New challenges in scar therapy: the novel scar therapy strategies based on nanotechnology DOI Creative Commons

Zhuoyang Chen,

Jia Gao, Lili Li

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: 19(28), P. 2413 - 2432

Published: Sept. 26, 2024

The pathological mechanism of scar is highly complex, encompassing the abnormalities diverse cytokines, signaling pathways and regulatory factors. To discover more preferable treatment options, a variety distinct approaches have been utilized clinically. Nevertheless, these treatments possess certain side effects are inclined to relapse. Presently, remains clinical conundrum, there an urgent demand for methods that safe, less traumatic lower recurrence rates. New drug delivery systems, novel therapeutic drugs therapy strategies can enable permeate skin effectively, decrease effects, enhance efficacy even achieve pain-free self-administration. Currently, nanotechnologies such as nanomicroneedles, photodynamics mediated by photosensitizers, bioelectrical stimulation 3D printed dressings developed effective scars. Additionally, innovative nanoscale fillers, including nano-fat engineered exosomes, serve agents efficient intervention nanomaterials absorption, stabilize safeguard active ingredients drugs, delay or control release bioavailability. This article reviews new explore safe keloid treatment.

Language: Английский

Therapeutic Potential of Microneedle Assisted Drug Delivery for Wound Healing: Current State of the Art, Challenges, and Future Perspective DOI

Devesh Kumar,

Shubham Pandey,

Jailani Shiekmydeen

et al.

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 8, 2025

Language: Английский

Citations

4
A Review of Patents and Innovative Biopolymer-Based Hydrogels DOI Creative Commons
Snežana Ilić‐Stojanović, Ljubiša Nikolić, Suzana Cakić

et al.

Gels, Journal Year: 2023, Volume and Issue: 9(7), P. 556 - 556

Published: July 7, 2023

Biopolymers represent a great resource for the development and utilization of new functional materials due to their particular advantages such as biocompatibility, biodegradability non-toxicity. “Intelligent gels” sensitive different stimuli (temperature, pH, ionic strength) have applications in many industries (e.g., pharmacy, biomedicine, food). This review summarizes research efforts presented patent non-patent literature. A discussion was conducted regarding biopolymer-based hydrogels natural proteins (i.e., fibrin, silk fibroin, collagen, keratin, gelatin) polysaccharides chitosan, hyaluronic acid, cellulose, carrageenan, alginate). In this analysis, latest advances modification characterization advanced biopolymeric formulations state-of-the-art administration drug delivery, wound healing, tissue engineering regenerative medicine were addressed.

Language: Английский

Citations

26
Multifunctional Hydrogel Microneedles (HMNs) in Drug Delivery and Diagnostics DOI Creative Commons
Hossein Omidian, Sumana Dey Chowdhury

Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 206 - 206

Published: March 15, 2025

Hydrogel microneedles (HMNs) have emerged as a transformative platform for minimally invasive drug delivery and biosensing, offering enhanced bioavailability, controlled release, real-time biomarker detection. By leveraging swelling hydrogels, nanomaterial integration, stimuli-responsive properties, HMNs provide precision medicine capabilities across diverse therapeutic diagnostic applications. However, challenges remain in mechanical stability, hydrogel-based MNs must balance flexibility with sufficient strength skin penetration. Drug retention release require optimization to prevent premature diffusion ensure sustained effects. Additionally, biosensing accuracy is influenced by variability interstitial fluid extraction signal transduction. Clinical translation hindered regulatory hurdles, scalability concerns, the need extensive safety validation human trials. This review critically examines key materials, fabrication techniques, functional testing frameworks of while addressing these limitations. Furthermore, we explore future research directions smart wearable MNs, AI-assisted hybrid drug–device platforms optimize transdermal medicine. Overcoming barriers will drive clinical adoption HMNs, paving way next-generation patient-centered therapeutics diagnostics.

Language: Английский

Citations

1
The State of the Art of Natural Polymer Functionalized Fe3O4 Magnetic Nanoparticle Composites for Drug Delivery Applications: A Review DOI Creative Commons
Abu Hassan Nordin, Zuliahani Ahmad, Siti Muhamad Nur Husna

et al.

Gels, Journal Year: 2023, Volume and Issue: 9(2), P. 121 - 121

Published: Feb. 1, 2023

Natural polymers have received a great deal of interest for their potential use in the encapsulation and transportation pharmaceuticals other bioactive compounds disease treatment. In this perspective, drug delivery systems (DDS) constructed by representative natural from animals (gelatin hyaluronic acid), plants (pectin starch), microbes (Xanthan gum Dextran) are provided. order to enhance efficiency DDS delivering medicine right location, reducing medication's adverse effects on neighboring organs or tissues, controlling release stop cycle over- under-dosing, incorporation Fe

