Synthesis and Characterization of pH-Responsive Sodium Alginate/Zein/γ- Alumina Nanocarriers for Targeted Curcumin Delivery in Lung Cancer DOI Creative Commons

Mohammad Najafi,

Davood Rabiei Faradonbeh,

Sakineh Hajebi

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Abstract Stimulus-responsive drug delivery systems based on anticancer of curcumin constitute a promising strategy to overcome some challenges Lung cancer treatment. In the present study, pH-responsive nanocarriers were designed by sodium alginate (SA), zein, and γ-alumina (γ-Al2O3) as nanocarrier via W/O/W double emulsion technique facilitate targeted lung cells. The characterize physical interactions crystalline structure confirmed FTIR XRD, respectively. size drug-loaded nanocomposites was 218.6 nm with monodisperse particle distribution, having rod-like shape approved DLS analysis FE-SEM, Sensitivity samples pH studied using ultraviolet − visible spectroscopy. UV vis spectroscopy results display higher absorption intensities in acidic tumor conditions (pH 5.4) than physiological (7.4). method significantly enhanced loading entrapment efficiency compared other reported systems. Cytotoxicity cell death further analyzed MTT flow cytometry assays. These suggest that SA/zein/γ-Al2O3 nanocomposite is promise system for therapy.

Language: Английский

Nano‐Porous Melt‐Blown Poly(Lactic Acid) Fiber Mat Air Filters for High Efficiency Particulate Capture DOI Creative Commons
Sahar Kalani, Dylan Jubinville, Tizazu H. Mekonnen

et al.

Advanced Sustainable Systems, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Abstract This study introduces a two‐step technique for developing nano‐porous, compostable melt‐blown nonwovens with high porosity, specifically engineered high‐performance particulate capture in air filter applications. The first step entails creating melt flow index material by melt‐blending low‐viscosity polylactic acid (PLA) sacrificial additive, polyethylene glycol (PEG), of varying molecular weights. Rheological, compatibility, and thermal analyses are conducted on the sample blends. MFI resulting blends ranges from 56 g/10 min (baseline PLA) to 238 (PLA/PEG 400–10%), confirming their suitability melt‐blowing process. These then formed into nonwoven mats using twin‐screw extruder, producing microfibers diameters between 1.05 2.64 µm. second involves boiling water etching remove PEG, nanopores within fibers. process leaves network (50–200 nm size), distributed throughout microfiber structure. PLA/PEG 2000 exhibits optimal properties, achieving ≈72% efficiency 0.3 µm NaCl particulates during filtration testing. represents an innovative eco‐friendly approach nano‐porous potential applications filtration, battery separators, where porosity is beneficial.

Language: Английский

Citations

2
Peptide-Functionalized Polymeric Nanoparticles for Delivery of Curcumin to Cancer Cells DOI
Neda Rostami,

Aiada Ghebleh,

Hadi Noei

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106337 - 106337

Published: Oct. 1, 2024

Language: Английский

Citations

11
Breaking barriers: Smart vaccine platforms for cancer immunomodulation DOI Creative Commons
Mohammad Mahmoudi Gomari,

Taha Ghantabpour,

Nima Pourgholamamiji

et al.

Cancer Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract Despite significant advancements in cancer treatment, current therapies often fail to completely eradicate malignant cells. This shortfall underscores the urgent need explore alternative approaches such as vaccines. Leveraging immune system's natural ability target and kill cells holds great therapeutic potential. However, development of vaccines is hindered by several challenges, including low stability, inadequate response activation, immunosuppressive tumor microenvironment, which limit their efficacy. Recent progress various fields, click chemistry, nanotechnology, exosome engineering, neoantigen design, offer innovative solutions these challenges. These achievements have led emergence smart vaccine platforms (SVPs), integrate protective carriers for messenger ribonucleic acid (mRNA) with functionalization strategies optimize targeted delivery. Click chemistry further enhances SVP performance improving encapsulation mRNA antigens facilitating precise delivery review highlights latest developments technologies therapy, exploring both opportunities challenges advancing transformative approaches.

Language: Английский

Citations

1
Exploring Advanced CRISPR Delivery Technologies for Therapeutic Genome Editing DOI Creative Commons
Neda Rostami, Mohammad Mahmoudi Gomari,

Edris Choupani

et al.

