Virtual and Physical Prototyping,
Journal Year:
2024,
Volume and Issue:
20(1)
Published: Dec. 31, 2024
The
uneven
mixing
of
high-viscosity
inks
and
cell
damage
caused
by
high-shear
stress
during
the
extrusion
process
has
persistently
posed
challenges
to
its
extensive
application
in
tissue
engineering.
To
reconcile
conflict
between
efficiency
shear
stress,
this
study
employed
computational
fluid
dynamics
analyse
flow
behaviour
processes
hydrogel
solutions
a
nozzle.
Results
indicate
that
with
inclination
blade,
reduction
outlet
diameter,
increase
printing
speed,
within
channel
significantly
escalates.
mixer
is
solely
related
structure
independent
velocity.
Following,
an
optimised
blade
method
were
proposed
evaluate
performance
mixer.
Finally,
empirical
equation
was
established
relating
maximum
nozzle
diameter
speed.
Journal of Tissue Engineering,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 1, 2025
The
field
of
three
dimensional
(3D)
bioprinting
has
witnessed
significant
advancements,
with
bioinks
playing
a
crucial
role
in
enabling
the
fabrication
complex
tissue
constructs.
This
review
explores
innovative
that
are
currently
shaping
future
3D
bioprinting,
focusing
on
their
composition,
functionality,
and
potential
for
engineering,
drug
delivery,
regenerative
medicine.
development
bioinks,
incorporating
natural
synthetic
materials,
offers
unprecedented
opportunities
personalized
However,
rapid
technological
progress
raises
regulatory
challenges
regarding
safety,
standardization,
long-term
biocompatibility.
paper
addresses
these
challenges,
examining
current
frameworks
need
updated
guidelines
to
ensure
patient
safety
product
efficacy.
By
highlighting
both
hurdles,
this
comprehensive
overview
landscape
emphasizing
necessity
cross-disciplinary
collaboration
between
scientists,
clinicians,
bodies
achieve
successful
clinical
applications.
Journal of Functional Biomaterials,
Journal Year:
2023,
Volume and Issue:
15(1), P. 7 - 7
Published: Dec. 22, 2023
Along
with
the
rapid
and
extensive
advancements
in
3D
printing
field,
a
diverse
range
of
uses
for
have
appeared
spectrum
medical
applications.
Vat
photopolymerization
(VPP)
stands
out
as
one
most
extensively
researched
methods
printing,
its
main
advantages
being
high
speed
ability
to
produce
high-resolution
structures.
A
major
challenge
using
VPP
3D-printed
materials
medicine
is
general
incompatibility
standard
resin
mixtures
requirements
biocompatibility
biofunctionality.
Instead
developing
completely
new
materials,
an
alternate
approach
solving
this
problem
involves
adapting
existing
biomaterials.
These
are
incompatible
their
pure
form
but
can
be
adapted
chemistry
process
through
use
innovative
addition
specific
pre-
post-printing
steps.
This
review's
primary
objective
highlight
biofunctional
biocompatible
that
been
VPP.
We
present
compare
suitability
these
different
applications
propose
other
biomaterials
could
further
order
fulfill
patient-specific
requirements.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(8), P. 1021 - 1021
Published: April 9, 2024
Stereolithography
has
emerged
as
a
recent
method
in
fabricating
complex
structures
with
high
accuracy.
Components
using
resin
have
poorer
properties.
The
current
study
investigates
the
improvement
properties
of
nano-graphite
composites
fabricated
by
SLA
technique.
are
compared
for
plain
and
0.2%,
0.5%,
1%,
3%,
5%
(w/v)
mixed
UV-curable
resin.
Various
analyses
were
conducted,
including
viscosity,
UV
spectroscopy,
moisture
content,
water
absorption,
gel
tensile,
bending,
hardness
testing,
microscopic
characterization.
results
from
experiments
showed
difference
each
percentage
specimen
tested,
such
property,
which
shows
that
greater
added
(5%),
opaquer
will
appear
less
light
be
reflected.
Viscosity
testing
to
resin,
viscosity.
spectroscopy
produced
information
about
electronic
structure
molecules,
their
composition,
purity,
concentration.
Observations
content
analysis
found
specimens
higher
percentages
affected
physical
mechanical
properties,
leading
easier
warping,
cracking,
decreased
strength,
etc.
Tensile
bending
added,
effect
on
fracture.
However,
certain
tests
did
not
consistently
yield
significant
variations
among
when
different
particularly
evident
chemical
resistance
testing.
This
offers
valuable
insights
into
application
via
method.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 17, 2025
The
cartilage
possesses
limited
regenerative
capacity,
necessitating
advanced
approaches
for
its
repair.
