Journal of Experimental Orthopaedics,
Journal Year:
2024,
Volume and Issue:
11(4)
Published: Oct. 1, 2024
Abstract
Purpose
The
present
study
aimed
to
evaluate
and
compare
the
effect
of
nanofibrillated
cellulose
(NFC)‐based
composite
with
dicalcium
phosphate
dihydrate
an
autologous
blood
clot
(ABC)
on
formation
new
bone
tissue
in
vivo
by
histological
histomorphometric
assessment.
Materials
Methods
A
total
72
rats
created
femoral
defects
(2
mm)
were
used.
divided
into
three
groups:
(1)
filling
defect
ABC,
(2)
NFC‐1—with
both
cortical
plate
intramedullary
space
area,
(3)
NFC‐2—with
only
area.
Histological
analysis
was
performed
assess
healing
after
14,
30
60
days.
Results
Complete
closure
detected
NFC‐2
group
Day
(
p
<
0.0001).
Moreover,
NFC
groups
30th
60th
days,
ongoing
osteogenesis
observed,
characterized
a
large
volume
newly
formed
circular
pattern
space.
Сonclusion
This
demonstrated
that
NFC‐based
composite,
which
is
located
below
level
plate,
tamponing
(NFC‐2),
improves
repair
at
site
has
potential
prolonged
osteoinductivity.
Level
Evidence
Not
applicable.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(14), P. 17092 - 17108
Published: March 27, 2024
The
increasing
aging
of
the
population
has
elevated
bone
defects
to
a
significant
threat
human
life
and
health.
Aerogel,
biomimetic
material
similar
an
extracellular
matrix
(ECM),
is
considered
effective
for
treatment
defects.
However,
most
aerogel
scaffolds
suffer
from
immune
rejection
poor
anti-inflammatory
properties
are
not
well
suited
growth.
In
this
study,
we
used
electrospinning
prepare
flexible
ZnO-SiO2
nanofibers
with
different
zinc
concentrations
further
assembled
them
into
three-dimensional
composite
scaffolds.
prepared
exhibited
ordered
pore
structure,
chitosan
(CS)
was
utilized
as
cross-linking
agent
aspirin
(ASA).
Interestingly,
1%ZnO-SiO2/CS@ASA
only
good
biocompatibility,
bioactivity,
anti-inflammation,
better
mechanical
but
also
significantly
promoted
vascularization
osteoblast
differentiation
in
vitro.
mouse
cranial
defect
model,
BV/TV
data
showed
higher
osteogenesis
rate
1%ZnO-SiO2/CS
group
(10.94
±
0.68%)
(22.76
1.83%),
compared
control
(5.59
2.08%),
vivo
studies
confirmed
ability
promote
situ
regeneration
new
bone.
This
may
be
attributed
fact
that
Si4+,
Zn2+,
ASA
released
can
angiogenesis
formation
by
stimulating
interaction
between
endothelial
cells
(ECs)
BMSCs,
inducing
macrophage
M2
type
downregulating
expression
pro-inflammatory
factor
(TNF-α)
modulate
local
inflammatory
response.
These
exciting
results
evidence
suggest
it
provides
strategy
Materials & Design,
Journal Year:
2024,
Volume and Issue:
243, P. 113091 - 113091
Published: June 14, 2024
Amidst
the
rapid
advancements
in
materials
science,
exploration
of
aerogel-based
biomaterials
has
garnered
extensive
attention
across
diverse
sectors,
including
biomedicine,
energy,
architecture,
and
sensing.
Comprehensive
studies
have
unveiled
utilization
organic,
inorganic,
hybridized
for
aerogel
preparation,
catapulting
to
global
prominence.
Endowed
with
distinctive
properties,
low
density,
a
hierarchical
porous
network,
high
porosity,
nanoscale
micropores,
aerogels
exhibited
broad
spectrum
applications,
particularly
realm
tissue
engineering.
The
deployment
engineering
is
dynamic
phase
development,
available
reports
indicating
varying
degrees
fields
such
as
blood
vessels,
soft
tissues,
nerves,
skin,
muscles,
heart,
bronchial
tubes,
bone,
cartilage—an
evolutionary
process.
This
paper
offers
comprehensive
review
evolution
properties
preparation
processes,
encapsulating
strategic
insights
application
It
succinctly
summarizes
recent
developments
research,
emphasizing
their
significance.
Additionally,
outlines
future
prospects
envisions
challenges
arising
from
current
studies.
Through
this
thorough
engineering,
aspires
make
profound
impact
on
regenerative
medicine,
offering
innovative
effective
strategies
biomedicine.
Cellulose,
Journal Year:
2023,
Volume and Issue:
31(1), P. 515 - 534
Published: Dec. 12, 2023
Abstract
Nanostructured
scaffolds
based
on
cellulose
with
advanced
performances
and
personalized
morphologies
for
bone
tissue
engineering
are
under
technological
development.
3D-printing
supercritical
carbon
dioxide
(scCO
2
)
technologies
innovative
processing
strategies
that,
when
combined,
allow
the
precise
fabrication
of
highly
porous
aerogel
scaffolds.
Novel
sterile
cellulose-in-cellulose
aerogels
decorated
superparamagnetic
iron
oxide
nanoparticles
(SPIONs)
synthesized
in
this
work
by
an
integrated
platform
scCO
.