Small Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 25, 2024

The genetic material within cells plays a pivotal role in shaping the structure and function of living organisms. Manipulating an organism's genome to correct inherited abnormalities or introduce new traits holds great promise. Genetic engineering techniques offers promising pathways for precisely altering cellular genetics. Among these methodologies, clustered regularly interspaced short palindromic repeat (CRISPR), honored with 2020 Nobel Prize Chemistry, has garnered significant attention its precision editing genomes. However, CRISPR system faces challenges when applied vivo, including low delivery efficiency, off-target effects, instability. To address challenges, innovative technologies targeted precise have emerged. Engineered carrier platforms represent substantial advancement, improving stability, precision, reducing side effects associated editing. These facilitate efficient local systemic various tissues cells, immune cells. This review explores recent advances, benefits, CRISPR-based delivery. It examines carriers nanocarriers (polymeric, lipid-derived, metallic, bionanoparticles), viral particles, virus-like exosomes, providing insights into their clinical utility future prospects.

Language: Английский

Citations

5
Advances in stimuli-responsive gold nanorods for drug-delivery and targeted therapy systems DOI Open Access
Sakineh Hajebi, Mohsen Chamanara,

Shadi Sadat Nasiri

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117493 - 117493

Published: Sept. 30, 2024

Language: Английский

Citations

5
Colorimetric Biosensor for Early Detection of MUC1-Positive Cells Using Aptamer-Conjugated Plasmonic Gold Nanostars DOI Creative Commons
Tozivepi Aaron Munyayi, Anine Crous

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(21), P. 24886 - 24896

Published: Oct. 30, 2024

Language: Английский

Citations

5
Application of Pistacia atlantica Pickering emulsion‐filled chitosan gel for targeted delivery of curcumin DOI Creative Commons
Sara Naji‐Tabasi, Monir‐sadat Shakeri,

Atena Modiri‐Dovom

et al.

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(4), P. 2809 - 2817

Published: Jan. 16, 2024

Abstract Emulsion‐filled hydrogels are a growing system in the food industry for delivering bioactive compounds. In this study, Baneh gum (BG) particles were prepared as Pickering emulsion stabilizer curcumin delivery. Then, BG was added to chitosan solution (1.5%, 2.0%, and 2.5% w/w) different (PE):hydrogel (HYD) ratios (1:3, 1:5, 1:7) create an emulsion‐filled gel. The highest amount of Cur stability after 3rd week storage observed sample containing 2.0% CS 1:7 PE:HYD ratio (97.36%). gel significantly protected antioxidant activity against thermal process ( p < .05). Curcumin loading provided better protection gastric condition compared system. hydrogel swells acidic environment, but its combination with anionic structure causes lower release stomach which can help digestive have controlled gastrointestinal tract.

Language: Английский

Citations

4
Investigating the Anti-tumor Mechanisms of Curcumin on Various Breast Cancer Cell Lines: A Systematic Review DOI
Mojtaba Esmaeli, Ali Ghanbari, Maryam Dehghanpour Dehabadi

et al.

Indian Journal of Gynecologic Oncology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 13, 2025

Language: Английский

Citations

0
Engineering Folic Acid‐Modified Nanoparticles to Enhance Letrozole's Anticancer Action DOI Creative Commons
Neda Rostami,

Abuzar Nikzad,

Shervin Shaybani

et al.

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Abstract The development of biodegradable nanoparticles (NPs) for delivering anticancer drugs, such as letrozole (LTZ), offers a targeted approach cancer therapy. In this study, we synthesized poly(ε‐caprolactone)‐ co ‐poly(ethylene glycol) (PCL‐ ‐PEG) and fabricated LTZ‐loaded PCL‐ ‐PEG NPs (LTZ‐NPs) via emulsion‐solvent evaporation. Folic acid (FA), folate receptor‐targeting molecule, was conjugated to the (LTZ‐FNPs) enhance treatment efficacy against hormone receptor‐positive breast cells. Both FNPs exhibited spherical morphology (60–90 nm), with showing higher drug entrapment efficiency controlled release. LTZ release minimal at physiological pH but increased in acidic, cancer‐like environments, following Korsmeyer‐Peppas model, indicating combination Fickian non‐Fickian diffusion. cytotoxicity assays, LTZ‐FNPs toxicity MCF‐7 cells than LTZ‐NPs. Controlled altered gene expression, reducing B‐cell leukemia/lymphoma 2 protein (Bcl2) increasing caspase 8 (Casp8), promoting apoptosis. A shift SubG1 phase further confirmed enhanced LTZ‐FNP‐mediated cell death. Furthermore, p53 expression increased, while matrix metalloproteinase 9 (MMP‐9) decreased, inhibiting invasion. This study introduces system FA‐functionalized, pH‐sensitive delivery LTZ. holds great potential selective, efficient minimizing systemic

Language: Английский

Citations

0
Application of biodegradable microsphere injections: an anticancer perspective DOI Creative Commons
Huanhuan Cai, Aixue Li,

Fu Qi

et al.

Materials Advances, Journal Year: 2024, Volume and Issue: 5(8), P. 3094 - 3112

Published: Jan. 1, 2024

Carrier materials for biodegradable microsphere injections and their application in cancer.

Language: Английский

Citations

3