This
study
introduces
a
bioink
designed
tissue
engineering
(TE)
by
incorporating
ionically
cross-linkable
alginate
into
the
photo-cross-linkable
MuMA
bioink,
resulting
in
double
cross-linked
interpenetrating
network
(IPN)
hydrogel.
Additionally,
hyaluronic
acid
(HA),
natural
component
of
and
synovial
fluid,
was
added
to
enhance
scaffold's
properties.
HA
has
been
demonstrated
improve
lubrication,
regulate
inflammation,
promote
cell
proliferation,
support
extracellular
matrix
(ECM)
deposition
regeneration,
making
it
valuable
TE.
Comprehensive
experiments
were
conducted
assess
morphology,
swelling,
degradation,
mechanical
rheological
properties,
printability,
biocompatibility.
Results
indicated
that
scaffolds
comprising
MuMA,
alginate,
exhibited
compressive
moduli
comparable
native
cartilage,
unlike
single
variants.
cross-linking
also
influenced
water
uptake,
porosity,
contributing
scaffold
durability
stability
chondrocyte
support.
Biocompatibility
tests
with
C28/I2
cells
cell-supportive
chondrogenic
potential
bioink.
establishes
mucin
as
versatile
material
specialized
applications.
Marine Drugs,
Journal Year:
2024,
Volume and Issue:
22(3), P. 134 - 134
Published: March 16, 2024
3D
bioprinting
is
a
disruptive,
computer-aided,
and
additive
manufacturing
technology
that
allows
the
obtention,
layer-by-layer,
of
complex
structures.
This
believed
to
offer
tremendous
opportunities
in
several
fields
including
biomedical,
pharmaceutical,
food
industries.
Several
processes
bio-ink
materials
have
emerged
recently.
However,
there
still
pressing
need
develop
low-cost
sustainable
with
superior
qualities
(excellent
mechanical,
viscoelastic
thermal
properties,
biocompatibility,
biodegradability).
Marine-derived
biomaterials,
polysaccharides
proteins,
represent
viable
renewable
source
for
formulations.
Therefore,
focus
this
review
centers
around
use
marine-derived
biomaterials
formulations
bio-ink.
It
starts
general
overview
followed
by
description
most
commonly
used
bioprinting,
special
attention
paid
chitosan,
glycosaminoglycans,
alginate,
carrageenan,
collagen,
gelatin.
The
challenges
facing
application
within
biomedical
pharmaceutical
along
future
directions
are
also
discussed.
Virtual and Physical Prototyping,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: July 22, 2024
Achieving
efficient
scaffolds
for
bone
tissue
engineering
(TE)
requires
smartly
defined
parameters
reaching
a
balance
between
physical–chemical
properties,
biocompatibility
and
complex
architectures.
Three-dimensional
(3D)
printing
offers
precise
geometry
control
of
the
desired
scaffold
at
micro-scale.
However,
performance
3D
is
highly
dependent
on
formulation,
challenge
being
to
achieve
suitable
ink
establish
most
parameters.
Gelatin
methacryloyl
(GelMA)
emerges
as
promising
due
superior
biological
photocrosslinking
ability
printability.
The
present
review
focuses
evolution
GelMA-based
inks
bioinks
from
simplest
advanced
multicomponent
formulations
capable
regeneration.
Additionally,
comparative
analysis
different
photoinitiators
covered,
indicating
each
one's
advantages
disadvantages.
Furthermore,
main
bioprinting
methods
that
are
used
in
GelMA
outlined
with
required
their
influence
final
product
performance.
Materials,
Journal Year:
2025,
Volume and Issue:
18(2), P. 429 - 429
Published: Jan. 17, 2025
Additive
manufacturing
is
a
technology
that
creates
objects
by
adding
successive
layers
of
material.
The
3D
method
an
alternative
to
subtractive
production,
in
which
production
involves
removing
material
from
the
initial
solid.
printing
requires
design
manufactured
object
using
computer
design,
for
example,
one
following
programs:
CAD,
3DCrafter,
Wings
3D,
Cinema
3,
Blender,
3ds
Max,
Autodesk
Inventor,
and
others.
It
also
possible
scan
existing
be
technology.
An
important
element
Industry
5.0
technology,
due
its
favorable
environmental
orientation
flexibility.
Three-dimensional
uses
recycled
materials
such
as
powders.
Therefore,
it
can
part
circular
economy,
contributing
protection.
not
only
complements
technologies
enabling
rapid
prototyping
but
plays
fundamental
role
sectors
dentistry
medicine.
This
article
consists
seven
chapters
relating
various
aspects
context
assumptions
challenges
5.0.
examines
impact
recycling
potential
illustrates
economic
integration
this
within
industries,
discusses
future
development
prospects.
