Frontiers in Bioengineering and Biotechnology,
Journal Year:
2022,
Volume and Issue:
10
Published: Nov. 18, 2022
Increasing
concern
about
age-related
diseases,
particularly
musculoskeletal
injuries
and
orthopedic
conditions,
highlights
the
need
for
strategies
such
as
tissue
engineering
to
address
them.
Surface
modification
has
been
developed
create
pro-healing
interfaces,
personalize
scaffolds
provide
novel
medicines.
Polydopamine,
a
mussel-inspired
adhesive
polymer
with
highly
reactive
functional
groups
that
adhere
nearly
all
substrates,
gained
attention
in
surface
biomaterials.
Polydopamine
was
primarily
modify
surfaces,
but
its
effectiveness
opened
up
promising
approaches
further
applications
bioengineering
carriers
nanoparticles.
This
review
focuses
on
recent
discoveries
of
role
polydopamine
coating
material,
focus
properties
make
it
suitable
tackling
disorders.
We
report
evolution
using
research,
discuss
papers
involving
progress
this
field.
The
current
research
bone,
cartilage,
muscle,
nerve,
tendon
regeneration
is
discussed,
thus
giving
comprehensive
overview
function
both
in-vitro
in-vivo
.
Finally,
concludes
presenting
critical
challenges
must
be
addressed
clinical
translation
biomaterial
while
exploring
future
perspectives
opportunities
area.
Polymers,
Journal Year:
2022,
Volume and Issue:
14(15), P. 3023 - 3023
Published: July 26, 2022
Nowadays,
there
are
still
numerous
challenges
for
well-known
biomedical
applications,
such
as
tissue
engineering
(TE),
wound
healing
and
controlled
drug
delivery,
which
must
be
faced
solved.
Hydrogels
have
been
proposed
excellent
candidates
these
they
promising
properties
the
mentioned
including
biocompatibility,
biodegradability,
great
absorption
capacity
tunable
mechanical
properties.
However,
depending
on
material
or
manufacturing
method,
resulting
hydrogel
may
not
up
to
specific
task
it
is
designed,
thus
different
approaches
enhance
performance
requirements
of
application
in
question.
The
main
purpose
this
review
article
was
summarize
most
recent
trends
technology,
going
through
used
polymeric
materials
popular
synthesis
methods
years,
strategies
enhancing
hydrogels'
properties,
cross-linking
manufacture
composite
hydrogels.
In
addition,
secondary
objective
briefly
discuss
other
novel
applications
hydrogels
that
past
few
years
drawn
a
lot
attention.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(26)
Published: Jan. 12, 2023
Abstract
Cartilage
degeneration
is
among
the
fundamental
reasons
behind
disability
and
pain
across
globe.
Numerous
approaches
have
been
employed
to
treat
cartilage
diseases.
Nevertheless,
none
shown
acceptable
outcomes
in
long
run.
In
this
regard,
convergence
of
tissue
engineering
microfabrication
principles
can
allow
developing
more
advanced
microfluidic
technologies,
thus
offering
attractive
alternatives
current
treatments
traditional
constructs
used
applications.
Herein,
developments
involving
hydrogel‐based
scaffolds,
promising
structures
for
regeneration,
ranging
from
hydrogels
with
channels
prepared
by
devices,
that
enable
therapeutic
delivery
cells,
drugs,
growth
factors,
as
well
cartilage‐related
organ‐on‐chips
are
reviewed.
Thereafter,
anatomy
types
damages,
present
treatment
options
briefly
overviewed.
Various
introduced,
advantages
scaffolds
over
thoroughly
discussed.
Furthermore,
available
technologies
fabricating
chips
presented.
The
preclinical
clinical
applications
regeneration
development
time
further
explained.
developments,
recent
key
challenges,
prospects
should
be
considered
so
develop
systems
repair
highlighted.
Materials Horizons,
Journal Year:
2023,
Volume and Issue:
11(1), P. 37 - 101
Published: Oct. 27, 2023
The
unique
network
characteristics
and
stimuli
responsiveness
of
supramolecular
hydrogels
have
rendered
them
highly
advantageous
in
the
field
wound
dressings,
showcasing
unprecedented
potential.
However,
there
are
few
reports
on
a
comprehensive
review
hydrogel
dressings
for
repair
hemostasis.
This
first
introduces
major
cross-linking
methods
hydrogels,
which
includes
hydrogen
bonding,
electrostatic
interactions,
hydrophobic
host-guest
metal
ligand
coordination
some
other
interactions.
Then,
we
advanced
materials
reported
recent
years
then
summarize
basic
principles
each
method.
Next,
classify
structures
before
outlining
their
forming
process
propose
potential
future
directions.
Furthermore,
also
discuss
raw
materials,
structural
design
principles,
material
used
to
achieve
functions
such
as
antibacterial
function,
tissue
adhesion,
substance
delivery,
anti-inflammatory
antioxidant
functions,
cell
behavior
regulation,
angiogenesis
promotion,
hemostasis
innovative
years.
