Overview of Electrospinning for Tissue Engineering Applications

Polymers, Journal Year: 2023, Volume and Issue: 15(11), P. 2418 - 2418

Published: May 23, 2023

Tissue engineering (TE) is an emerging field of study that incorporates the principles biology, medicine, and for designing biological substitutes to maintain, restore, or improve tissue functions with goal avoiding organ transplantation. Amongst various scaffolding techniques, electrospinning one most widely used techniques synthesise a nanofibrous scaffold. Electrospinning as potential technique has attracted great deal interest been discussed in many studies. The high surface-to-volume ratio nanofibres, coupled their ability fabricate scaffolds may mimic extracellular matrices, facilitates cell migration, proliferation, adhesion, differentiation. These are all very desirable properties TE applications. However, despite its widespread use distinct advantages, electrospun suffer from two major practical limitations: poor penetration load-bearing Furthermore, have low mechanical strength. Several solutions offered by research groups overcome these limitations. This review provides overview nanofibres In addition, we describe current on nanofibre fabrication characterisation, including main limitations some possible

Language: Английский

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Polymeric Materials, Advances and Applications in Tissue Engineering: A Review

Bioengineering, Journal Year: 2023, Volume and Issue: 10(2), P. 218 - 218

Published: Feb. 6, 2023

Tissue Engineering (TE) is an interdisciplinary field that encompasses materials science in combination with biological and engineering sciences. In recent years, increase the demand for therapeutic strategies improving quality of life has necessitated innovative approaches to designing intelligent biomaterials aimed at regeneration tissues organs. Polymeric porous scaffolds play a critical role TE providing favorable environment tissue restoration establishing interaction biomaterial cells inducing substances. This article reviewed various polymeric scaffold their production techniques, as well basic elements principles TE. Several interesting eight main application areas epithelial, bone, uterine, vascular, nerve, cartilaginous, cardiac, urinary were included aim learning about current Different polymer-based medical devices approved use clinical trials wide variety are currently available commercial products. However, there still obstacles limit translation implants humans, much research work needed regenerative medicine.

Language: Английский

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Recent Developments in Stimuli-Responsive Polymer for Emerging Applications: A Review

Results in Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 103900 - 103900

Published: Jan. 1, 2025

Language: Английский

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Multifunctional Coatings on Implant Materials—A Systematic Review of the Current Scenario

Coatings, Journal Year: 2022, Volume and Issue: 13(1), P. 69 - 69

Published: Dec. 30, 2022

The challenges and demands of implant materials are changing as a result the substantial expansion in global population. Suitable implants required for aged people, physical injuries, patients who need revised surgeries, contaminated implants, accident victims. Hence, requirement is drastically increasing day by day. Metals, ceramics, polymers used biomedical industries long-term suffering patients. Stainless steel, titanium its alloys, aluminum cobalt, zirconium, etc. (metals), hydroxyapatite (ceramic), polyurethane, polyethylene, polyimide, (polymers), some examples that fulfill requirements. There many other obstructions, such adhesion, inflammation, bacterial attack, which minimize implant’s performance activity. However, coatings on ideal significant to avoid failure enhance durability longevity. Advanced techniques, chemical methods, suitable coating approaches promote surface with respect mechanical, biological, multifunctional activities. This review paper focuses investigates several strategies bioactive implants’ coatings, analysis, emerging applications industries.

Language: Английский

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Thermosensitive Polymer-Modified Mesoporous Silica for pH and Temperature-Responsive Drug Delivery

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 795 - 795

Published: Feb. 28, 2023

A mesoporous silica-based drug delivery system (MS@PNIPAm-PAAm NPs) was synthesized by conjugating the PNIPAm-PAAm copolymer onto silica (MS) surface as a gatekeeper that responds to temperature and pH changes. The studies are carried out in vitro at different (7.4, 6.5, 5.0) temperatures (such 25 °C 42 °C, respectively). conjugated (PNIPAm-PAAm) acts below lower critical solution (LCST) (<32 °C) collapsed globule structure above LCST (>32 °C), resulting controlled from MS@PNIPAm-PAAm system. Furthermore, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay cellular internalization results support prepared NPs being biocompatible readily taken up MDA-MB-231 cells. NPs, with their pH-responsive release behavior good biocompatibility, could be used vehicle where sustained higher is required.

Language: Английский

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Temperature- and pH-Responsive Schizophrenic Copolymer Brush Coatings with Enhanced Temperature Response in Pure Water

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(6), P. 8676 - 8690

Published: Feb. 3, 2023

Novel brush coatings were fabricated with glass surface-grafted chains copolymerized using surface-initiated atom transfer radical polymerization (SI-ATRP) from 2-(2-methoxyethoxy)ethyl methacrylate (OEGMA188) and acrylamide (AAm), taken in different proportions. P(OEGMA188-co-AAm) brushes AAm mole fraction >44% (determined XPS TOF-SIMS spectroscopy) nearly constant the depth copolymer composition (TOF-SIMS profiling) exhibit unusual temperature-induced transformations: The contact angle of water droplets on increases by ∼45° temperature, compared to 17-18° for POEGMA188 PAAm. thickness immersed morphology imaged air show a temperature response (using reflectance spectroscopy AFM, respectively), but this is weak absent This suggests mechanisms more complex than simple transition between hydrated loose coils hydrophobic collapsed chains. For POEGMA188, hydrogen bonds ether oxygens poly(ethylene glycol) hydrogens are formed below Tc disrupted above when polymer-polymer interactions favored. Different bond structures PAAm include free amide groups, cis-trans-multimers, trans-multimers groups. Here, groups dominate at T < favored > Tc, such as cis-trans-multimers can still be hydrated. enhanced temperature-dependent wettability high formation structures, realized bonding OEGMA188 fragments AAm, where molecules caged. Furthermore, pH buffer solutions 'schizophrenic' behavior wettability, transitions that mimic LCST UCST = 3, 5 7, any blocked 9.

