Efficacy of Eggshell Membrane in Knee Osteoarthritis: A Systematic Review and Meta-Analysis DOI Open Access
Ana María García-Muñoz, María Salud Abellán-Ruiz, Ana I. García‐Guillén

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2640 - 2640

Published: Aug. 10, 2024

Osteoarthritis (OA) is a prevalent, degenerative joint disease, with knee OA being particularly common and impactful. This systematic review meta-analysis aimed to assess the efficacy of eggshell membrane (ESM) supplementation in improving functionality reducing pain individuals OA. A comprehensive search was conducted across PubMed, Scopus, Web Science, Cochrane Database up July 2024, following PRISMA guidelines. Seven randomized controlled trials (RCTs) met inclusion criteria, five included meta-analysis. The studies compared ESM placebo, evaluating outcomes based on assessment tools such as Western Ontario McMaster Universities Index (WOMAC), Visual Analogue Scale (VAS), Knee Injury Outcome Score (KOOS). Results indicated that significantly reduced improved functionality, notable improvements total WOMAC score (effect size −0.34; 95% CI: −0.56 −0.13; p < 0.001) subscale (SMD −0.23; −0.42 −0.04; 0.02). findings support promising adjunctive treatment for OA, offering safe, natural supplement enhance quality life. Further high-quality RCTs are needed confirm these results explore long-term effects mechanisms ESM.

Language: Английский

Neuropsychiatric Systemic Lupus Erythematosus: Molecules Involved in Its Imunopathogenesis, Clinical Features, and Treatment DOI Creative Commons
Angel A Justiz-Vaillant, Darren Gopaul,

Sachin Soodeen

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(4), P. 747 - 747

Published: Feb. 6, 2024

Systemic lupus erythematosus (SLE) is an idiopathic chronic autoimmune disease that can affect any organ in the body, including neurological system. Multiple factors, such as environmental (infections), genetic (many HLA alleles DR2 and DR3, genes C4), immunological influences on self-antigens, nuclear antigens, lead to formation of multiple autoantibodies cause deleterious damage bodily tissues organs. The production autoantibodies, anti-dsDNA, anti-SS(A), anti-SS(B), anti-Smith, anti-neuronal DNA are characteristic features this disease. This results from a failure mechanisms responsible for maintaining self-tolerance T cells, B or both. Immune complexes, circulating antibodies, cytokines, autoreactive lymphocytes tissue injury diagnosis SLE rheumatological challenge despite availability clinical criteria. NPSLE was previously referred cerebritis sclerosis. However, these terms no longer recommended because there definitive pathological neuropsychiatric manifestations SLE. Currently, treatment options primarily based symptomatic presentations. These include use antipsychotics, antidepressants, anxiolytic medications psychiatric mood disorders. Antiepileptic drugs treat seizures, immunosuppressants (e.g., corticosteroids, azathioprine, mycophenolate mofetil), directed against inflammatory responses along with non-pharmacological interventions.

Language: Английский

Citations

25
Application of collagen in bone regeneration DOI Creative Commons

Rebecca H. Li,

Shiqing Xu, Yan Guo

et al.

Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 50, P. 129 - 143

Published: Jan. 1, 2025

At present, there is a significant population of individuals experiencing bone deficiencies caused by injuries, ailments affecting the bones, congenital abnormalities, and cancer. The management substantial defects global orthopedic challenge due to intricacies involved in promoting restoring growth fresh osseous tissue. Autografts are widely regarded as "gold standard" for repairing because their superior tissue acceptance ability control osteogenesis. However, patients undergoing autografts may encounter various challenges, including but not limited hernia, bleeding, nerve impairment, death. Therefore, researchers regenerative medicine striving find alternatives. Collagen most abundant protein human body, its triple helix structure gives it unique characteristics that contribute strength functionality tissues. commonly processed into forms such scaffolds, sponges, membranes, hydrogels, composite materials, compatibility with affinity water, minimal potential immune reactions, adaptability, transport nutrients or drugs. As an alternative material field regeneration, collagen becoming increasingly important. objective this review provide comprehensive analysis primary types sources collagen, processes synthesis degradation, well advancements made regeneration research applications. A investigation role undertaken, providing valuable points reference more profound comprehension applications field. concluding section provides overview prospective avenues research, underscoring promising future highlighting regeneration. Translational Potential Article. exploration diverse functions translational demonstrated review, these findings underscore treatment option clinical implications, thus paving way innovative efficacious therapeutic strategies domain.

Language: Английский

Citations

4
Advantages of animal leather over alternatives and its medical applications DOI Creative Commons
Hsiuying Wang

European Polymer Journal, Journal Year: 2024, Volume and Issue: 214, P. 113153 - 113153

Published: May 18, 2024

The leather industry, grounded in ancient practices, utilizes animal skins composed of collagen protein polymer as materials. This versatile animal-based material is crucial for crafting items like shoes, clothing, and car interiors. While has faced criticisms environmental challenges the production process, including wastewater solid waste generation, well concerns about ethics, it holds numerous merits compared to synthetic plant-based vegan leather. paper reviews advantages its potential medical application. widespread use reveals that, despite passage time, remains an important humans. benefits leather, comparison encompass biodegradability, biocompatibility, natural feel aesthetics, breathability, durability, longevity. Animal-based been utilized various applications, pharmaceuticals, sensors, implants. These could make more suitable manufacturing implants alternatives. Therefore, this suggests further development equipment materials based on promote human health.

Language: Английский

Citations

10
Agarose-collagen composite microsphere implants: A biocompatible and robust approach for skin tissue regeneration DOI
Qi Wang,

Huiyu Yan,

Jingting Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134510 - 134510

Published: Aug. 5, 2024

Language: Английский

Citations

2
Efficacy of Eggshell Membrane in Knee Osteoarthritis: A Systematic Review and Meta-Analysis DOI Open Access
Ana María García-Muñoz, María Salud Abellán-Ruiz, Ana I. García‐Guillén

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2640 - 2640

Published: Aug. 10, 2024

Osteoarthritis (OA) is a prevalent, degenerative joint disease, with knee OA being particularly common and impactful. This systematic review meta-analysis aimed to assess the efficacy of eggshell membrane (ESM) supplementation in improving functionality reducing pain individuals OA. A comprehensive search was conducted across PubMed, Scopus, Web Science, Cochrane Database up July 2024, following PRISMA guidelines. Seven randomized controlled trials (RCTs) met inclusion criteria, five included meta-analysis. The studies compared ESM placebo, evaluating outcomes based on assessment tools such as Western Ontario McMaster Universities Index (WOMAC), Visual Analogue Scale (VAS), Knee Injury Outcome Score (KOOS). Results indicated that significantly reduced improved functionality, notable improvements total WOMAC score (effect size −0.34; 95% CI: −0.56 −0.13; p < 0.001) subscale (SMD −0.23; −0.42 −0.04; 0.02). findings support promising adjunctive treatment for OA, offering safe, natural supplement enhance quality life. Further high-quality RCTs are needed confirm these results explore long-term effects mechanisms ESM.

Language: Английский

Citations

1