Viruses,
Journal Year:
2024,
Volume and Issue:
16(1), P. 77 - 77
Published: Jan. 3, 2024
Enhancing
cross-protections
against
diverse
influenza
viruses
is
desired
for
vaccinations.
Neuraminidase
(NA)-specific
antibody
responses
have
been
found
to
independently
correlate
with
a
broader
protection
spectrum.
Here,
we
report
sequential
immunization
regimen
that
includes
priming
NA
protein
followed
by
boosting
peptide
nanoclusters,
which
targeted
enhancement
of
in
BALB/c
mice
certain
cross-protective
B-cell
epitopes
was
achieved.
The
nanoclusters
were
fabricated
via
desolvation
absolute
ethanol
and
only
composed
composite
peptides.
Unlike
KLH
conjugates,
would
not
induce
influenza-unrelated
immunity.
We
the
incorporation
hemagglutinin
H2-d
class
II
restriction
into
peptides
could
be
beneficial
enhancing
peptide-specific
response.
Of
note,
boosters
N2
induced
stronger
serum
cross-reactivities
heterologous
even
heterosubtypic
N7
N9
than
triple
immunizations
prototype
recombinant
tetrameric
(rt)
N2.
mouse
challenge
experiments
HK68
H3N2
also
demonstrated
strong
effectiveness
nanocluster
conferring
protection.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(17), P. 2536 - 2536
Published: Sept. 7, 2024
In
the
last
few
decades,
there
has
been
a
growing
interest
in
use
of
biodegradable
polymeric
nanoparticles
(BPNPs)
as
carriers
for
various
therapeutic
agents
drug
delivery
systems.
BPNPs
have
potential
to
improve
efficacy
numerous
active
by
facilitating
targeted
desired
site
body.
Biodegradable
polymers
are
especially
promising
nanocarriers
substances
characterized
poor
solubility,
instability,
rapid
metabolism,
and
system
elimination.
Such
molecules
can
be
efficiently
encapsulated
subsequently
released
from
nanoparticles,
which
greatly
improves
their
stability
bioavailability.
Biopolymers
seem
most
suitable
candidates
used
platforms,
due
biocompatibility
biodegradability.
Other
unique
properties
include
low
cost,
flexibility,
stability,
minimal
side
effects,
toxicity,
good
entrapment
potential,
long-term
controlled
release.
An
overview
summarizing
research
results
years
field
successful
fabrication
loaded
with
is
provided.
The
possible
challenges
involving
nanoparticle
under
physiological
conditions
possibility
scaling
up
production
while
maintaining
quality,
well
future
possibilities
employing
BPNPs,
also
reviewed.
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
278, P. 134977 - 134977
Published: Aug. 24, 2024
Antibiotic
resistance
(ABR)
poses
a
universal
concern
owing
to
the
widespread
use
of
antibiotics
in
various
sectors.
Nanotechnology
emerges
as
promising
solution
combat
ABR,
offering
targeted
drug
delivery,
enhanced
bioavailability,
reduced
toxicity,
and
stability.
This
comprehensive
review
explores
concepts
antibiotic
resistance,
its
mechanisms,
multifaceted
approaches
ABR.
The
provides
an
in-depth
exploration
polymeric
nanoparticles
advanced
delivery
systems,
focusing
on
strategies
for
targeting
microbial
infections
contributing
fight
against
Nanoparticles
revolutionize
antimicrobial
approaches,
emphasizing
passive
active
targeting.
role
molecules,
including
small
peptides,
proteins,
carbohydrates,
stimuli-responsive
is
being
explored
recent
research
works.
complex
comprehension
mechanisms
ABR
strategic
nanotechnology
present
avenue
advancing
tactics,
ensuring
treatment
efficacy,
minimizing
toxic
effects,
mitigating
development
Polymeric
nanoparticles,
derived
from
natural
or
synthetic
polymers,
are
crucial
overcoming
Natural
polymers
like
chitosan
alginate
exhibit
inherent
antibacterial
properties,
while
such
polylactic
acid
(PLA),
polyethylene
glycol
(PEG),
polycaprolactone
(PCL)
can
be
engineered
specific
effects.
study
valuable
source
information
researchers,
healthcare
professionals,
policymakers
engaged
urgent
quest
overcome
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
175, P. 116717 - 116717
Published: May 14, 2024
Knee
osteoarthritis
(OA)
involves
articular
cartilage
degradation
driven
mainly
by
inflammation.
Kaempferol
(KM),
known
for
its
anti-inflammatory
property,
holds
potential
OA
treatment.
This
study
investigated
the
of
hyaluronic
acid
(HA)-coated
gelatin
nanoparticles
loaded
with
KM
(HA-KM
GNP)
treating
knee
OA.
was
encapsulated
into
(KM
and
then
coated
HA
to
form
HA-KM
GNPs.
Physical
properties
were
characterized,
biocompatibility
cellular
uptake
assessed
in
rat
chondrocytes.