Finally,
existing
problems
well
development
directions
strategy,
design,
discussed.
is
proposed
stimulate
further
exploration
by
researchers
future.
Applied Sciences,
Journal Year:
2023,
Volume and Issue:
13(13), P. 7744 - 7744
Published: June 30, 2023
In
a
variety
of
industries,
Additive
Manufacturing
has
revolutionized
the
whole
design–fabrication
cycle.
Traditional
3D
printing
is
typically
employed
to
produce
static
components,
which
are
not
able
fulfill
dynamic
structural
requirements
and
inappropriate
for
applications
such
as
soft
grippers,
self-assembly
systems,
smart
actuators.
To
address
this
limitation,
an
innovative
technology
emerged,
known
“4D
printing”.
It
processes
materials
by
using
fabricating
structures
that
can
be
reconfigured
applying
different
inputs,
heat,
humidity,
magnetism,
electricity,
light,
etc.
At
present,
4D
still
growing
technology,
it
presents
numerous
challenges
regarding
materials,
design,
simulation,
fabrication
processes,
applied
strategies,
reversibility.
work
critical
review
technologies,
provided.
The
complexation
of
nucleic
acids
and
collagen
forms
a
platform
biomaterial
greater
than
the
sum
its
parts.
This
union
biomacromolecules
merges
extracellular
matrix
functionality
with
designable
bioactivity
acids,
enabling
advances
in
regenerative
medicine,
tissue
engineering,
gene
delivery,
targeted
therapy.
review
traces
historical
foundations
critical
applications
DNA-collagen
complexes
highlights
their
capabilities,
demonstrating
them
as
biocompatible,
bioactive,
tunable
materials.
These
form
structures
across
length
scales,
including
nanoparticles,
microfibers,
hydrogels,
process
controlled
by
relative
amount
each
component
type
acid
collagen.
broad
distribution
different
types
within
body
contributes
to
extensive
biological
relevance
complexes.
Functional
can
these
complexes,
such
siRNA,
antisense
oligonucleotides,
DNA
origami
nanostructures,
and,
particular,
single-stranded
aptamers,
often
distinguished
rapid
self-assembly
at
room
temperature
formation
without
external
stimuli
modifications.
simple
seamless
integration
collagenous
matrices
enhances
biomimicry
bioactivity,
provides
stability
against
enzymatic
degradation,
positioning
an
advanced
system
for
many
angiogenesis,
bone
regeneration,
wound
healing,
more.
International Materials Reviews,
Journal Year:
2023,
Volume and Issue:
68(7), P. 901 - 942
Published: Jan. 27, 2023
Hyaluronic
acid
(HA)
is
of
immense
importance
to
biomaterials
science
and
biomedical
engineering.
It
finding
applications
in
diverse
areas
bioengineering
ranging
from
scaffolds
for
disease
modelling
tissue
culture
reconstruction.
This
review
focuses
on
recent
research
the
role
HA
as
a
photo-cross-linked
bioink
its
combating
bone
cartilage-related
disease,
injury
disorders.
Photo
chemical
modifications
3D
fabrication
technologies
employed
produce
HA-modified
materials
are
analysed
provide
fundamental
understanding
structure–function-property
relationships
that
influence
printability,
shape
fidelity
biological
performance
both
in-vitro
in-vivo.
The
article
concludes
with
future
vision
HA-based
bioinks
their
deployment
light-based
bioprinting
cartilage
repair.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: July 24, 2023
Abstract
Functional
hydrogels
show
potential
application
in
repairing
spinal
cord
injury
(SCI)
due
to
their
unique
chemical,
physical,
and
biological
properties
functions.
In
this
comprehensive
review,
we
present
recent
advance
the
material
design,
functional
regulation,
SCI
repair
applications
of
bioactive
hydrogels.
Different
from
previously
released
reviews
on
three-dimensional
scaffolds
for
repair,
work
focuses
strategies
design
biologically
regulation
hydrogels,
specifically
aiming
how
these
significant
efforts
can
promoting
performance
SCI.
We
demonstrate
various
methods
techniques
fabrication
with
components
such
as
DNA,
proteins,
peptides,
biomass
polysaccharides,
biopolymers
obtain
including
cell
biocompatibility,
self-healing,
anti-bacterial
activity,
injectability,
bio-adhesion,
bio-degradation,
other
multi-functions
The
drugs/growth
factors,
polymers,
nanoparticles,
one-dimensional
materials,
two-dimensional
materials
highly
effective
treating
are
introduced
discussed
detail.
This
shows
new
viewpoints
ideas
synthesis
state-of-the-art
knowledges
science
nanotechnology,
will
bridge
connection
biomedicine,
further
inspire
clinical
biomedical
fields.