Language: Английский

Citations

22
A Sustainable Solution to Skin Diseases: Ecofriendly Transdermal Patches DOI Creative Commons

Eylul Gulsen Yilmaz,

Emre Ece, Özgecan Erdem

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 579 - 579

Published: Feb. 8, 2023

Skin is the largest epithelial surface of human body, with a area 2 m2 for average adult human. Being an external organ, it susceptible to more than 3000 potential skin diseases, including injury, inflammation, microbial and viral infections, cancer. Due its nature, offers large accessible site administrating several medications against these diseases. The dermal transdermal delivery such are often ensured by utilizing dermal/transdermal patches or microneedles made biocompatible biodegradable materials. These tools provide controlled drugs action in rapid therapeutically effective manner enhanced diffusivity minimal side effects. Regrettably, they usually fabricated using synthetic materials possible harmful environmental Manufacturing green synthesis routes raw hence essential both ecological economic sustainability. In this review, natural chitosan/chitin, alginate, keratin, gelatin, cellulose, hyaluronic acid, pectin, collagen utilized designing ecofriendly will be explored. Their implementation wound healing, cancer, inflammations, infections discussed, significance studies evaluated future perspectives.

Language: Английский

Citations

17
Fucoidan-incorporated dissolving microneedles: A novel approach to anticoagulant transdermal delivery DOI

Stephanie Stephanie,

Cindy Kristina Enggi,

Sulistiawati Sulistiawati

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 95, P. 105587 - 105587

Published: March 14, 2024

Language: Английский

Citations

8
Research Progress of Hydrogel Microneedles in Wound Management DOI Creative Commons

Ming Ji,

Fangbiao Zhan, Xingan Qiu

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(8), P. 4771 - 4790

Published: July 10, 2024

Microneedles are a novel drug delivery system that offers advantages such as safety, painlessness, minimally invasive administration, simplicity of use, and controllable delivery. As type polymer microneedle with three-dimensional network structure, hydrogel microneedles (HMNs) possess excellent biocompatibility biodegradability encapsulate various therapeutic drugs while maintaining activity, thus attracting significant attention. Recently, they have been widely employed to promote wound healing demonstrated favorable effects. Although there reviews about HMNs, few them focus on management. Herein, we present comprehensive overview the design preparation methods particular emphasis their application status in healing, including acute infected diabetic scarless healing. Finally, examine limitations HMNs management provide suggestions for future research directions.

Language: Английский

Citations

7
Understanding the journey of biopolymeric nanoformulations for oral drug delivery: Conventional to advanced treatment approaches DOI
Ameya Sharma,

Nitin Jangra,

Divya Dheer

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 218, P. 113338 - 113338

Published: July 26, 2024

Language: Английский

Citations

7
Targeting Diverse Wounds and Scars: Recent Innovative Bio‐design of Microneedle Patch for Comprehensive Management DOI
Z. Zhuang, Yong Wang,

Zi‐Xuan Feng

et al.

Small, Journal Year: 2023, Volume and Issue: 20(18)

Published: Dec. 1, 2023

Abstract Wounds and the subsequent formation of scars constitute a unified complex phased process. Effective treatment is crucial; however, diverse therapeutic approaches for different wounds scars, as well varying needs at stages, present significant challenges in selecting appropriate interventions. Microneedle patch (MNP), novel minimally invasive transdermal drug delivery system, has potential integrated programmed various diseases shown promising applications types scars. In this comprehensive review, latest biotechnological innovations MNPs these fields are thoroughly explored, summarizing their powerful abilities to accelerate healing, inhibit scar formation, manage related symptoms. Moreover, scenarios discussed. Additionally, side effects, manufacturing processes, material selection explore clinical translational investigated. This groundwork can provide theoretical basis serve catalyst future pursuit favorable options skin tissue regeneration.

Language: Английский

Citations

15
Visible light-driven photodynamic therapy for hypertrophic scars with MOF armored microneedles patch DOI Creative Commons
Danyang Chen, Yixuan Zhang, Long Wei

et al.

Frontiers in Chemistry, Journal Year: 2023, Volume and Issue: 11

Published: Feb. 16, 2023

Photodynamic therapy (PDT) is widely used for the treatment of hypertrophic scars in clinical practice. However, low transdermal delivery photosensitizers scar tissue and protective autophagy induced by greatly reduces therapeutic efficiency. Therefore, it necessary to deal with these difficulties overcoming obstacles treatment. In this study, a photosensitizer photocatalytic performance was designed synthesized using innovative MOFs (metal-organic frameworks). Additionally, MOFs, together an inhibitor chloroquine (CQ), loaded high mechanical strength microneedle patch (MNP) delivery. With functionalized MNP, were delivered deep inside scars. Inhibition increases levels reactive oxygen species (ROS) under high-intensity visible-light irradiation. Multiprong approaches have been remove successfully enhance its anti-scarring effect. vitro experiments indicated that combined increased toxicity fibroblasts (HSFs), downregulated level collagen type I expression as well transforming growth factor-β1 (TGF-β1)expression, decreased marker protein LC3II/I ratio, P62. vivo showed MNP had good puncture performance, significant effects observed rabbit ear model. These results indicate has potential value.

Language: Английский

Citations

14