Polymers,
Journal Year:
2024,
Volume and Issue:
16(9), P. 1182 - 1182
Published: April 23, 2024
Polymers
derived
from
natural
biomass
have
emerged
as
a
valuable
resource
in
the
field
of
biomedicine
due
to
their
versatility.
Polysaccharides,
peptides,
proteins,
and
lignin
demonstrated
promising
results
various
applications,
including
drug
delivery
design.
However,
several
challenges
need
be
addressed
realize
full
potential
these
polymers.
The
current
paper
provides
comprehensive
overview
latest
research
perspectives
this
area,
with
particular
focus
on
developing
effective
methods
efficient
systems.
This
review
aims
offer
insights
into
opportunities
associated
use
polymers
provide
roadmap
for
future
field.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(2), P. 206 - 206
Published: Jan. 10, 2024
Degradable
polymers
(both
biomacromolecules
and
several
synthetic
polymers)
for
biomedical
applications
have
been
promising
very
much
in
the
recent
past
due
to
their
low
cost,
biocompatibility,
flexibility,
minimal
side
effects.
Here,
we
present
an
overview
with
updated
information
on
natural
degradable
where
a
brief
account
different
polysaccharides,
proteins,
viz.
polyesters/polyamino
acids/polyanhydrides/polyphosphazenes/polyurethanes
relevant
has
provided.
The
various
approaches
transformation
of
these
by
physical/chemical
means
cross-linking,
as
polyblends,
nanocomposites/hybrid
composites,
interpenetrating
complexes,
interpolymer/polyion
functionalization,
polymer
conjugates,
block
graft
copolymers,
are
described.
degradation
mechanism,
drug
loading
profiles,
toxicological
aspects
polymeric
nanoparticles
formed
also
defined.
Biomedical
polymer-based
biomaterials
wound
dressing/healing,
biosensors,
delivery
systems,
tissue
engineering,
regenerative
medicine,
etc.,
highlighted.
In
addition,
use
such
nano
systems
solve
current
problems
is
briefly
reviewed.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 976 - 976
Published: March 17, 2023
Concurrent
developments
in
anticancer
nanotechnological
treatments
have
been
observed
as
the
burden
of
cancer
increases
every
year.
The
21st
century
has
seen
a
transformation
study
medicine
thanks
to
advancement
field
material
science
and
nanomedicine.
Improved
drug
delivery
systems
with
proven
efficacy
fewer
side
effects
made
possible.
Nanoformulations
varied
functions
are
being
created
using
lipids,
polymers,
inorganic
peptide-based
nanomedicines.
Therefore,
thorough
knowledge
these
intelligent
nanomedicines
is
crucial
for
developing
very
promising
systems.
Polymeric
micelles
often
simple
make
high
solubilization
characteristics;
result,
they
seem
be
alternative
other
nanosystems.
Even
though
recent
studies
provided
an
overview
polymeric
micelles,
here
we
included
discussion
on
“intelligent”
from
We
also
summarized
state-of-the-art
most
micellar
respect
treatments.
Additionally,
gave
significant
attention
clinical
translation
potential
treatment
various
cancers.
Journal of Drug Delivery Science and Technology,
Journal Year:
2023,
Volume and Issue:
82, P. 104307 - 104307
Published: Feb. 27, 2023
Breast
cancer
refers
to
a
very
common
deadly
class
of
malignant
tumors,
especially
in
women
worldwide.
In
the
present
study,
promising
methodology
has
been
developed
simultaneously
improve
drug
loading
performance
and
achieve
sustained
release
5-fluorouracil
(5-FU)
as
model
for
breast
cancer.
For
this
purpose,
pH-sensitive
biocompatible
hydrogel
chitosan/agarose/graphene
oxide
(CS/AG/GO)
was
first
synthesized
with
glyoxal
cross-linker.
5-FU-loaded
nanocomposites
(NCs)
CS/AG/GO
were
then
prepared
via
water-in-oil-in-water
(W/O/W)
emulsification
technique.
XRD
FTIR
analyses
confirmed
successful
synthesis
nanocarriers
gave
insight
on
their
crystalline
structure
molecular
interactions
between
components.
DLS
demonstrated
that
comprise
nanoparticles
an
average
size
197
nm
PDI
0.34.
SEM
revealed
spherical
morphology
zeta
potential
measurements
indicated
surface
charge
+23.5
mV.
The
entrapment
efficiencies
(57%
92%,
respectively)
significantly
higher
than
those
reported
previously
other
nanocarriers.
A
effective
profile
observed
at
pH
5.4;
48
h,
almost
entire
5-FU
content
released.
