Mitigating Photoaged Skin Aging with Single Injection of Recombinant Human Collagen Type Iii DOI
Yafang Chen, Kang Li, Hu Chen

et al.

Published: Jan. 1, 2023

Delaying aging is an eternal goal for humanity. Collagen-based materials, employed as dermal fillers to smoothen wrinkles, have attained extensive utilization. Nevertheless, traditional animal-derived collagen protein primarily presents concerns pertaining disease risks, potential immunological reactions, and batch instability. In this investigation, the filler composed of recombinant human type III (rhCol III) with excellent injectability was fabricated using synthetic biology. The in vitro examination cell interaction rhCol revealed commendable biocompatibility, concentration-dependent impacts on proliferation, migration secretion. Subsequently, we established a skin damage animal model through UV-photoaging introduced bioactive material vivo implantation, systematically comparing its biological effect pCollagen, hyaluronic acid (HA) saline thorough histological observation, immunofluorescence staining, hydroxyproline quantification analysis specific gene expression. Outcomes indicated prompted augmented production I (Col I), elastic fibers, thereby contributing remodeling extracellular matrix (ECM). summary, our investigation contributed robust biosafety proficient attenuation UV-induced photoaging by under single injection. Despite imperative ongoing efforts required successful translation from bench clinic, discernibly superior safety efficacy profile positioned it promising candidate within domain fillers.

Language: Английский

An evaluation of the effectiveness of ‘ULTRACOL 200′ in enhancing nasolabial fold wrinkles through cutaneous repair DOI Creative Commons
Nguyen Ngan Giang, Hyunjee Kim, Pham Ngoc Chien

et al.

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(4)

Published: April 1, 2024

Abstract Background Injectable filler, a nonsurgical beauty method, has gained popularity in rejuvenating sagging skin. In this study, polydioxanone (PDO) was utilized as the main component of ULTRACOL200 filler that helps stimulate collagenesis and provide skin radiant effects. The study aimed to evaluate compare effectiveness with other commercialized products visually improving dermatological problems. Methods Herein, 31 participants aged between 20 59 years were enrolled study. 1 mL testing product, well quantity for compared groups injected into each face side individually. Subsequently, texture sunken volume measured using ANTERA 3D CS imaging technology at three periods: before application, 4 weeks after initial 2nd application ULTRACOL200. Results final results wrinkle evaluation consistently demonstrated significant enhancement. Consequently, subjective questionnaires provided efficacy illustrating satisfactory responses twice applications. Conclusion investigation contributed substantially comprehension PDO‐based (ULTRACOL200) enhancement profound insight future clinical trials.

Language: Английский

Citations

2
Advances in Protein- and Lipid-based Materials for Cosmetic Applications DOI

Muniba Iqbal,

Sadia Farooq, Ajaz Hussain

et al.

Royal Society of Chemistry eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 280 - 318

Published: Aug. 23, 2024

Proteins and lipids are very large natural molecules that possess many attributes for skin care hair growth. Therefore, these the materials derived from them play a potential role in aesthetic aspects of our society. In this context, present chapter focuses on protein- lipid-based field cosmetics. The sources proteins used cosmetics have also been highlighted, keeping view nanoscale protein/lipid Moreover, recent advancements shown, which may be equally beneficial readers who love to use as beauty ingredients people associated with cosmetic industry.

Language: Английский

Citations

2
Tailoring biomaterials for skin anti-aging DOI Creative Commons

Xin Dan,

Songjie Li, Han Chen

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 28, P. 101210 - 101210

Published: Aug. 28, 2024

Skin aging is the phenomenon of degenerative changes in structure and function skin tissues over time manifested by a gradual loss elasticity firmness, an increased number wrinkles, hyperpigmentation. anti-aging refers to reduction through medical cosmetic technologies. In recent years, new biomaterials have been continuously developed for improving appearance mechanical tissue filling, regulating collagen synthesis degradation, inhibiting pigmentation, repairing barrier. This review summarizes mechanisms associated with aging, describes that are commonly used aesthetics their possible modes action, discusses application strategies this area. Moreover, synergistic effects such other active ingredients, as stem cells, exosomes, growth factors, antioxidants, on regeneration evaluated. Finally, challenges development prospects field discussed, novel ideas future innovations area summarized.

Language: Английский

Citations

2
Manufacturing Process of Hyaluronic Acid Dermal Fillers DOI Open Access

Gi‐Woong Hong,

Jovian Wan,

Young‐Jin Park

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(19), P. 2739 - 2739

Published: Sept. 27, 2024

Hyaluronic acid (HA) fillers are extensively utilized in aesthetic medicine due to their biocompatibility, reversibility, and effectiveness enhancing skin hydration, volume, overall appearance. These predominantly produced through microbial fermentation, followed by a critical cross-linking process that enhances longevity resisting enzymatic degradation. This review provides thorough examination of the manufacturing processes differentiate HA fillers, with particular attention distinctions between biphasic monophasic variants. Unlike previous studies, this emphasizes specific techniques substantial impact on fillers’ rheological properties, such as elasticity cohesiveness, which crucial clinical performance patient outcomes. Additionally, offers comprehensive comparison non-HA alternatives, including calcium hydroxylapatite, poly-l-lactic acid, polymethyl methacrylate, highlighting unique advantages potential complications associated each type. By presenting novel insights into latest advancements challenges filler technology, aims provide clinicians deeper understanding thereby guiding them making informed decisions optimize safety results.

