Development of folic acid functionalized bilosomes for delivery of vorinostat to breast cancer cells: Characterization and cytocidal effects on MCF-7 and 4T1 breast cancer cell lines DOI Creative Commons

Anahita Rashidi,

Somayeh Taymouri, Mahboubeh Rostami

et al.

Advanced Pharmaceutical Bulletin, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Purpose: Breast cancer is a prevalent form of in woman. Vorinostat (VOR) chemotherapeutic drug that has been utilized for treatment breast cancer, but its effectiveness limited due to low bioavailability and several side effects. The primary aim this study prepare folic acid (FA) conjugated pegylated bilosomes containing VOR the selective targeting cells with FA receptor expression. Accordingly, lithocholic (LCA) was used as bile anti-cancer anti-proliferation Methods: loaded were prepared using thin-film hydration method optimized by applying two-level fractional factorial design. Various properties considered bilosomes, including particle size, zeta potential (ZP), polydispersity index (PdI), encapsulation efficiency (EE) % loading (DL) %, then investigated synthesized FA-PEG-Cholesterol incorporated bilosomes. efficacy FA-PEG- also evaluated vitro MCF-7 4T1 cell lines. Furthermore, drug-free FA-PEG-bilosomes biocompatibility L929 line. Results: exhibited spherical particles size 305.33 ± 18.50 nm, PdI 0.37 0.03, -17.66 0.15 mV, EE 92.91 0.22 DL% 23.64 0.04%. Incorporation FA-PEG-cholesterol nanobilosomes increased absolute value potential. In cytotoxicity revealed FA- PEG-bilosomes demonstrated greater cytotoxic effect, compared free VOR- both cells. Conclusion: This showed could be promising formulation (+) tumors.

Language: Английский

Polysaccharide hydrogel platforms as suitable carriers of liposomes and extracellular vesicles for dermal applications DOI Creative Commons
Leila Pourtalebi Jahromi,

Markus Rothammer,

Gregor Fuhrmann

et al.

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 200, P. 115028 - 115028

Published: July 28, 2023

Lipid-based nanocarriers have been extensively investigated for their application in drug delivery. Particularly, liposomes are now clinically established treating various diseases such as fungal infections. In contrast, extracellular vesicles (EVs) - small cell-derived nanoparticles involved cellular communication just recently sparked interest carriers but development is still at the preclinical level. To drive this further, methods and technologies exploited context of liposome research should be applied domain EVs to facilitate accelerate clinical translation. One crucial steps EV-based therapeutics designing them proper dosage forms specific applications. This review offers a comprehensive overview state-of-the-art polysaccharide-based hydrogel platforms designed artificial natural with delivery skin. We discuss physicochemical biological properties try create sound basis optimization EV-embedded hydrogels versatile therapeutic avenues.

Language: Английский

Citations

27
Transfersome, an ultra-deformable lipid-based drug nanocarrier: an updated review with therapeutic applications DOI

Simrah,

Abdul Hafeez, Shazia Usmani

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2023, Volume and Issue: 397(2), P. 639 - 673

Published: Aug. 19, 2023

Language: Английский

Citations

24
Dual-action of clotrimazole loaded − nanosponges vaginal gel for spermicidal action and treatment of vaginal candidiasis: Optimization, in-vitro, ex-vivo, and in-vivo experiments DOI
Doaa A. Helal,

A. Abuzinadah Osama,

Mohamed A. El-Nabarawi

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 670, P. 125193 - 125193

Published: Jan. 8, 2025

Language: Английский

Citations

1
Enhanced Therapy for Diabetic Neuropathy Utilizing Venlafaxine Hydrochloride-Loaded Transferosome-Based Transdermal Gel DOI Creative Commons
Kiran Patil, Pramod S. Salve, Ujban Hussain

et al.

Nano Trends, Journal Year: 2025, Volume and Issue: 9, P. 100085 - 100085

Published: Jan. 31, 2025

Language: Английский

Citations

1
Transferosome-Enhanced Transdermal Therapy: A Novel Approach for Duloxetine Delivery for Management of Neuropathic Pain DOI
Pramod S. Salve,

Mohammad Qutub,

Ujban Hussain

et al.

