Polymerizable Cholinium-Based Antibiotics for Polymer Carriers: Systems with Combined Load of Cloxacillin and Ampicillin DOI Creative Commons
Shadi Keihankhadiv, Dorota Neugebauer

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 5973 - 5973

Published: Dec. 18, 2024

Single and dual-drug delivery systems (DDSs) based on linear choline polymers were designed through the controlled polymerization of a pharmaceutically functionalized monomer, i.e., [2-(methacryloyloxy)ethyl]trimethylammonium, with counterions cloxacillin (TMAMA/CLX), or its copolymerization [2-(methacryloyloxy)ethyl]trimethylammonium ampicillin (TMAMA/AMP), providing antibiotic properties. This strategy was effective in attaining well-defined copolymers 38–93 mol. % TMAMA content, which regulated by initial ratio to methyl methacrylate comonomer. The polymer compositions total monomer conversion (40–75%), resulting variable degree (DPn = 160–300) pharmaceutical anion contents (CLX− 51–80% AMP− 78–87%). In aqueous solution, formed particles sizes ranging between 274 380 nm for CLX− 288–348 CLX−/AMP− systems. vitro drug release, driven exchange anions phosphate ions phosphate-buffered saline (PBS), imitating physiological fluid, demonstrated release efficiencies 58–76% (10.5–13.6 µg/mL) single systems, 91–100% (12.9–15.1 97–100% (21.1–23.3 dual Compared conventional delivering antibiotics without carrier, choline-based DDS attained satisfactory levels loading content (co-)release from carriers, offering promising alternative delivery.

Language: Английский

Tailoring Silk Sericin Grafting: Comparing One‐Step and Two‐Step Approaches for PNIPAM/PAMPS Block Nanoparticles DOI Creative Commons
Ionuț-Cristian Radu,

Derniza‐Elena Cozorici,

Erika Blanzeanu

et al.

Macromolecular Materials and Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: July 8, 2024

Abstract Structurally defined, protein‐grafted nanoparticles are widely used in various biomedical applications, particularly as intelligent nanocarriers for drug delivery. The integration of synthetic polymers with natural proteins such silk sericin enhances the functionality and stability these nanocarriers, making them suitable targeted controlled release. In this context, an optimized grafting procedure is presented, employing a protein macroinitiator atom transfer radical polymerization (ATRP). This study aims to elucidate significance process tailoring structure through chemistry grafts. uses block copolymers N ‐isopropylacrylamide (NIPAM) 2‐acrylamido‐2‐methylpropanesulfonic acid (AMPS), Poly‐(AMPS‐block‐NIPAM)/Poly‐(NIPAM‐block‐AMPS). employs both one‐step two‐step synthesis methods produce well‐defined, biofunctionalized sericin. Subsequently, sericin‐based prepared, demonstrating procedure. synthesized products undergo structural analysis using H‐NMR, FTIR‐ATR, XPS, DLS, zeta potential measurements. addition, their thermal behavior assessed differential scanning calorimetry. To further investigate prepared nanoparticles, SEM DLS analyses conducted. Through optimization, position length each precisely determined, significantly influencing properties grafted characteristics resulting nanoparticles.

Language: Английский

Citations

1
Recent advances in the synthesis and shell-sheddable disassembly of acid/glutathione-degradable block copolymer nanoassemblies for drug delivery DOI

Brandon Andrade‐Gagnon,

Jung Kwon Oh

Polymer Chemistry, Journal Year: 2024, Volume and Issue: 15(37), P. 3709 - 3735

Published: Jan. 1, 2024

Recent advances in synthetic strategies for single-location shell-sheddable and dual-location shell-sheddable/core-degradable block copolymer nanoassemblies exhibitng acidic pH or/and glutathione responsefor effective drug delivery.

Language: Английский

Citations

1
Radical Ring-Opening Polymerization: Unlocking the Potential of Vinyl Polymers for Drug Delivery, Tissue Engineering, and More DOI

Mina Ghorbani,

Elisabeth Prince

Biomacromolecules, Journal Year: 2024, Volume and Issue: 26(1), P. 118 - 139

Published: Dec. 29, 2024

Synthetic vinyl polymers have long been recognized for their potential to be utilized in drug delivery, tissue engineering, and other biomedical applications. The synthetic control that chemists over structure properties is unmatched, allowing polymer-based materials precisely engineered a range of therapeutic Yet, lack biodegradability compromises the biocompatibility has held back translation into clinically used treatments disease thus far. In recent years, radical ring-opening polymerization (rROP) emerged as promising strategy render biodegradable bioresorbable. While rROP touted preparing applications, approved not yet realized. This review highlights opportunities leveraging unlock use

Language: Английский

Citations

1
Controlled polymerization in microfluidics: Advancement in nanogel synthesis DOI Creative Commons
Tejasvi Pandey, Aditi Sharma, Anuradha Sandhu

et al.

