Assessment of artificial bone materials with different structural pore sizes obtained from 3D printed polycaprolactone/β-tricalcium phosphate (3D PCL/β-TCP) DOI
Qianjuan Zhao,

Rong Shan,

Liu Shengxi

et al.

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(6), P. 065004 - 065004

Published: Aug. 29, 2024

Abstract Artificial bone is the alternative candidate for defect treatment under circumstance that there exits enormous challenge to remedy caused by attributes like trauma and tumors. However, impact of pore size discrepancy regulating new generation still ambiguous. Using direct 3D printing technology, customized polycaprolactone/ β -tricalcium phosphate (PCL/ -TCP) artificial bones with different structural sizes (1.8, 2.0, 2.3, 2.5, 2.8 mm) were successfully prepared, abbreviated as PCL/ -TCP. -TCP exhibited a porous structure morphology similar natural possessed outstanding mechanical properties. Computational fluid dynamics analysis indicated increased from 1.8 mm, both velocity difference (from 4.64 × 10 −5 7.23 −6 m s −1 ) depressurization 7.17 −2 2.25 Pa) decreased medium passed through. In vitro biomimetic mineralization experiments confirmed could induce calcium–phosphate complex within 4 weeks. Moreover, CCK-8 Calcein AM live cell staining demonstrated advantageous compatibility, promoting MC3T3-E1 proliferation adhesion. vivo in rats further promoted formation, 2.5 mm group showing most significant effect. conclusion, promote formation was recommended repair.

Language: Английский

Eco-friendly polylactic acid/modified thermoplastic starch films enhanced with clove essential oil and cochineal for dual-functional active and intelligent food packaging DOI
Mohammad Mohammadi, Mohammad Fasihi

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123320 - 123320

Published: Jan. 1, 2025

Language: Английский

Citations

2
Influence of size and crystallinity of nanohydroxyapatite (nHA) particles on the properties of Polylactic Acid/nHA nanocomposite scaffolds produced by 3D printing DOI Creative Commons

Arthur João Reis Lima Rodovalho,

Willams Teles Barbosa, Jaqueline Leite Vieira

et al.

Journal of Materials Research and Technology, Journal Year: 2024, Volume and Issue: 30, P. 3101 - 3111

Published: April 9, 2024

Polylactic acid (PLA) and hydroxyapatite (HA) composite scaffolds have been widely studied for applications in bone tissue engineering (BTE) due to their bioactive biocompatible properties. However, there is a need more knowledge about the influence of size crystallinity HA nanoparticles (nHA) on properties PLA/nHA nanocomposite produced by 3D printing. In this study, printing was used produce PLA incorporated with nHA filler different particle sizes crystallinities. Initially, nanocomposites were prepared casting scaffolds, which characterized analysis thermal, morphological, physical-chemical, mechanical, biological vitro. The results showed that particles mainly influenced scaffolds' mechanical properties, degradation rate, bioactivity. Incorporating provided gain compressive strength compared pure PLA, superior natural cancellous bone, varies between 2 12 MPa. lower crystallinity, 39.46 %, promoted higher rate bioactivity vitro its solubility simulated fluid. All cell viability above 90 %. suitable BTE applications.

Language: Английский

Citations

5
Impact of biological environment on bending fatigue lifetime in additive-manufactured Polylactic acid fabricated by 3D-printing DOI Creative Commons

Fatemeh Zahra Hosseini,

Morteza Kianifar, Mohammad Azadi

et al.

Polymer Testing, Journal Year: 2024, Volume and Issue: 138, P. 108562 - 108562

Published: Sept. 1, 2024

Language: Английский

Citations

4
Effect of simulated body fluid on the fatigue resistance of 3D-printed PLA and PLA-wood structures under cyclic bending loading DOI
Morteza Kianifar, Mohammad Azadi, Fatemeh Heidari

et al.

International Journal of Fatigue, Journal Year: 2025, Volume and Issue: unknown, P. 108876 - 108876

Published: Feb. 1, 2025

Language: Английский

Citations

0
Mechanical and Biological Properties of Additive Manufactured Polyester‐Based Scaffolds Treated by Surface Etching DOI Open Access
Xia Gao,

Cong Yang,

Junlin Zhu

et al.

Macromolecular Chemistry and Physics, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Abstract Currently, material extrusion‐based additive manufacturing (MEAM) technique, also known as fused filament fabrication (FFF) technique has been widely used to prepare customized porous scaffolds for bone tissue engineering. However, often lack desirable osteogenic properties due the poor hydrophilicity of polymer materials FFF technique. In this work, biocompatible suitable are prepared by blending polycaprolactone (PCL), polylactic acid (PLA), and tricalcium phosphate (TCP) at various compositions. These composite subsequently printed into cylindrical with controllable pore sizes ranging from 200–800 µm, regulating infill density during process. The FFF‐printed have highest modulus a PLA/PCL ratio 0.7 size ≈ 200 µm. Furthermore, surface treatment is applied these in sodium hydroxide solution. As result, roughness, serum adsorption significantly enhanced. More importantly, surface‐treated can promote differentiation MC3T3‐E1 cells, comparable commercial Bio‐Oss substitutes. Thus, study offers cost‐effective development bioactive potential engineering applications.

Language: Английский

Citations

0
Synthesis and Characterization of Pure and Co-Substituted ß-TCP Powders DOI

Fouzi Addou,

A Yacoubi,

Mohamed El Massaoudi

et al.

