Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 22, 2024
Abstract
Nano-
and
micro-fiber-based
scaffolds
bear
enormous
potential
for
their
use
in
cell
culture
tissue
engineering,
since
they
mimic
natural
collagen
structures
may
thus
serve
as
biomimetic
adhesive
substrates.
They
have,
however,
so
far
been
restricted
to
small
scale
production
research
labs
with
high
batch-to-batch
variation.
are
commonly
produced
via
electrospinning
or
melt
electro-writing
delicate
nature
poses
obstacles
detachment,
storage,
transportation.
This
study
focuses
on
overcoming
challenges
the
throughput
practical
handling,
introducing
new
methods
reproducibly
prepare
such
suitable
quantitative
applications.
Attention
is
given
seamless
handling
transfer
of
samples
without
compromising
structural
integrity.
Challenges
detaching
fibers
damage
well
transport
addressed.
Cell
studies
demonstrate
methodological
advantages,
emphasizing
standardized
testing
biological
readouts
these
fiber
materials.
The
developed
applicable
across
various
approaches
can
essentially
contribute
utilization
laboratory
commercial
New Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
The
development
of
electrospun
nanofibers
by
incorporating
2D
Cr
2
CT
x
MXene
into
PVA
matrices
is
investigated
towards
electrocatalytic
water
splitting.
Journal of Applied Biomaterials & Functional Materials,
Journal Year:
2024,
Volume and Issue:
22
Published: Jan. 1, 2024
Nanofibrous
scaffolds
have
emerged
as
promising
candidates
for
localized
drug
delivery
systems
in
the
treatment
of
cutaneous
cancers.
In
this
study,
we
prepared
an
electrospun
nanofibrous
scaffold
incorporating
5-fluorouracil
(5-FU)
and
etoposide
(ETP)
chemotherapy
targeting
melanoma
cancer.
The
was
composed
polyvinyl
alcohol
(PVA)
chitosan
(CS),
via
electrospinning
process
loaded
with
chemotherapeutic
agents.
We
conducted
relevant
physicochemical
characterizations,
assessed
cytotoxicity,
evaluated
apoptosis
against
A375
cells.
5-FU/ETP
co-loaded
PVA/CS
exhibited
nanofibers
(NFs)
average
diameter
321
±
61
nm,
defect-free
homogenous
morphology.
FTIR
spectroscopy
confirmed
successful
incorporation
chemotherapeutics
into
scaffold.
Additionally,
demonstrated
a
hydrophilic
surface,
proper
mechanical
strength,
high
porosity,
efficient
liquid
absorption
capacity.
Notably,
sustained
controlled
release
observed
from
Furthermore,
significantly
increased
cytotoxicity
(95%)
(74%)
Consequently,
holds
promise
valuable
system
eradication
tumors
mitigation
adverse
reactions
associated
chemotherapy.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(20), P. 2853 - 2853
Published: Oct. 10, 2024
Tissue
engineering
has
great
potential
for
the
restoration
of
damaged
tissue
due
to
injury
or
disease.
During
development,
scaffolds
provide
structural
support
cell
growth.
To
grow
healthy
tissue,
principal
components
such
must
be
biocompatible
and
nontoxic.
Poly(ε-caprolactone)
(PCL)
is
a
biopolymer
that
been
used
as
key
component
composite
applications
its
mechanical
strength
biodegradability.
However,
PCL
alone
can
have
low
adherence
wettability.
Blends
biomaterials
incorporated
achieve
synergistic
scaffold
properties
engineering.
Electrospun
PCL-based
consist
single
blended-composition
nanofibers
with
multi-layered
internal
architectures
(i.e.,
core-shell
nanofibers).
Nanofiber
diameter,
composition,
properties,
biocompatibility,
drug-loading
capacity
are
among
tunable
electrospun
scaffolds.
Scaffold
including
wettability,
strength,
biocompatibility
further
enhanced
layering,
surface
modification,
coating
techniques.
