Biomimetic Natural Biomaterial Nanocomposite Scaffolds: A Rising Prospect for Bone Replacement DOI Open Access

Maja A. Zaczek-Moczydłowska,

Kamil Joszko, Mahboubeh Kavoosi

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13467 - 13467

Published: Dec. 16, 2024

Biomimetic natural biomaterial (BNBM) nanocomposite scaffolds for bone replacement can reduce the rate of implant failure and associated risks post-surgical complications patients. Traditional implants, like allografts, autografts, have limitations, such as donor site morbidity potential patient inflammation. Over two million transplant procedures are performed yearly, success varies depending on material used. This emphasizes importance developing new biomaterials replacement. Innovative BNBM nanocomposites modern fabrication promote colonization desired cellular components provide necessary mechanical properties. Recent studies highlighted advantages replacement; therefore, this review focuses application cellulose, chitosan, alginates, collagen, hyaluronic acid, synthetic polymers enhanced with nanoparticles used in regeneration work outlines most up-to-date overview perspectives selected promising that could be scaffold replace other biomorphic materials metallics, ceramics, future. In summary, concluding remarks highlight disadvantages nanocomposites, prospects, future directions tissue

Language: Английский

Hydroxyapatite–polymer nanocomposites for drug delivery applications: A mini review DOI Creative Commons

Farnaz Behmagham,

Shahad Mohammed Dhiaa,

Abbas Hameed Abdul Hussein

et al.

European Journal of Medicinal Chemistry Reports, Journal Year: 2024, Volume and Issue: unknown, P. 100231 - 100231

Published: Oct. 1, 2024

Language: Английский

Citations

4
Chitosan/hydroxyapatite hydrogels for localized drug delivery and tissue engineering: A Review DOI Creative Commons

Khashayar Khodaverdi,

Seyed Morteza Naghib, Masoud Mozafari

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2024, Volume and Issue: unknown, P. 100640 - 100640

Published: Dec. 1, 2024

Language: Английский

Citations

2
Cheminformatics-based design and biomedical applications of a new Hydroxyphenylcalix[4] resorcinarene as anti-cancer agent DOI Creative Commons
Solhe F. Alshahateet, Rakan M. Altarawneh, Salah A. Al‐Trawneh

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 13, 2024

Abstract The distinct conformational characteristics, functionality, affordability, low toxicity, and usefulness make calixarene-based compounds a promising treatment option for cancer. aim of the present study is to synthesize new compound assess its anticancer potential on some human cancer cells. synthesized C-4-Hydroxyphenylcalix[4] resorcinarene ( HPCR ) was characterized by several spectroscopic techniques such as 1HNMR, 13CNMR, X-ray crystallographic analysis confirm purity identity. IC 50 values were identified cell lines (U-87, MCF-7, A549) dermal fibroblasts line (HDF) after with standard drug Cisplatin. A significant selective growth inhibitory activity against U-87 A549 obtained at an concentration 100 μM. MOE docking module (version 2015) utilized extent inhibition four cancer-related proteins (3RJ3, 7AXD, 6DUK, 1CGL).

Language: Английский

Citations

1
Multifunctional Biocomposites: Synthesis, Characterization, and Prospects for Regenerative Medicine and Controlled Drug Delivery DOI Creative Commons
Mohamed Aaddouz, Ridouan El Yousfi, Rachid Sabbahi

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(15), P. 3483 - 3483

Published: July 25, 2024

This article presents a new method for preparing multifunctional composite biomaterials with applications in advanced biomedical fields. The consist of dicalcium phosphate (DCPD) and bioactive silicate glasses (SiO

Language: Английский

Citations

0
Biomimetic Natural Biomaterial Nanocomposite Scaffolds: A Rising Prospect for Bone Replacement DOI Open Access

Maja A. Zaczek-Moczydłowska,

Kamil Joszko, Mahboubeh Kavoosi

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13467 - 13467

Published: Dec. 16, 2024

Biomimetic natural biomaterial (BNBM) nanocomposite scaffolds for bone replacement can reduce the rate of implant failure and associated risks post-surgical complications patients. Traditional implants, like allografts, autografts, have limitations, such as donor site morbidity potential patient inflammation. Over two million transplant procedures are performed yearly, success varies depending on material used. This emphasizes importance developing new biomaterials replacement. Innovative BNBM nanocomposites modern fabrication promote colonization desired cellular components provide necessary mechanical properties. Recent studies highlighted advantages replacement; therefore, this review focuses application cellulose, chitosan, alginates, collagen, hyaluronic acid, synthetic polymers enhanced with nanoparticles used in regeneration work outlines most up-to-date overview perspectives selected promising that could be scaffold replace other biomorphic materials metallics, ceramics, future. In summary, concluding remarks highlight disadvantages nanocomposites, prospects, future directions tissue

Language: Английский

Citations

0