Advances in environmental engineering and green technologies book series, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: March 28, 2025

According to the similarity of calcium phosphate structure with that human bone, they are most used in different medical applications. Among these bioceramics, β-TCP has very important and properties, which can be modified by several approaches, including changing chemical composition substitution. This chapter objects work on cationic substitution using magnesium (Mg) copper (Cu); this study aims synthesize pure monophasic powders other substituted bivalent ions Mg copper, aqueous precipitation method controlled amounts Mg2+ and/or Cu2+ ions. The results obtained describe variation unit cell parameters grain size nature rate.

Language: Английский

Citations

0
Highly Porous 3D Nanofibrous Scaffold of Polylactic Acid/Polyethylene Glycol/Calcium Phosphate for Bone Regeneration by a Two-Step Solution Blow Spinning (SBS) Facile Route DOI Open Access
Vanderlane C. Silva, Déborah dos Santos Gomes,

Eudes Leonnan Gomes de Medeiros

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(21), P. 3041 - 3041

Published: Oct. 29, 2024

This work presents the successful production of highly porous 3D nanofibrous hybrid scaffolds polylactic acid (PLA)/polyethylene glycol (PEG) blends with incorporation calcium phosphate (CaP) bioceramics by a facile two-step process using solution blow spinning (SBS) technique. CaP nanofibers were obtained at two calcium/phosphorus (Ca/P) ratios, 1.67 and 1.1, SBS calcination 1000 °C. They incorporated in PLA/PEG 10 20 wt% to form cotton-wool-like scaffolds. Morphological analysis showed that fibrous had randomly interconnected structure. Also, mean fiber diameter ranged from 408 ± 141 nm 893 496 nm. Apatite deposited considerably within 14 days simulated body fluid (SBF) test for containing mix hydroxyapatite (HAp) tri-calcium phosphate-β (β-TCP) phases. The Ca/P ration 1.1 better vitro bioactivity induce mineralization bone regeneration. Cellular tests evidenced developed can support osteogenic differentiation proliferation pre-osteoblastic MC3T3-E1 cells into mature osteoblasts. results have potential applications tissue engineering.

Language: Английский

Citations

3
Review of the Synthesis and Degradation Mechanisms of Some Biodegradable Polymers in Natural Environments DOI Open Access
Xiao Yao, Xue Yang, Yisang Lu

et al.

Polymers, Journal Year: 2024, Volume and Issue: 17(1), P. 66 - 66

Published: Dec. 30, 2024

The escalating demand for sustainable materials has been fueling the rapid proliferation of biopolymer market. Biodegradable polymers within natural habitats predominantly undergo degradation mediated by microorganisms. These microorganisms secrete enzymes that cleave long-chain into smaller fragments metabolic assimilation. This review is centered around dissecting mechanisms specific biodegradable polymers, namely PLA, starch-based and plant fiber-based polymers. Recent investigations have unveiled PLA exhibits augmented biocompatibility when combined with HA, its subject to influence enzymatic abiotic determinants. In case chemical or physical modifications can modulate their kinetics, as evidenced Wang et al.’s superhydrophobic nanocomposite cryogel. For effects temperature, humidity, cellulose on properties, along implications various treatments additives, are probed, exemplified Liu study jute/SiO2/PP composites. Specifically, respect polymerization process role catalysts such SnCl2 in governing structure biodegradability expounded detail. SBF interaction β-TCP particles constitute crucial aspects. catalyzed amylase glucosidase environmental impacts temperature addition structural ramifications amylose amylopectin, further elucidated. biodegradation plasma treatment, electron beam irradiation, nanoparticles, crosslinking agents water resistance stability explicated experimental substantiation. manuscript also delineates technological accomplishments. incorporated HA demonstrates enhanced finds utility drug delivery systems. Starch-based be engineered tailored degradation. Plant acquire durability through thereby widening application spectrum. Synthetic surface modification methodologies harnessed optimize these materials. paper consolidates reaction conditions, research techniques, merits, demerits delves A comprehensive understanding conducive progression context development conservation.

Language: Английский

Citations

2
Assessment of artificial bone materials with different structural pore sizes obtained from 3D printed polycaprolactone/β-tricalcium phosphate (3D PCL/β-TCP) DOI
Qianjuan Zhao,

Rong Shan,

Liu Shengxi

et al.

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(6), P. 065004 - 065004

Published: Aug. 29, 2024

Abstract Artificial bone is the alternative candidate for defect treatment under circumstance that there exits enormous challenge to remedy caused by attributes like trauma and tumors. However, impact of pore size discrepancy regulating new generation still ambiguous. Using direct 3D printing technology, customized polycaprolactone/ β -tricalcium phosphate (PCL/ -TCP) artificial bones with different structural sizes (1.8, 2.0, 2.3, 2.5, 2.8 mm) were successfully prepared, abbreviated as PCL/ -TCP. -TCP exhibited a porous structure morphology similar natural possessed outstanding mechanical properties. Computational fluid dynamics analysis indicated increased from 1.8 mm, both velocity difference (from 4.64 × 10 −5 7.23 −6 m s −1 ) depressurization 7.17 −2 2.25 Pa) decreased medium passed through. In vitro biomimetic mineralization experiments confirmed could induce calcium–phosphate complex within 4 weeks. Moreover, CCK-8 Calcein AM live cell staining demonstrated advantageous compatibility, promoting MC3T3-E1 proliferation adhesion. vivo in rats further promoted formation, 2.5 mm group showing most significant effect. conclusion, promote formation was recommended repair.

Language: Английский

Citations

0