Anti-inflammatory
chondrogenic
evaluated
using
IL-1β-stimulated
chondrocytes,
compared
HA-coated
without
(HA
alone.
Preclinical
efficacy
tested
an
anterior
cruciate
ligament
transection
(ACLT)-induced
model
treated
intra-articular
injection
GNP.
Results
show
spherical
GNPs
(88.62
±
3.90
nm)
positive
surface
charge.
Encapsulation
efficiency
98.34
%
a
sustained
release
rate
18
over
48
h.
Non-toxic
concentration
2.5
μg/mL.
In
GNP
significantly
down-regulated
RNA
expression
IL-1β,
TNF-α,
COX-2,
MMP-9,
MMP-13,
while
up-regulating
SOX9
GNP,
KM.
vivo
imaging
demonstrated
higher
fluorescence
intensity
within
joints
3
hours
post
(185.2%
34.1%
vs.
45.0%
16.7%).
significant
effectiveness
reducing
subchondral
sclerosis,
attenuating
inflammation,
inhibiting
matrix
degradation,
restoring
thickness,
severity
ACLT
model.
conclusion,
promise
therapy.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(7), P. 851 - 851
Published: June 28, 2024
Recent
advances
in
regenerative
medicine
provide
encouraging
strategies
to
produce
artificial
skin
substitutes.
Gelatin
scaffolds
are
successfully
used
as
wound-dressing
materials
due
their
superior
properties,
such
biocompatibility
and
the
ability
mimic
extracellular
matrix
of
surrounding
environment.
In
this
study,
five
gelatin
combination
solutions
were
prepared
electrospun
using
an
electrospinning
technique.
After
careful
screening,
optimal
concentration
most
promising
was
selected
for
further
investigation.
The
obtained
crosslinked
with
25%
glutaraldehyde
vapor
characterized
by
scanning
electron
microscopy,
energy-dispersive
X-ray
spectroscopy,
Fourier-transform
infrared
spectroscopy.
incorporation
antibiotic
agents
ciprofloxacin
hydrochloride
gentamicin
sulfate
into
membranes
improved
already
existing
antibacterial
properties
antibiotic-free
against
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(8), P. 1822 - 1822
Published: Aug. 11, 2024
The
increase
in
the
variety
of
nano-based
tools
offers
new
possibilities
to
approach
therapy
poorly
treatable
tumors,
which
includes
glioblastoma
multiforme
(GBM;
a
primary
brain
tumor).
available
nanocomplexes
exhibit
great
potential
as
vehicles
for
targeted
delivery
anti-GBM
compounds,
including
chemotherapeutics,
nucleic
acids,
and
inhibitors.
main
advantages
nanoparticles
(NPs)
include
improved
drug
stability,
increased
penetration
blood-brain
barrier,
better
precision
tumor
targeting.
Importantly,
alongside
their
drug-delivery
ability,
NPs
may
also
present
theranostic
properties,
applications
imaging
or
photothermal
malignant
cells.
can
be
classified
into
two
categories
according
core,
metal
non-metal
based.
Among
NPs,
most
studied
regard
GBM
treatment
are
exosomes,
liposomes,
cubosomes,
polymeric
micelles,
dendrimers,
nanogels,
carbon
nanotubes,
silica-
selenium-based
NPs.
They
characterized
by
satisfactory
stability
biocompatibility,
limited
toxicity,
high
accumulation
tissue.
Moreover,
they
easily
functionalized
cargo
Therefore,
discussed
here,
offer
promising
improving
outcomes
aggressive
tumors.
Frontiers in Molecular Biosciences,
Journal Year:
2024,
Volume and Issue:
11
Published: July 30, 2024
The
result
of
infection
bone
with
microorganisms
is
osteomyelitis
and
septic
arthritis.
Methicillin-resistant
Staphylococcus
aureus
(MRSA)
responsible
for
most
its
cases
(more
than
50%).
Since
MRSA
resistant
to
many
treatments,
it
accompanied
by
high
costs
numerous
complications,
necessitating
more
effective
new
treatments.
Recently,
development
gelatin
nanoparticles
have
attracted
the
attention
scientists
biomedicine
itself,
been
utilized
as
a
delivery
vehicle
antibiotics
because
their
biocompatibility,
biodegradability,
cost-effectiveness.
Promising
results
reported
modification
combinations
chemical
agents.
Although
these
findings
suggested
that
has
potential
be
suitable
option
continuous
release
in
arthritis
treatment,
they
still
not
become
routine
clinical
practices.
deliver
antibiotic
using
gelatin-derived
composites
vancomycin
which
showed
good
efficacy.
To
date,
number
pre-clinical
studies
evaluated
utility
gelatin-based
management
osteomyelitis.
Gelatin-based
were
found
satisfactory
performance
control
infection,
well
promotion
defect
repair
chronic
models.
This
review
summarized
available
evidence
provides
insight
into
controlled
antibiotics.
