Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(4), P. 736 - 736
Published: March 26, 2024
This
study
evaluated
the
biocompatibility
and
accuracy
of
3D-printed
β-tricalcium
phosphate
(β-TCP)
pure
ceramic
scaffolds.
A
specific
shaping
process
associating
a
digital
light
processing
(DLP)
3D
printer
heat
treatment
was
developed
to
produce
β-TCP
scaffolds
leaving
no
polymer
binder
residue.
The
characterised
using
X-ray
diffraction,
infrared
spectroscopy
detection
pollutants.
open
porosity
produced
matrices
their
resorption
were
studied
by
hydrostatic
weighing
calcium
release
measures.
printed
mean
osteoblast
cultures.
Finally,
macroporous
cubic
produced.
They
scanned
micro-Computed
Tomography
scanner
(micro-CT
scan)
compared
numeric
models.
results
demonstrated
that
DLP
printing
with
produces
enhanced
biocompatibility.
also
our
technique,
top-down
sintering
green
parts.
Thus,
this
production
is
promising
will
enable
us
explore
complex
phosphocalcic
special
focus
on
development
functional
vascular
network.
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(6), P. 1838 - 1838
Published: March 8, 2025
Bone
regeneration
has
emerged
as
a
critical
research
and
clinical
advancement
field,
fueled
by
the
growing
demand
for
effective
treatments
in
orthopedics
oncology.
Over
past
two
decades,
significant
progress
biomaterials
surgical
techniques
led
to
development
of
novel
solutions
treating
bone
defects,
surpassing
use
traditional
autologous
grafts.
This
review
aims
assess
latest
approaches
regeneration,
including
autologous,
allogenic,
xenogenic
grafts,
naturally
derived
biomaterials,
innovative
synthetic
substitutes
such
bioceramics,
bioactive
glasses,
metals,
polymers,
composite
materials,
other
specialized
applications.
A
comprehensive
literature
search
was
conducted
on
PubMed,
focusing
studies
published
between
2019
2024,
meta-analyses,
reviews,
systematic
reviews.
The
evaluated
range
strategies,
examining
outcomes,
materials
used,
techniques,
effectiveness
various
defects.
identified
numerous
studies,
with
inclusion
criteria
focused
those
exploring
strategies.
These
provided
valuable
insights
into
biological
outcomes
different
graft
types.
Results
indicated
that
while
advancements
show
promising
potential,
challenges
remain
optimizing
therapeutic
strategies
across
diverse
patient
populations
settings.
findings
emphasize
need
an
integrated
approach
combines
scientific
research,
practice,
technological
innovation
improve
therapies.
Further
is
required
establish
standardized
protocols
determine
optimal
application
enhance
quality
care.
Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(6), P. 2270 - 2270
Published: March 8, 2024
Regenerative
dentistry
has
experienced
remarkable
advancement
in
recent
years.
The
interdisciplinary
discoveries
stem
cell
applications
and
scaffold
design
fabrication,
including
novel
techniques
biomaterials,
have
demonstrated
immense
potential
the
field
of
tissue
engineering
regenerative
therapy.
Scaffolds
play
a
pivotal
role
by
facilitating
regeneration
restoring
damaged
or
missing
dental
structures.
These
biocompatible
biomimetic
structures
serve
as
temporary
framework
for
cells
to
adhere,
proliferate,
differentiate
into
functional
tissues.
This
review
provides
concise
overview
evolution
strategies
dentistry,
along
with
analysis
(Bard
v2.0
based
on
Gemini
neural
network
architecture)
most
commonly
employed
materials
used
fabrication
during
last
10
Additionally,
it
delves
bioprinting,
colonization
procedures,
outlines
prospects
regenerating
whole
tooth
future.
Moreover,
discusses
optimal
conditions
maximizing
mesenchymal
utilization
optimizing
personalization
through
precise
3D
bioprinting.
highlights
advancements
development,
particularly
advent
bioprinting
technologies,
is
comprehensive
literature
search
influential
publications
this
field.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 12766 - 12766
Published: Nov. 27, 2024
Bone
defects
and
fractures
present
significant
clinical
challenges,
particularly
in
orthopedic
maxillofacial
applications.
While
minor
bone
may
be
capable
of
healing
naturally,
those
a
critical
size
necessitate
intervention
through
the
use
implants
or
grafts.
The
utilization
traditional
methodologies,
encompassing
autografts
allografts,
is
constrained
by
several
factors.
These
include
potential
for
donor
site
morbidity,
restricted
availability
suitable
donors,
possibility
immune
rejection.
This
has
prompted
extensive
research
field
tissue
engineering
to
develop
advanced
synthetic
bio-derived
materials
that
can
support
regeneration.
optimal
substitute
must
achieve
balance
between
biocompatibility,
bioresorbability,
osteoconductivity,
osteoinductivity
while
simultaneously
providing
mechanical
during
process.
Recent
innovations
three-dimensional
printing,
nanotechnology,
bioactive
coatings
create
scaffolds
mimic
structure
natural
enhance
cell
proliferation
differentiation.
Notwithstanding
advancements
above,
challenges
remain
optimizing
controlled
release
growth
factors
adapting
various
contexts.
review
provides
comprehensive
overview
current
materials,
focusing
on
their
biological
mechanisms,
design
considerations,
It
explores
role
emerging
technologies,
such
as
additive
manufacturing
stem
cell-based
therapies,
advancing
field.
