Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(39)
Published: Aug. 20, 2024
Abstract
Hydrogel
sensors
are
widely
utilized
in
soft
robotics
and
tissue
engineering
due
to
their
excellent
mechanical
properties
biocompatibility.
However,
high‐water
environments,
traditional
hydrogels
can
experience
significant
swelling,
leading
decreased
electrical
performance,
potentially
losing
shape,
sensing
capabilities.
This
study
addresses
these
challenges
by
leveraging
the
Hofmeister
effect,
coupled
with
directional
freezing
salting‐out
techniques,
develop
a
layered,
high‐strength,
tough,
antiswelling
PVA/MXene
hydrogel.
In
particular,
process
enhances
self‐entanglement
of
PVA,
resulting
an
S‐PM
hydrogel
tensile
strength
up
2.87
MPa.
Furthermore,
retains
its
structure
after
7
d
only
6%
change
resistance.
Importantly,
performance
is
improved
postswelling,
capability
rarely
achievable
hydrogels.
Moreover,
demonstrates
faster
response
times
more
stable
resistance
rates
underwater
tests,
making
it
crucial
for
long‐term
continuous
monitoring
challenging
aquatic
ensuring
sustained
operation
monitoring.
Chemical Society Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Hydrogels
are
emerging
as
promising
candidates
for
brain–computer
interfaces.
This
review
highlights
the
current
advancements
in
implantable
hydrogel
electrodes
neural
signal
recording,
neuromodulation,
and
brain
disorder
treatment.
Journal of Polymer Engineering,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
Abstract
This
study
presents
a
quantitative
assessment
of
cross-linked
polyvinyl
alcohol
(PVA)
granules
as
sensing
elements
for
detecting
aliphatic
carboxylic
acids
and
their
sodium
salts
in
aqueous
solutions.
Swelling
kinetics
were
measured
across
solute
concentrations
ranging
from
0.2
N
to
1.0
N,
with
the
granule
radius
varying
between
0.31-
0.43-mm.
Results
indicated
that
both
carbon
chain
length
presence
additional
carboxyl
groups
exert
pronounced
effect
on
equilibrium
swelling
degree,
thereby
highlighting
interplay
hydrophobic
interactions
hydrogen-bond
formation.
To
interpret
these
observations,
heterophase
physicomathematical
model
was
employed,
yielding
three
main
kinetic
coefficients
(K
1
,
K
2
3
)
capture
solvent
flux,
polymer
network
elasticity,
transport.
The
fits
exhibited
root-mean-square
deviations
below
%,
attesting
its
reliability
describing
complex
-
deswelling
processes.
Additionally,
three-dimensional
surfaces
constructed
illustrate
how
evolves
over
time
concentration,
revealing
initial
curves
can
serve
rapid
indicator
concentration.
By
leveraging
reversible
nature
swelling,
this
method
offers
non-invasive,
cost-effective
approach
suitable
monitoring
organic
diverse
fields
such
environmental
analysis,
pharmaceutical
processes,
chemical
engineering.
Hydrogel-based
sensors
typically
demonstrate
conspicuous
swelling
behavior
in
aqueous
environments,
which
can
severely
compromise
the
mechanical
integrity
and
distort
sensing
signals,
thereby
considerably
constraining
their
widespread
applicability.
Drawing
inspiration
from
multilevel
heterogeneous
structures
biological
tissues,
an
antiswelling
hydrogel
sensor
endowed
with
high
strength,
rapid
self-recovery,
low
ratio
was
fabricated
through
a
water-induced
phase
separation
coordination
cross-linking
strategy.
A
dense
architecture
developed
by
integration
of
"rigid"
quadridentate
carboxyl-Zr4+
bonds
"soft"
hydrophobic
unit-rich
regions
featuring
π-π
stacking
cation-π
interactions
into
hydrogels.
This
unique
structural
design
facilitated
progressive
breaking
cross-links
within
network
to
under
external
loads,
effectively
dissipating
energy
imparting
hydrogels
exceptional
characteristics,
evidenced
strength
1.42
MPa,
complete
self-recovery
3
min.
Simultaneously,
dynamic
synergistically
conferred
augmented
elastic
retractive
forces
on
enhancing
density,
providing
prominent
capabilities
water
(with
only
-2.49%),
solutions
diverse
pH
(1-9),
seawater.
Moreover,
manifested
favorable
strain-sensitivity
(gauge
factor
up
2.45)
frequency
response
virtue
collaborative
contribution
ions
(Cl-
Zr4+).
Consequently,
were
utilized
assemble
underwater
capacity
transmit
information
using
Morse
code.
bioinspired
methodology
achieved
desired
mechanical,
swelling-resistant,
performance
hydrogels,
contributing
innovative
insights
toward
advancement
technology.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 3, 2025
Intra-articular
drug
injections
are
effective
for
osteoarthritis
(OA),
but
challenges
such
as
the
complex
microenvironment
and
rapid
diffusion
require
frequent
injections.
Herein,
we
propose
a
biofunctional
hydrogel-based
strategy
prolonged
delivery
remodeling.
We
to
functionalize
zeolitic
imidazolate
framework-8
with
tannic
acid
(TA-ZIF),
anchor
PTH-related
peptide-1
(PTHrP-1)
within
this
framework
(TA-ZIF@P1)
incorporate
phenylboronic
acid-modified
gelatin-based
hydrogel
(GP
hydrogel)
system
(GP@TA-ZIF@P1,
GPTP
responsive
release
properties
that
respond
pathological
microenvironments
of
OA.
The
facilitated
controlled,
sustained
PTHrP-1
via
dynamic
boronic
esters,
in
vitro
vivo
studies
showing
continuous
over
28
days.
It
not
only
promotes
chondrocyte
proliferation
also
exhibits
significant
cytoprotective
effects
under
hyperactive
ROS
IL-1β-induced
conditions.
Notably,
transcriptome
sequencing
confirms
facilitates
both
chondrogenesis
inflammatory
conditions
by
deactivating
Wnt/β-Catenin
signaling
pathways
enhancing
PI3K/AKT
pathway.
Additionally,
delays
catabolic
metabolism
cartilage
explants
from
mice
environments.
In
surgical
model
mouse
OA,
show
intra-articular
injection
hydrogels
reduced
periarticular
bone
remodeling
promoted
production
glycosaminoglycans
while
offering
chondroprotection
against
degeneration.
To
sum
up,
pioneering
research
on
treatment
combined
system,
offers
valuable
insights
paradigm
controlled
PTHrP-1,
representing
advancement
OA
strategies.