Methylcellulose
(MC)
bacterial
nanocellulose
(BC)
two
versatile
cellulosic
polysaccharides
remarkable
physicochemical
biological
performances,
whereas
SPIONs
commonly
used
to
functionalize
biomaterials
aimed
at
engineering.
Aerogels
hierarchical
porosity
high
structural
resolution
were
obtained
according
nitrogen
adsorption–desorption
analysis,
confocal,
scanning
transmission
microscopies
(SEM
TEM).
The
magnetic
properties
SPIONs-doped
confirmed
correct
functionalization
nanostructures.
Finally,
NIH/3T3
fibroblast
cell
viability,
hemocompatibility
human
blood
safety
tests
(
ovo
HET-CAM
vivo
Artemia
salina
indicate
biocompatibility
aerogels.
Graphical
abstract
Polymers for Advanced Technologies,
Journal Year:
2023,
Volume and Issue:
35(1)
Published: Dec. 7, 2023
Abstract
Biomaterials
are
essential
in
medicine
because
these
biological
macromolecules
have
appropriately
replaced
classical
tissue
grafting
techniques
for
their
valuable
features.
Bone
engineering
has
persistently
developed
since
“tissue
engineering”
was
suggested.
Carboxymethyl
cellulose
(CMC)
is
the
first
FDA‐approved
water‐soluble
derivative
of
that
could
be
targeted
desired
bone
graft.
Numerous
studies
on
CMC
as
a
component
created
recently
been
published.
Because
its
carboxylate
groups,
hydrophilic.
can
crosslink
with
varied
materials,
such
synthetic
and
natural
polymers,
enabling
innovative
structure
biomaterials.
These
groups
responsible
situ
gelations
bio‐adhesion
characteristics.
In
this
review,
current
progress
inherent
characteristics
CMC‐based
scaffold
materials
discussed.
ACS Omega,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 11, 2025
Aging,
trauma,
infection,
illness,
and
accidents
can
lead
to
the
disruption
of
various
human
tissues,
including
skin,
bone,
cartilage.
Tissue
engineering
aims
promote
growth
cells
tissues
within
body,
with
scaffolds
serving
as
vehicles
deliver
a
combination
mechanical
molecular
signals
create
new
for
body
reconstruction.
Composite
materials
have
gained
significant
attention
an
attractive
alternative
scaffolding
due
their
ability
enhance
multiple
material
properties.
For
instance,
cellulose
nanofibers
are
known
high
specific
surface
area,
flexibility,
elasticity.
However,
limited
bioactivity
slow
degradation
rates
restrict
suitability
tissue
applications.
In
contrast,
niobium-based
materials,
which
biocompatible
nontoxic,
been
underexplored
in
this
field.
study,
silver
niobate
is
investigated
first
time
component
composite
designed
provide
biological
activity
aerogel,
thereby
creating
multifunctional
scaffold
regeneration.
Silver
nanoparticles
were
successfully
synthesized
characterized
by
X-ray
diffraction
(XRD),
Fourier
transform
infrared
(FTIR),
scanning
electron
microscopy
(SEM).
The
aerogels
demonstrated
improved
thermal
stability,
hydrophilicity,
bioactivity,
antimicrobial
against
Staphylococcus
aureus.
Additionally,
developed
showed
no
cytotoxic
effects
on
primary
dermal
fibroblast
(HDFn)
cells.
These
findings
suggest
that
niobate-based
aerogel
holds
potential
applications
regeneration,
offering
promising
avenue
development
advanced
biomaterials
regenerative
medicine.
Tissue Engineering Part A,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 5, 2025
Successful
bioprinting
requires
an
appropriate
combination
of
bioinks,
cells,
and
a
delivery
platform.
To
demonstrate
the
potential
in
situ
for
regeneration
cartilage
lesions
we
combined
clinically
relevant
embryonic-derived
mesenchymal
stem
cells
(ES-MSCs)
with
fibrin-based
bioink
that
was
delivered
into
chondral
defects
created
human
ex
vivo
osteoarthritic
(OA)
tissue
using
We
used
integrated
multitool,
6-axis
system
to
laser
scan
map
surface
bioprint
within
vitro
vivo.
For
neotissue
generation,
ES-MSCs
were
encapsulated
at
20
×
106
per
mL
chondro-inductive
bioinks
composed
fibrinogen
mixed
nanocellulose
or
hyaluronic
acid.
After
as
free-standing
constructs
defects,
gels
cross-linked
thrombin
cultured
up
8
weeks
chondrogenic
medium.
Print
fidelity
assessed
printed
after
cross-linking
culture.
In
bioprinted
evaluated
cell
viability,
mechanical
properties,
histology
(Safranin
O
collagen
type
II
immunostaining),
gene
expression
genes.
Adding
significantly
improved
print
fidelity.
fibrinogen-based
formulations
generated
cartilage-like
neotissues
positive
Safranin
staining.
Chondrogenic
genes
(COLA2A1,
ACAN,
COMP,
SOX9)
upregulated
negligible
hypertrophic
markers
(COL10A1
RUNX2).
The
properties
increased
from
30
50
kPa
3
∼150
demonstrated
feasibility
combining
printable
hydrogel
platform
promoted
neocartilage
generation
repair
OA
tissues.
