Role of Biomaterials in Promoting Wound Healing DOI
Saeedeh Zare Jalise, Mohsen Sheykhhasan

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 367 - 412

Published: April 25, 2025

Because biomaterials can improve tissue repair and regeneration, their use in wound healing has drawn much attention. Biomaterials facilitate cellular connections, create favorable microenvironments, offer mechanical support, making them vital for promoting healing. These materials fall into three categories: natural, synthetic, hybrid. Natural polymers such as collagen, alginate, chitosan mimic the extracellular matrix biocompatibility, while synthetic like PLGA provide adjustable qualities strength degradation rates. Advanced hydrogels, nanoparticles, electrospun fibers enhance moisture retention, control drug release, reduce infection. They release bioactive chemicals growth factors antimicrobial peptides, preventing chronic wounds. This chapter examines various used healing, therapeutic uses, modes of action, well future developments challenges design, scalability.

Language: Английский

Potential of Chitosan/Gelatin-Based Nanofibers in Delivering Drugs for the Management of Varied Complications: A Review DOI Open Access
Popat Mohite, Abhijeet Puri, Shubham Munde

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(4), P. 435 - 435

Published: Feb. 7, 2025

Drug delivery systems have revolutionized traditional drug administration methods by addressing various challenges, such as enhancing solubility, prolonging effectiveness, minimizing adverse effects, and preserving potency. Nanotechnology-based systems, particularly nanoparticles (NPs) nanofibers (NFs), emerged promising solutions for biomedicine delivery. NFs, with their ability to mimic the porous fibrous structures of biological tissues, garnered significant interest in drug-delivering applications. Biopolymers gelatin (Ge) chitosan (CH) gained much more attention due biocompatibility, biodegradability, versatility biomedical CH exhibits exceptional anti-bacterial activity, wound healing capabilities, whereas Ge provides good biocompatibility cell adhesion properties. Ge/CH-based NFs stimulate cellular connections facilitate tissue regeneration owing structural resemblance extracellular matrix. This review explores additive preparation, including electrospinning, force pinning, template synthesis, focusing on electrospinning factors influencing fiber structure. The properties CH, role release, formulation strategies, characterization techniques electrospun fibers are discussed. Furthermore, this addresses applications delivering active moieties management orthopedics regulatory considerations, along challenges related them. Thus, aims provide a comprehensive overview potential

Language: Английский

Citations

3
Fabrication of Chitosan/PEO/Rosmarinic acid based nanofibrous mat for diabetic burn wound healing and its anti-bacterial efficacy in mice DOI

Farhin Khan,

Bidya Mondal,

Baishakhi Bairagi

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140416 - 140416

Published: Jan. 1, 2025

Language: Английский

Citations

0
Fabrication and in Vivo Evaluation of Hybrid Squalene-Loaded Nanofiber Scaffolds Based on Poly(ε-Caprolactone)/Polyvinyl Alcohol/Chitosan for Wound Healing Applications DOI
Fariba Noori, Azam Bozorgi,

Ahmad Reza Farmani

et al.

Journal of Polymers and the Environment, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Language: Английский

Citations

0
Tri-layer gradient fibre-aligned electrospun composite: Accelerating skin wound healing DOI
Limin Gong, Hongli Ma, Hui Fang

et al.

Materials Today Communications, Journal Year: 2025, Volume and Issue: 45, P. 112320 - 112320

Published: April 1, 2025

Language: Английский

Citations

0
Safety and feasibility of electrospinning technology for pediatric burns: Insights from a retrospective cohort study DOI Creative Commons
Or Givol, Michelle Cleary, Rachel Kornhaber

et al.

Burns, Journal Year: 2025, Volume and Issue: unknown, P. 107509 - 107509

Published: April 1, 2025

Language: Английский

Citations

0
Nanofiber Application in Wound Healing DOI
Fatimah Ahmedy,

Nur Syazana Aqila Mhd Sazuli,

Lubna Abdul Kadir

et al.

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 289 - 326

Published: April 11, 2025

Nanofiber technology presents significant potential across various medical applications, with particular emphasis on its role in wound healing. This chapter examines the ability of nanofibers to mimic extracellular matrix, facilitating critical processes such as cell adhesion, migration, nutrient and oxygen delivery, inflammation modulation, controlled release bioactive molecules. These properties position optimal candidates for advanced dressings, biodegradable scaffolds, cell-seeded constructs. Empirical studies substantiate their efficacy mitigating inflammation, preventing infections, minimizing scar formation. However, challenges persist, including issues related scalability, cost-effectiveness, mechanical stability, biocompatibility, regulatory approval. concludes by addressing these outlining research gaps that must be bridged fully harness nanofiber technology, particularly long-term safety, mechanistic insights, adaptation low-resource settings.

Language: Английский

Citations

0
Role of Biomaterials in Promoting Wound Healing DOI
Saeedeh Zare Jalise, Mohsen Sheykhhasan

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 367 - 412

Published: April 25, 2025

Because biomaterials can improve tissue repair and regeneration, their use in wound healing has drawn much attention. Biomaterials facilitate cellular connections, create favorable microenvironments, offer mechanical support, making them vital for promoting healing. These materials fall into three categories: natural, synthetic, hybrid. Natural polymers such as collagen, alginate, chitosan mimic the extracellular matrix biocompatibility, while synthetic like PLGA provide adjustable qualities strength degradation rates. Advanced hydrogels, nanoparticles, electrospun fibers enhance moisture retention, control drug release, reduce infection. They release bioactive chemicals growth factors antimicrobial peptides, preventing chronic wounds. This chapter examines various used healing, therapeutic uses, modes of action, well future developments challenges design, scalability.

Language: Английский

Citations

0