Recent Review on Biological Barriers and Host–Material Interfaces in Precision Drug Delivery: Advancement in Biomaterial Engineering for Better Treatment Therapies

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 1076 - 1076

Published: Aug. 16, 2024

Preclinical and clinical studies have demonstrated that precision therapy has a broad variety of treatment applications, making it an interesting research topic with exciting potential in numerous sectors. However, major obstacles, such as inefficient unsafe delivery systems severe side effects, impeded the widespread use medicine. The purpose drug (DDSs) is to regulate time place release action. They aid enhancing equilibrium between medicinal efficacy on target hazardous effects off target. One promising approach biomaterial-assisted biotherapy, which takes advantage biomaterials’ special capabilities, high biocompatibility bioactive characteristics. When administered via different routes, molecules deal biological barriers; DDSs help them overcome these hurdles. With their adaptable features ample packing capacity, biomaterial-based allow for targeted, localised, prolonged medications. Additionally, they are being investigated more controlling interface host tissue implanted biomedical materials. This review discusses innovative nanoparticle designs non-personalised applications improve therapies. We prioritised design trends address heterogeneous barriers, because we believe intelligent can patient outcomes by enabling improving general efficacy. additionally reviewed most recent literature biomaterials used biotherapy vaccine development, covering delivery, stem cell therapy, gene other similar fields; also addressed difficulties future biotherapies.

Language: Английский

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From Stents to Smart Implants Employing Biomimetic Materials: The Impact of 4D Printing on Modern Healthcare

Biomimetics, Journal Year: 2025, Volume and Issue: 10(2), P. 125 - 125

Published: Feb. 19, 2025

The sector of 4D printing represents a new frontier in additive manufacturing that allows for material's capability to adapt and respond various stimuli, such as thermal transitions, humidity, pH levels. adaptability material has great potential healthcare applications, especially designing personalized responsive medical devices. This article looks into the revolutionary applications printing, referencing self-repairable implants, smart stents, drug delivery systems, response-based prosthetic advances 3D have created platform innovations take place, while properties unique allow methods tackling existing health issues. However, large-scale application medicine is currently hampered by limitations, regulation challenges, financial challenges. In spite these ongoing technologies, combined with artificial intelligence machine learning, provide surpass hence improving precision, efficacy, personalization work outlines at areas future, analyzes contributing healthcare, recognizing challenges need be overcome order unlock its full potential.

Language: Английский

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Advances in 4D Shape-Memory Resins for AI-Aided Personalized Scaffold Bioengineering

Bratislavské lekárske listy/Bratislava medical journal, Journal Year: 2025, Volume and Issue: 126(2), P. 140 - 145

Published: Feb. 1, 2025

Abstract This paper introduces an innovative workflow for developing personalized bioengineered scaffolds by combining AI-driven auto-segmentation of Cone Beam Computed Tomography (CBCT) scans with the design temperature-responsive photocurable resins, or 4D polymers. Using Diagnocat software, AI segmentation achieves precise morphological replication anatomical structures, creating accurate 3D models that are tailored to each patient's unique anatomy. These guide fabrication varying porosities and geometries, using TC-85—a biocompatible, temperature-sensitive resin distinct mechanical viscoelastic properties. The resin’s temperature responsiveness enables dynamically adapt physiological conditions, enhancing functionality morphologically shifting stimulate adherent cells. approach demonstrates advantages automated underscores potential advanced bioengineering applications.

Language: Английский

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Three-Dimensional-Printed Elements Based on Polymer and Composite Materials in Dentistry: A Narrative Review

Bratislavské lekárske listy/Bratislava medical journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Abstract 3D printing technologies are manufacturing based on computer-designed digital models that allow fabrication of layered three-dimensional objects. This review aims to present a summary the literature published 3D-printed polymer and composite materials in dentistry. A search was performed using PubMed database identify eligible articles. In total 508 articles were identified original query, with 362 being eliminated exclusion criteria 146 screened their abstracts, 68 studied detail. Subsequently, these divided into three groups area application: (1) restorative dentistry, which included printed crowns, bridges, veneers; (2) regenerative dentistry tissue engineering, such as scaffolds; (3) oral guides other appliances, surgical guides, dental implants, splints. this technology is described, including its benefits regarding working time, accuracy overall design products. The shows most application printable polymers composites Even though for properties effects human body well environment, novel specific revolutionary characteristics have emerged recent years given special attention. However, more research needed ensure safety use confirm both vivo vitro conditions.

Language: Английский

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Three-Dimensionally-Printed Polymer and Composite Materials for Dental Applications with Focus on Orthodontics

Polymers, Journal Year: 2024, Volume and Issue: 16(22), P. 3151 - 3151

Published: Nov. 12, 2024

Three-dimensional printing has transformed dentistry by enabling the production of customized dental restorations, aligners, surgical guides, and implants. A variety polymers composites are used, each with distinct properties. This review explores materials used in 3D for applications, focusing on trends identified through a literature search PubMed, Scopus, Web Science. The most studied areas include 3D-printed crowns, bridges, removable prostheses, aligners. development new is still ongoing also holds great promise terms environmentally friendly technologies. Modern manufacturing technologies have promising future all dentistry: prosthetics, periodontology, oral surgery, implantology, orthodontics, regenerative dentistry. However, further studies needed to safely introduce latest materials, such as nanodiamond-reinforced PMMA, PLA reinforced nanohydroxyapatite or magnesium, PLGA tricalcium phosphate PEEK hydroxyapatite titanium into clinical practice.

