs
was
optimized
by
a
central
composite
design
(CCD).
obtained
showed
physicochemical
features
suitable
drug
internalization
tumor
cells
(sizes
below
200
nm,
monodispersity,
negative
surface
charge)
ability
maintain
slow
sustained
release
40
days.
In
vitro
studies
using
human
cell
line
(U215)
revealed
NPs’
accumulate
target
further
promoting
antiproliferative
activity
inducing
production
intracellular
reactive
oxygen
species
(ROS).
Furthermore,
encapsulation
developed
nanosystems
conferred
higher
protection
healthy
cells.
