Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 113918 - 113918
Published: Jan. 1, 2025
Language: Английский
Polymer Composites, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
Abstract In this study, 3D printing technology is used to develop nanocomposite scaffolds based on polylactic acid (PLA) and hydroxyapatite (HA). PLA was functionalized with itaconic anhydride (PLA f ) via radical grafting improve affinity the inorganic nanofiller accelerate hydrolytic degradation. Fourier‐transform infrared (FTIR) Nuclear Magnetic Resonance (NMR) spectroscopies confirmed occurrence of chemical functionalization. Preliminary characterization films PLA, relative nanocomposites through water contact angle measurements highlighted an increase wettability for , due hydrophilic groups grafted onto polymer chain. Thermal analysis showed glass transition temperature ( T g in nanocomposites, likely enhanced matrix‐nanoparticle interactions. Scanning electron microscopy (SEM) revealed more defined homogeneous fibers ‐HA5 ‐HA10, meanwhile results from compression tests indicated improved processability mechanical properties ‐based scaffolds, as evidenced by increased values Young modulus. Hydrolytic degradation studies Phosphate Buffered Saline (PBS) solution greater weight loss molecular decrease ‐HA5, suggesting faster hydrophilicity. Biological human Mesenchymal Stem Cells (hMSCs) demonstrated that all promoted cell proliferation, ‐HA formulations showing higher effect cellular behavior terms growth alkaline phosphatase (ALP) levels, indicating functionalization improves attachment, proliferation early osteogenic differentiation. Highlights Functionalization enhances hydrophilicity HA affinity. Nanocomposite are successfully developed printing. ink printability, making uniform structures. exhibit accelerated support adhesion
Language: Английский
Citations
1
Med-X, Journal Year: 2025, Volume and Issue: 3(1)
Published: Jan. 8, 2025
Abstract Implantable sensors can provide access to accurate, continuous, and minimally invasive monitoring of physiological signals from internal organs tissues, thereby facilitating timely diagnosis, closed-loop intervention, advanced health management. Among the various types implantable sensors, those capable measuring physical parameters–such as temperature, force, flow–are particularly important due their ability monitor conditions critical nearly all insights into a wide range conditions. This review presents recent progress in four key sensors: strain pressure temperature flow sensors. It covers engineering principles, design considerations, vivo performances, clinical relevance. The also addresses challenges future opportunities development such flexibility stretchability, biocompatibility, long-term stability, translation these sensing technologies bench clinic. Graphical
Language: Английский
Citations
1
Bioengineering, Journal Year: 2025, Volume and Issue: 12(1), P. 46 - 46
Published: Jan. 8, 2025
In the last thirty years, tissue engineering (TI) has emerged as an alternative method to regenerate tissues and organs restore their function by implanting specific lineage cells, growth factors, or biomolecules functionalizing a matrix scaffold. Recently, several pathologies have led bone loss damage, such malformations, resorption associated with benign malignant tumors, periodontal disease, traumas, others in which discontinuity integrity is observed. Bone characterized different stiffness, mechanical traction, compression resistance of compartments, can influence susceptibility injury destruction. For this reason, research into repairing defects began years ago find scaffold improve regeneration. Different techniques be used manufacture 3D scaffolds for regeneration based on optimizing reproducible controlled hierarchical porous structure like extracellular bone. Additionally, synthesized facilitate inclusion mesenchymal stem cells factors that osteogenesis, recruiting new neighborhood generate optimal environment review, current state-of-the-art manufacturing use polycaprolactone (PCL) biomaterial will described reporting relevant studies focusing processing techniques, from traditional—i.e., freeze casting, thermally induced phase separation, gas foaming, solvent particle leaching—to more recent approaches, additive (i.e., printing/bioprinting, electrofluid dynamics/electrospinning), well integrated techniques. As technique, work aims offer comprehensive overview benefits/limitations PCL-based order establish relationship between composition, namely integration other phases’ structural properties pore morphology properties) vivo response.