Moreover,
cytotoxicity
against
cell
(BCC)
lines
(MCF-7)
observed:
viability
upon
incubation
CS/AG/GO/5-FU
about
23%,
demonstrating
its
anti-cancer
capability.
Therefore,
NCs
can
potentially
act
nanovehicles
programmed
treatment.
Frontiers in Molecular Biosciences,
Journal Year:
2023,
Volume and Issue:
10
Published: Aug. 8, 2023
Nanogels
are
highly
recognized
as
adaptable
drug
delivery
systems
that
significantly
contribute
to
improving
various
therapies
and
diagnostic
examinations
for
different
human
diseases.
These
three-dimensional,
hydrophilic
cross-linked
polymers
have
the
ability
absorb
large
amounts
of
water
or
biological
fluids.
Due
growing
demand
enhancing
current
therapies,
nanogels
emerged
next-generation
system.
They
effectively
address
limitations
conventional
therapy,
such
poor
stability,
particle
size,
low
loading
efficiency.
find
extensive
use
in
controlled
therapeutic
agents,
reducing
adverse
effects
enabling
lower
doses
while
maintaining
enhanced
efficacy
patient
compliance.
considered
an
innovative
system
highlights
shortcomings
traditional
methods.
This
article
covers
several
topics,
including
involvement
nanomedicine
sector,
their
advantages
limitations,
ideal
properties
like
biocompatibility,
biodegradability,
capacity,
permeability,
non-immunological
response,
colloidal
stability.
Additionally,
it
provides
information
on
nanogel
classification,
synthesis,
release
mechanisms,
applications.
The
also
discusses
barriers
associated
with
brain
targeting
progress
nanocarriers
delivering
agents
central
nervous
Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
25(2), P. 541 - 563
Published: Jan. 19, 2024
Nanoformulation
of
active
payloads
or
pharmaceutical
ingredients
(APIs)
has
always
been
an
area
interest
to
achieve
targeted,
sustained,
and
efficacious
delivery.
Various
delivery
platforms
have
explored,
but
loading
APIs
challenging
because
the
chemical
structural
properties
these
molecules.
Polymersomes
made
from
amphiphilic
block
copolymers
(ABCPs)
shown
enormous
promise
as
a
tunable
API
platform
confer
multifold
advantages
over
lipid-based
systems.
For
example,
COVID
booster
vaccine
comprising
polymersomes
encapsulating
spike
protein
(ACM-001)
recently
completed
Phase
I
clinical
trial
provides
case
for
developing
safe
drug
products
based
on
ABCP
platforms.
However,
several
limitations
need
be
resolved
before
they
can
reach
their
full
potential.
In
this
Perspective,
we
would
like
highlight
such
aspects
requiring
further
development
translating
ABCP-based
proof
concept
viable
commercial
product.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(4), P. 1135 - 1135
Published: April 3, 2023
The
main
factors
that
determine
the
low
effectiveness
of
chemotherapy
are
target
bioavailability
antitumor
drugs
and
efflux
process.
In
attempts
to
overcome
this
problem,
several
approaches
proposed
here.
Firstly,
development
polymeric
micellar
systems
based
on
chitosan
grafted
by
fatty
acids
(different
types
optimize
their
properties),
which,
one
hand,
increase
solubility
cytostatics
and,
other
effectively
interact
with
tumor
cells
due
polycationic
properties
chitosan,
allowing
for
more
effective
penetration
cytostatic
into
cells.
Secondly,
use
adjuvants-synergists
(such
as
eugenol)
included
in
same
formulation-that
selectively
enhance
accumulation
retention
pH-
temperature-sensitive
micelles
developed
show
high
entrapment
efficiency
both
eugenol
(EG)
>60%
release
drug
a
prolonged
manner
40
h
weakly
acidic
medium
corresponding
microenvironment
tumors.
slightly
alkaline
environment,
circulates
longer
(more
than
60
h).
thermal
sensitivity
is
realized
an
molecular
mobility
which
undergoes
phase
transition
at
32-37
°C.
effect
doxorubicin
(Dox)
cancerous
A549
model
healthy
human
embryonic
renal
epithelium
(HEK293T)
was
studied
FTIR
spectroscopy
fluorescence
microscopy.
Micellar
Dox
penetrates
cancer
2-3
times
efficiently
when
using
EG
adjuvant,
inhibits
efflux,
demonstrated
significant
ratio
intra-
extracellular
concentrations
cytostatic.
However,
here
it
worth
remembering
about
they
should
not
be
damaged:
according
changes
spectra,
HEK293T
combination
reduced
20-30%
compared
simple
Thus,
experimental
developments
combined
have
been
treatment
multiple
resistance.