Language: Английский

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Increasing Bioavailability of Trans-Ferulic Acid by Encapsulation in Functionalized Mesoporous Silica

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 660 - 660

Published: Feb. 16, 2023

Two types of mesoporous materials, MCM-41 and MCM-48, were functionalized by the soft-template method using (3-aminopropyl)triethoxysilane (APTES) as a modifying agent. The obtained silica materials loaded with trans-ferulic acid (FA). In order to establish morphology structure series specific techniques used such as: X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Brunauer-Emmet-Teller (BET), Fourier Transform Infrared Spectroscopy (FTIR) thermogravimetric analysis (TGA). We monitored in vitro release FA at two different pH values, simulated gastric fluid (SGF) intestinal (SIF). Additionally, Staphylococcus aureus ATCC 25923, Escherichia coli 25922, Pseudomonas aeruginosa 27853 Candida albicans 10231 evaluate antimicrobial activity materials. conclusion can be employed controlled systems for polyphenols extracted from natural sources.

Language: Английский

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Conductive and Thermo-Responsive Composite Hydrogels with Poly(N-isopropylacrylamide) and Carbon Nanotubes Fabricated by Two-Step Photopolymerization

Polymers, Journal Year: 2023, Volume and Issue: 15(4), P. 1022 - 1022

Published: Feb. 18, 2023

Biocompatible and conductive polymer hydrogels are the subject of intensive research in bioengineering field because their use bioelectronic devices for fabrication electro-responsive tissues drug delivery systems. In this study, we report synthesis composite consisting a poly(N-isopropylacrylamide) (PNIPAM) matrix embedding carboxyl-functionalized multi-walled carbon nanotubes (MWCNT-COOH) using two-step photopolymerization method. Thermo-responsive with controlled hydrophilicity conductivity were prepared by varying nanotube concentration range 0.5–3 wt%. The thermal response PNIPAM-based was measured differential scanning calorimetry both ultrapure water PBS solution as swelling liquid. Results show that endothermic peak associated temperature-induced volume phase transition (VPT) shifts to higher temperatures upon increasing nanotubes, indicating more energy is required dissociate hydrogen bonds polymer/filler network. solution, ratios VPT reduced salt-induced screening oppositely charged assembly, electrical resistivity decreases factor 10 respect water-swollen hydrogels.

Language: Английский

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Polymer Brushes and Surface Nanostructures: Molecular Design, Precise Synthesis, and Self-Assembly

Langmuir, Journal Year: 2024, Volume and Issue: 40(5), P. 2439 - 2464

Published: Jan. 27, 2024

For over two decades, polymer brushes have found wide applications in industry and scientific research. Now, brush research has been a significant focus the community of science. In this review paper, we give an introduction to synthesis, self-assembly, one-dimensional (1D) on backbones, two-dimensional (2D) flat surfaces, three-dimensional (3D) spherical particles. Examples synthesis different substrates are provided. Studies formation surface nanostructures solid surfaces also reviewed article. Multicomponent able self-assemble into micelles (s-micelles). If s-micelles linked through cleavable linkages, can be cleaved from substrates, hierarchical structures. The by coassembly "free" chains (coassembly approach) or polymerization-induced self-assembly approach, is discussed. colloid biomedical science summarized. Finally, perspectives development offered

Language: Английский

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PNIPAM/PEDOT:PSS Hydrogels for Multifunctional Organic Electrochemical Transistors

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(40)

Published: April 26, 2024

Abstract The development of multifunctional organic materials represents a vibrant area research, with applications spanning from biosensing to drug delivery. This study shows the bioelectronic device suitable for prolonged temperature monitoring and delivery applications. relies on conducting thermo‐responsive hydrogel made poly(3,4‐ethylenedioxythiophene) doped poly(styrene sulfonate) (PEDOT:PSS) poly(N‐isopropylacrylamide) (PNIPAM). is 4D printable by Digital Light Processing (DLP) method exhibits optimal biocompatibility. features low critical solution (LCST) ≈35 °C, above which its resistance changes dramatically due shrinkage it undergoes temperature. integration PNIPAM/PEDOT into an electrochemical transistor (OECT) as gate electrode allows generate miniaturized reversible response variations between 25 45 along high sensitivity 0.05 °C −1 . Furthermore, demonstrates utility in delivery, achieving Insulin‐FITC release rate 82 ± 4% at 37 mimicking human body conditions. hydrogel's functionality store insulin does not compromise thermo‐responsivity overall performance OECT. OECT opens new avenues customizable personalized sensing drug‐delivery systems.

Language: Английский

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