Language: Английский

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Scaffold Application for Bone Regeneration with Stem Cells in Dentistry: Literature Review

Cells, Journal Year: 2024, Volume and Issue: 13(12), P. 1065 - 1065

Published: June 19, 2024

Bone tissue injuries within oral and dental contexts often present considerable challenges because traditional treatments may not be able to fully restore lost or damaged bone tissue. Novel approaches involving stem cells targeted 3D scaffolds have been investigated in the search for workable solutions. The use of cell-assisted regeneration is a crucial component engineering techniques designed overcome drawbacks grafts. This study provides detailed review scaffold applications with dentistry. focuses on while covering broad range studies explaining dentistry through presentation conducted this field. role different regenerative medicine covered great detail reviewed literature. These addressed wide subjects, including effects platelet concentrates during surgery specific combinations, such as human pulp animal model regeneration, promote models. Noting developments, research works consider methods improve vascularization explore 3D-printed scaffolds, secretome applications, mesenchymal cells, biomaterials regeneration. thorough assessment outlines possible developments these cycles insights suggestions additional study. Furthermore, alternative creative regenerating include biophysical stimuli, mechanical stimulation, magnetic field therapy, laser nutritional supplements diet, gene biomimetic materials. innovative offer promising avenues future development

Language: Английский

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How is AI Transforming Medical Research, Education and Practice?

Bratislavské lekárske listy/Bratislava medical journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Abstract Artificial intelligence is rapidly reshaping medical research, education, and clinical practice. This brief communication reviews new AI applications—from personalized learning immersive simulations in education to AI-assisted diagnostics settings—and examines the accompanying ethical practical challenges. Drawing on insights from last November’s editorial Bratislava Medical Journal, paper argues that while offers powerful tools, human oversight remains essential. Future efforts must establish clear governance frameworks update educational curricula foster effective human–machine collaboration, ensuring uniquely elements of science creativity endure.

Language: Английский

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The Role of Tissue Engineering in Orthodontic and Orthognathic Treatment: A Narrative Review

Oral, Journal Year: 2025, Volume and Issue: 5(1), P. 21 - 21

Published: March 20, 2025

Background: Orthodontics and orthognathic surgery present challenges such as extended treatment durations, patient discomfort, complications like root resorption. Recent advancements in tissue engineering nanotechnology offer promising solutions by improving bone regeneration, periodontal repair, biomaterial integration. Objectives: This review explores the integration of scaffold-based orthodontics, focusing on their roles accelerating reducing times, minimizing adverse effects to enhance predictability success orthodontic interventions. Methods: Relevant literature was selected from PubMed, Scopus, Web Science, studies related scaffold technology, biomaterials, orthodontics. Keywords included “tissue engineering”, “orthodontics”, “biomaterials”, “scaffolds”, “nanotechnology”, “bone regeneration”. Priority given peer-reviewed original studies, systematic reviews, meta-analyses addressing innovative approaches clinical outcomes. Results: Findings indicate that scaffolds regeneration while nanoparticles improve drug delivery efficiency. These contribute faster, more predictable treatments with reduced complications. However, high costs, regulatory hurdles, need for long-term validation remain barriers widespread adoption. Conclusions: Tissue minimally invasive, biologically driven treatment. While significant progress has been made, further cost-effective strategies, approvals are needed integrate these innovations into routine practice.

Language: Английский

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Biological and mechanical challenges in the endodontic treatment of immature teeth with pulp necrosis: insights based on a Series of Atypical Clinical Cases

Biomaterial Investigations in Dentistry, Journal Year: 2025, Volume and Issue: 12, P. 40 - 59

Published: April 4, 2025

Over the past two decades, dental pulp regeneration has become a major focus in endodontology. The currently applied clinical strategies are referred to as ‘revitalisation’ procedures. These biology-based treatment aim at regenerating lost tissues necrotic teeth, absence or even more presence of periapical bone lesion, signs and symptoms. Such approaches generally – but not exclusively used immature teeth promote root maturation, both length thickness, ultimately reduce their risk fracture. A growing body evidence led increased understanding reliability these strategies, which now considered valid alternative option besides conventional ones, mainly apical plug technique. However, all systematic reviews evaluating outcomes concluded that there is lack robust long-term studies on subject; most published cases revitalisation having relatively short-term follow-up, usually under 2 years. In this context, several challenges remain be addressed better understand promises limitations procedures compared other options, placement an made hydraulic calcium silicate cement. purpose paper was therefore identify some important remaining related such procedures, can broadly categorised into biological mechanical affecting success tooth survival. Meeting requires close collaboration between researchers clinicians, establish guidelines, evaluate outcomes, update guidelines accordingly. it always easy for reality faced by practitioners. order facilitate mutual understanding, aforementioned were illustrated providing context through series atypical with follow-up (4–8 years).

Language: Английский

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Revisiting the Role of Review Articles in the Age of AI-Agents: Integrating AI-Reasoning and AI-Synthesis Reshaping the Future of Scientific Publishing

Bratislavské lekárske listy/Bratislava medical journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Language: Английский

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