In
this
article,
we
review
nanofibrous
fabrication
in
reported
recent
literature.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
14(4)
Published: Dec. 15, 2024
Soft
nano-
and
microfiber-based
polymer
scaffolds
bear
enormous
potential
for
their
use
in
cell
culture
tissue
engineering
since
they
mimic
natural
collagen
structures
may
thus
serve
as
biomimetic
adhesive
substrates.
They
have,
however,
so
far
been
restricted
to
small-scale
production
research
labs
with
high
batch-to-batch
variation.
are
commonly
produced
via
electrospinning
or
melt
electrowriting
delicate
nature
poses
obstacles
detachment,
storage,
transportation.
This
study
focuses
on
overcoming
challenges
the
throughput
practical
handling,
introducing
new
methods
reproducibly
prepare
such
suitable
quantitative
applications.
Attention
is
given
seamless
handling
transfer
of
samples
without
compromising
structural
integrity.
Challenges
detaching
fibers
damage
well
transport
addressed.
Cell
studies
demonstrate
methodological
advantages,
emphasizing
standardized
testing
biological
readouts
these
fiber
materials.
The
developed
applicable
across
various
approaches
can
essentially
contribute
utilization
laboratory
commercial
International Journal of Food Science & Technology,
Journal Year:
2024,
Volume and Issue:
59(8), P. 5742 - 5753
Published: June 25, 2024
Summary
In
the
storage
process,
meat
is
susceptible
to
external
factors
that
produce
corruption
and
deterioration,
affecting
consumers'
health.
Therefore,
preparing
an
indicator
membrane
can
detect
freshness
in
real
time,
non‐destructively,
visually
significant.
Herein,
was
prepared
by
electrostatic
spinning
technology
using
polyvinyl
alcohol
(PVA)
as
substrate
curcumin
(CUR)
indigo
(IND)
mixed
for
detection.
When
were
at
3:1
(w/w),
CUR
transformed
from
ketone
type
enol
with
gradual
increase
of
pH,
IND
underwent
electron
leaps,
which
resulted
green,
brown,
reddish‐brown
colour
changes
solution,
development
effect
effectively
improved.
The
characterisation
results
showed
average
fibre
diameter
PVA/0.8
252
nm,
hybrid
successfully
loaded
nanofibres,
water
contact
angle
103.6°,
hydrophobic.
addition,
sensitive
trimethylamine
(limit
detection
17.38
ppm)
triethylamine
27.77
but
insensitive
saline,
ethanol,
ethyl
acetate,
other
contaminants
specificity.
Finally,
indicating
green
brown
during
mutton
rotten,
naked
eye
judge
mutton.
PVA/CUR/IND
has
excellent
potential
application
real‐time
non‐destructive
freshness.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
16(1), P. 36 - 36
Published: Dec. 27, 2023
BGP-15
is
an
active
ingredient
with
many
advantages,
e.g.,
beneficial
cardiovascular
and
anti-inflammatory
effects.
The
transdermal
administration
of
has
great
potential,
which
not
been
investigated
yet,
despite
the
fact
that
it
a
non-invasive
safe
form
treatment.
aim
our
study
was
to
formulate
patches
containing
optimize
production
Box–Behnken
design
experiment.
most
optimal
formulation
further
combined
penetration
enhancers
improve
bioavailability
ingredient,
in
vitro
drug
release
permeation
from
were
investigated.
FTIR
spectra
BGP-15,
formulations
components
also
studied.
based
on
tested
parameters
dried
for
24
h,
67%
polyvinyl
alcohol
(PVA)
content
low
ethanol
content.
selected
enhancer
excipients
cytotoxic
HaCaT
cells.
measurements
SEM
photography
proved
compatibility
substance
vehicle;
present
polymer
matrix
dissolved
form.
significantly
enhanced
by
combination
Transcutol
Labrasol.
confirmed
formulated
successfully
enabled
BGP-15.