Language: Английский

Citations

2
Recent advances in collagen-based hydrogels: Materials, preparation and applications DOI
Jia She, Jinru Liu, Yanlu Mu

et al.

Reactive and Functional Polymers, Journal Year: 2024, Volume and Issue: 207, P. 106136 - 106136

Published: Dec. 12, 2024

Language: Английский

Citations

2
Evaluation of the Effectiveness of an Innovative Polycomponent Formulation on Adult and Aged Human Dermal Fibroblasts DOI Creative Commons
Francesca Rosaria Augello, Francesca Lombardi, Serena Artone

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(9), P. 2410 - 2410

Published: Aug. 28, 2023

Skin aging is a dynamic process that determines structural alterations in ECM and reduction dermal fibroblasts. The recent availability on the market of an innovative polycomponent formulation (KARISMA Rh Collagen® FACE, K) containing noncrosslinked high-molecular-weight hyaluronic acid (HMW-HA), human recombinant polypeptide collagen-1 alpha chain, carboxymethyl cellulose (CMC), attracted our scientific interest evaluating its biomolecular effects adult aged After treatment with increasing K concentrations, cell proliferation, collagen I, prolyl 4-hydroxylase (P4HA1), essential protein biosynthesis, α-SMA levels were assessed. fibroblast contractility, TGF-β1 levels, oxidative stress markers also evaluated. exposure led to significant dose-dependent increase proliferation migration Of note, counteracted H2O2-induced by promoting reducing β-galactosidase activity, neutralizing aging-associated damage. Moreover, P4HA1, α-SMA, improved contractility fibroblasts observed after treatment. Overall, results show evidence efficacious improving biological functions suppressing events associated cellular aging, thus supporting regenerative bio-revitalizing action helpful preventing or treating skin aging.

Language: Английский

Citations

5
The Potential of Collagen Treatment for Comorbid Diseases DOI Open Access
Hsiuying Wang

Polymers, Journal Year: 2023, Volume and Issue: 15(19), P. 3999 - 3999

Published: Oct. 5, 2023

Collagen, the most abundant protein in our bodies, plays a crucial role maintaining structural integrity of various tissues and organs. Beyond its involvement skin elasticity joint health, emerging research suggests that collagen may significantly impact treatment complex diseases, particularly those associated with tissue damage inflammation. The versatile functions collagen, including regeneration, improving increasing bone strength, make it potentially useful treating different diseases. To best my knowledge, strategy using to treat comorbid diseases has not been widely studied. This paper aims explore potential rheumatoid arthritis, osteoarthritis, osteoporosis, psoriatic sarcopenia, gastroesophageal reflux, periodontitis, aging, diabetes mellitus. Collagen-based therapies have shown promise managing comorbidities due their properties. multifaceted nature positions as promising candidate for addressing conditions. Its roles wound healing, musculoskeletal disorders, cardiovascular gastrointestinal conditions highlight diverse therapeutic applications context comorbidity management.

Language: Английский

Citations

5
Biocompatibility Study of Purified and Low-Temperature-Sterilized Injectable Collagen for Soft Tissue Repair: Intramuscular Implantation in Rats DOI Creative Commons

Tae-Hoon Koo,

Jason Keonhag Lee, Shawn P. Grogan

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(10), P. 619 - 619

Published: Sept. 26, 2024

The clinical application of collagen-based biomaterials is expanding rapidly, especially in tissue engineering and cosmetics. While oral supplements injectable skin boosters are popular for enhancing health, evidence supporting their effectiveness remains limited. Injectable products show potential revitalizing skin, but safety concerns persist due to challenges sterilization the risk biological contamination. Traditional methods (heat irradiation) can denature collagen. This study addresses these issues by introducing a novel technique: double filtration low-temperature steam collagen gel. In vitro tests documented sterility confirmed that did not cytotoxicity, degradation, integrity, viscosity characteristics changes after processing sterilization. gel induced new expression proliferation human dermal fibroblasts when cells were cultured with An vivo found no adverse effects rats or significant lesions at implantation site over 13 weeks. These results suggest this method process gels safe effective booster. Advanced likely mitigate risks associated products, though further research needed validate benefits.

Language: Английский

Citations

1
Collagen for Cosmetic Ingredients DOI
Nur Izyan Wan Azelee,

Siti Maryam Jasman,

Zaitul Iffa Abd Rasid

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Biocompatibility Study of Purified and Low-Temperature Sterilized Injectable Collagen for Soft Tissue Repair: Intramuscular Implantation in Rats DOI Open Access

Tae-Hoon Koo,

Jason K Lee,

Shawn P. Grogan

et al.

Published: Aug. 16, 2024

The clinical application of collagen-based biomaterials is expanding rapidly, especially in tissue engineering and cosmetics. While oral supplements injectable skin boosters are popular for enhancing health, evidence supporting their effectiveness remains limited. Injectable products show potential revitalizing skin, but safety concerns persist due to challenges sterilization the risk biological contamination. Traditional methods (heat irradiation) can denature collagen. This study addresses these issues by introducing a novel technique: double filtration low-temperature steam collagen gel. In vitro tests document sterility confirm that structure remained intact without modification. An vivo found no adverse effects rats or significant lesions at implantation site over 13 weeks. These results suggest this method process gels safe effective booster. Advanced processing likely mitigate risks associated with products, though further research needed validate benefits.

Language: Английский

Citations

0