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: March 17, 2025

Language: Английский

Citations

1
Optimization, In Vitro and Ex Vivo Assessment of Nanotransferosome Gels Infused with a Methanolic Extract of Solanum xanthocarpum for the Topical Treatment of Psoriasis DOI Creative Commons
Nilanchala Sahu, Perwez Alam, Asad Ali

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(2), P. 119 - 119

Published: Feb. 2, 2024

The goal of this investigation is to improve the topical delivery medicine by preparing and maximizing potential a nanotransferosome gel infused with Solanum xanthocarpum methanolic extract (SXE) provide localized regulated distribution. Thin-film hydration was used create SXE-infused nanotransferosomes (SXE-NTFs), Box–Behnken design them. Phospholipon 90G (X1), cholesterol (X2) sodium cholate (X3) were chosen as independent variables, their effects on vesicle size (Y1), polydispersity index (PDI) (Y2) percentage entrapment efficiency (EE) (Y3) observed both individually in combination. For SXE-NTFs, 146.3 nm, PDI 0.2594, EE 82.24 ± 2.64%, drug-loading capacity 8.367 0.07% drug release rate 78.86 5.24%. Comparing antioxidant activity conventional ascorbic acid, it determined be 83.51 3.27%. Ex vivo permeation tests revealed that SXE-NTF (82.86 2.38%) considerably outperformed SXE (35.28 1.62%) terms permeation. In addition, seemed from confocal laser scanning microscopy (CLSM) picture Wistar rat’s skin rhodamine-B-loaded had higher penetration capability than control. Dermatokinetic studies showed better retention gel. According experimental results, promising successful formulation.

Language: Английский

Citations

7
Microneedle-based arrays – breakthrough strategy for the treatment of bacterial and fungal skin infections DOI Creative Commons
Oliwia Kordyl, Zuzanna Styrna, Monika Wojtyłko

et al.

Microbes and Infection, Journal Year: 2024, Volume and Issue: unknown, P. 105426 - 105426

Published: Sept. 1, 2024

Language: Английский

Citations

3
Thyme Oil–Containing Fluconazole-Loaded Transferosomal Bigel for Transdermal Delivery DOI
B. Krishna Das, Amit Kumar Nayak, Subrata Mallick

et al.

AAPS PharmSciTech, Journal Year: 2023, Volume and Issue: 24(8)

Published: Nov. 21, 2023

Language: Английский

Citations

7
Full factorial design-based development and characterization of ciclopirox olamine loaded transferosomes: An efficient approach for the management of Athlete's foot DOI

Triveni Triveni,

Upendra Nagaich, Dinesh Kumar Mishra

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 99, P. 105939 - 105939

Published: July 4, 2024

Language: Английский

Citations

2
Itraconazole Loaded Biosurfactin Micelles with Enhanced Antifungal Activity: Fabrication, Evaluation and Molecular Simulation DOI Creative Commons
Faisal Usman, Mudassir Farooq, Tanveer A. Wani

et al.

Antibiotics, Journal Year: 2023, Volume and Issue: 12(10), P. 1550 - 1550

Published: Oct. 19, 2023

Itraconazole (ITZ) is a broad-spectrum antifungal for superficial subcutaneous and systemic fungal infections. This study aimed to enhance the activity of ITZ using surfactin A (SA), cyclic lipopeptide produced by SA-producing Bacillus strain NH-100, possessing strong activity. SA was extracted, ITZ-loaded micelles formulations were prepared via single-pot rinsing method characterized particle size, zeta potential, infrared spectroscopy. In vitro dissolution at pH 1.2, as well hemolysis studies, also carried out. The fabricated stable non-spherical in shape, with an average size about 179 nm, FTIR spectra depicted no chemical interaction among formulation components. showed decreased comparison pure ITZ. drug released followed Korsmeyer–Peppas model, having R2 0.98 diffusion release mechanism. acidic buffer, all range 73–89% 2 h. molecular simulation outstanding binding stability profile ITZ-SA complex. aromatic ring mediates π-alkyl contact side chain SA. It can be concluded that micelles, owing significant enhanced up 6-fold due synergistic effect SA, promising delivery platform poorly soluble

Language: Английский

Citations

6