SPE Polymers, Journal Year: 2023, Volume and Issue: 5(2), P. 113 - 126

Published: Dec. 23, 2023

Abstract This comprehensive review provides a detailed examination of controlled polymerization in the development nanogels‐based microfluidic devices. Here, we have explored integration atom transfer radical (ATRP) and reversible addition‐fragmentation chain (RAFT) techniques within platforms for synthesis nanogels. The synergistic combination ATRP RAFT with microfluidics has emerged as powerful tool precise control over reactions, enabling fabrication well‐defined, multifunctional nanogels tailored properties. begins thorough introduction to principles RAFT, highlighting their respective advantages polymerization. Subsequently, it elucidates its profound impact on processes. merging these enables reaction kinetics, monomer conversions, molecular weight distributions, facilitating unprecedented precision reproducibility. Furthermore, this delves into chemical mechanisms underlying reactions environments, emphasizing role various initiators, catalysts, agents. Special attention is given microscale flow conditions kinetics polymer structure. In addition, discusses emerging trends field, such incorporation novel monomers exploration environmentally benign conditions. Highlights mechanism by which can obtain tailormade material. nanogel must ensure gelation be confined dimensions here plays key role.

Language: Английский

Citations

3
Polymer materials—challenges and hope DOI Creative Commons
Marek Kowalczuk

Frontiers in Soft Matter, Journal Year: 2023, Volume and Issue: 3

Published: Nov. 2, 2023

Polymer materials play an important role in various aspects of our lives. Most them are solid, therefore, the key importance such polymeric is related to their versatility, lightness, economy, durability and strength, corrosion resistance, electrical thermal insulation (except conductive polymers), appropriate interface between body medical devices, as well design flexibility. In general, lies versatile properties, cost-effectiveness, applicability a variety industries, including automotive, aerospace, electronics, healthcare, construction, packaging, more. The purpose this mini-review encourage future authors submit outstanding contributions frontiers years come.

Language: Английский

Citations

3
A Commentary on “Chitosan, a Natural Polymer, is an Excellent Sustained-Release Carrier for Amide Local Anesthetics” [Letter] DOI Creative Commons
Yanlin Wu, Jiannong Fang,

Yu-Rui Jian

et al.

Journal of Pain Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 3801 - 3802

Published: Nov. 1, 2024

Language: Английский

Citations

0
Polymerizable Cholinium-Based Antibiotics for Polymer Carriers: Systems with Combined Load of Cloxacillin and Ampicillin DOI Creative Commons
Shadi Keihankhadiv, Dorota Neugebauer

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 5973 - 5973

Published: Dec. 18, 2024

Single and dual-drug delivery systems (DDSs) based on linear choline polymers were designed through the controlled polymerization of a pharmaceutically functionalized monomer, i.e., [2-(methacryloyloxy)ethyl]trimethylammonium, with counterions cloxacillin (TMAMA/CLX), or its copolymerization [2-(methacryloyloxy)ethyl]trimethylammonium ampicillin (TMAMA/AMP), providing antibiotic properties. This strategy was effective in attaining well-defined copolymers 38–93 mol. % TMAMA content, which regulated by initial ratio to methyl methacrylate comonomer. The polymer compositions total monomer conversion (40–75%), resulting variable degree (DPn = 160–300) pharmaceutical anion contents (CLX− 51–80% AMP− 78–87%). In aqueous solution, formed particles sizes ranging between 274 380 nm for CLX− 288–348 CLX−/AMP− systems. vitro drug release, driven exchange anions phosphate ions phosphate-buffered saline (PBS), imitating physiological fluid, demonstrated release efficiencies 58–76% (10.5–13.6 µg/mL) single systems, 91–100% (12.9–15.1 97–100% (21.1–23.3 dual Compared conventional delivering antibiotics without carrier, choline-based DDS attained satisfactory levels loading content (co-)release from carriers, offering promising alternative delivery.

Language: Английский

Citations

0