Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104999 - 104999
Published: April 1, 2025
Language: Английский
TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: 187, P. 118208 - 118208
Published: Feb. 27, 2025
Language: Английский
Citations
4
Analytica Chimica Acta, Journal Year: 2023, Volume and Issue: 1288, P. 342152 - 342152
Published: Dec. 16, 2023
Language: Английский
Citations
28
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: May 23, 2024
Remote health monitoring and treatment serve as critical drivers for advancing equity, bridging geographical socioeconomic disparities, ensuring equitable access to quality healthcare those in underserved or remote regions. By democratizing healthcare, this approach offers timely interventions, continuous monitoring, personalized care independent of one's location status, thereby striving an distribution resources outcomes. Meanwhile, microneedle arrays (MNAs), revolutionize painless minimally invasive interstitial fluid drug delivery diagnostics. This paper introduces integrated theranostic MNA system employing array colorimetric sensors quantitatively measure -pH, glucose, lactate, alongside a remotely-triggered enabling on-demand delivery. Integration ultrasonic atomizer streamlines the delivery, facilitating rapid, pumpless, point-of-care enhancing portability while reducing complexities. An accompanying smartphone application interfaces sensing components. Demonstrated capabilities include detecting pH (3 8), glucose (up 16 mm), lactate 1.6 showcasing assessing performance via scratch assay. innovative confronts challenges, particularly managing chronic diseases requiring long-term treatment, also offering avenues non-invasive through microneedle-based sensors.
Language: Английский
Citations
18
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 19, 2024
Abstract Hydrogel‐forming microneedles are constructed from or coated with polymeric, hydrophilic materials that swell upon insertion into the skin. Designed to dissolve disintegrate postinsertion, these can deliver drugs, vaccines, other therapeutics. Recent advancements have broadened their application scope include collection, transport, and extraction of dermal interstitial fluid (ISF) for medical diagnostics. This review presents a brief introduction characteristics ISF, methods sampling, critical assessment state‐of‐the‐art in hydrogel‐forming ISF Key factors evaluated including material composition, swelling behavior, biocompatibility, mechanical strength necessary effective microneedle performance collection. The also discusses successful examples assays sensor integrations, highlighting notable achievements, identifying research opportunities, addressing challenges potential solutions. Despite predominance synthetic hydrogels reported technologies due favorable gelation properties, there is significant variety biopolymers composites literature. field lacks consensus on optimal material, fabrication methods, though emerging evidence suggests processing techniques utility
Language: Английский
Citations
12
Surfaces and Interfaces, Journal Year: 2024, Volume and Issue: 45, P. 103847 - 103847
Published: Jan. 4, 2024
Language: Английский
Citations
11
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 254, P. 127745 - 127745
Published: Oct. 29, 2023
Language: Английский
Citations
23
Gels, Journal Year: 2024, Volume and Issue: 10(11), P. 719 - 719
Published: Nov. 7, 2024
Microneedle (MN) technology has emerged as a promising approach for delivering therapeutic agents to the skin, offering significant potential in treating various dermal conditions. Among these technologies, hydrogel-forming microneedles (HFMNs) represent transformative advancement management of diseases through non-invasive drug delivery. These innovative devices consist micrometer-sized needles made native or crosslinked hydrophilic polymers, capable penetrating stratum corneum without damaging underlying tissues. Upon insertion, HFMNs rapidly absorb interstitial fluid, swelling form hydrogel conduit that enables efficient transport directly into microcirculation. The nature enhances patient compliance by eliminating pain and discomfort associated with traditional hypodermic needles. This allows delivery wide range drugs, including macromolecules biomacromolecules, which are often difficult administer dermally due their size polarity. Moreover, provide controlled regulated release profiles, enabling sustained effects while minimizing systemic side effects. Additionally, can be used both real-time fluid monitoring, valuable insights disease states treatment responses. dual functionality positions versatile dermatology tool effectively addressing complications. review explores use polymeric biomaterials HFMN fabrication application major disorders, such acne, psoriasis, other skin Furthermore, highlights MN-based treatments, underscoring reduce improve adherence, supported recent literature.
Language: Английский
Citations
9
Small, Journal Year: 2024, Volume and Issue: 20(23)
Published: Jan. 23, 2024
Interstitial fluid (ISF) is an attractive alternative to regular blood sampling for health checks and disease diagnosis. Porous microneedles (MNs) are well suited collecting ISF in a minimally invasive manner. However, traditional methods of molding MNs from microfabricated templates involve prohibitive fabrication costs fixed designs. To overcome these limitations, this study presents facile economical additive manufacturing approach create porous MNs. Compared layerwise build sequences, direct ink drawing with nanocomposite inks can define sharp tailored shapes achieve vastly improved efficiency. The key strategy the yield-stress that easily formulated by dispersing silica nanoparticles into cellulose acetate polymer solution. As-printed solidified interconnected microstructure inside coagulation bath deionized water. resulting exhibit high mechanical strength porosity. This also allows be integrated on various substrates. In particular, filter paper substrates highly flexible rapidly collect non-flat skin sites. extracted used quantitative analysis biomarkers, including glucose, = calcium ions, ions. Overall, developments allow transdermal diagnosis therapy.
Language: Английский
Citations
8
Biomedical Physics & Engineering Express, Journal Year: 2024, Volume and Issue: 10(4), P. 045004 - 045004
Published: April 26, 2024
The transdermal drug delivery based on microneedles (MNs) provides a suitable and painless self-administration for diabetic patients. In this work, the hydrogel-forming MNs were firstly fabricated using poly(vinyl alcohol) (PVA) chitosan (CS) as matrix. A hypoglycemic drug, metformin (Met), had been loaded into MIL-100(Fe). Then, both of free Met Met-loaded MIL-100(Fe) integrated regulation blood glucose levels (BGLs) rats. After penetrated skin, could be released from MNs. Due to absorption interstitial fluid subsequent release MIL-100(Fe), leading sustainable long-term behaviors. notable effect low risk hypoglycemia obtained rat modelsin vivo. as-fabricated expected become new type platform high-dose drugs form effect.
Language: Английский
Citations
7
Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: 21(11), P. 1559 - 1572
Published: May 9, 2024
Three-Dimensional (3D) microneedles have recently gained significant attention due to their versatility, biocompatibility, enhanced permeation, and predictable behavior. The incorporation of biological agents into these 3D constructs has advanced the traditional microneedle an effective platform for wide-ranging applications.
Language: Английский
Citations
7