Language: Английский
Citations
1
Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 250, P. 114570 - 114570
Published: Feb. 18, 2025
Language: Английский
Citations
1
Machining Science and Technology, Journal Year: 2024, Volume and Issue: 28(2), P. 215 - 265
Published: March 1, 2024
Micro Electro-Discharge Machining is a precision machining process that uses electrical discharge to produce small-scale components with high accuracy. A metal workpiece machined in this by repeatedly generating spark between tool electrode and the workpiece, removing material controlled manner. The significance of µ-EDM lies its ability highly accurate complex surface finish, making it ideal for use various industries, including aerospace, medical, electronics. critical parameters success include energy, voltage, current, pulse duration, gap shape size electrode. This review article discusses used machine biological materials also examines µ-EDM, dry procedure, features biomedical biocompatibility, 3D micro wear composition, thin film coating microelectrodes. impact introducing nanoparticles dielectric fluids further clarified article. study addresses prospective future research subjects application areas order fulfill demanding criteria biomaterials their usage production bioimplants.
Language: Английский
Citations
8
Regenerative Engineering and Translational Medicine, Journal Year: 2024, Volume and Issue: unknown
Published: March 4, 2024
Language: Английский
Citations
7
Journal of Composites Science, Journal Year: 2024, Volume and Issue: 8(9), P. 334 - 334
Published: Aug. 23, 2024
Stress shielding is a problem for traditional metal bone fixation plates made of magnesium and titanium alloys. This can be solved by using composite materials with low elastic modulus. study analyzed the effect carbon fiber reinforced PEEK (CFRP) composites on stress under static loading finite element simulations. Callus formation times relative to healing period were gradually imposed according elapsed time, considering 1% 75% as stages. The Inventor© 3D CAD 2024 software was used modeling, ANSYS© FEA R2023 analysis. results showed that alloys transferred less than CFRP plate. In particular, use plate resulted in higher peak more uniform field bone, especially bone-plate contact area, where risk phases.
Language: Английский
Citations
6
BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)
Published: Oct. 4, 2024
Language: Английский
Citations
6
Polymer Engineering and Science, Journal Year: 2024, Volume and Issue: 64(5), P. 1905 - 1920
Published: Feb. 22, 2024
Abstract There are several enviable attributes of titanium and its alloys that contribute to their popularity in biomedical devices equipment, including rather low modulus, excellent corrosion resistance, biocompatibility, good machinability, formability, strength comprehensive impact fatigue. Nevertheless, do not meet all medical requirements due unique properties alloys, so surface modifications must be made enhance mechanical, chemical, biological characteristics. As a review engineering, this article discusses specific polymers for coating applications as well various polymer coatings functionalization improvements. The versatility biopolymer makes them extremely appropriate broad range uses. To the engineering tissue drug delivery, study summarized analyzed most recent advances coatings. Surface qualities can adjusted criteria or integrated with new capabilities. Moreover, containing different inorganic ions growth tissue, proliferation cells, healing, transfer biomolecules, like active molecules, agents antimicrobial, factors growth, medications. Highlights modification avenues Ti materials orthopedic replacements critically reviewed. Basic descriptions presented. Advances behavior thoroughly scrutinized. Fundamental methods based on physical, chemical principles particularly Main types used surfaces
Language: Английский
Citations
4
Coatings, Journal Year: 2024, Volume and Issue: 14(3), P. 350 - 350
Published: March 14, 2024
Zinc and its alloys have garnered significant attention in the field of biological implantation due to their biodegradable, osteogenic, mechanical properties. However, degradation zinc always lead an increase local ion concentration, bare metal surfaces lack biocompatibility for implantation. To address these issues, a layer calcium–phosphorus (CaP) coating was prepared on surface Zn-0.5Li alloy. The micro-structure observed with scanning electron microscopy (SEM) white light interferometry microscope. phases coatings were characterized through X-ray diffraction (XRD) photoelectron spectroscopy (XPS). bonding strength between substrate investigated using scratch tester diamond stylus, corrosion properties assessed electrochemical method. For evaluation osteogenic properties, MC3T3-E1 cells cultured coating. Live/dead staining proliferation tests performed assess cell viability growth. Cell adhesion morphology SEM, level alkaline phosphatase (ALP) material evaluated by ALP activity measurement. CaP alloy improved alloy’s property, could be promising modification option biodegradable
Language: Английский
Citations
4