Chitosan-Based Biomaterial in Wound Healing: A Review

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 28, 2024

Wound healing is an evolving and intricate technique that vital to the restoration of tissue integrity function. Over past few decades, chitosan a biopolymer derived from chitin, became known as emerging biomaterial in field wounds due its distinctive characteristics including biocompatibility, biodegradability, affinity biomolecules, wound-healing activity. This natural polymer exhibits excellent capabilities by accelerating development new skin cells, reducing inflammation, preventing infections. Due distinct biochemical innate antibacterial activity, has been extensively researched wound dressing. Chronic wounds, such diabetic ulcers liver disease, are growing medical problem. Chitosan-based biomaterials promising solution domain care. The article analyzes depth chitosan-based their impact on also methods enhance advantages incorporating bioactive compounds. literature review aimed improve understanding knowledge about use healing.

Language: Английский

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Hybrid Organic–Inorganic Materials Prepared by Sol–Gel and Sol–Gel-Coating Method for Biomedical Use: Study and Synthetic Review of Synthesis and Properties

Coatings, Journal Year: 2024, Volume and Issue: 14(4), P. 425 - 425

Published: April 1, 2024

The need to improve the expectancy and quality of life subjects affected by disabling pathologies that require replacement or regeneration tissues parts body has fueled development innovative, better-performing materials are capable integrating into being tolerated tissues. Materials with these characteristics, i.e., bio-functionality, bio-safety, biocompatibility, defined as biomaterials. One many methods for producing such is sol–gel technique. This process mainly used preparation ceramic oxides at low temperatures, through hydrolysis polycondensation reactions organometallic compounds within a hydroalcoholic solution. study based on specific type biomaterial: organic–inorganic hybrids. aim this provide an overview advantages disadvantages technique, well describe chemical biological characterization, uses, future prospects In particular, use plant drugs organic components hybrid material innovation manuscript. properties extracts numerous, reason, they deserve great attention from scientific community.

Language: Английский

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Innovative 3D printing technologies and advanced materials revolutionizing orthopedic surgery: current applications and future directions

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 11, 2025

Three-dimensional (3D) printing has rapidly become a transformative force in orthopedic surgery, enabling the creation of highly customized and precise medical implants surgical tools. This review aims to provide more systematic comprehensive perspective on emerging 3D technologies—ranging from extrusion-based methods bioink powder bed fusion—and broadening array materials, including bioactive agents cell-laden inks. We highlight how these technologies materials are employed fabricate patient-specific implants, guides, prosthetics, advanced tissue engineering scaffolds, significantly enhancing outcomes patient recovery. Despite notable progress, field faces challenges such as optimizing mechanical properties, ensuring structural integrity, addressing regulatory complexities across different regions, considering environmental impacts cost barriers, especially low-resource settings. Looking ahead, innovations smart functionally graded (FGMs), along with advancements bioprinting, hold promise for overcoming obstacles expanding capabilities orthopedics. underscores pivotal role interdisciplinary collaboration ongoing research harnessing full potential additive manufacturing, ultimately paving way effective, personalized, durable solutions that improve quality life.

Language: Английский

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Surface-activated 3D-printed PEEK implant enhances anti-infection and osteogenesis

Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 273, P. 111258 - 111258

Published: Feb. 1, 2024

Language: Английский

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Powder Bed Fusion 3D Printing in Precision Manufacturing for Biomedical Applications: A Comprehensive Review

Materials, Journal Year: 2024, Volume and Issue: 17(3), P. 769 - 769

Published: Feb. 5, 2024

Precision manufacturing requirements are the key to ensuring quality and reliability of biomedical implants. The powder bed fusion (PBF) technique offers a promising solution, enabling creation complex, patient-specific implants with high degree precision. This technology is revolutionizing industry, paving way for new era personalized medicine. review explores details 3D printing its application in field. It begins an introduction 3D-printing various classifications. Later, it analyzes numerous fields which has been successfully deployed where precision components required, including fabrication scaffolds tissue engineering. also discusses potential advantages limitations using terms precision, customization, cost effectiveness. In addition, highlights current challenges prospects technology. work valuable insights researchers engaged field, aiming contribute advancement context applications.