Future
highlights
need
multidisciplinary
collaboration
rigorous
testing
graft
substitutes,
improving
outcomes
quality
life
patients
with
complex
defects.
Biomaterials Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Biphasic
calcium
phosphate
(BCP)
is
a
bioceramic
widely
used
in
hard
tissue
engineering
for
bone
replacement.
BCP
consists
of
β-tricalcium
(β-TCP)
-
highly
soluble
and
resorbable
phase
hydroxyapatite
(HA)
stable
phase,
creating
balance
between
solubility
resorption,
optimally
supporting
cell
interactions
growth.
The
β-TCP/HA
ratio
significantly
affects
the
solubility,
cellular
response,
with
higher
β-TCP
increasing
resorption
due
to
its
solubility.
commonly
synthesized
by
calcining
calcium-deficient
apatite
(CDA)
at
temperatures
above
700
°C
via
direct
or
indirect
methods.
This
study
investigated
effects
pH
sintering
temperature
on
wet
precipitation,
aiming
achieve
an
80/20
ratio,
which
known
be
optimal
regeneration.
By
maintaining
constant
Ca/P
precursor
1.533,
conditions
were
determined
5.5-6
900
°C,
chosen
material
stability
successful
synthesis
was
confirmed
using
X-ray
diffraction
(XRD)
Fourier
transform
infrared
(FTIR)
spectroscopy.
At
same
time,
material's
physical
chemical
properties
further
characterized
through
scanning
electron
microscopy
(SEM)
degradation
studies
simulated
body
fluid
(SBF).
In
vitro
tests
demonstrated
excellent
cytocompatibility
osteogenic
differentiation,
while
vivo
rabbit
femur
defects
significant
regeneration,
bone-to-tissue
volume
ratios
exceeding
50%
within
four
weeks.
These
results
highlight
potential
BCPs
biomaterials
research.
Mineral
nanoparticles
and
osteoinductive
biomaterials
are
essential
in
advancing
bone
regeneration
by
addressing
skeletal
conditions
injuries
that
compromise
structural
integrity
functionality.
These
stimulate
the
differentiation
of
precursor
cells
into
osteoblasts,
creating
biocompatible
environments
conducive
to
tissue
regeneration.
Among
most
promising
innovations,
mineral-based
nanocomposite
hydrogels
have
emerged
as
effective
strategies
for
enhancing
potential.
This
review
explores
diverse
types
biomaterials,
including
natural
sources,
synthetic
compounds,
hybrid
designs
incorporate
mineralized
nanoparticles.
Emphasis
is
placed
on
polymeric
delivery
platforms
these
materials,
highlighting
their
dual
role
supports
bioactive
agents
promote
osteogenesis.
Challenges
such
immune
rejection,
biodegradability,
mechanical
stability,
short
vivo
residence
time
critically
discussed,
alongside
impact
clinical
translation.
By
presenting
a
comprehensive
analysis
mechanisms,
applications,
limitations,
this
identifies
opportunities
integrating
with
emerging
fields
like
immunology
biomechanics.
Ultimately,
work
aims
provide
actionable
insights
advance
development
novel,
clinically
relevant
solutions
improve
patient
outcomes
address
growing
global
need
repair
Annals of Anatomy - Anatomischer Anzeiger,
Journal Year:
2024,
Volume and Issue:
255, P. 152273 - 152273
Published: May 15, 2024
When
the
natural
process
of
bone
remodeling
is
disturbed,
need
arises
for
a
stimulant
material
in
order
to
enhance
formation
new
healthy
and
strong
osseous
tissue
replace
damaged
one.
Recent
studies
have
reported
synthetic
biomaterials
be
very
good
option
supporting
regeneration.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(5), P. 1049 - 1049
Published: May 9, 2024
The
reconstruction
of
bone
deficiencies
remains
a
challenge
due
to
the
limitations
autologous
grafting.
objective
this
study
is
evaluate
regeneration
efficacy
additive
manufacturing
tricalcium
phosphate
(TCP)
implants
using
lithography-based
ceramic
(LCM).
LCM
uses
LithaBone
TCP
300
slurry
for
3D
printing,
producing
cylindrical
scaffolds.
Four
models
internal
scaffold
geometry
were
developed
and
compared.
in
vitro
studies
included
cell
culture,
differentiation,
seeding,
morphological
detection
early
osteogenesis.
vivo
involved
42
Wistar
rats
divided
into
four
groups
(control,
membrane,
membrane
with
TCP).
In
each
animal,
unilateral
right
mandibular
defects
total
thickness
5
mm
surgically
performed.
animals
sacrificed
3
6
months
after
surgery.
Bone
neoformation
was
evaluated
by
conventional
histology,
radiology,
micro-CT.
Model
A
(spheres
intersecting
aligned
arrays)
showed
higher
penetration
interconnection.
Histological
radiological
analysis
micro-CT
revealed
increased
formation
grafted
groups,
especially
when
combined
membrane.
Our
innovative
printing
technology,
precise
design
efficient
cleaning,
shows
potential
regeneration.
However,
further
refinement
technique
long-term
clinical
are
crucial
establish
safety
these
advanced
printed
scaffolds
human
patients.
