Chitosan nanoparticles for nasal drug delivery

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106623 - 106623

Published: Jan. 1, 2025

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Co-delivery of carboplatin and doxorubicin using ZIF-8 coated chitosan-poly(N-isopropyl acrylamide) nanoparticles through a dual pH/thermo responsive strategy to breast cancer cells

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 269, P. 131971 - 131971

Published: May 3, 2024

Language: Английский

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Chitosan-based biomaterials for bone tissue engineering

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140923 - 140923

Published: Feb. 1, 2025

Language: Английский

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In Situ Gels for Nasal Delivery: Formulation, Characterization and Applications

Macromolecular Materials and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract The nasal route offers many advantages for drug delivery: quick onset of action, better patient compliance, avoidance first‐pass metabolism and bypassing the blood‐brain barrier. Despite potential this route, several challenges exist, such as short retention time caused by mucociliary clearance (MCC). In situ forming gels, which undergo a sol‐to‐gel transition with specific triggers at site present real opportunities in field. They combine intrinsic characteristics hydrogels (elasticity water‐holding capacity) responsiveness, allowing easy application drugs (spraying or extruding through nozzle), well prolonged cavity. incorporation mucoadhesive polymers, additives nanocarriers can further tune properties gels delivery platforms. This review summarizes advances delivery. We first describe target then both “classic” gelling polymers (poloxamers polysaccharides) – form bulk reported studies on novel bespoke materials; we characterization methods, highlighting lack standardization accepted values, discuss applications spraying, conclude future prospects.

Language: Английский

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Cellulose-based hydrogels in tissue engineering and regenerative medicine

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 209 - 227

Published: Jan. 1, 2025

Language: Английский

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Enzymatically Degradable Electrospun Nanogel Scaffolds Promoted in Vitro Proliferation of rADSC

ACS Applied Polymer Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Scaffolds that mimic the extracellular matrix (ECM) can promote proliferation of stem cells. Poly(N-isopropylacrylamide) (PNIPAM)/gelatin (PG) nanogel electrospun membranes were designed to replicate hierarchical and dynamic nature ECMs. First, PG nanogels with semi-interpenetrating network structures synthesized by emulsion polymerization. Characterization using 1H NMR FTIR spectroscopies confirmed successful incorporation gelatin into PNIPAM-based network. The spherical a size 184.1–231.9 nm, they demonstrated thermoresponsive behavior. rehydrated nanofibers exhibited an average diameter 663.6 ± 50.1 nm Young's modulus 1.3 0.1 MPa at 37 °C. membrane completely degraded within 10 min collagenase treatment. Adipose-derived cells from rats good on membranes, cell in PNI50 group being 1.47 times tissue culture plate (TCP) group. showed potential for expansion.

Language: Английский

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Chitosan, derivatives, and its nanoparticles: Preparation, physicochemical properties, biological activities, and biomedical applications – A comprehensive review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142832 - 142832

Published: April 1, 2025

Language: Английский

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Synthesis of Thermoresponsive Chitosan-graft-Poly(N-isopropylacrylamide) Hybrid Copolymer and Its Complexation with DNA

Polymers, Journal Year: 2024, Volume and Issue: 16(10), P. 1315 - 1315

Published: May 8, 2024

A hybrid synthetic-natural, thermoresponsive graft copolymer composed of poly(N-isopropyl acrylamide) (PNIPAM) side chains, prepared via RAFT polymerization, and a chitosan (Chit) polysaccharide backbone, was synthesized radical addition-fragmentation reactions using the “grafting to” technique, in aqueous solution. ATR-FTIR, TGA, polyelectrolyte titrations 1H NMR spectroscopy were employed order to validate Chit-g-PNIPAM chemical structure. Additionally, spectra back conductometric titration utilized quantify content grafted PNIPAM chains. The resulting contains dual functionality, namely both pH responsive free amino groups, with electrostatic complexation/coordination properties, Particle size measurements dynamic light scattering (DLS) used study behavior copolymer. Thermal properties examined by TGA showed that, grafting modification PNIPAM, Chit structure became more thermally stable. lower critical solution temperature (LCST) determined DLS at 25–45 °C. Furthermore, electrophoretic demonstrated that is suitable binding DNA molecules forms nanosized polyplexes different phosphate groups ratios, potential application as gene delivery systems.

Language: Английский

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In Vitro and Ex Vivo Evaluation of Novel Methacrylated Chitosan-PNIPAAm-Hyaluronic Acid Hydrogels Loaded with Progesterone for Applications in Vaginal Delivery

Polymers, Journal Year: 2024, Volume and Issue: 16(15), P. 2160 - 2160

Published: July 30, 2024

Miscarriage is defined as the loss of a pregnancy before 24 weeks and administration progesterone in has considerably decreased risk premature birth. Progesterone (PGT) starting from luteal phase stabilizes pregnancy, promotes differentiation endometrium, facilitates implantation embryo. Within present study, novel hybrid hydrogels based on chitosan methacrylate (CHT), hyaluronic acid (HA), poly(N-isopropylacrylamide) (PNIPAAm) for vaginal delivery were evaluated. The characterized by Fourier transform infrared spectroscopy (FTIR) scanning electron microscopy (SEM) structural identity assessment evaluation their morphological aspects. ability to swell, release capacity, enzymatic degradation, cytotoxicity, mucoadhesion also reported. demonstrated mucoadhesive properties contact with tissue swine bovine origin substrates, biodegradability controlled simulated environment. Cytocompatibility tests confirmed support cell viability growth. results showed pH-dependent behavior, drug release, good cytocompatibility, properties. higher amounts better bioadhesive This study provides insights into potential these progesterone, promising therapeutic effects no cytotoxicity observed. experimental indicated that composition moderate content PNIPAAm was suitable progesterone.

Language: Английский

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Recent Progress on Regulating the LCST of PNIPAM-Based Thermochromic Materials

ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

PNIPAM-based thermoresponsive materials have garnered significant attention in the fields of biomedicine and smart due to their temperature-sensitive properties. The ability regulate lower critical solution temperature (LCST) allows for precise control over phase behavior polymer, facilitating reversible transitions at specific temperatures. This capability is crucial expanding applications various contexts, such as drug release different environmental temperatures color-changing windows. review comprehensively summarizes strategies regulating LCST PNIPAM explores its potential applications. manuscript discusses key factors influencing transition from two perspectives: chain regulation molecular incorporation, including polymer structure, cross-linking density, solvent properties, role additives. Additionally, impact preparation conditions on also introduced. Recent advancements regulatory mechanisms are reviewed, highlighting advantages disadvantages each strategy, well future development directions. provides a systematic theoretical foundation practical guidance design with tunable LCST.

Language: Английский

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