Recent Advances in the Use of Vitamin D Organic Nanocarriers for Drug Delivery

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1090 - 1090

Published: Aug. 30, 2024

Nanotechnology, now established as a transformative technology, has revolutionized medicine by enabling highly targeted drug delivery. The use of organic nanocarriers in delivery systems significantly enhances the bioavailability vitamins and their analogs, thereby improving cellular therapeutic effects. Vitamin D, known for its crucial role bone health, also influences various metabolic functions, such proliferation, differentiation, immunomodulation, is increasingly explored anticancer potential. Given versatile properties biocompatibility, vitamin D an attractive candidate encapsulation within systems. This review provides comprehensive overview synthesis, metabolism, signaling, well applications customized Moreover, it examines design engineering that incorporate discusses advances this field, including synergistic effects achieved through combination with other agents. By highlighting these innovations, valuable insights into development advanced potential to enhance outcomes.

Language: Английский

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3D-printed polycaprolactone scaffolds functionalized with poly(lactic-co-glycolic) acid microparticles enhance bone regeneration through tunable drug release

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Marine L-Arginase encapsulated in Poly (lactic-co-glycolic acid) Nanoparticles: A Novel Anti-Tumor Strategy for Effective Hepatocellular carcinoma Treatment In Vitro and In Vivo

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106980 - 106980

Published: April 1, 2025

Language: Английский

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Opportunities and Challenges for Nanomaterials as Vaccine Adjuvants

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Abstract Adjuvants, as a critical component of vaccines, are capable eliciting more robust and sustained immune responses. Nanomaterials have shown unique advantages broad application prospects in adjuvant development due to their high adjustability distinctive physicochemical properties. This review focuses on nanoadjuvants immunological mechanisms. First, various types adjuvants introduced with an emphasis metal oxide nanoparticles, coordination polymers, liposomes, polymer other inorganic nanoparticles that can serve vaccine adjuvants. Second, this describes the current status clinical applications nanoadjuvants. Next, mechanisms action for been thoroughly elucidated, including depot effect, NLRP3 inflammasome activation, targeting C‐type lectin receptors, activation toll‐like cGAS‐STING signaling pathway. Finally, challenges opportunities associated also addressed.

Language: Английский

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An Updated Review Summarizing the Anticancer Potential of Poly(Lactic‐co‐Glycolic Acid) (PLGA) Based Curcumin, Epigallocatechin Gallate, and Resveratrol Nanocarriers

Biopolymers, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

ABSTRACT The utilization of nanoformulations derived from natural products for the treatment many human diseases, including cancer, is a rapidly developing field. Conventional therapies used cancer have limited efficacy and greater number adverse effects. Hence, it imperative to develop innovative anticancer drugs with superior effectiveness. Among diverse array compounds, resveratrol, curcumin, epigallocatechin gallate (EGCG) gained considerable attention in recent years. Despite their strong properties, medicinally significant phytochemicals such as EGCG certain disadvantages, solubility water, stability, bioavailability problems. Encapsulating these poly(lactic‐ co ‐glycolic acid) (PLGA), polymer that nontoxic, biodegradable, biocompatible, an effective method delivering medication tumor location. In addition, PLGA nanoparticles can be modified targeting molecules specifically target cells, thereby improving effectiveness fighting tumors. Combining plant‐based medicine (phytotherapy) nanotechnology clinical environment has potential enhance improve overall health outcomes patients. Therefore, crucial comprehensive understanding different aspects advancements using PLGA‐based nanocarriers phytochemicals. This review addresses most delivery systems EGCG, emphasizing possibility resolving issues related therapeutic compounds.

Language: Английский

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Transferrin-Conjugated Polymeric Nanoparticles for Receptor-Mediated Delivery of Resveratrol-Cyclodextrin Complex in Non-Small Cell Lung Cancer (NSCLC) Cells

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106588 - 106588

Published: Dec. 1, 2024

Language: Английский

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Biomimetic etoposide-loaded PLGA nanoparticles induce immunogenic cell death against colorectal cancer

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106349 - 106349

Published: Oct. 1, 2024

Language: Английский

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Research progress and prospect of tumor nanovaccine combination therapy strategy

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110771 - 110771

Published: Dec. 1, 2024

Language: Английский

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