Journal of Applied Mechanics,
Journal Year:
2023,
Volume and Issue:
91(1)
Published: July 25, 2023
Abstract
Micro/nanoscale
additive
manufacturing
provides
a
powerful
tool
for
advanced
materials
and
structures
with
complex
precise
features.
For
instance,
the
feature
resolution
of
two-photon
polymerization
(2PP)
can
reach
200
nm.
At
this
scale,
properties
change,
influence
size
effect
cannot
be
ignored.
Therefore,
it
is
necessary
to
assess
changes
in
material
mechanical
considering
effects.
In
work,
several
micrometric
polymeric
specimens
are
printed
via
2PP,
their
assessed
using
compression
tests.
Detailed
printing
testing
procedures
effects
parameter
settings
provided.
The
experimental
results
show
that
microstructures’
have
direct
on
Young’s
modulus.
particular,
large
surface-volume
ratio
higher
other
words,
smaller
structure
size,
stiffness.
reported
findings
play
significant
role
development
fabrication
strategies
microstructures
where
high
stiffness
accuracy
fundamental.
Science Advances,
Journal Year:
2024,
Volume and Issue:
10(36)
Published: Sept. 6, 2024
Liquid
crystalline
(LC)
materials
are
especially
suited
for
the
preparation
of
active
three-dimensional
(3D)
and
4D
microstructures
using
two-photon
laser
printing.
To
achieve
desired
actuation,
alignment
LCs
has
to
be
controlled
during
printing
process.
In
most
cases
studied
before,
relied
on
surface
modifications
complex
patterns
concomitant
actuation
were
not
possible.
Here,
we
introduce
a
strategy
spatially
aligning
LC
domains
in
space
by
3D-printed
polydimethylsiloxane-based
microscaffolds
as
confinement
barriers,
which
induce
director
field.
The
field
resulting
from
boundary
conditions
is
calculated
with
Landau
de
Gennes
theory
validated
comparing
experimentally
measured
theoretically
predicted
birefringence
patterns.
We
demonstrate
our
procedures
structures
varying
complexity
then
employed
them
fabricate
that
show
actuation.
Overall,
obtain
excellent
agreement
between
experiment.
This
opens
door
rational
design
functional
(micro)printing
future.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 21, 2024
Abstract
In
the
present
study,
influence
of
topographic
and
mechanical
cues
on
neuronal
growth
cones
(NGCs)
network
directionality
in
3D‐engineered
cell
culture
models
is
explored.
Two‐photon
polymerization
(2PP)
employed
to
fabricate
nanopillar
arrays
featuring
tunable
effective
shear
modulus.
Large
variations
properties
are
obtained
by
altering
aspect
ratio
nanostructures.
The
seeded
with
different
lines,
including
neural
progenitor
cells
(NPCs)
derived
from
human
induced
pluripotent
stem
(iPSCs),
I
3
Neurons,
primary
hippocampal
neurons.
All
types
exhibit
preferential
orientations
according
topology,
as
shown
neurites
creating
a
high
number
oriented
orthogonal
networks.
Furthermore,
differentiation
maturation
NPCs
affected
nanopillars,
expression
mature
marker
Synapsin
I.
Lastly,
NGCs
influenced
modulus
terms
spreading
area,
stochastic
optical
reconstruction
microscopy
(STORM)
assess
cytoskeleton
organization
at
nanometric
resolution.
developed
approach,
involving
laser‐assisted
3D
microfabrication,
neuro‐mechanobiology,
super‐resolution
microscopy,
paves
way
for
prospective
comparative
studies
evolution
networks
healthy
diseased
(e.g.,
neurodegenerative)
conditions.
Polymers,
Journal Year:
2023,
Volume and Issue:
15(22), P. 4377 - 4377
Published: Nov. 10, 2023
Recent
developments
in
micro-scale
additive
manufacturing
(AM)
have
opened
new
possibilities
state-of-the-art
areas,
including
microelectromechanical
systems
(MEMS)
with
intrinsically
soft
and
compliant
components.
While
fabrication
materials
further
complicates
AM,
a
photocurable
polydimethylsiloxane
(PDMS)
resin,
IP-PDMS,
has
recently
entered
the
market
of
two-photon
polymerization
(2PP)
AM.
To
facilitate
development
microdevices
components
through
application
2PP
technique
IP-PDMS
material,
this
research
paper
presents
comprehensive
material
characterization
IP-PDMS.
The
significance
study
lies
scarcity
existing
on
thorough
investigation
its
properties,
many
which
are
reported
here
for
first
time.
Particularly,
uncured
work
evaluates
surface
tension
26.7
±
4.2
mN/m,
contact
angle
glass
11.5
0.6°,
spin-coating
behavior,
transmittance
more
than
90%
above
440
nm
wavelength,
FTIR
all
properties
For
cured
novel
characterizations
include
small
mechanical
creep,
velocity-dependent
friction
coefficient
glass,
typical
dielectric
permittivity
value
2.63
0.02,
high
dielectric/breakdown
strength
3D-printed
elastomers
up
to
73.3
13.3
V/µm
values
spin
coated
elastomer
85.7
12.4
V/µm,
while
measured
water
103.7
0.5°,
Young's
modulus
5.96
0.2
MPa,
viscoelastic
DMA
compared
previously
values.