Language: Английский

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3D and 4D printing of biomedical materials: current trends, challenges, and future outlook

Exploration of Medicine, Journal Year: 2024, Volume and Issue: 5(1), P. 17 - 47

Published: Feb. 6, 2024

Three-dimensional (3D) and four-dimensional (4D) printing have emerged as the next-generation fabrication technologies, covering a broad spectrum of areas, including construction, medicine, transportation, textiles. 3D printing, also known additive manufacturing (AM), allows complex structures with high precision via layer-by-layer addition various materials. On other hand, 4D technology enables smart materials that can alter their shape, properties, functions upon stimulus, such solvent, radiation, heat, pH, magnetism, current, pressure, relative humidity (RH). Myriad biomedical (BMMs) currently serve in many engineering fields aiding patients’ needs expanding life-span. BMMs provides geometries are impossible conventional processing techniques, while yields dynamic BMMs, which intended to be long-term contact biological systems owing time-dependent stimuli responsiveness. This review comprehensively covers most recent technological advances towards fabricating for tissue engineering, drug delivery, surgical diagnostic tools, implants prosthetics. In addition, challenges gaps printed along future outlook, extensively discussed. The current addresses scarcity literature on composition, performances medical applications pros cons. Moreover, content presented would immensely beneficial material scientists, chemists, engineers engaged AM clinicians field. Graphical abstract.

Language: Английский

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Tunable mechanical properties of chitosan-based biocomposite scaffolds for bone tissue engineering applications: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 272, P. 132820 - 132820

Published: May 31, 2024

Language: Английский

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Radiopacity Enhancements in Polymeric Implant Biomaterials: A Comprehensive Literature Review

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(3), P. 1323 - 1334

Published: Feb. 8, 2024

Polymers as biomaterials possess favorable properties, which include corrosion resistance, light weight, biocompatibility, ease of processing, low cost, and an ability to be easily tailored meet specific applications. However, their inherent X-ray attenuation, resulting from the atomic numbers constituent elements, i.e., hydrogen (1), carbon (6), nitrogen (7), oxygen (8), makes them difficult visualize radiographically. Imparting radiopacity radiolucent polymeric implants is necessary enable noninvasive evaluation implantable medical devices using conventional imaging methods. Numerous studies have undertaken this by blending various polymers with contrast agents consisting heavy elements. The selection appropriate agent important, primarily ensure that it does not cause detrimental effects relevant mechanical physical properties polymer depending upon intended application. Furthermore, its biocompatibility adjacent tissues excretion body require thorough evaluation. We aimed summarize current knowledge on incorporated into synthetic in context devices. While a single review was found discussed biomaterials, publication outdated address contemporary employed implant Our provides up-to-date overview polymers, encompassing both temporary permanent implants. expect our results will significantly inform guide strategic agents, considering requirements

Language: Английский

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Biomaterials-based hydrogels for therapeutic applications

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: May 23, 2024

Conventional therapeutic models based on the premise of a universal solution are facing decrease in efficiency, emphasized by large number patients who show resistance or do not respond positively to classic treatments. This perspective highlights urgency for more precise approaches personalized treatments that adaptable specific complexities and unique challenges faced each patient. Hydrogels biocompatible biodegradable systems well-controlled targeted administration agents, being formed 3D reticulated networks water-soluble polymeric biomaterials, natural, synthetic, hybrid origin, with intrinsic extrinsic properties. Due easily adjustable porous structure, hydrogels allow encapsulation macromolecular drugs, proteins, small molecules, cells, hormones, growth factors gel matrix their subsequent controlled release. The biomaterials used, crosslinking methods, design, functionalization strategies obtaining improved properties presented. different possibilities application described transdermally, as dressing materials, oral, ocular, spray-able, injectable, up intracellular level. chapter extensively investigates advances advantages enable effective, noninvasive, provide greater patient comfort wide range applications.

Language: Английский

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Critical review on biodegradable and biocompatibility magnesium alloys: Progress and prospects in bio-implant applications

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 169, P. 113111 - 113111

Published: Sept. 6, 2024

Language: Английский

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