Friction,
permittivity,
water,
some
breakdown
measurements
were
performed
spin-coated
samples.
Based
characterization,
shows
itself
be
promising
MEMS,
microfluidics,
storage
devices,
smart
technologies.
Small,
Journal Year:
2023,
Volume and Issue:
20(2)
Published: Sept. 10, 2023
Abstract
Bioinspired
fibrillar
structures
are
promising
for
a
wide
range
of
disruptive
adhesive
applications.
Especially
micro/nanofibrillar
on
gecko
toes
can
have
strong
and
controllable
adhesion
shear
surfaces
with
residual‐free,
repeatable,
self‐cleaning,
other
unique
features.
Synthetic
dry
adhesives
inspired
by
such
biological
fibrils
optimized
in
different
aspects
to
increase
their
performance.
Previous
fibril
designs
optimization
limited
predefined
standard
shapes
narrow
primarily
based
human
intuition,
which
restricts
maximum
This
study
combines
the
machine
learning‐based
finite‐element‐method‐based
mechanics
simulations
find
shear‐optimized
automatically.
In
addition,
fabrication
limitations
integrated
into
more
experimentally
relevant
results.
The
computationally
discovered
fabricated,
validated,
compared
simulations.
results
show
that
computed
perform
better
than
designs.
design
method
be
used
future
real‐world
shear‐based
gripping
or
nonslip
surface
applications,
as
robotic
pick‐and‐place
grippers,
climbing
robots,
gloves,
electronic
devices,
medical
wearable
devices.
Electrophoresis,
Journal Year:
2023,
Volume and Issue:
45(13-14), P. 1130 - 1141
Published: Aug. 17, 2023
Abstract
Microfluidics
offers
a
versatile
and
promising
platform
for
various
applications
in
biomedical
other
fields,
boasting
cost‐effectiveness,
rapid
analysis
time,
compact
equipment
footprint.
However,
achieving
controlled
microfluidic
motion
within
implantable
devices
presents
significant
challenge.
In
this
study,
we
propose
novel
bidirectional
micro‐pump
design
that
leverages
two
sharp‐edge
microcantilever
arrays,
driven
by
ultrasound,
to
enable
selective
flow
direction
manipulating
the
ultrasound
frequency.
Through
systematic
numerical
simulation,
demonstrate
feasibility
of
further
optimize
its
performance
through
comprehensive
parametric
analysis.
This
work
provides
valuable
guidance
practical
development
sharp‐edge‐based
acoustic
micro‐pumps,
particularly
potential
such
as
drug
release
vivo
sampling
advanced
diagnostics.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: April 17, 2023
Abstract
We
developed
a
versatile
lab-on-chip
(LOC)
workcell
that
enables
the
design
and
automatic
execution
of
experiments
on
LOC
devices,
improving
how
we
establish,
optimize,
productionalize
processes.
Key
features
include
direct
docking
cooling
native
laboratory
tubes,
programmable
reagent
mixing
dilutions,
parallel
operation
multiple
chips,
precise
flowrate
pressure
control,
clogging
detection
response,
microscope
chip
temperature
regulation,
scheduled
cleaning.
All
functionality
is
controlled
seamlessly
from
an
easy-to-write
protocol
file,
based
extensible
hardware
software
infrastructures
to
promote
community
development.
To
showcase
platform’s
use
versatility,
demonstrate
series
5
different
automated
at
varying
levels
complexity,
executed
across
both
Quake-valve
droplet
microfluidic
systems.
In
particular,
was
instructed
map
parameter
regime
generates
viable
droplets,
allow
user
select
diameters
production
frequencies
interest
for
single
bacterial
cell
encapsulation.
Furthermore,
three
out
days
in
row,
platform
successfully
performed
complex
15.5h
long
experiment,
integrating
full
core
workflow
required
by
typical
protein-characterization
lab:
protein
expression,
purification,
dilution
generation,
quantitative
binding
characterization
(generating
55296
images
process).
Experiments
conducted
through
are
easier
set
up,
offer
increased
control
over
experiment
conditions
parameters,
can
be
heavily
parallelized.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
29, P. 101325 - 101325
Published: Nov. 2, 2024
The
effect
of
mechanical
cues
on
cellular
behaviour
has
been
reported
in
multiple
studies
so
far,
and
a
specific
aspect
interest
is
the
role
mechanotransductive
proteins
neuronal
development.
Among
these,
yes-associated
protein
(YAP)
responsible
for
functions
development
such
as
progenitor
cells
migration
differentiation
while
myocardin-related
transcription
factor
A
(MRTFA)
facilitates
neurite
outgrowth
axonal
pathfinding.
Both
have
indirectly
intertwined
fates
via
their
signalling
pathways.
There
little
literature
investigating
roles
YAP
MRTFA
